DGIdb - MAPK12 Gene Record

MAPK12 6300 Druggable Genome

Alternate Names:

6300
MITOGEN-ACTIVATED PROTEIN KINASE 12
MAPK12
ERK-6
ERK3
ERK6
MAPK 12
P38GAMMA
PRKM12
SAPK-3
SAPK3
602399
6874
ENSG00000188130
OTTHUMG00000030145
P53778
MK12_HUMAN
MITOGEN-ACTIVATED PROTEIN KINASE 12 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 6) (ERK-6) (ERK5) (STRESS-ACTIVATED PROTEIN KINASE-3) (MITOGEN-ACTIVATED PROTEIN KINASE P38 GAMMA) (MAP KINASE P38 GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P53778]
PA30619
MAP KINASE P38
T79798

Gene Info:

Interpro Acc	IPR002290
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Human Readable Name	KINASE
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Target Class	Enzymes
Target Subclass	EC:2.7.11.24
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

TUMOR SUPPRESSOR
KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod
Jnawali HN et al., 2014, Anti-inflammatory activity of rhamnetin and a model of its binding to c-Jun NH2-terminal kinase 1 and p38 MAPK., J Nat Prod
Olajide OA et al., 2013, Anti-neuroinflammatory properties of synthetic cryptolepine in human neuroblastoma cells: possible involvement of NF-κB and p38 MAPK inhibition., Eur J Med Chem
Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem
Kravchenko VV et al., 2008, Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule., Science
Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod
Chen WY et al., 2015, Sesamol reduces the atherogenicity of electronegative L5 LDL in vivo and in vitro., J Nat Prod
Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

CRYPTOLEPINE HYDROCHLORIDE MAPK12

Interaction Score: 1.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23507189

Sources:
DTC
ARRY-797 MAPK12

Interaction Score: 1.19

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ARRY-797

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
DIHYDROTANSHINONE I MAPK12

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26339922

Sources:
DTC
MILTIRONE MAPK12

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26339922

Sources:
DTC
PH-797804 MAPK12

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name PH-797804

Novel drug target Novel Target

PMIDs:
None found

Sources:
DTC TdgClinicalTrial
CHEMBL8483 MAPK12

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18566250

Sources:
DTC
OPHIOBOLIN O MAPK12

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22130129

Sources:
DTC
XANTHOHUMOL MAPK12

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22111577

Sources:
DTC
VALZIFLOCEPT MAPK12

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
KERACYANIN MAPK12

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17360708

Sources:
DTC
BMS-582949 MAPK12

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-582949

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
RHAMNETIN MAPK12

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24397781

Sources:
DTC
NEFLAMAPIMOD MAPK12

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SEMAPIMOD MAPK12

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name CPSI-2364

PMIDs:
None found

Sources:
TdgClinicalTrial
PEXMETINIB MAPK12

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ARRY-614

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
VX-702 MAPK12

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name VX-702

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
PIRFENIDONE MAPK12

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pirfenidone,Esbriet , Deskar, Pirespa

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
SB-203580 MAPK12

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25692815

Sources:
DTC
SB-202190 MAPK12

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22951114

Sources:
DTC
DORAMAPIMOD MAPK12

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DTC
CI-1040 MAPK12

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SORAFENIB MAPK12

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20124951

Sources:
PharmGKB
CHEMBL225519 MAPK12

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 MAPK12

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 MAPK12

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 MAPK12

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000188130
- Version: 101_38
Alternate Names:

MAPK12 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P53778
- Version: 11-September-2012
Alternate Names:

MAPK12 Uniprot Gene Name

6300 Entrez Gene Id

MK12_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR002290

Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Interpro Type Domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P53778
- Version: January-2014
Alternate Names:

MAPK12 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.24

Publications:

RussLampel: ENSG00000188130

Version: 26-July-2011

Alternate Names:

MAPK12 Display Id

MITOGEN-ACTIVATED PROTEIN KINASE 12 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 6) (ERK-6) (ERK5) (STRESS-ACTIVATED PROTEIN KINASE-3) (MITOGEN-ACTIVATED PROTEIN KINASE P38 GAMMA) (MAP KINASE P38 GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P53778] Description

ENSG00000188130 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: MAPK12
- Version: 18-August-2020
Alternate Names:

PA30619 PharmGKB ID

Gene Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

DTC: MAPK12

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem

Feng R et al., 2007, Cyanidin-3-rutinoside, a natural polyphenol antioxidant, selectively kills leukemic cells by induction of oxidative stress., J Biol Chem

Zhou X et al., 2015, Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells., J Nat Prod

HingoraniCasas: ENSG00000188130
- Version: 31-May-2017
Alternate Names:

ENSG00000188130 Gene Symbol

MAPK12 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: MAPK12
- Version: 19.3
Alternate Names:

ENSG00000188130 Ensembl Gene ID

ERK6 Human Protein Atlas Gene Synonym

p38gamma Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: MAPK12
- Version: 01-February-2022
Alternate Names:

ERK6 GO Gene Synonym

SAPK3 GO Gene Synonym

Gene Info:

Gene Categories:

TUMOR SUPPRESSOR, SERINE THREONINE KINASE

Publications:
dGene: MAPK12
- Version: 27-Jun-2013
Alternate Names:

6300 Gene ID

ERK3 dGene Synonym

ERK6 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: MAP kinase p38
- Version: 2020.06.01
Alternate Names:

MAPK12 TTD Gene Abbreviation

T79798 TTD Target ID

Gene Info:

Publications:
Pharos: MAPK12
- Version: 01-February-2022
Alternate Names:

Mitogen-activated protein kinase 12 Gene Name

P53778 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:

Trial Name	pirfenidone,Esbriet , Deskar, Pirespa
Novel drug target	Novel Target

MAPK12	Uniprot Gene Name
6300	Entrez Gene Id
MK12_HUMAN	Uniprot Id

MAPK12	Display Id
MITOGEN-ACTIVATED PROTEIN KINASE 12 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 6) (ERK-6) (ERK5) (STRESS-ACTIVATED PROTEIN KINASE-3) (MITOGEN-ACTIVATED PROTEIN KINASE P38 GAMMA) (MAP KINASE P38 GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P53778]	Description
ENSG00000188130	Ensembl Gene Id

Mitogen-activated protein kinase 12	Gene Name
P53778	UniProt ID

MAPK12 Gene Record

MAPK12 6300 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23507189

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ARRY-797 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26339922

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26339922

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name PH-797804 Novel drug target Novel Target

PMIDs: None found

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18566250

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22130129

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22111577

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17360708

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name BMS-582949 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24397781

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name CPSI-2364

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ARRY-614 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name VX-702 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name pirfenidone,Esbriet , Deskar, Pirespa Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25692815

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
23507189

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ARRY-797

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
26339922

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26339922

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name PH-797804

Novel drug target Novel Target

PMIDs:
None found

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
18566250

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22130129

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22111577

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
17360708

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BMS-582949

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
24397781

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name CPSI-2364

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ARRY-614

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name VX-702

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pirfenidone,Esbriet , Deskar, Pirespa

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
25692815

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22951114

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
20124951

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a