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MAPK13 Gene Record

  • Summary
  • Interactions
  • Claims
  • MAPK13 5603 Druggable Genome

    Alternate Names:

    5603
    MITOGEN-ACTIVATED PROTEIN KINASE 13
    MAPK13
    MAPK 13
    MAPK-13
    PRKM13
    SAPK4
    p38delta
    602899
    6875
    ENSG00000156711
    OTTHUMG00000014587
    PA30620
    O15264
    MK13_HUMAN
    MITOGEN-ACTIVATED PROTEIN KINASE 13 (EC 2.7.1.37) (STRESS-ACTIVATED PROTEIN KINASE-4) (MITOGEN-ACTIVATED PROTEIN KINASE P38 DELTA) (MAP KINASE P38 DELTA). [SOURCE:UNIPROT/SWISSPROT;ACC:O15264]

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:2.7.11.24
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002290
    Human Readable Name KINASE
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
    Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod
    Olajide OA et al., 2013, Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition., Eur J Med Chem
    Jnawali HN et al., 2014, Anti-inflammatory activity of rhamnetin and a model of its binding to c-Jun NH2-terminal kinase 1 and p38 MAPK., J Nat Prod
    Chen WY et al., 2015, Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro., J Nat Prod
    Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
    Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod
    Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
  • CRYPTOLEPINE HYDROCHLORIDE   MAPK13

    Interaction Score: 1.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23507189


    Sources:
    DTC

  • DIHYDROTANSHINONE I   MAPK13

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26339922


    Sources:
    DTC

  • MILTIRONE   MAPK13

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26339922


    Sources:
    DTC

  • CHEMBL8483   MAPK13

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18566250


    Sources:
    DTC

  • XANTHOHUMOL   MAPK13

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22111577


    Sources:
    DTC

  • OPHIOBOLIN O   MAPK13

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22130129


    Sources:
    DTC

  • KERACYANIN   MAPK13

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17360708


    Sources:
    DTC

  • BMS-582949   MAPK13

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name BMS-582949
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ARRY-797   MAPK13

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name ARRY-797

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • RHAMNETIN   MAPK13

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24397781


    Sources:
    DTC

  • PH-797804   MAPK13

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name PH-797804

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • SEMAPIMOD   MAPK13

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name CPSI-2364
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PEXMETINIB   MAPK13

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name ARRY-614
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PIRFENIDONE   MAPK13

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name pirfenidone,Esbriet , Deskar, Pirespa
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • VX-702   MAPK13

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name VX-702

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • SB-203580   MAPK13

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25692815


    Sources:
    DTC

  • DORAMAPIMOD   MAPK13

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SORAFENIB   MAPK13

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20124951


    Sources:
    PharmGKB

  • SNS-314   MAPK13

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL225519   MAPK13

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LINIFANIB   MAPK13

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • R-406   MAPK13

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ILORASERTIB   MAPK13

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000156711

    • Version: 101_38

    Alternate Names:
    MAPK13 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000156711

    • Version: 26-July-2011

    Alternate Names:
    MITOGEN-ACTIVATED PROTEIN KINASE 13 (EC 2.7.1.37) (STRESS-ACTIVATED PROTEIN KINASE-4) (MITOGEN-ACTIVATED PROTEIN KINASE P38 DELTA) (MAP KINASE P38 DELTA). [SOURCE:UNIPROT/SWISSPROT;ACC:O15264] Description
    MAPK13 Display Id
    ENSG00000156711 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: O15264

    • Version: January-2014

    Alternate Names:
    MAPK13 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.24

    Publications:

  • HopkinsGroom: O15264

    • Version: 11-September-2012

    Alternate Names:
    MK13_HUMAN Uniprot Id
    ENSG00000156711 Ensembl Gene Id
    5603 Entrez Gene Id

    Gene Info:
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002290

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • PharmGKB: MAPK13

    • Version: 18-August-2020

    Alternate Names:
    PA30620 PharmGKB ID

    Gene Info:

    Publications:
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

  • DTC: MAPK13

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
    Chen WY et al., 2015, Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro., J Nat Prod
    Jnawali HN et al., 2014, Anti-inflammatory activity of rhamnetin and a model of its binding to c-Jun NH2-terminal kinase 1 and p38 MAPK., J Nat Prod

  • HingoraniCasas: ENSG00000156711

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000156711 Gene Symbol
    MAPK13 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: MAPK13

    • Version: 01-February-2022

    Alternate Names:
    PRKM13 GO Gene Synonym
    SAPK4 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • dGene: MAPK13

    • Version: 27-Jun-2013

    Alternate Names:
    5603 Gene ID
    PRKM13 dGene Synonym
    SAPK4 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • Pharos: MAPK13

    • Version: 01-February-2022

    Alternate Names:
    Mitogen-activated protein kinase 13 Gene Name
    O15264 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21