• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

MAPK10 Gene Record

  • Summary
  • Interactions
  • Claims
  • MAPK10 5602 Druggable Genome

    Alternate Names:

    5602
    MITOGEN-ACTIVATED PROTEIN KINASE 10
    MAPK10
    JNK3
    JNK3A
    PRKM10
    SAPK1b
    p493F12
    p54bSAPK
    602897
    6872
    ENSG00000109339
    OTTHUMG00000130604
    P53779
    MK10_HUMAN
    MAPK 10
    MAP kinase 10
    c-Jun N-terminal kinase 3
    Stress-activated protein kinase JNK3
    Stress-activated protein kinase 1b
    MAP kinase p49 3F12
    PA30617
    1498
    BE0001097
    MITOGEN-ACTIVATED PROTEIN KINASE 10 (EC 2.7.1.37) (STRESS-ACTIVATED PROTEIN KINASE JNK3) (C-JUN N-TERMINAL KINASE 3) (MAP KINASE P49 3F12). [SOURCE:UNIPROT/SWISSPROT;ACC:P53779]
    NP_002744
    NM_002753
    T00663
    BE0009865

    Gene Info:

    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Status Swiss-Prot
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR002290
    Interpro Type Domain
    Human Readable Name KINASE
    Target Class Enzymes
    Target Subclass EC:2.7.11.24
    GuideToPharmacology Gene Category Name JNK subfamily
    GuideToPharmacology Gene Category ID 518
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

    Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
    Nakajima et al., 2006, Differential roles of MAP kinases in atorvastatin-induced VEGF release in cardiac myocytes., Life Sci.
    Hupfeld et al., 2003, Beta -Arrestin 1 down-regulation after insulin treatment is associated with supersensitization of beta 2 adrenergic receptor Galpha s signaling in 3T3-L1 adipocytes., Proc. Natl. Acad. Sci. U.S.A.
    Paine et al., 2000, Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway., J. Biol. Chem.
    Alblas et al., 1998, The role of MAP kinase in TPA-mediated cell cycle arrest of human breast cancer cells., Oncogene
    Duncan et al., 2005, Signal transduction pathways leading to increased eIF4E phosphorylation caused by oxidative stress., Free Radic. Biol. Med.
    Kim MH et al., 2013, Syntheses and biological evaluation of 1-heteroaryl-2-aryl-1H-benzimidazole derivatives as c-Jun N-terminal kinase inhibitors with neuroprotective effects., Bioorg Med Chem
    Manuvakhova et al., 2006, Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells., Oncogene
    Bowen et al., 2007, Irinotecan changes gene expression in the small intestine of the rat with breast cancer., Cancer Chemother. Pharmacol.
    Flynn et al., 1996, Insulin-stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway., FEBS Lett.
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
    Saeed et al., 2004, Signaling mechanisms mediated by G-protein coupled receptors in human platelets., Acta Pharmacol. Sin.
    Jang S et al., 2015, Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury., Redox Biol
    Augustine C et al., 2014, Traumatic injury elicits JNK-mediated human astrocyte retraction in vitro., Neuroscience
    Jang S et al., 2014, Inhibition of JNK aggravates the recovery of rat hearts after global ischemia: the role of mitochondrial JNK., PLoS One
    Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
  • CHEMBL248643   MAPK10

    Interaction Score: 4.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL252967   MAPK10

    Interaction Score: 3.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • CHEMBL437747   MAPK10

    Interaction Score: 3.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17139284 17016423


    Sources:
    DrugBank

  • CHEMBL250409   MAPK10

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • GW572738X   MAPK10

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL482708   MAPK10

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL485323   MAPK10

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL561540   MAPK10

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL248176   MAPK10

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1083185   MAPK10

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL549385   MAPK10

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL203631   MAPK10

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1233749   MAPK10

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • HALICIN   MAPK10

    Interaction Score: 2.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26491845 24838066 25423094


    Sources:
    DrugBank

  • CHEMBL7064   MAPK10

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL220320   MAPK10

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • BRIMAPITIDE   MAPK10

    Interaction Score: 1.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • TANZISERTIB   MAPK10

    Interaction Score: 0.81

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • FIBROBLAST GROWTH FACTOR-1   MAPK10

    Interaction Score: 0.6

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16682955


    Sources:
    NCI

  • CC-401   MAPK10

    Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction c-Jun N-terminal kinase 3 inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BENTAMAPIMOD   MAPK10

    Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction c-Jun N-terminal kinase, JNK inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BRIMAPITIDE, C-TERMINAL ACID   MAPK10

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AM-111
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PAMAPIMOD   MAPK10

    Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction In a biochemical assay.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL35482   MAPK10

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10753939 9467952


    Sources:
    NCI

  • EPINEPHRINE   MAPK10

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15210061


    Sources:
    NCI

  • ISOPROTERENOL   MAPK10

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12509508


    Sources:
    NCI

  • SB-202190   MAPK10

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22951114


    Sources:
    DTC

  • WORTMANNIN   MAPK10

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15683719


    Sources:
    NCI

  • DORAMAPIMOD   MAPK10

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • INSULIN   MAPK10

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8766822


    Sources:
    NCI

  • SB-203580   MAPK10

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • IRINOTECAN   MAPK10

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16799812


    Sources:
    NCI

  • CHEMBL406845   MAPK10

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SIROLIMUS   MAPK10

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15683719


    Sources:
    NCI

  • ATORVASTATIN   MAPK10

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16701707


    Sources:
    NCI

  • AST-487   MAPK10

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HESPERADIN   MAPK10

    Interaction Score: 0.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • SORAFENIB   MAPK10

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20124951


    Sources:
    PharmGKB

  • SP-600125   MAPK10

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23498914


    Sources:
    DTC

  • JNJ-7706621   MAPK10

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • IMATINIB   MAPK10

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GEFITINIB   MAPK10

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TOZASERTIB   MAPK10

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • R-406   MAPK10

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOVITINIB   MAPK10

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   MAPK10

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FOSTAMATINIB   MAPK10

    Interaction Score: 0.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26516587


    Sources:
    DrugBank

  • Ensembl: ENSG00000109339

    • Version: 101_38

    Alternate Names:
    MAPK10 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P53779

    • Version: January-2014

    Alternate Names:
    MAPK10 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.24

    Publications:

  • RussLampel: ENSG00000109339

    • Version: 26-July-2011

    Alternate Names:
    MAPK10 Display Id
    ENSG00000109339 Ensembl Gene Id
    MITOGEN-ACTIVATED PROTEIN KINASE 10 (EC 2.7.1.37) (STRESS-ACTIVATED PROTEIN KINASE JNK3) (C-JUN N-TERMINAL KINASE 3) (MAP KINASE P49 3F12). [SOURCE:UNIPROT/SWISSPROT;ACC:P53779] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P53779

    • Version: 11-September-2012

    Alternate Names:
    MK10_HUMAN Uniprot Id
    P53779 Uniprot Accession
    5602 Entrez Gene Id

    Gene Info:
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Uniprot Status Swiss-Prot
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 5602

    • Version: 29-September-2020

    Alternate Names:
    6872 HUGO Gene ID
    6872 HUGO Gene Symbol
    mitogen-activated protein kinase 10 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name JNK subfamily
    GuideToPharmacology Gene Category ID 518

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: MAPK10

    • Version: 18-August-2020

    Alternate Names:
    PA30617 PharmGKB ID

    Gene Info:

    Publications:
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

  • DrugBank: BE0001097

    • Version: 5.1.7

    Alternate Names:
    MAPK10 DrugBank Gene Name
    P53779 UniProt Accession
    5602 Entrez Gene Id

    Gene Info:

    Publications:
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • DrugBank: BE0009865

    • Version: 5.1.7

    Alternate Names:
    MAPK10 DrugBank Gene Name
    P53779 UniProt Accession
    5602 Entrez Gene Id

    Gene Info:

    Publications:
    Jang S et al., 2015, Critical role of c-jun N-terminal protein kinase in promoting mitochondrial dysfunction and acute liver injury., Redox Biol
    Augustine C et al., 2014, Traumatic injury elicits JNK-mediated human astrocyte retraction in vitro., Neuroscience
    Jang S et al., 2014, Inhibition of JNK aggravates the recovery of rat hearts after global ischemia: the role of mitochondrial JNK., PLoS One

  • NCI: MAPK10

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Bowen et al., 2007, Irinotecan changes gene expression in the small intestine of the rat with breast cancer., Cancer Chemother. Pharmacol.
    Duncan et al., 2005, Signal transduction pathways leading to increased eIF4E phosphorylation caused by oxidative stress., Free Radic. Biol. Med.
    Pan et al., 2007, K252a prevents nigral dopaminergic cell death induced by 6-hydroxydopamine through inhibition of both mixed-lineage kinase 3/c-Jun NH2-terminal kinase 3 (JNK3) and apoptosis-inducing kinase 1/JNK3 signaling pathways., Mol. Pharmacol.

  • DTC: MAPK10

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Selig R et al., 2012, A frozen analogue approach to aminopyridinylimidazoles leading to novel and promising p38 MAP kinase inhibitors., J Med Chem
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Kim MH et al., 2013, Syntheses and biological evaluation of 1-heteroaryl-2-aryl-1H-benzimidazole derivatives as c-Jun N-terminal kinase inhibitors with neuroprotective effects., Bioorg Med Chem

  • HingoraniCasas: ENSG00000109339

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000109339 Gene Symbol
    MAPK10 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: JNK3

    • Version: chembl_23

    Alternate Names:
    JNK3A GENE_SYMBOL
    PRKM10 GENE_SYMBOL
    SAPK1B GENE_SYMBOL

    Gene Info:

    Publications:

  • HumanProteinAtlas: MAPK10

    • Version: 19.3

    Alternate Names:
    ENSG00000109339 Ensembl Gene ID
    JNK3 Human Protein Atlas Gene Synonym
    p493F12 Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: MAPK10

    • Version: 03-September-2020

    Alternate Names:
    Mitogen-activated protein kinase 10 Gene Name
    P53779 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • dGene: MAPK10

    • Version: 27-Jun-2013

    Alternate Names:
    5602 Gene ID
    JNK3 dGene Synonym
    JNK3A dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: Stress-activated protein kinase JNK3

    • Version: 2020.06.01

    Alternate Names:
    JNK3 TTD Gene Abbreviation
    T00663 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21