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MAPK1 Gene Record

  • Summary
  • Interactions
  • Claims
  • MAPK1 5594 Druggable GenomeClinically ActionableDrug Resistance

    Alternate Names:

    5594
    MITOGEN-ACTIVATED PROTEIN KINASE 1
    MAPK1
    ERK
    ERK-2
    ERK2
    ERT1
    MAPK2
    P42MAPK
    PRKM1
    PRKM2
    p38
    p40
    p41
    p41mapk
    p42-MAPK
    176948
    6871
    ENSG00000100030
    OTTHUMG00000030508
    1495
    P28482
    NP_002736
    NM_002745
    Extracellular signal-regulated kinase 2
    MAP kinase isoform p42
    Mitogen-activated protein kinase 2
    MAP kinase 1
    MAPK 1
    MAP kinase 2
    MAPK 2
    MK01_HUMAN
    BE0000923
    MITOGEN-ACTIVATED PROTEIN KINASE 1 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 2) (ERK-2) (MITOGEN-ACTIVATED PROTEIN KINASE 2) (MAP KINASE 2) (MAPK 2) (P42-MAPK) (ERT1). [SOURCE:UNIPROT/SWISSPROT;ACC:P28482]
    4532
    PA30616
    T58970
    BE0009853
    BE0009668

    Gene Info:

    GuideToPharmacology Gene Category Name ERK subfamily
    GuideToPharmacology Gene Category ID 514
    Target Class Enzymes
    Target Subclass EC:2.7.11.24
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Ser/Thr_dual-sp_kinase_dom
    Interpro Acc IPR002290
    Human Readable Name KINASE
    Interpro Type Domain
    Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain
    Gene Biotype PROTEIN_CODING
    (18 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUG RESISTANCE
    TRANSCRIPTION FACTOR BINDING
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

    Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett
    Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem
    Cavell BE et al., 2012, Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2., J Nat Prod
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Wang et al., Irofulven (6-hydroxymethylacylfulvene, MGI 114)-induced apoptosis in human pancreatic cancer cells is mediated by ERK and JNK kinases., Anticancer Res.
    Milosevic et al., 2006, Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling., J. Neurochem.
    Pavón et al., 2006, ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice., Biol. Psychiatry
    Liu G et al., 2007, Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives., Bioorg Med Chem
    Van Allen et al., 2015, Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma., JAMA Oncol
    Panet et al., 2002, Na(+)/K(+)/Cl(-) cotransporter activates mitogen-activated protein kinase in fibroblasts and lymphocytes., J. Cell. Physiol.
    Jang SW et al., 2007, Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death., Proc Natl Acad Sci U S A
    Dubey et al., 2004, Catecholamines block the antimitogenic effect of estradiol on human coronary artery smooth muscle cells., J. Clin. Endocrinol. Metab.
    Vaniotis et al., 2011, Nuclear β-adrenergic receptors modulate gene expression in adult rat heart., Cell. Signal.
    Adissu et al., 2004, Antagonistic growth regulation of cell lines derived from human lung adenocarcinomas of Clara cell and aveolar type II cell lineage: Implications for chemoprevention., Int. J. Oncol.
    Azzi et al., 2003, Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors., Proc. Natl. Acad. Sci. U.S.A.
    Yeh et al., 2005, beta-Adrenergic-responsive activation of extracellular signal-regulated protein kinases in salivary cells: role of epidermal growth factor receptor and cAMP., Am. J. Physiol., Cell Physiol.
    Oudit et al., 2003, Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure., Circulation
    Yang T et al., 2012, The novel agent ophiobolin O induces apoptosis and cell cycle arrest of MCF-7 cells through activation of MAPK signaling pathways., Bioorg Med Chem Lett
    Goetz EM et al., 2014, ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors., Cancer Res
    Samadi AK et al., 2010, Withaferin A, a cytotoxic steroid from Vassobia breviflora, induces apoptosis in human head and neck squamous cell carcinoma., J Nat Prod
    Germann UA et al., 2017, Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib)., Mol Cancer Ther
    Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem
    Andreani A et al., 2012, Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action., J Med Chem
    Hong JY et al., 2011, Growth inhibition of human lung cancer cells via down-regulation of epidermal growth factor receptor signaling by yuanhuadine, a daphnane diterpene from Daphne genkwa., J Nat Prod
    Kamal A et al., 2013, Synthesis and study of benzothiazole conjugates in the control of cell proliferation by modulating Ras/MEK/ERK-dependent pathway in MCF-7 cells., Bioorg Med Chem Lett
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
    Festa M et al., 2011, Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways., J Nat Prod
    Tanigawa et al., 2007, Rebamipide inhibits gastric cancer cell growth., Dig. Dis. Sci.
    Shoemaker et al., 2005, Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors., J. Pharmacol. Exp. Ther.
    Yang CL et al., 2009, Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages., J Med Chem
    Zhu et al., 2002, Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice., Nature
    Iurisci I et al., 2006, Improved tumor control through circadian clock induction by Seliciclib, a cyclin-dependent kinase inhibitor., Cancer Res
    Knowling M et al., 2006, A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial., Invest New Drugs
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
  • CHEMBL387385   MAPK1

