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MAP2K2 5605 Druggable GenomeClinically ActionableDrug Resistance
Alternate Names:
5605 MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 MAP2K2 CFC4 MAPKK2 MEK2 MKK2 PRKMK2 601263 6842 ENSG00000126934 OTTHUMG00000134286 P36507 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 MP2K2_HUMAN ERK activator kinase 2 MAPK/ERK kinase 2 MAP kinase kinase 2 MAPKK 2 MEK 2 MEK 2063 DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 (EC 2.7.1.-) (MAP KINASE KINASE 2) (MAPKK 2) (ERK ACTIVATOR KINASE 2) (MAPK/ERK KINASE 2) (MEK2). [SOURCE:UNIPROT/SWISSPROT;ACC:P36507] NP_109587 NM_030662 T89055 4542 Gene Info:
Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain Human Readable Name DRUGGABLE GENOME Interpro Acc IPR002290 Interpro Short Name Ser/Thr_dual-sp_kinase_dom Human Readable Name KINASE Uniprot Status Swiss-Prot Interpro Type Domain Uniprot Evidence 1: Evidence at protein level Target Class Enzymes Target Subclass EC:2.7.12.2 GuideToPharmacology Gene Category Name STE7 family GuideToPharmacology Gene Category ID 623 Gene Biotype PROTEIN_CODING Gene Categories: Category Details
KINASE SERINE THREONINE KINASE TYROSINE KINASE DRUG RESISTANCE DRUGGABLE GENOME CLINICALLY ACTIONABLE ENZYME Publications:
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Interaction Score: 1.56
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Interaction Score: 0.78
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Direct Interaction yes -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase; MEK1/2 inhibitor Direct Interaction yes -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Direct Interaction yes -
Interaction Score: 0.78
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Direct Interaction yes -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Direct Interaction yes -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor -
Interaction Score: 0.69
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Notes -
Interaction Score: 0.67
Interaction Types & Directionality:
allosteric modulator inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Direct Interaction yes Direct Interaction? True PMIDs:
None found
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Interaction Score: 0.67
Interaction Types & Directionality:
allosteric modulator inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Direct Interaction yes Specific Action of the Ligand Negative -
Interaction Score: 0.61
Interaction Types & Directionality:
allosteric modulator inhibitor (inhibitory) Interaction Info:
Novel drug target Novel Target Trial Name ARRY-162 Specific Action of the Ligand Negative -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Direct Interaction yes -
Interaction Score: 0.57
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Direct Interaction yes -
Interaction Types & Directionality:
n/a Interaction Info:
Novel drug target Novel Target Trial Name ARRY-300 -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Trial Name WX-554 Novel drug target Novel Target Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor -
Interaction Score: 0.4
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Notes Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Direct Interaction yes -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
-
Interaction Score: 0.39
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Direct Interaction yes -
Interaction Score: 0.28
Interaction Types & Directionality:
antagonist (inhibitory) inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True -
Interaction Score: 0.25
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Interaction Score: 0.22
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Direct Interaction yes -
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Dual specificity mitogen-activated protein kinase kinase 2 inhibitor Direct Interaction yes -
Interaction Score: 0.1
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Interaction Score: 0.1
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.09
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Interaction Score: 0.06
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Interaction Score: 0.05
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Interaction Score: 0.04
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Interaction Score: 0.03
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Interaction Score: 0.03
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Interaction Score: 0.03
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Interaction Score: 0.02
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Interaction Score: 0.01
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Interaction Score: 0.01
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Interaction Score: 0.01
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- Version: 101_38
Alternate Names:
MAP2K2 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 11-September-2012
Alternate Names:
P36507 Uniprot Accession 5605 Entrez Gene Id ENSG00000126934 Ensembl Gene Id Gene Info:
Interpro Name Serine/threonine- / dual-specificity protein kinase, catalytic domain Human Readable Name DRUGGABLE GENOME Interpro Acc IPR002290 Gene Categories:
KINASE, DRUGGABLE GENOME Publications:
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- Version: 26-July-2011
Alternate Names:
DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 2 (EC 2.7.1.-) (MAP KINASE KINASE 2) (MAPKK 2) (ERK ACTIVATOR KINASE 2) (MAPK/ERK KINASE 2) (MEK2). [SOURCE:UNIPROT/SWISSPROT;ACC:P36507] Description MAP2K2 Display Id ENSG00000126934 Ensembl Gene Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: January-2014
Alternate Names:
MAP2K2 Gene Symbol Gene Info:
Target Class Enzymes Target Subclass EC:2.7.12.2 Publications:
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- Version: 29-September-2020
Alternate Names:
6842 HUGO Gene ID 6842 HUGO Gene Symbol mitogen-activated protein kinase kinase 2 HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name STE7 family GuideToPharmacology Gene Category ID 623 Gene Categories:
ENZYME Publications:
-
Alternate Names:
5605 Entrez Gene ID 4542 CIViC Gene ID Gene Info:
Gene Categories:
DRUG RESISTANCE Publications:
-
Alternate Names:
Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000126934 Gene Symbol MAP2K2 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
-
Alternate Names:
MEK2 Gene Symbol Gene Info:
Publications:
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- Version: 20-Jun-2017
Alternate Names:
5605 Entrez Gene Id MAP2K2 MyCancerGenome Gene Symbol MEK MyCancerGenome Reported Gene Name Gene Info:
Publications:
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- Version: chembl_23
Alternate Names:
MKK2 GENE_SYMBOL PRKMK2 GENE_SYMBOL MAP2K2 GENE_SYMBOL Gene Info:
Publications:
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Alternate Names:
5605 OncoKB Entrez Id MKK2 OncoKB Gene Synonym PRKMK2 OncoKB Gene Synonym Gene Info:
Publications:
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Alternate Names:
MAP2K2 Gene Symbol Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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Alternate Names:
5605 Gene ID MAPKK2 dGene Synonym MEK2 dGene Synonym Gene Info:
Gene Categories:
KINASE, SERINE THREONINE KINASE Publications:
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- Version: 2020.06.01
Alternate Names:
MEK2 TTD Gene Abbreviation T89055 TTD Target ID Gene Info:
Publications:
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Alternate Names:
MEK2 GO Gene Synonym MKK2 GO Gene Synonym PRKMK2 GO Gene Synonym Gene Info:
Gene Categories:
SERINE THREONINE KINASE, TYROSINE KINASE Publications:
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Alternate Names:
Dual specificity mitogen-activated protein kinase kinase 2 Gene Name P36507 UniProt ID Gene Info:
Gene Categories:
KINASE Publications:
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- Version: 30-February-2014
Alternate Names:
Gene Info:
Publications:
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- Version: 15-June-2013
Alternate Names:
Gene Info:
Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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- Version: 03-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
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- Version: 04-September-2020
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
CLINICALLY ACTIONABLE Publications:
-
Alternate Names:
Gene Info:
Gene Categories:
DRUG RESISTANCE Publications: