DGIdb - MAOB Gene Record

MAOB 4129 Druggable GenomeDrug Resistance

Alternate Names:

4129
MONOAMINE OXIDASE B
MAOB
309860
6834
ENSG00000069535
OTTHUMG00000021388
P27338
MA0B
AMINE OXIDASE [FLAVIN-CONTAINING] B (EC 1.4.3.4) (MONOAMINE OXIDASE TYPE B) (MAO-B). [SOURCE:UNIPROT/SWISSPROT;ACC:P27338]
AOFB_HUMAN
Monoamine oxidase type B
MAO-B
Amine oxidase [flavin-containing] B
2490
T83011
NM_000898
NP_000889

Gene Info:

Target Class	Enzymes
Target Subclass	EC:1.4.3
Target Subclass	EC:1.4.3.4
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Interpro Acc	IPR002937
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Amine oxidase
Interpro Short Name	Amino_oxidase
Uniprot Status	Swiss-Prot
Target Main Class	Enzymes
Transmembrane Helix Count	1
Target Subclass	1.4.3
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Catecholamine turnover
GuideToPharmacology Gene Category ID	766

(9 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
DRUGGABLE GENOME
ENZYME

Publications:

McIntyre et al., 2006, The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms., Expert Opin Drug Saf
Nolen, 2003, [Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression]., Ned Tijdschr Geneeskd
Volz et al., 1998, Monoamine oxidase inhibitors. A perspective on their use in the elderly., Drugs Aging
Wooters et al., 2007, The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats., Behav Pharmacol
Chiche et al., 2009, Antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes., Mol. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Pickar et al., 1982, Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients., Arch. Gen. Psychiatry
Chenu et al., 2009, Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area., Int. J. Neuropsychopharmacol.
Ulus et al., 2000, Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors., Biochem. Pharmacol.
Sulzer et al., 2005, Mechanisms of neurotransmitter release by amphetamines: a review., Prog. Neurobiol.
Chau et al., 2010, Rasagiline protects against alpha-synuclein induced sensitivity to oxidative stress in dopaminergic cells., Neurochem. Int.
Uzun et al., Investigation of oral selegiline and rasagiline administration on QT interval in conscious rabbits., Eur Rev Med Pharmacol Sci
Weinreb et al., 2010, Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity., Prog. Neurobiol.
Chen et al., 2007, Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease., Clin Ther
Youdim et al., Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition., J. Neurosci. Res.
Naoi et al., 2009, Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson's disease., Expert Rev Neurother
Leegwater-Kim et al., 2010, The role of rasagiline in the treatment of Parkinson's disease., Clin Interv Aging
Youdim et al., 2001, Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]., Cell. Mol. Neurobiol.
Mason, 1985, Chronic administration of type A monoamine oxidase inhibitors increases duration of thiopentone anaesthesia in the rat., Physiol. Behav.
Kettler et al., 1990, Comparison of monoamine oxidase-A inhibition by moclobemide in vitro and ex vivo in rats., Acta Psychiatr Scand Suppl
Macleod et al., 2005, Monoamine oxidase B inhibitors for early Parkinson's disease., Cochrane Database Syst Rev
Patkar et al., 2006, Transdermal selegiline: the new generation of monoamine oxidase inhibitors., CNS Spectr
Heinonen et al., 1994, Pharmacokinetic aspects of l-deprenyl (selegiline) and its metabolites., Clin. Pharmacol. Ther.
Baker et al., 2007, Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders?, J Psychiatry Neurosci
Lee et al., 2007, Transdermal selegiline for the treatment of major depressive disorder., Neuropsychiatr Dis Treat
Heinonen et al., 1998, Safety of selegiline (deprenyl) in the treatment of Parkinson's disease., Drug Saf
2002, Selegiline: a second look. Six years later: too risky in Parkinson's disease., Prescrire Int
Magyar et al., Pharmacokinetic aspects of deprenyl effects., Pol J Pharmacol Pharm
Azzaro et al., 2007, Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules., J Clin Pharmacol
Deleu et al., 2002, Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease., Clin Pharmacokinet
Chrisp et al., 1991, Selegiline. A review of its pharmacology, symptomatic benefits and protective potential in Parkinson's disease., Drugs Aging
Stössel A et al., 2013, Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones., J Med Chem
Jagrat et al., 2011, Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies., Bioorg. Med. Chem. Lett.
Okaecwe T et al., 2012, Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives., Bioorg Med Chem
Adams et al., 1994, Chronic treatment with levodopa and/or selegiline does not affect behavioral recovery induced by fetal ventral mesencephalic grafts in unilaterally 6-hydroxydopamine-lesioned rats., Exp. Neurol.
Baraczka et al., 1983, Changes in dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in human cerebrospinal fluid after L-dopa and deprenyl administration., J. Neural Transm.
Mertens MD et al., 2014, Alkynyl-coumarinyl ethers as MAO-B inhibitors., Bioorg Med Chem
Marzo et al., 2004, Pharmacokinetics and pharmacodynamics of safinamide, a neuroprotectant with antiparkinsonian and anticonvulsant activity., Pharmacol. Res.
2004, Safinamide: FCE 26743, NW 1015, PNU 151774, PNU 151774E., Drugs R D
Finberg et al., 2002, Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, reserpine reversal, serotonergic and dopaminergic behaviours., Neuropharmacology
Gatch et al., 2006, Effects of monoamine oxidase inhibitors on cocaine discrimination in rats., Behav Pharmacol
Wiest et al., 1999, 3H[2-(2-benzofuranyl)-2-imidazoline] (BFI) binding in human platelets: modulation by tranylcypromine., Naunyn Schmiedebergs Arch. Pharmacol.
Lang et al., 2004, Liquid chromatographic and tandem mass spectrometric assay for evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors: application of biomarkers in drug discovery., Anal. Biochem.
Cohen et al., 1999, Reduction of oral ethanol self-administration in rats by monoamine oxidase inhibitors., Pharmacol. Biochem. Behav.
Salsali et al., 2004, Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6., Cell. Mol. Neurobiol.
Shioda et al., 2010, Mirtazapine abolishes hyperthermia in an animal model of serotonin syndrome., Neurosci. Lett.
Shioda et al., 2004, Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine., Prog. Neuropsychopharmacol. Biol. Psychiatry
Todd et al., 1995, GABA-elevating effects of the antidepressant/antipanic drug phenelzine in brain: effects of pretreatment with tranylcypromine, (-)-deprenyl and clorgyline., J Affect Disord
Löscher et al., 1999, Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy., J. Pharmacol. Exp. Ther.
Manley-King CI et al., 2011, Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues., Bioorg Med Chem
Bonnet U, 2003, Moclobemide: therapeutic use and clinical studies., CNS Drug Rev
Manley-King CI et al., 2011, Inhibition of monoamine oxidase by C5-substituted phthalimide analogues., Bioorg Med Chem
Strydom B et al., 2010, Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues., Bioorg Med Chem
Tang et al., 1998, Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments., J. Neurosci. Res.
Fang et al., 1995, Inhibition of monoamine oxidases by haloperidol and its metabolites: pharmacological implications for the chemotherapy of schizophrenia., Psychopharmacology (Berl.)
Booysen HP et al., 2011, Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase., Bioorg Med Chem
Huang M et al., 2015, Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease., Bioorg Med Chem Lett
Fuentes et al., 1979, Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats., Eur. J. Pharmacol.
Murphy et al., 1998, Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)., J. Neural Transm. Suppl.
Villeneuve et al., 2009, Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells., Am. J. Physiol. Heart Circ. Physiol.
Milczek EM et al., 2008, Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B., J Med Chem
Coelho Cerqueira E et al., 2011, Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO., Bioorg Med Chem
Nag S et al., 2012, Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B)., Bioorg Med Chem

PARGYLINE MAOB

Interaction Score: 23.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
25542589 16034956 16641841 7995016 17823646 477738 19300583 9673855 9564606 19542488 12199263 6441926 17715422 11978145 1794016

Sources:
DTC TTD
RASAGILINE MAOB

Interaction Score: 8.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name rasagiline mesylate, TVP-1012,Agilect

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
20624440 19499843 20600573 18035186 15573406 11752352 19673610 20517484 12043833

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
TRANYLCYPROMINE MAOB

Interaction Score: 7.69

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
12504917 16495723 14574774 9829163 10494892 15351283 10548268 15049511 20655983 15276688 11752352 8749840 10027835

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
SELEGILINE MAOB

Interaction Score: 3.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16034956 16641841 7995016 17823646 19300583 9673855 12199263 6441926 17715422 11752352 11978145 1794016 23631427 21680183

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
[18F]FLUORORASAGILINE MAOB

Interaction Score: 2.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22436387

Sources:
DTC
ISOCARBOXAZID MAOB

Interaction Score: 2.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Monoamine oxidase inhibitor

Trial Name -

PMIDs:
4070383 2248058

Sources:
TdgClinicalTrial ChemblInteractions TEND
BUDIPINE MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL1927670 MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22055712

Sources:
DTC
MOFEGILINE MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053775

Sources:
DTC
LAZABEMIDE MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL1927684 MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22055712

Sources:
DTC
INDELOXAZINE MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL602466 MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20093036

Sources:
DTC
CHEMBL602260 MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20093036

Sources:
DTC
CHEMBL1813518 MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21778064

Sources:
DTC
MOCLOBEMIDE MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
21680183 12595913

Sources:
DTC GuideToPharmacology
SULPHADOXINE MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL1642672 MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21134756

Sources:
DTC
CHEMBL2088301 MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22705191

Sources:
DTC
CHEMBL221877 MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SAFINAMIDE MESYLATE MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RASAGILINE MESYLATE MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL2088303 MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22705191

Sources:
DTC
GUAIACOL HYDROCHLORIDE MAOB

Interaction Score: 1.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PHENELZINE MAOB

Interaction Score: 1.25

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Irreversible inhibition

PMIDs:
16370964 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD
SAFINAMIDE MAOB

Interaction Score: 0.81

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
23631427 24560738 15082032 15563241

Sources:
DTC TdgClinicalTrial ChemblInteractions GuideToPharmacology TTD
4-HYDROXYBENZALDEHYDE MAOB

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SELEGILINE HYDROCHLORIDE MAOB

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ANISALDEHYDE MAOB

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PARGYLINE HYDROCHLORIDE MAOB

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Monoamine oxidase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
PIPERONAL MAOB

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
EUGENOL MAOB

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NAPHTHOQUINONE MAOB

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22071524

Sources:
DTC
LADOSTIGIL MAOB

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
INDANTADOL MAOB

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name V3381

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
LINEZOLID MAOB

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
PHENELZINE SULFATE MAOB

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PSORALEN MAOB

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
METHAMPHETAMINE MAOB

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name low dose intravenous methamphetamine

PMIDs:
10799660 15955613

Sources:
TdgClinicalTrial
FLAVANONE MAOB

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PIPERINE MAOB

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TRYPTAMINE MAOB

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LEVODOPA MAOB

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7867755 6420516

Sources:
NCI
MELATONIN MAOB

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9726430

Sources:
NCI
MENADIONE MAOB

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22071524

Sources:
DTC
RALFINAMIDE MAOB

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HALOPERIDOL MAOB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7617809

Sources:
NCI

Ensembl: ENSG00000069535
- Version: 101_38
Alternate Names:

MAOB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P27338
- Version: January-2014
Alternate Names:

MA0B Gene Symbol

MAOB Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.4.3

Target Subclass EC:1.4.3.4

Publications:
HopkinsGroom: P27338
- Version: 11-September-2012
Alternate Names:

MAOB Uniprot Gene Name

P27338 Uniprot Accession

4129 Entrez Gene Id

Gene Info:

Interpro Type Domain

Interpro Acc IPR002937

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: P27338
- Version: 01-August-2011
Alternate Names:

4129 Entrez Gene Id

P27338 Uniprot Accession

MAOB Gene Symbol

Gene Info:

Target Main Class Enzymes

Transmembrane Helix Count 1

Target Subclass 1.4.3

Publications:

RussLampel: ENSG00000069535

Version: 26-July-2011

Alternate Names:

AMINE OXIDASE [FLAVIN-CONTAINING] B (EC 1.4.3.4) (MONOAMINE OXIDASE TYPE B) (MAO-B). [SOURCE:UNIPROT/SWISSPROT;ACC:P27338] Description

ENSG00000069535 Ensembl Gene Id

MAOB Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 4129
- Version: 29-September-2020
Alternate Names:

6834 HUGO Gene ID

6834 HUGO Gene Symbol

monoamine oxidase B HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Catecholamine turnover

GuideToPharmacology Gene Category ID 766

Gene Categories:

ENZYME

Publications:

NCI: MAOB

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Fang et al., 1995, Inhibition of monoamine oxidases by haloperidol and its metabolites: pharmacological implications for the chemotherapy of schizophrenia., Psychopharmacology (Berl.)

Quitkin et al., 1984, l-Deprenyl in atypical depressives., Arch. Gen. Psychiatry

Adams et al., 1994, Chronic treatment with levodopa and/or selegiline does not affect behavioral recovery induced by fetal ventral mesencephalic grafts in unilaterally 6-hydroxydopamine-lesioned rats., Exp. Neurol.

DTC: MAOB

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Manley-King CI et al., 2011, Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues., Bioorg Med Chem

Okaecwe T et al., 2012, Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives., Bioorg Med Chem

Manley-King CI et al., 2011, Inhibition of monoamine oxidase by C5-substituted phthalimide analogues., Bioorg Med Chem

ChemblInteractions: MAOB
- Version: chembl_23
Alternate Names:

MAOB GENE_SYMBOL

Amine oxidase [flavin-containing] B UNIPROT

Monoamine oxidase type B UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000069535
- Version: 31-May-2017
Alternate Names:

ENSG00000069535 Gene Symbol

MAOB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Monoamine oxidase type B
- Version: 2020.06.01
Alternate Names:

MAO-B TTD Gene Abbreviation

T83011 TTD Target ID

Gene Info:

Publications:
Pharos: MAOB
- Version: 01-May-2021
Alternate Names:

Amine oxidase [flavin-containing] B Gene Name

P27338 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: MAOB
- Version: 01-May-2021
Alternate Names:

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Trial Name	rasagiline mesylate, TVP-1012,Agilect
Novel drug target	Established target
Specific Action of the Ligand	Inhibition

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Direct Interaction	yes
Mechanism of Interaction	Monoamine oxidase inhibitor
Trial Name	-

Mechanism of Interaction	Monoamine oxidase B inhibitor
Direct Interaction	yes

MAOB	Uniprot Gene Name
P27338	Uniprot Accession
4129	Entrez Gene Id

AMINE OXIDASE [FLAVIN-CONTAINING] B (EC 1.4.3.4) (MONOAMINE OXIDASE TYPE B) (MAO-B). [SOURCE:UNIPROT/SWISSPROT;ACC:P27338]	Description
ENSG00000069535	Ensembl Gene Id
MAOB	Display Id

6834	HUGO Gene ID
6834	HUGO Gene Symbol
monoamine oxidase B	HUGO Gene Name

MAOB	GENE_SYMBOL
Amine oxidase [flavin-containing] B	UNIPROT
Monoamine oxidase type B	UNIPROT

Amine oxidase [flavin-containing] B	Gene Name
P27338	UniProt ID

antagonist (inhibitory)
inhibitor (inhibitory)

MAOB Gene Record

MAOB 4129 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 25542589 16034956 16641841 7995016 17823646 477738 19300583 9673855 9564606 19542488 12199263 6441926 17715422 11978145 1794016

Sources: DTC TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name rasagiline mesylate, TVP-1012,Agilect Novel drug target Established target Specific Action of the Ligand Inhibition

PMIDs: 20624440 19499843 20600573 18035186 15573406 11752352 19673610 20517484 12043833

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Inhibition

PMIDs: 12504917 16495723 14574774 9829163 10494892 15351283 10548268 15049511 20655983 15276688 11752352 8749840 10027835

Sources: TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 16034956 16641841 7995016 17823646 19300583 9673855 12199263 6441926 17715422 11752352 11978145 1794016 23631427 21680183

Sources: DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22436387

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Monoamine oxidase inhibitor Trial Name -

PMIDs: 4070383 2248058

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22055712

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19053775

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22055712

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20093036

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20093036

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21778064

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 21680183 12595913

Sources: DTC GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21134756

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
25542589 16034956 16641841 7995016 17823646 477738 19300583 9673855 9564606 19542488 12199263 6441926 17715422 11978145 1794016

Sources:
DTC TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name rasagiline mesylate, TVP-1012,Agilect

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
20624440 19499843 20600573 18035186 15573406 11752352 19673610 20517484 12043833

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
12504917 16495723 14574774 9829163 10494892 15351283 10548268 15049511 20655983 15276688 11752352 8749840 10027835

Sources:
TdgClinicalTrial TEND GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16034956 16641841 7995016 17823646 19300583 9673855 12199263 6441926 17715422 11752352 11978145 1794016 23631427 21680183

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
22436387

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Monoamine oxidase inhibitor

Trial Name -

PMIDs:
4070383 2248058

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
22055712

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19053775

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
22055712

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
20093036

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20093036

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21778064

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
21680183 12595913

Sources:
DTC GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
21134756

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22705191

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22705191

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD