DGIdb - MAPK1 Gene Record

MAPK1 5594 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

5594
MITOGEN-ACTIVATED PROTEIN KINASE 1
MAPK1
ERK
ERK-2
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
p42-MAPK
176948
6871
ENSG00000100030
OTTHUMG00000030508
1495
P28482
NP_002736
NM_002745
Extracellular signal-regulated kinase 2
MAP kinase isoform p42
Mitogen-activated protein kinase 2
MAP kinase 1
MAPK 1
MAP kinase 2
MAPK 2
MK01_HUMAN
BE0000923
MITOGEN-ACTIVATED PROTEIN KINASE 1 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 2) (ERK-2) (MITOGEN-ACTIVATED PROTEIN KINASE 2) (MAP KINASE 2) (MAPK 2) (P42-MAPK) (ERT1). [SOURCE:UNIPROT/SWISSPROT;ACC:P28482]
4532
PA30616
T58970
BE0009853
BE0009668

Gene Info:

GuideToPharmacology Gene Category Name	ERK subfamily
GuideToPharmacology Gene Category ID	514
Target Class	Enzymes
Target Subclass	EC:2.7.11.24
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Acc	IPR002290
Human Readable Name	KINASE
Interpro Type	Domain
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Gene Biotype	PROTEIN_CODING

(18 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUG RESISTANCE
TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
RNA DIRECTED DNA POLYMERASE
CLINICALLY ACTIONABLE
ENZYME
TRANSCRIPTION FACTOR

Publications:

Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett
Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem
Cavell BE et al., 2012, Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2., J Nat Prod
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Wang et al., Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases., Anticancer Res.
Milosevic et al., 2006, Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling., J. Neurochem.
Pavón et al., 2006, ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice., Biol. Psychiatry
Liu G et al., 2007, Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives., Bioorg Med Chem
Van Allen et al., 2015, Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma., JAMA Oncol
Panet et al., 2002, Na(+)/K(+)/Cl(-) cotransporter activates mitogen-activated protein kinase in fibroblasts and lymphocytes., J. Cell. Physiol.
Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A
Azzi et al., 2003, Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors., Proc. Natl. Acad. Sci. U.S.A.
Yeh et al., 2005, beta-Adrenergic-responsive activation of extracellular signal-regulated protein kinases in salivary cells: role of epidermal growth factor receptor and cAMP., Am. J. Physiol., Cell Physiol.
Oudit et al., 2003, Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure., Circulation
Vaniotis et al., 2011, Nuclear β-adrenergic receptors modulate gene expression in adult rat heart., Cell. Signal.
Dubey et al., 2004, Catecholamines block the antimitogenic effect of estradiol on human coronary artery smooth muscle cells., J. Clin. Endocrinol. Metab.
Adissu et al., 2004, Antagonistic growth regulation of cell lines derived from human lung adenocarcinomas of Clara cell and aveolar type II cell lineage: Implications for chemoprevention., Int. J. Oncol.
Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
Goetz EM et al., 2014, ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors., Cancer Res
Samadi AK et al., 2010, Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma., J Nat Prod
Germann UA et al., 2017, Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)., Mol Cancer Ther
Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem
Andreani A et al., 2012, Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action., J Med Chem
Hong JY et al., 2011, Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa., J Nat Prod
Kamal A et al., 2013, Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells., Bioorg Med Chem Lett
Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod
Tanigawa et al., 2007, Rebamipide inhibits gastric cancer cell growth., Dig. Dis. Sci.
Shoemaker et al., 2005, Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors., J. Pharmacol. Exp. Ther.
Yang CL et al., 2009, Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages., J Med Chem
Zhu et al., 2002, Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice., Nature
Iurisci I et al., 2006, Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor., Cancer Res
Knowling M et al., 2006, A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial., Invest New Drugs
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

RAVOXERTINIB MAPK1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Publications:

Goetz EM et al., 2014, ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors., Cancer Res
ULIXERTINIB MAPK1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Biochemical assay determination

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Publications:

Germann UA et al., 2017, Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)., Mol Cancer Ther
CHIR-99021 MAPK1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Publications:
MK-8353 MAPK1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Publications:

ISOPROTERENOL MAPK1

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Publications:

Azzi et al., 2003, Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors., Proc. Natl. Acad. Sci. U.S.A.

Yeh et al., 2005, beta-Adrenergic-responsive activation of extracellular signal-regulated protein kinases in salivary cells: role of epidermal growth factor receptor and cAMP., Am. J. Physiol., Cell Physiol.

Oudit et al., 2003, Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure., Circulation

MINOCYCLINE MAPK1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Zhu et al., 2002, Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice., Nature
PURVALANOL B MAPK1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
SPINASAPONIN A METHYL ESTER MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett
CHEMBL329785 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem
PHENETHYLISOTHIOCYANATE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Cavell BE et al., 2012, Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2., J Nat Prod
OLOMOUCINE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
CHEMBL2088731 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem
IROFULVEN MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Wang et al., Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases., Anticancer Res.
URACIL MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Milosevic et al., 2006, Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling., J. Neurochem.
LEVODOPA MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Pavón et al., 2006, ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice., Biol. Psychiatry
CHEMBL29197 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Liu G et al., 2007, Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives., Bioorg Med Chem
ERLOTINIB MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Van Allen et al., 2015, Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma., JAMA Oncol
BUMETANIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Panet et al., 2002, Na(+)/K(+)/Cl(-) cotransporter activates mitogen-activated protein kinase in fibroblasts and lymphocytes., J. Cell. Physiol.
GAMBOGIC AMIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A
GAMBOGIC ACID MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A
PESUDOGINSENOSIDE RP1 METHYL ESTER MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett
OPHIOBOLIN O MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
WITHAFERIN A MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Samadi AK et al., 2010, Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma., J Nat Prod
CHEMBL259551 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
WEDELOLACTONE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem
CHEMBL2063687 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Andreani A et al., 2012, Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action., J Med Chem

YUANHUADINE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Hong JY et al., 2011, Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa., J Nat Prod

CHEMBL2063681 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Andreani A et al., 2012, Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action., J Med Chem
DEMETHYLWEDELOLACTONE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem
ETOPOSIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kamal A et al., 2013, Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells., Bioorg Med Chem Lett
SORAFENIB MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
COMBRETASTATIN A4 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem
XANTHOHUMOL MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod
REBAMIPIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Tanigawa et al., 2007, Rebamipide inhibits gastric cancer cell growth., Dig. Dis. Sci.
SB-220025 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
ETHER MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Shoemaker et al., 2005, Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors., J. Pharmacol. Exp. Ther.
CHEMBL2088730 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem

CIMIRACEMATE A MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Yang CL et al., 2009, Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages., J Med Chem

SELICICLIB MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Iurisci I et al., 2006, Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor., Cancer Res

PERIFOSINE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Knowling M et al., 2006, A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial., Invest New Drugs

