5605 |
MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 |
MAP2K2 |
CFC4 |
MAPKK2 |
MEK2 |
MKK2 |
PRKMK2 |
601263 |
6842 |
ENSG00000126934 |
OTTHUMG00000134286 |
P36507 |
DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 |
MP2K2_HUMAN |
ERK activator kinase 2 |
MAPK/ERK kinase 2 |
MAP kinase kinase 2 |
MAPKK 2 |
MEK 2 |
BE0004744 |
MEK |
2063 |
DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 (EC 2.7.1.-) (MAP KINASE KINASE 2) (MAPKK 2) (ERK ACTIVATOR KINASE 2) (MAPK/ERK KINASE 2) (MEK2). [SOURCE:UNIPROT/SWISSPROT;ACC:P36507] |
NP_109587 |
NM_030662 |
T89055 |
4542 |
Interpro Name | Serine/threonine- / dual-specificity protein kinase, catalytic domain |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR002290 |
Interpro Short Name | Ser/Thr_dual-sp_kinase_dom |
Human Readable Name | KINASE |
Uniprot Status | Swiss-Prot |
Interpro Type | Domain |
Uniprot Evidence | 1: Evidence at protein level |
Target Class | Enzymes |
Target Subclass | EC:2.7.12.2 |
GuideToPharmacology Gene Category Name | STE7 family |
GuideToPharmacology Gene Category ID | 623 |
Gene Biotype | PROTEIN_CODING |
KINASE |
SERINE THREONINE KINASE |
TYROSINE KINASE |
DRUG RESISTANCE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
ENZYME |
inhibitor (inhibitory) |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Notes |
allosteric modulator |
inhibitor (inhibitory) |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Direct Interaction | yes |
Direct Interaction? | True |
allosteric modulator |
inhibitor (inhibitory) |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Direct Interaction | yes |
Specific Action of the Ligand | Negative |
inhibitor (inhibitory) |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Direct Interaction | yes |
allosteric modulator |
inhibitor (inhibitory) |
Novel drug target | Novel Target |
Trial Name | ARRY-162 |
Specific Action of the Ligand | Negative |
inhibitor (inhibitory) |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Direct Interaction | yes |
n/a |
Novel drug target | Novel Target |
Trial Name | ARRY-300 |
inhibitor (inhibitory) |
Trial Name | WX-554 |
Novel drug target | Novel Target |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
inhibitor (inhibitory) |
Notes | |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Direct Interaction | yes |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | True |
inhibitor (inhibitory) |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Dual specificity mitogen-activated protein kinase kinase 2 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
MAP2K2 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
P36507 | Uniprot Accession |
5605 | Entrez Gene Id |
ENSG00000126934 | Ensembl Gene Id |
Interpro Name | Serine/threonine- / dual-specificity protein kinase, catalytic domain |
Human Readable Name | DRUGGABLE GENOME |
Interpro Acc | IPR002290 |
KINASE, DRUGGABLE GENOME |
DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 (EC 2.7.1.-) (MAP KINASE KINASE 2) (MAPKK 2) (ERK ACTIVATOR KINASE 2) (MAPK/ERK KINASE 2) (MEK2). [SOURCE:UNIPROT/SWISSPROT;ACC:P36507] | Description |
MAP2K2 | Display Id |
ENSG00000126934 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
MAP2K2 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.12.2 |
6842 | HUGO Gene ID |
6842 | HUGO Gene Symbol |
mitogen-activated protein kinase kinase 2 | HUGO Gene Name |
GuideToPharmacology Gene Category Name | STE7 family |
GuideToPharmacology Gene Category ID | 623 |
ENZYME |
5605 | Entrez Gene ID |
4542 | CIViC Gene ID |
DRUG RESISTANCE |
MAP2K2 | DrugBank Gene Name |
P36507 | UniProt Accession |
5605 | Entrez Gene Id |
ENSG00000126934 | Gene Symbol |
MAP2K2 | Ensembl Id |
DRUGGABLE GENOME |
MEK2 | Gene Symbol |
5605 | Entrez Gene Id |
MAP2K2 | MyCancerGenome Gene Symbol |
MEK | MyCancerGenome Reported Gene Name |
MKK2 | GENE_SYMBOL |
PRKMK2 | GENE_SYMBOL |
MAP2K2 | GENE_SYMBOL |
5605 | OncoKB Entrez Id |
MKK2 | OncoKB Gene Synonym |
PRKMK2 | OncoKB Gene Synonym |
Dual specificity mitogen-activated protein kinase kinase 2 | Gene Name |
P36507 | UniProt ID |
KINASE |
MEK2 | GO Gene Synonym |
MKK2 | GO Gene Synonym |
PRKMK2 | GO Gene Synonym |
SERINE THREONINE KINASE, TYROSINE KINASE |
MAP2K2 | Gene Symbol |
CLINICALLY ACTIONABLE |
5605 | Gene ID |
MAPKK2 | dGene Synonym |
MEK2 | dGene Synonym |
KINASE, SERINE THREONINE KINASE |
MEK2 | TTD Gene Abbreviation |
T89055 | TTD Target ID |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
DRUG RESISTANCE |