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL219841   MAPK1

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1079087   MAPK1

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL259551   MAPK1

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • RAVOXERTINIB   MAPK1

    Interaction Score: 0.66

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    25320010


    Sources:
    TTD GuideToPharmacology ChemblInteractions

  • ULIXERTINIB   MAPK1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Biochemical assay determination
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    28939558


    Sources:
    TTD DrugBank GuideToPharmacology ChemblInteractions

  • CHEMBL220320   MAPK1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CIMIRACEMATE A   MAPK1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19835377


    Sources:
    DTC

  • CHEMBL2088730   MAPK1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22982122


    Sources:
    DTC

  • CHEMBL2063681   MAPK1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22283430


    Sources:
    DTC

  • CHEMBL2063687   MAPK1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22283430


    Sources:
    DTC

  • PESUDOGINSENOSIDE RP1 METHYL ESTER   MAPK1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20951582


    Sources:
    DTC

  • CHEMBL1485809   MAPK1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TURPENTINE   MAPK1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • CHEMBL2088731   MAPK1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22982122


    Sources:
    DTC

  • CHEMBL329785   MAPK1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22982122


    Sources:
    DTC

  • SPINASAPONIN A METHYL ESTER   MAPK1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20951582


    Sources:
    DTC

  • REBAMIPIDE   MAPK1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17171453


    Sources:
    NCI

  • MK-8353   MAPK1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • BENZALKONIUM CHLORIDE   MAPK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL261237   MAPK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ARISTOYUNNOLIN A   MAPK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • VOLVALERENAL D   MAPK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MADOLIN T   MAPK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MADOLIN A   MAPK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL2333543   MAPK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL2333548   MAPK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • IROFULVEN   MAPK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12014623


    Sources:
    NCI

  • ARISTOLACTONE   MAPK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MADOLIN U   MAPK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DEMETHYLWEDELOLACTONE   MAPK1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22926226


    Sources:
    DTC

  • YUANHUADINE   MAPK1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21916433


    Sources:
    DTC

  • PURVALANOL B   MAPK1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11752352


    Sources:
    DrugBank

  • ETHER   MAPK1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16081674


    Sources:
    NCI

  • XANTHOHUMOL   MAPK1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22111577


    Sources:
    DTC

  • MUNDULONE ACETATE   MAPK1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OPHIOBOLIN O   MAPK1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22130129


    Sources:
    DTC

  • CHEMBL484662   MAPK1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GAMBOGIC AMIDE   MAPK1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17911251


    Sources:
    DTC

  • URACIL   MAPK1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17076658


    Sources:
    NCI

  • CHEMBL76589   MAPK1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OLOMOUCINE   MAPK1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CANTHARIDIN   MAPK1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PERIFOSINE   MAPK1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16528479


    Sources:
    DrugBank

  • DIPHENHYDRAMINE HYDROCHLORIDE   MAPK1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL532849   MAPK1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ZALCITABINE   MAPK1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHELERYTHRINE CHLORIDE   MAPK1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENMEDIPHAM   MAPK1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MUNDULONE   MAPK1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1939691   MAPK1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL184074   MAPK1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL29197   MAPK1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17681471


    Sources:
    DTC

  • SAPPANONE A TRIMETHYL ETHER   MAPK1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GAMBOGIC ACID   MAPK1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17911251


    Sources:
    DTC

  • ISOPROTERENOL   MAPK1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:

    PMIDs:
    15292328 20732414 15138589 13679574 15689414 12963636


    Sources:
    DrugBank

  • NAFTOPIDIL   MAPK1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL580183   MAPK1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL581194   MAPK1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TREQUINSIN HYDROCHLORIDE   MAPK1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • WEDELOLACTONE   MAPK1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22926226


    Sources:
    DTC

  • CHIR-99021   MAPK1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology

  • CHEMBL597035   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL210618   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL580340   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL531322   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL126804   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TYRPHOSTIN AG-1478   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • WITHAFERIN A   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20726569


    Sources:
    DTC

  • CHLORHEXIDINE HYDROCHLORIDE   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • O-DEMETHYLATED ADAPALENE   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL530280   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DERRUBONE   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL585628   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1270169   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RELCOVAPTAN   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL581872   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL581574   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1814509   MAPK1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SELICICLIB   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17108108


    Sources:
    DrugBank

  • BUMETANIDE   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11807827


    Sources:
    NCI

  • CHEMBL547833   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BISINDOLYLMALEIMIDE IX   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALPHA-NAPHTHOFLAVONE   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW282974X   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NECA   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SANGUINARIUM CHLORIDE   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MINOCYCLINE   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11986668


    Sources:
    DrugBank

  • CHEMBL88272   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • COMBRETASTATIN A4   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22982122


    Sources:
    DTC

  • CHEMBL421215   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • R-1487   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BIOCHANIN   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1493528   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PATULIN   MAPK1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DAPH   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • U-0126   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GF-109203   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LITHOCHOLIC ACID   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL609606   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SB-220025   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DTC DrugBank

  • CHEMBL285819   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL578944   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1224755   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL261557   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL222556   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ECONAZOLE NITRATE   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL154580   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIHYDROGAMBOGIC ACID   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLOROTHALONIL   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GUTHION   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PD-169316   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • IPRIFLAVONE   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CAPTAN   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SANGUINARINE SULFATE   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL586031   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ZIRAM   MAPK1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FISETIN   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PLUMBAGIN   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL428789   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL84010   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHLORANIL   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TYRPHOSTIN 47   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • QUINALIZARIN   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ISOVELLERAL   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1519374   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LORATADINE   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • INDIRUBIN-3-MONOXIME   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ZAFIRLUKAST   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GENTIAN VIOLET   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL2095095   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLIOQUINOL   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LEVODOPA   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16139809


    Sources:
    NCI

  • ACID BLUE 129   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CALCIMYCIN   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GR-127935   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENYLMERCURIC ACETATE   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MERCURIC CHLORIDE   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PURPURIN   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL578741   MAPK1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CI-1040   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MIBEFRADIL   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SANGUINARIUM   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • THIMEROSAL   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SB-203580   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ETOPOSIDE   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23999041


    Sources:
    DTC

  • HAEMATOXYLIN   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ERLOTINIB   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26181029


    Sources:
    CIViC

  • PHENETHYLISOTHIOCYANATE   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22607231


    Sources:
    DTC

  • PIMOZIDE   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIFLUOPERAZINE   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MITOXANTRONE HYDROCHLORIDE   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DAUNORUBICIN HYDROCHLORIDE   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOXORUBICIN HYDROCHLORIDE   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SB-202190   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL505670   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOTRIMAZOLE   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL541400   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL35482   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MITOXANTRONE   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SORAFENIB   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20124951


    Sources:
    PharmGKB

  • GO-6976   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ELLAGIC ACID   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GOSSYPOL   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL429095   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALSTERPAULLONE   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NIFEDIPINE   MAPK1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL225519   MAPK1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROGESTERONE   MAPK1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RG-1530   MAPK1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SP-600125   MAPK1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TAE-684   MAPK1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   MAPK1

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000100030

    • Version: 101_38

    Alternate Names:
    MAPK1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P28482

    • Version: January-2014

    Alternate Names:
    MAPK1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.11.24

    Publications:

  • RussLampel: ENSG00000100030

    • Version: 26-July-2011

    Alternate Names:
    MITOGEN-ACTIVATED PROTEIN KINASE 1 (EC 2.7.1.37) (EXTRACELLULAR SIGNAL-REGULATED KINASE 2) (ERK-2) (MITOGEN-ACTIVATED PROTEIN KINASE 2) (MAP KINASE 2) (MAPK 2) (P42-MAPK) (ERT1). [SOURCE:UNIPROT/SWISSPROT;ACC:P28482] Description
    ENSG00000100030 Ensembl Gene Id
    MAPK1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P28482

    • Version: 11-September-2012

    Alternate Names:
    MAPK1 Uniprot Gene Name
    MK01_HUMAN Uniprot Id
    ENSG00000100030 Ensembl Gene Id

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 5594

    • Version: 29-September-2020

    Alternate Names:
    6871 HUGO Gene ID
    6871 HUGO Gene Symbol
    mitogen-activated protein kinase 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name ERK subfamily
    GuideToPharmacology Gene Category ID 514

    Gene Categories:
    ENZYME

    Publications:

  • PharmGKB: MAPK1

    • Version: 18-August-2020

    Alternate Names:
    PA30616 PharmGKB ID

    Gene Info:

    Publications:
    Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

  • CIViC: MAPK1

    • Version: 14-September-2020

    Alternate Names:
    5594 Entrez Gene ID
    4532 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Ercan et al., 2012, Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors., Cancer Discov
    Van Allen et al., 2015, Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma., JAMA Oncol

  • DrugBank: BE0009668

    • Version: 5.1.7

    Alternate Names:
    MAPK1 DrugBank Gene Name
    P28482 UniProt Accession
    5594 Entrez Gene Id

    Gene Info:

    Publications:
    Alfonso L et al., 2014, Molecular targets of aspirin and cancer prevention., Br J Cancer
    Nishio T et al., 2016, Dual effects of acetylsalicylic acid on ERK signaling and Mitf transcription lead to inhibition of melanogenesis., Mol Cell Biochem
    Weissmann G et al., 2002, Non-prostaglandin effects of aspirin III and salicylate: inhibition of integrin-dependent human neutrophil aggregation and inflammation in COX 2- and NF kappa B (P105)-knockout mice., Adv Exp Med Biol

  • DrugBank: BE0009853

    • Version: 5.1.7

    Alternate Names:
    MAPK1 DrugBank Gene Name
    P28482 UniProt Accession
    5594 Entrez Gene Id

    Gene Info:

    Publications:
    Zhu et al., 2002, Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice., Nature

  • DrugBank: BE0000923

    • Version: 5.1.7

    Alternate Names:
    MAPK1 DrugBank Gene Name
    P28482 UniProt Accession
    5594 Entrez Gene Id

    Gene Info:

    Publications:
    Dubey et al., 2004, Catecholamines block the antimitogenic effect of estradiol on human coronary artery smooth muscle cells., J. Clin. Endocrinol. Metab.
    Vaniotis et al., 2011, Nuclear β-adrenergic receptors modulate gene expression in adult rat heart., Cell. Signal.
    Adissu et al., 2004, Antagonistic growth regulation of cell lines derived from human lung adenocarcinomas of Clara cell and aveolar type II cell lineage: Implications for chemoprevention., Int. J. Oncol.

  • TTD: Extracellular signal-regulated kinase 2

    • Version: 2020.06.01

    Alternate Names:
    ERK2 TTD Gene Abbreviation
    T58970 TTD Target ID

    Gene Info:

    Publications:
    Goetz EM et al., 2014, ERK mutations confer resistance to mitogen-activated protein kinase pathway inhibitors., Cancer Res

  • NCI: MAPK1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Shoemaker et al., 2005, Agonist-directed trafficking of response by endocannabinoids acting at CB2 receptors., J. Pharmacol. Exp. Ther.
    Imbe et al., 2005, Effects of peripheral inflammation on activation of ERK in the rostral ventromedial medulla., Brain Res.
    Veit et al., 2004, Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells., Cancer Res.

  • DTC: MAPK1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Liang C et al., 2010, Oleanane-type triterpenoids from Panax stipuleanatus and their anticancer activities., Bioorg Med Chem Lett
    Kamal A et al., 2012, Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents., Eur J Med Chem
    Lee YJ et al., 2012, Demethylwedelolactone derivatives inhibit invasive growth in vitro and lung metastasis of MDA-MB-231 breast cancer cells in nude mice., Eur J Med Chem

  • HingoraniCasas: ENSG00000100030

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000100030 Gene Symbol
    MAPK1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: ERK2

    • Version: chembl_23

    Alternate Names:
    PRKM1 GENE_SYMBOL
    PRKM2 GENE_SYMBOL
    MAPK1 GENE_SYMBOL

    Gene Info:

    Publications:

  • Pharos: MAPK1

    • Version: 03-September-2020

    Alternate Names:
    Mitogen-activated protein kinase 1 Gene Name
    P28482 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, TRANSCRIPTION FACTOR

    Publications:

  • GO: MAPK1

    • Version: 05-September-2020

    Alternate Names:
    ERK2 GO Gene Synonym
    PRKM1 GO Gene Synonym
    PRKM2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE, TRANSCRIPTION FACTOR BINDING

    Publications:

  • Tempus: MAPK1

    • Version: 11-November-2018

    Alternate Names:
    MAPK1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: MAPK1

    • Version: 27-Jun-2013

    Alternate Names:
    5594 Gene ID
    ERK dGene Synonym
    ERK2 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • MskImpact: MAPK1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: MAPK1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: MAPK1

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21