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MAPK12 Gene Record

  • Summary
  • Interactions
  • Claims
  • MAPK12 6300 Druggable Genome

    Alternate Names:

    6300
    MITOGEN-ACTIVATED PROTEIN KINASE 12
    MAPK12
    ERK-6
    ERK3
    ERK6
    MAPK 12
    P38GAMMA
    PRKM12
    SAPK-3
    SAPK3
    602399
    6874
    ENSG00000188130
    OTTHUMG00000030145
    P53778
    MK12_HUMAN
    MITOGEN-ACTIVATED PROTEIN KINASE 12 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 6) (ERK-6) (ERK5) (STRESS-ACTIVATED PROTEIN KINASE-3) (MITOGEN-ACTIVATED PROTEIN KINASE P38 GAMMA) (MAP KINASE P38 GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P53778]
    PA30619
    MAP KINASE P38
    1501
    BE0002790
    NP_002960
    XM_003846644
    T79798

    Gene Info:

    Interpro Acc IPR002290
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Human Readable Name KINASE
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Target Class Enzymes
    Target Subclass EC:2.7.11.24
    GuideToPharmacology Gene Category Name p38 subfamily
    GuideToPharmacology Gene Category ID 519
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

    Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
    Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod
    Jnawali HN et al., 2014, Anti-inflammatory activity of rhamnetin and a model of its binding to c-Jun NH2-terminal kinase 1 and p38 MAPK., J Nat Prod
    Olajide OA et al., 2013, Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition., Eur J Med Chem
    Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
    Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem
    Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
    Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod
    Chen WY et al., 2015, Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro., J Nat Prod
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
  • CRYPTOLEPINE HYDROCHLORIDE   MAPK12

    Interaction Score: 1.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23507189


    Sources:
    DTC

  • ARRY-797   MAPK12

    Interaction Score: 1.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name ARRY-797
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • DIHYDROTANSHINONE I   MAPK12

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26339922


    Sources:
    DTC

  • MILTIRONE   MAPK12

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26339922


    Sources:
    DTC

  • PH-797804   MAPK12

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name PH-797804
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    DTC TdgClinicalTrial

  • CHEMBL8483   MAPK12

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18566250


    Sources:
    DTC

  • OPHIOBOLIN O   MAPK12

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22130129


    Sources:
    DTC

  • XANTHOHUMOL   MAPK12

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22111577


    Sources:
    DTC

  • VALZIFLOCEPT   MAPK12

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • KERACYANIN   MAPK12

    Interaction Score: 0.6

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17360708


    Sources:
    DTC

  • BMS-582949   MAPK12

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name BMS-582949
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • RHAMNETIN   MAPK12

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24397781


    Sources:
    DTC

  • NEFLAMAPIMOD   MAPK12

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SEMAPIMOD   MAPK12

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name CPSI-2364

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PIRFENIDONE   MAPK12

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name pirfenidone,Esbriet , Deskar, Pirespa
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • VX-702   MAPK12

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name VX-702
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • CEP-1347   MAPK12

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • DORAMAPIMOD   MAPK12

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    DTC GuideToPharmacology

  • SB-203580   MAPK12

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25692815


    Sources:
    DTC

  • PEXMETINIB   MAPK12

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name ARRY-614
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • SB-202190   MAPK12

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22951114


    Sources:
    DTC

  • CI-1040   MAPK12

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SORAFENIB   MAPK12

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20124951


    Sources:
    PharmGKB

  • CHEMBL225519   MAPK12

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • R-406   MAPK12

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYC-116   MAPK12

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   MAPK12

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000188130

    • Version: 101_38

    Alternate Names:
    MAPK12 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P53778

    • Version: 11-September-2012

    Alternate Names:
    MAPK12 Uniprot Gene Name
    6300 Entrez Gene Id
    MK12_HUMAN Uniprot Id

    Gene Info:
    Interpro Acc IPR002290
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Interpro Type Domain

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P53778

    • Version: January-2014

    Alternate Names:
    MAPK12 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.24

    Publications:

  • RussLampel: ENSG00000188130

    • Version: 26-July-2011

    Alternate Names:
    MAPK12 Display Id
    MITOGEN-ACTIVATED PROTEIN KINASE 12 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 6) (ERK-6) (ERK5) (STRESS-ACTIVATED PROTEIN KINASE-3) (MITOGEN-ACTIVATED PROTEIN KINASE P38 GAMMA) (MAP KINASE P38 GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P53778] Description
    ENSG00000188130 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 6300

    • Version: 29-September-2020

    Alternate Names:
    6874 HUGO Gene ID
    6874 HUGO Gene Symbol
    mitogen-activated protein kinase 12 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name p38 subfamily
    GuideToPharmacology Gene Category ID 519

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: MAPK12

    • Version: 18-August-2020

    Alternate Names:
    PA30619 PharmGKB ID

    Gene Info:

    Publications:
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

  • DTC: MAPK12

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
    Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem
    Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod

  • HingoraniCasas: ENSG00000188130

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000188130 Gene Symbol
    MAPK12 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: MAPK12

    • Version: 19.3

    Alternate Names:
    ENSG00000188130 Ensembl Gene ID
    ERK6 Human Protein Atlas Gene Synonym
    p38gamma Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: MAPK12

    • Version: 03-September-2020

    Alternate Names:
    Mitogen-activated protein kinase 12 Gene Name
    P53778 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • GO: MAPK12

    • Version: 05-September-2020

    Alternate Names:
    ERK6 GO Gene Synonym
    SAPK3 GO Gene Synonym

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications:

  • dGene: MAPK12

    • Version: 27-Jun-2013

    Alternate Names:
    6300 Gene ID
    ERK3 dGene Synonym
    ERK6 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • DrugBank: BE0002790

    • Version: 5.1.7

    Alternate Names:
    MAPK12 DrugBank Gene Name
    P53778 UniProt Accession
    6300 Entrez Gene Id

    Gene Info:

    Publications:

  • TTD: MAP kinase p38

    • Version: 2020.06.01

    Alternate Names:
    MAPK12 TTD Gene Abbreviation
    T79798 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21