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MAPK12 6300 Druggable Genome
Alternate Names:
6300 MITOGEN-ACTIVATED PROTEIN KINASE 12 MAPK12 ERK-6 ERK3 ERK6 MAPK 12 P38GAMMA PRKM12 SAPK-3 SAPK3 602399 6874 ENSG00000188130 OTTHUMG00000030145 P53778 MK12_HUMAN MITOGEN-ACTIVATED PROTEIN KINASE 12 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 6) (ERK-6) (ERK5) (STRESS-ACTIVATED PROTEIN KINASE-3) (MITOGEN-ACTIVATED PROTEIN KINASE P38 GAMMA) (MAP KINASE P38 GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P53778] PA30619 MAP KINASE P38 1501 NP_002960 XM_003846644 T79798 Gene Info:
Interpro Acc IPR002290 Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain Interpro Type Domain Uniprot Evidence 1: Evidence at protein level Interpro Short Name Ser/Thr_dual-sp_kinase_dom Human Readable Name KINASE Human Readable Name DRUGGABLE GENOME Uniprot Status Swiss-Prot Target Class Enzymes Target Subclass EC:2.7.11.24 GuideToPharmacology Gene Category Name p38 subfamily GuideToPharmacology Gene Category ID 519 Gene Biotype PROTEIN_CODING Gene Categories: Category Details
KINASE SERINE THREONINE KINASE DRUGGABLE GENOME ENZYME TRANSCRIPTION FACTOR Publications:
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Interaction Score: 1.23
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Interaction Types & Directionality:
n/a Interaction Info:
Trial Name ARRY-797 Novel drug target Novel Target -
Interaction Score: 0.98
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Interaction Types & Directionality:
n/a Interaction Info:
Trial Name PH-797804 Novel drug target Novel Target -
Interaction Score: 0.82
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Interaction Score: 0.82
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Interaction Score: 0.82
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Interaction Score: 0.82
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Interaction Score: 0.7
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Interaction Score: 0.61
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name BMS-582949 Novel drug target Novel Target -
Interaction Score: 0.49
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Interaction Types & Directionality:
n/a Interaction Info:
Novel drug target Novel Target Trial Name CPSI-2364 -
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name VX-702 Novel drug target Novel Target -
Interaction Score: 0.35
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name pirfenidone,Esbriet , Deskar, Pirespa Novel drug target Novel Target -
Interaction Score: 0.22
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition -
Interaction Score: 0.16
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name ARRY-614 Novel drug target Novel Target -
Interaction Score: 0.04
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Interaction Score: 0.02
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- Version: 101_38
Alternate Names:
MAPK12 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 11-September-2012
Alternate Names:
MAPK12 Uniprot Gene Name 6300 Entrez Gene Id MK12_HUMAN Uniprot Id Gene Info:
Interpro Acc IPR002290 Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain Interpro Type Domain Gene Categories:
KINASE, DRUGGABLE GENOME Publications:
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- Version: January-2014
Alternate Names:
MAPK12 Gene Symbol Gene Info:
Target Class Enzymes Target Subclass EC:2.7.11.24 Publications:
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- Version: 26-July-2011
Alternate Names:
MAPK12 Display Id MITOGEN-ACTIVATED PROTEIN KINASE 12 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 6) (ERK-6) (ERK5) (STRESS-ACTIVATED PROTEIN KINASE-3) (MITOGEN-ACTIVATED PROTEIN KINASE P38 GAMMA) (MAP KINASE P38 GAMMA). [SOURCE:UNIPROT/SWISSPROT;ACC:P53778] Description ENSG00000188130 Ensembl Gene Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 29-September-2020
Alternate Names:
6874 HUGO Gene ID 6874 HUGO Gene Symbol mitogen-activated protein kinase 12 HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name p38 subfamily GuideToPharmacology Gene Category ID 519 Gene Categories:
ENZYME Publications:
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Alternate Names:
PA30619 PharmGKB ID Gene Info:
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Alternate Names:
Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000188130 Gene Symbol MAPK12 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 19.3
Alternate Names:
ENSG00000188130 Ensembl Gene ID ERK6 Human Protein Atlas Gene Synonym p38gamma Human Protein Atlas Gene Synonym Gene Info:
Gene Categories:
ENZYME Publications:
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Alternate Names:
6300 Gene ID ERK3 dGene Synonym ERK6 dGene Synonym Gene Info:
Gene Categories:
KINASE, SERINE THREONINE KINASE Publications:
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- Version: 2020.06.01
Alternate Names:
MAPK12 TTD Gene Abbreviation T79798 TTD Target ID Gene Info:
Publications:
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Alternate Names:
ERK6 GO Gene Synonym SAPK3 GO Gene Synonym Gene Info:
Gene Categories:
SERINE THREONINE KINASE Publications:
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Alternate Names:
Mitogen-activated protein kinase 12 Gene Name P53778 UniProt ID Gene Info:
Gene Categories:
KINASE, TRANSCRIPTION FACTOR Publications: