DGIdb - MAPK10 Gene Record

MAPK10 5602 Druggable Genome

Alternate Names:

5602
MITOGEN-ACTIVATED PROTEIN KINASE 10
MAPK10
JNK3
JNK3A
PRKM10
SAPK1b
p493F12
p54bSAPK
602897
6872
ENSG00000109339
OTTHUMG00000130604
P53779
MK10_HUMAN
MAPK 10
MAP kinase 10
c-Jun N-terminal kinase 3
Stress-activated protein kinase JNK3
Stress-activated protein kinase 1b
MAP kinase p49 3F12
PA30617
1498
MITOGEN-ACTIVATED PROTEIN KINASE 10 (EC 2.7.1.37) (STRESS-ACTIVATED PROTEIN KINASE JNK3) (C-JUN N-TERMINAL KINASE 3) (MAP KINASE P49 3F12). [SOURCE:UNIPROT/SWISSPROT;ACC:P53779]
NP_002744
NM_002753
T00663

Gene Info:

Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Uniprot Status	Swiss-Prot
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR002290
Interpro Type	Domain
Human Readable Name	KINASE
Target Class	Enzymes
Target Subclass	EC:2.7.11.24
GuideToPharmacology Gene Category Name	JNK subfamily
GuideToPharmacology Gene Category ID	518
Gene Biotype	PROTEIN_CODING

(11 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME
TRANSCRIPTION FACTOR

Publications:

Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
Nakajima et al., 2006, Differential roles of MAP kinases in atorvastatin-induced VEGF release in cardiac myocytes., Life Sci.
Hupfeld et al., 2003, Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes., Proc. Natl. Acad. Sci. U.S.A.
Alblas et al., 1998, The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells., Oncogene
Paine et al., 2000, Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway., J. Biol. Chem.
Duncan et al., 2005, Signal transduction pathways leading to increased eIF4E phosphorylation caused by oxidative stress., Free Radic. Biol. Med.
Kim MH et al., 2013, Syntheses and biological evaluation of 1-heteroaryl-2-aryl-1H-benzimidazole derivatives as c-Jun N-terminal kinase inhibitors with neuroprotective effects., Bioorg Med Chem
Manuvakhova et al., 2006, Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells., Oncogene
Bowen et al., 2007, Irinotecan changes gene expression in the small intestine of the rat with breast cancer., Cancer Chemother. Pharmacol.
Flynn et al., 1996, Insulin-stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway., FEBS Lett.
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
Saeed et al., 2004, Signaling mechanisms mediated by G-protein coupled receptors in human platelets., Acta Pharmacol. Sin.

BRIMAPITIDE MAPK10

Interaction Score: 2.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
TANZISERTIB MAPK10

Interaction Score: 1.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
FIBROBLAST GROWTH FACTOR-1 MAPK10

Interaction Score: 1.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16682955

Sources:
NCI
CC-401 MAPK10

Interaction Score: 0.71

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction c-Jun N-terminal kinase 3 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
BENTAMAPIMOD MAPK10

Interaction Score: 0.71

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction c-Jun N-terminal kinase, JNK inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BRIMAPITIDE, C-TERMINAL ACID MAPK10

Interaction Score: 0.71

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AM-111

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
PAMAPIMOD MAPK10

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In a biochemical assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL35482 MAPK10

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9467952 10753939

Sources:
NCI
ISOPROTERENOL MAPK10

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12509508

Sources:
NCI
EPINEPHRINE MAPK10

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15210061

Sources:
NCI
SB-202190 MAPK10

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22951114

Sources:
DTC
WORTMANNIN MAPK10

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15683719

Sources:
NCI
DORAMAPIMOD MAPK10

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
INSULIN MAPK10

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8766822

Sources:
NCI
SB-203580 MAPK10

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IRINOTECAN MAPK10

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16799812

Sources:
NCI
CHEMBL406845 MAPK10

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SIROLIMUS MAPK10

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15683719

Sources:
NCI
ATORVASTATIN MAPK10

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16701707

Sources:
NCI
AST-487 MAPK10

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HESPERADIN MAPK10

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
SORAFENIB MAPK10

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20124951

Sources:
PharmGKB
SP-600125 MAPK10

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23498914

Sources:
DTC
JNJ-7706621 MAPK10

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IMATINIB MAPK10

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GEFITINIB MAPK10

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB MAPK10

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 MAPK10

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOVITINIB MAPK10

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 MAPK10

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000109339
- Version: 101_38
Alternate Names:

MAPK10 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P53779
- Version: January-2014
Alternate Names:

MAPK10 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.24

Publications:

RussLampel: ENSG00000109339

Version: 26-July-2011

Alternate Names:

MAPK10 Display Id

ENSG00000109339 Ensembl Gene Id

MITOGEN-ACTIVATED PROTEIN KINASE 10 (EC 2.7.1.37) (STRESS-ACTIVATED PROTEIN KINASE JNK3) (C-JUN N-TERMINAL KINASE 3) (MAP KINASE P49 3F12). [SOURCE:UNIPROT/SWISSPROT;ACC:P53779] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P53779
- Version: 11-September-2012
Alternate Names:

MK10_HUMAN Uniprot Id

P53779 Uniprot Accession

5602 Entrez Gene Id

Gene Info:

Interpro Short Name Ser/Thr_dual-sp_kinase_dom

Uniprot Status Swiss-Prot

Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 5602
- Version: 29-September-2020
Alternate Names:

6872 HUGO Gene ID

6872 HUGO Gene Symbol

mitogen-activated protein kinase 10 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name JNK subfamily

GuideToPharmacology Gene Category ID 518

Gene Categories:

ENZYME

Publications:
PharmGKB: MAPK10
- Version: 18-August-2020
Alternate Names:

PA30617 PharmGKB ID

Gene Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

NCI: MAPK10

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Bowen et al., 2007, Irinotecan changes gene expression in the small intestine of the rat with breast cancer., Cancer Chemother. Pharmacol.

Duncan et al., 2005, Signal transduction pathways leading to increased eIF4E phosphorylation caused by oxidative stress., Free Radic. Biol. Med.

Pan et al., 2007, K252a prevents nigral dopaminergic cell death induced by 6-hydroxydopamine through inhibition of both mixed-lineage kinase 3/c-Jun NH2-terminal kinase 3 (JNK3) and apoptosis-inducing kinase 1/JNK3 signaling pathways., Mol. Pharmacol.

DTC: MAPK10

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Kim MH et al., 2013, Syntheses and biological evaluation of 1-heteroaryl-2-aryl-1H-benzimidazole derivatives as c-Jun N-terminal kinase inhibitors with neuroprotective effects., Bioorg Med Chem

HingoraniCasas: ENSG00000109339
- Version: 31-May-2017
Alternate Names:

ENSG00000109339 Gene Symbol

MAPK10 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: JNK3
- Version: chembl_23
Alternate Names:

JNK3A GENE_SYMBOL

PRKM10 GENE_SYMBOL

SAPK1B GENE_SYMBOL

Gene Info:

Publications:
HumanProteinAtlas: MAPK10
- Version: 19.3
Alternate Names:

ENSG00000109339 Ensembl Gene ID

JNK3 Human Protein Atlas Gene Synonym

p493F12 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
dGene: MAPK10
- Version: 27-Jun-2013
Alternate Names:

5602 Gene ID

JNK3 dGene Synonym

JNK3A dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Stress-activated protein kinase JNK3
- Version: 2020.06.01
Alternate Names:

JNK3 TTD Gene Abbreviation

T00663 TTD Target ID

Gene Info:

Publications:
GO: MAPK10
- Version: 01-May-2021
Alternate Names:

JNK3 GO Gene Synonym

JNK3A GO Gene Synonym

PRKM10 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
Pharos: MAPK10
- Version: 01-May-2021
Alternate Names:

Mitogen-activated protein kinase 10 Gene Name

P53779 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Direct Interaction	yes
Mechanism of Interaction	c-Jun N-terminal kinase 3 inhibitor

Mechanism of Interaction	c-Jun N-terminal kinase, JNK inhibitor
Direct Interaction	yes

Details of the Assay for Interaction	In a biochemical assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

MAPK10	Display Id
ENSG00000109339	Ensembl Gene Id
MITOGEN-ACTIVATED PROTEIN KINASE 10 (EC 2.7.1.37) (STRESS-ACTIVATED PROTEIN KINASE JNK3) (C-JUN N-TERMINAL KINASE 3) (MAP KINASE P49 3F12). [SOURCE:UNIPROT/SWISSPROT;ACC:P53779]	Description

MK10_HUMAN	Uniprot Id
P53779	Uniprot Accession
5602	Entrez Gene Id

6872	HUGO Gene ID
6872	HUGO Gene Symbol
mitogen-activated protein kinase 10	HUGO Gene Name

JNK3	GO Gene Synonym
JNK3A	GO Gene Synonym
PRKM10	GO Gene Synonym

Mitogen-activated protein kinase 10	Gene Name
P53779	UniProt ID

Trial Name	AM-111
Novel drug target	Novel Target

MAPK10 Gene Record

MAPK10 5602 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16682955

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction c-Jun N-terminal kinase 3 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction c-Jun N-terminal kinase, JNK inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name AM-111 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction In a biochemical assay. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9467952 10753939

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12509508

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15210061

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22951114

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15683719

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8766822

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16799812

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15683719

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
16682955

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction c-Jun N-terminal kinase 3 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction c-Jun N-terminal kinase, JNK inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AM-111

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction In a biochemical assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
9467952 10753939

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12509508

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15210061

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22951114

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15683719

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
8766822

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16799812

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15683719

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16701707

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19035792

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20124951

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23498914

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found