CHEMBL220320 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
CHEMBL1079087 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
CHEMBL219841 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
CHEMBL387385 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
DIHYDROGAMBOGIC ACID MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PROGESTERONE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MITOXANTRONE HYDROCHLORIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GENTIAN VIOLET MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL609606 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
DAUNORUBICIN HYDROCHLORIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TREQUINSIN HYDROCHLORIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL154580 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CANTHARIDIN MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ZAFIRLUKAST MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL76589 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ECONAZOLE NITRATE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
IPRIFLAVONE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PATULIN MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TRIFLUOPERAZINE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL222556 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL1270169 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PD-169316 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
SAPPANONE A TRIMETHYL ETHER MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL1519374 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHLORANIL MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MADOLIN U MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TURPENTINE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ARISTOLACTONE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ZIRAM MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL1485809 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MIBEFRADIL MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL2333548 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
HAEMATOXYLIN MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
LITHOCHOLIC ACID MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL84010 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GUTHION MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL1493528 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
SANGUINARIUM CHLORIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL261557 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL585628 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL581194 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
BIOCHANIN MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL1224755 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CLIOQUINOL MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CLOTRIMAZOLE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ELLAGIC ACID MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL580183 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL586031 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
DERRUBONE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL484662 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RG-1530 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
R-1487 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL35482 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ISOVELLERAL MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL225519 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL2333543 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL1814509 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
SP-600125 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL581574 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
INDIRUBIN-3-MONOXIME MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
NECA MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL530280 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TAE-684 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GOSSYPOL MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL581872 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL2095095 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CALCIMYCIN MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
O-DEMETHYLATED ADAPALENE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHLORHEXIDINE HYDROCHLORIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MITOXANTRONE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL428789 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL184074 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
NIFEDIPINE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL505670 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL1939691 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MADOLIN A MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MUNDULONE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GF-109203 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PF-00562271 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
QUINALIZARIN MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MADOLIN T MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
FISETIN MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GW282974X MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MERCURIC CHLORIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
SANGUINARIUM MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TYRPHOSTIN AG-1478 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
LORATADINE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PHENMEDIPHAM MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CI-1040 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
VOLVALERENAL D MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL421215 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ACID BLUE 129 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL126804 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ALPHA-NAPHTHOFLAVONE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
BISINDOLYLMALEIMIDE IX MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PHENYLMERCURIC ACETATE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GR-127935 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL531322 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
SANGUINARINE SULFATE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
NAFTOPIDIL MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ALSTERPAULLONE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
SB-203580 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHELERYTHRINE CHLORIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
THIMEROSAL MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PIMOZIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
GO-6976 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL578741 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
U-0126 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MUNDULONE ACETATE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
DOXORUBICIN HYDROCHLORIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHLOROTHALONIL MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL88272 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL429095 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ARISTOYUNNOLIN A MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
SB-202190 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PLUMBAGIN MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL578944 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RELCOVAPTAN MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
PURPURIN MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL261237 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL580340 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
DAPH MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
ZALCITABINE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CAPTAN MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL541400 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
BENZALKONIUM CHLORIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL547833 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL532849 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL285819 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
TYRPHOSTIN 47 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL210618 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
DIPHENHYDRAMINE HYDROCHLORIDE MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
CHEMBL597035 MAPK1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000100030
- Version: 101_38
Alternate Names:

MAPK1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P28482
- Version: January-2014
Alternate Names:

MAPK1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.24

Publications:

RussLampel: ENSG00000100030

Version: 26-July-2011

Alternate Names:

MITOGEN-ACTIVATED PROTEIN KINASE 1 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 2) (ERK-2) (MITOGEN-ACTIVATED PROTEIN KINASE 2) (MAP KINASE 2) (MAPK 2) (P42-MAPK) (ERT1). [SOURCE:UNIPROT/SWISSPROT;ACC:P28482] Description

ENSG00000100030 Ensembl Gene Id

MAPK1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P28482
- Version: 11-September-2012
Alternate Names:

MAPK1 Uniprot Gene Name

MK01_HUMAN Uniprot Id

ENSG00000100030 Ensembl Gene Id

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 5594
- Version: 29-September-2020
Alternate Names:

6871 HUGO Gene ID

6871 HUGO Gene Symbol

mitogen-activated protein kinase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name ERK subfamily

GuideToPharmacology Gene Category ID 514

Gene Categories:

ENZYME

Publications:
PharmGKB: MAPK1
- Version: 18-August-2020
Alternate Names:

PA30616 PharmGKB ID

Gene Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

CIViC: MAPK1

Version: 14-September-2020

Alternate Names:

5594 Entrez Gene ID

4532 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Ercan et al., 2012, Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors., Cancer Discov

Van Allen et al., 2015, Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma., JAMA Oncol

DrugBank: BE0009668

Version: 5.1.7

Alternate Names:

MAPK1 DrugBank Gene Name

P28482 UniProt Accession

5594 Entrez Gene Id

Gene Info:

Publications:

Nishio T et al., 2016, Dual effects of acetylsalicylic acid on ERK signaling and Mitf transcription lead to inhibition of melanogenesis., Mol Cell Biochem

Alfonso L et al., 2014, Molecular targets of aspirin and cancer prevention., Br J Cancer

Weissmann G et al., 2002, Non-prostaglandin effects of aspirin III and salicylate: inhibition of integrin-dependent human neutrophil aggregation and inflammation in COX 2- and NF kappa B (P105)-knockout mice., Adv Exp Med Biol

DrugBank: BE0009853
- Version: 5.1.7
Alternate Names:

MAPK1 DrugBank Gene Name

P28482 UniProt Accession

5594 Entrez Gene Id

Gene Info:

Publications:

Zhu et al., 2002, Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice., Nature

DrugBank: BE0000923

Version: 5.1.7

Alternate Names:

MAPK1 DrugBank Gene Name

P28482 UniProt Accession

5594 Entrez Gene Id

Gene Info:

Publications:

Vaniotis et al., 2011, Nuclear β-adrenergic receptors modulate gene expression in adult rat heart., Cell. Signal.

Azzi et al., 2003, Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors., Proc. Natl. Acad. Sci. U.S.A.

Adissu et al., 2004, Antagonistic growth regulation of cell lines derived from human lung adenocarcinomas of Clara cell and aveolar type II cell lineage: Implications for chemoprevention., Int. J. Oncol.

TTD: Extracellular signal-regulated kinase 2
- Version: 2020.06.01
Alternate Names:

ERK2 TTD Gene Abbreviation

T58970 TTD Target ID

Gene Info:

Publications:

Goetz EM et al., 2014, ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors., Cancer Res

NCI: MAPK1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Shoemaker et al., 2005, Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors., J. Pharmacol. Exp. Ther.

Imbe et al., 2005, Effects of peripheral inflammation on activation of ERK in the rostral ventromedial medulla., Brain Res.

Veit et al., 2004, Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells., Cancer Res.

DTC: MAPK1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett

Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem

Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem

HingoraniCasas: ENSG00000100030
- Version: 31-May-2017
Alternate Names:

ENSG00000100030 Gene Symbol

MAPK1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ERK2
- Version: chembl_23
Alternate Names:

PRKM1 GENE_SYMBOL

PRKM2 GENE_SYMBOL

MAPK1 GENE_SYMBOL

Gene Info:

Publications:
Pharos: MAPK1
- Version: 03-September-2020
Alternate Names:

Mitogen-activated protein kinase 1 Gene Name

P28482 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
GO: MAPK1
- Version: 05-September-2020
Alternate Names:

ERK2 GO Gene Synonym

PRKM1 GO Gene Synonym

PRKM2 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE, KINASE, TRANSCRIPTION FACTOR BINDING

Publications:
Tempus: MAPK1
- Version: 11-November-2018
Alternate Names:

MAPK1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: MAPK1
- Version: 27-Jun-2013
Alternate Names:

5594 Gene ID

ERK dGene Synonym

ERK2 dGene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE, KINASE

Publications:
MskImpact: MAPK1
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: MAPK1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: MAPK1
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Details of the Assay for Interaction	Biochemical assay determination
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

MITOGEN-ACTIVATED PROTEIN KINASE 1 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 2) (ERK-2) (MITOGEN-ACTIVATED PROTEIN KINASE 2) (MAP KINASE 2) (MAPK 2) (P42-MAPK) (ERT1). [SOURCE:UNIPROT/SWISSPROT;ACC:P28482]	Description
ENSG00000100030	Ensembl Gene Id
MAPK1	Display Id

MAPK1	Uniprot Gene Name
MK01_HUMAN	Uniprot Id
ENSG00000100030	Ensembl Gene Id

6871	HUGO Gene ID
6871	HUGO Gene Symbol
mitogen-activated protein kinase 1	HUGO Gene Name

MAPK1	DrugBank Gene Name
P28482	UniProt Accession
5594	Entrez Gene Id

MAPK1 Gene Record

MAPK1 5594 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

Publications: Goetz EM et al., 2014, ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors., Cancer Res

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Biochemical assay determination Specific Action of the Ligand Inhibition Endogenous Drug? False

Publications: Germann UA et al., 2017, Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)., Mol Cancer Ther

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

Publications:

Interaction Types & Directionality: inducer (activating)

Interaction Info:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Zhu et al., 2002, Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice., Nature

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Publications: Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Cavell BE et al., 2012, Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2., J Nat Prod

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Wang et al., Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases., Anticancer Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Milosevic et al., 2006, Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling., J. Neurochem.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Pavón et al., 2006, ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice., Biol. Psychiatry

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Liu G et al., 2007, Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives., Bioorg Med Chem

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Van Allen et al., 2015, Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma., JAMA Oncol

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Panet et al., 2002, Na(+)/K(+)/Cl(-) cotransporter activates mitogen-activated protein kinase in fibroblasts and lymphocytes., J. Cell. Physiol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Samadi AK et al., 2010, Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma., J Nat Prod

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

Publications:

Goetz EM et al., 2014, ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors., Cancer Res

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Biochemical assay determination

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Publications:

Germann UA et al., 2017, Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)., Mol Cancer Ther

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Interaction Types & Directionality:

inducer (activating)

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Zhu et al., 2002, Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice., Nature

Interaction Types & Directionality:

inhibitor (inhibitory)

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Interaction Types & Directionality:

n/a

Publications:

Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett

Interaction Types & Directionality:

n/a

Publications:

Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem

Interaction Types & Directionality:

n/a

Publications:

Cavell BE et al., 2012, Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2., J Nat Prod

Interaction Types & Directionality:

n/a

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality:

n/a

Publications:

Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem

Interaction Types & Directionality:

n/a

Publications:

Wang et al., Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases., Anticancer Res.

Interaction Types & Directionality:

n/a

Publications:

Milosevic et al., 2006, Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling., J. Neurochem.

Interaction Types & Directionality:

n/a

Publications:

Pavón et al., 2006, ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice., Biol. Psychiatry

Interaction Types & Directionality:

n/a

Publications:

Liu G et al., 2007, Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives., Bioorg Med Chem

Interaction Types & Directionality:

n/a

Publications:

Van Allen et al., 2015, Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma., JAMA Oncol

Interaction Types & Directionality:

n/a

Publications:

Panet et al., 2002, Na(+)/K(+)/Cl(-) cotransporter activates mitogen-activated protein kinase in fibroblasts and lymphocytes., J. Cell. Physiol.

Interaction Types & Directionality:

n/a

Publications:

Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A

Interaction Types & Directionality:

n/a

Publications:

Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A

Interaction Types & Directionality:

n/a

Publications:

Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett

Interaction Types & Directionality:

n/a

Publications:

Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett

Interaction Types & Directionality:

n/a

Publications:

Samadi AK et al., 2010, Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma., J Nat Prod

Interaction Types & Directionality:

n/a

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality:

n/a

Publications:

Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem

Interaction Types & Directionality:

n/a

Publications:

Andreani A et al., 2012, Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action., J Med Chem

Interaction Types & Directionality:

n/a

Publications:

Hong JY et al., 2011, Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa., J Nat Prod

Interaction Types & Directionality:

n/a

Publications:

Andreani A et al., 2012, Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action., J Med Chem

Interaction Types & Directionality:

n/a

Publications:

Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem

Interaction Types & Directionality:

n/a

Publications:

Kamal A et al., 2013, Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells., Bioorg Med Chem Lett

Interaction Types & Directionality:

n/a

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

Interaction Types & Directionality:

n/a

Publications:

Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem

Interaction Types & Directionality:

n/a

Publications:

Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod

Interaction Types & Directionality:

n/a

Publications:

Tanigawa et al., 2007, Rebamipide inhibits gastric cancer cell growth., Dig. Dis. Sci.

Interaction Types & Directionality:

n/a

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Interaction Types & Directionality:

n/a

Publications:

Shoemaker et al., 2005, Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors., J. Pharmacol. Exp. Ther.