DGIdb - MAOB Gene Record

MAOB 4129 Druggable GenomeDrug Resistance

Alternate Names:

4129
MONOAMINE OXIDASE B
MAOB
309860
6834
ENSG00000069535
OTTHUMG00000021388
P27338
MA0B
AMINE OXIDASE [FLAVIN-CONTAINING] B (EC 1.4.3.4) (MONOAMINE OXIDASE TYPE B) (MAO-B). [SOURCE:UNIPROT/SWISSPROT;ACC:P27338]
AOFB_HUMAN
BE0002196
Monoamine oxidase type B
MAO-B
Amine oxidase [flavin-containing] B
2490
T83011
NM_000898
NP_000889

Gene Info:

Target Class	Enzymes
Target Subclass	EC:1.4.3
Target Subclass	EC:1.4.3.4
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Interpro Acc	IPR002937
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Amine oxidase
Interpro Short Name	Amino_oxidase
Uniprot Status	Swiss-Prot
Target Main Class	Enzymes
Transmembrane Helix Count	1
Target Subclass	1.4.3
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Catecholamine turnover
GuideToPharmacology Gene Category ID	766

(10 More Sources)

Gene Categories: Category Details

DRUG RESISTANCE
DRUGGABLE GENOME
ENZYME

Publications:

Nolen, 2003, [Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression]., Ned Tijdschr Geneeskd
Volz et al., 1998, Monoamine oxidase inhibitors. A perspective on their use in the elderly., Drugs Aging
Wooters et al., 2007, The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats., Behav Pharmacol
Chenu et al., 2009, Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area., Int. J. Neuropsychopharmacol.
McIntyre et al., 2006, The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms., Expert Opin Drug Saf
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Chiche et al., 2009, Antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes., Mol. Pharmacol.
Pickar et al., 1982, Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients., Arch. Gen. Psychiatry
Clarke et al., 1982, A comparison of cardiac and vascular clorgyline-resistant amine oxidase and monoamine oxidase. Inhibition by amphetamine, mexiletine and other drugs., Biochem. Pharmacol.
Egashira et al., 1999, The inhibition of monoamine oxidase activity by various antidepressants: differences found in various mammalian species., Jpn. J. Pharmacol.
Ulus et al., 2000, Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors., Biochem. Pharmacol.
Sulzer et al., 2005, Mechanisms of neurotransmitter release by amphetamines: a review., Prog. Neurobiol.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Youdim et al., 2001, Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]., Cell. Mol. Neurobiol.
Naoi et al., 2009, Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson's disease., Expert Rev Neurother
Uzun et al., Investigation of oral selegiline and rasagiline administration on QT interval in conscious rabbits., Eur Rev Med Pharmacol Sci
Chau et al., 2010, Rasagiline protects against alpha-synuclein induced sensitivity to oxidative stress in dopaminergic cells., Neurochem. Int.
Chen et al., 2007, Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease., Clin Ther
Youdim et al., Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition., J. Neurosci. Res.
Weinreb et al., 2010, Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity., Prog. Neurobiol.
Leegwater-Kim et al., 2010, The role of rasagiline in the treatment of Parkinson's disease., Clin Interv Aging
Hovevey-Sion et al., 1989, Effects of monoamine oxidase inhibitors on levels of catechols and homovanillic acid in striatum and plasma., Neuropharmacology
Kettler et al., 1990, Comparison of monoamine oxidase-A inhibition by moclobemide in vitro and ex vivo in rats., Acta Psychiatr Scand Suppl
Mason, 1985, Chronic administration of type A monoamine oxidase inhibitors increases duration of thiopentone anaesthesia in the rat., Physiol. Behav.
Heinonen et al., 1994, Pharmacokinetic aspects of l-deprenyl (selegiline) and its metabolites., Clin. Pharmacol. Ther.
Deleu et al., 2002, Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease., Clin Pharmacokinet
Jagrat et al., 2011, Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies., Bioorg. Med. Chem. Lett.
Stössel A et al., 2013, Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones., J Med Chem
Lee et al., 2007, Transdermal selegiline for the treatment of major depressive disorder., Neuropsychiatr Dis Treat
Magyar et al., Pharmacokinetic aspects of deprenyl effects., Pol J Pharmacol Pharm
Patkar et al., 2006, Transdermal selegiline: the new generation of monoamine oxidase inhibitors., CNS Spectr
Heinonen et al., 1998, Safety of selegiline (deprenyl) in the treatment of Parkinson's disease., Drug Saf
Azzaro et al., 2007, Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules., J Clin Pharmacol
Chrisp et al., 1991, Selegiline. A review of its pharmacology, symptomatic benefits and protective potential in Parkinson's disease., Drugs Aging
2002, Selegiline: a second look. Six years later: too risky in Parkinson's disease., Prescrire Int
Baker et al., 2007, Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders?, J Psychiatry Neurosci
Macleod et al., 2005, Monoamine oxidase B inhibitors for early Parkinson's disease., Cochrane Database Syst Rev
Okaecwe T et al., 2012, Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives., Bioorg Med Chem
Adams et al., 1994, Chronic treatment with levodopa and/or selegiline does not affect behavioral recovery induced by fetal ventral mesencephalic grafts in unilaterally 6-hydroxydopamine-lesioned rats., Exp. Neurol.
Baraczka et al., 1983, Changes in dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in human cerebrospinal fluid after L-dopa and deprenyl administration., J. Neural Transm.
2004, Safinamide: FCE 26743, NW 1015, PNU 151774, PNU 151774E., Drugs R D
Marzo et al., 2004, Pharmacokinetics and pharmacodynamics of safinamide, a neuroprotectant with antiparkinsonian and anticonvulsant activity., Pharmacol. Res.
Mertens MD et al., 2014, Alkynyl-coumarinyl ethers as MAO-B inhibitors., Bioorg Med Chem
Finberg et al., 2002, Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, reserpine reversal, serotonergic and dopaminergic behaviours., Neuropharmacology
Gatch et al., 2006, Effects of monoamine oxidase inhibitors on cocaine discrimination in rats., Behav Pharmacol
Wiest et al., 1999, 3H[2-(2-benzofuranyl)-2-imidazoline] (BFI) binding in human platelets: modulation by tranylcypromine., Naunyn Schmiedebergs Arch. Pharmacol.
Lang et al., 2004, Liquid chromatographic and tandem mass spectrometric assay for evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors: application of biomarkers in drug discovery., Anal. Biochem.
Cohen et al., 1999, Reduction of oral ethanol self-administration in rats by monoamine oxidase inhibitors., Pharmacol. Biochem. Behav.
Salsali et al., 2004, Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6., Cell. Mol. Neurobiol.
Shioda et al., 2010, Mirtazapine abolishes hyperthermia in an animal model of serotonin syndrome., Neurosci. Lett.
Shioda et al., 2004, Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine., Prog. Neuropsychopharmacol. Biol. Psychiatry
Todd et al., 1995, GABA-elevating effects of the antidepressant/antipanic drug phenelzine in brain: effects of pretreatment with tranylcypromine, (-)-deprenyl and clorgyline., J Affect Disord
Löscher et al., 1999, Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy., J. Pharmacol. Exp. Ther.
Green et al., 1980, p-Methoxyamphetamine, a potent reversible inhibitor of type-A monoamine oxidase in vitro and in vivo., J. Pharm. Pharmacol.
Ask et al., 1983, Selective inhibition of monoamine oxidase in monoaminergic neurons in the rat brain., Naunyn Schmiedebergs Arch. Pharmacol.
Manley-King CI et al., 2011, Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues., Bioorg Med Chem
Rothman, 1999, Does phentermine inhibit monoamine oxidase?, Lancet
Nandigama et al., 2002, Phentermine inhibition of recombinant human liver monoamine oxidases A and B., Biochem. Pharmacol.
Kilpatrick et al., 2001, Monoamine oxidase inhibition is unlikely to be relevant to the risks associated with phentermine and fenfluramine: a comparison with their abilities to evoke monoamine release., Int. J. Obes. Relat. Metab. Disord.
Rothman, 1999, Is phentermine an inhibitor of monoamine oxidase? A critical appraisal., Synapse
Bonnet U, 2003, Moclobemide: therapeutic use and clinical studies., CNS Drug Rev
Manley-King CI et al., 2011, Inhibition of monoamine oxidase by C5-substituted phthalimide analogues., Bioorg Med Chem
Strydom B et al., 2010, Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues., Bioorg Med Chem
Tang et al., 1998, Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments., J. Neurosci. Res.
Fang et al., 1995, Inhibition of monoamine oxidases by haloperidol and its metabolites: pharmacological implications for the chemotherapy of schizophrenia., Psychopharmacology (Berl.)
Booysen HP et al., 2011, Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase., Bioorg Med Chem
Villeneuve et al., 2009, Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells., Am. J. Physiol. Heart Circ. Physiol.
Huang M et al., 2015, Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease., Bioorg Med Chem Lett
Fuentes et al., 1979, Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats., Eur. J. Pharmacol.
Murphy et al., 1998, Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)., J. Neural Transm. Suppl.
Milczek EM et al., 2008, Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B., J Med Chem
Coelho Cerqueira E et al., 2011, Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO., Bioorg Med Chem
Murata et al., 2001, Zonisamide has beneficial effects on Parkinson's disease patients., Neurosci. Res.
Okada, 1994, [Effects of carbamazepine and zonisamide on dopaminergic system in rat striatum and hippocampus]., Nihon Shinkei Seishin Yakurigaku Zasshi
Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.
Okada et al., 1995, Effects of zonisamide on dopaminergic system., Epilepsy Res.
Murata, 2004, Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease., Curr. Pharm. Des.
Farooq et al., 2008, Therapeutic role of zonisamide in neuropsychiatric disorders., Mini Rev Med Chem
Murata, 2010, Zonisamide: a new drug for Parkinson's disease., Drugs Today
Nag S et al., 2012, Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B)., Bioorg Med Chem
Binda C et al., 2011, Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs., ACS Med Chem Lett
Binda C et al., 2003, Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures., Proc Natl Acad Sci U S A
Vermeiren C et al., 2018, The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases., Mov Disord
Sterling J et al., 1998, (R)(+)-N-propargyl-1-aminoindan (rasagiline) and derivatives: highly selective and potent inhibitors of monoamine oxidase B., J Neural Transm Suppl

PARGYLINE MAOB

Interaction Score: 7.52

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19542488 7995016 11978145 25542589 477738 19300583 9564606 6441926 16641841 9673855 17715422 1794016 12199263 17823646 16034956

Sources:
DTC TTD DrugBank
TRANYLCYPROMINE MAOB

Interaction Score: 5.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
12504917 16495723 14574774 9829163 10494892 15351283 10548268 15049511 20655983 15276688 11752352 8749840 10027835

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology
RASAGILINE MAOB

Interaction Score: 3.9

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name rasagiline mesylate, TVP-1012,Agilect

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
12043833 19673610 19499843 20624440 18035186 15573406 20600573 11752352 20517484

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology
AZILECT MAOB

Interaction Score: 2.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
9564630 10592235

Sources:
DrugBank
SELEGILINE MAOB

Interaction Score: 1.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
7995016 11978145 21680183 23631427 19300583 6441926 16641841 9673855 11752352 17715422 1794016 12199263 17823646 16034956

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
CHEMBL371428 MAOB

Interaction Score: 1.67

Interaction Types & Directionality:

ligand

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL436947 MAOB

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL239507 MAOB

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL1233960 MAOB

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL239508 MAOB

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
[18F]FLUORORASAGILINE MAOB

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22436387

Sources:
DTC
ISOCARBOXAZID MAOB

Interaction Score: 1.67

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Monoamine oxidase inhibitor

Trial Name -

PMIDs:
2248058 4070383

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions
MOCLOBEMIDE MAOB

Interaction Score: 1.04

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
21680183 12595913

Sources:
DTC DrugBank GuideToPharmacology
BUDIPINE MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL1927670 MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22055712

Sources:
DTC
MOFEGILINE MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053775

Sources:
DTC
LAZABEMIDE MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL1927684 MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22055712

Sources:
DTC
INDELOXAZINE MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL602466 MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20093036

Sources:
DTC
CHEMBL602260 MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20093036

Sources:
DTC
CHEMBL1813518 MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21778064

Sources:
DTC
SULPHADOXINE MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL1642672 MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21134756

Sources:
DTC
CHEMBL2088301 MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22705191

Sources:
DTC
CHEMBL221877 MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SAFINAMIDE MESYLATE MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RASAGILINE MESYLATE MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHEMBL2088303 MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22705191

Sources:
DTC
GUAIACOL HYDROCHLORIDE MAOB

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PHENTERMINE MAOB

Interaction Score: 0.72

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10799660 10218558 11911838 11673765 10231134

Sources:
DrugBank
PHENELZINE MAOB

Interaction Score: 0.64

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Irreversible inhibition

PMIDs:
14574774 9829163 17912044 18700056 16370964 11752352 19201819 7092487

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology
FLORTAUCIPIR F 18 MAOB

Interaction Score: 0.56

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
29278274

Sources:
DrugBank
SAFINAMIDE MAOB

Interaction Score: 0.56

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
15563241 15082032 23631427 24560738

Sources:
DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
FARNESOL MAOB

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
4-HYDROXYBENZALDEHYDE MAOB

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ISATIN MAOB

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
SELEGILINE HYDROCHLORIDE MAOB

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ANISALDEHYDE MAOB

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PARGYLINE HYDROCHLORIDE MAOB

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Monoamine oxidase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ZIMELDINE MAOB

Interaction Score: 0.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10580379

Sources:
DrugBank
PIPERONAL MAOB

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PARA-METHOXYAMPHETAMINE MAOB

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
6103055 6646243

Sources:
DrugBank
NAPHTHOQUINONE MAOB

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22071524

Sources:
DTC
CHEMBL1233973 MAOB

Interaction Score: 0.28

Interaction Types & Directionality:

ligand

Interaction Info:

PMIDs:
12913124 10592235

Sources:
DrugBank
LADOSTIGIL MAOB

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NIALAMIDE MAOB

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2506486

Sources:
DrugBank
CHEMBL126506 MAOB

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15955613

Sources:
DrugBank
NOMIFENSINE MAOB

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10580379

Sources:
DrugBank
EPHEDRA MAOB

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
10799660 15955613

Sources:
DrugBank
INDANTADOL MAOB

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name V3381

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
ZONISAMIDE MAOB

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11755227 7856330 19948168 8991786 14965331 18782051 20502722

Sources:
DrugBank
EUGENOL MAOB

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
METHAMPHETAMINE MAOB

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name low dose intravenous methamphetamine

PMIDs:
10799660 15955613

Sources:
TdgClinicalTrial DrugBank
LINEZOLID MAOB

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
PHENELZINE SULFATE MAOB

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PSORALEN MAOB

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PIOGLITAZONE MAOB

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22282722

Sources:
DrugBank
FLAVANONE MAOB

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
AMPHETAMINE MAOB

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
7059347

Sources:
DrugBank
TRYPTAMINE MAOB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LEVODOPA MAOB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7867755 6420516

Sources:
NCI
PIPERINE MAOB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MENADIONE MAOB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22071524

Sources:
DTC
MELATONIN MAOB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9726430

Sources:
NCI
RALFINAMIDE MAOB

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FLAVIN ADENIN DINUCLEOTIDE MAOB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
HALOPERIDOL MAOB

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7617809

Sources:
NCI

Ensembl: ENSG00000069535
- Version: 101_38
Alternate Names:

MAOB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P27338
- Version: January-2014
Alternate Names:

MA0B Gene Symbol

MAOB Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.4.3

Target Subclass EC:1.4.3.4

Publications:
HopkinsGroom: P27338
- Version: 11-September-2012
Alternate Names:

MAOB Uniprot Gene Name

P27338 Uniprot Accession

4129 Entrez Gene Id

Gene Info:

Interpro Type Domain

Interpro Acc IPR002937

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: P27338
- Version: 01-August-2011
Alternate Names:

4129 Entrez Gene Id

P27338 Uniprot Accession

MAOB Gene Symbol

Gene Info:

Target Main Class Enzymes

Transmembrane Helix Count 1

Target Subclass 1.4.3

Publications:

RussLampel: ENSG00000069535

Version: 26-July-2011

Alternate Names:

AMINE OXIDASE [FLAVIN-CONTAINING] B (EC 1.4.3.4) (MONOAMINE OXIDASE TYPE B) (MAO-B). [SOURCE:UNIPROT/SWISSPROT;ACC:P27338] Description

ENSG00000069535 Ensembl Gene Id

MAOB Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 4129
- Version: 29-September-2020
Alternate Names:

6834 HUGO Gene ID

6834 HUGO Gene Symbol

monoamine oxidase B HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Catecholamine turnover

GuideToPharmacology Gene Category ID 766

Gene Categories:

ENZYME

Publications:

DrugBank: BE0002196

Version: 5.1.7

Alternate Names:

MAOB DrugBank Gene Name

P27338 UniProt Accession

4129 Entrez Gene Id

Gene Info:

Publications:

Clarke et al., 1982, A comparison of cardiac and vascular clorgyline-resistant amine oxidase and monoamine oxidase. Inhibition by amphetamine, mexiletine and other drugs., Biochem. Pharmacol.

Ulus et al., 2000, Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors., Biochem. Pharmacol.

Rothman, 1999, Does phentermine inhibit monoamine oxidase?, Lancet

NCI: MAOB

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Fang et al., 1995, Inhibition of monoamine oxidases by haloperidol and its metabolites: pharmacological implications for the chemotherapy of schizophrenia., Psychopharmacology (Berl.)

Quitkin et al., 1984, l-Deprenyl in atypical depressives., Arch. Gen. Psychiatry

Adams et al., 1994, Chronic treatment with levodopa and/or selegiline does not affect behavioral recovery induced by fetal ventral mesencephalic grafts in unilaterally 6-hydroxydopamine-lesioned rats., Exp. Neurol.

DTC: MAOB

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Manley-King CI et al., 2011, Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues., Bioorg Med Chem

Okaecwe T et al., 2012, Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives., Bioorg Med Chem

Manley-King CI et al., 2011, Inhibition of monoamine oxidase by C5-substituted phthalimide analogues., Bioorg Med Chem

ChemblInteractions: MAOB
- Version: chembl_23
Alternate Names:

MAOB GENE_SYMBOL

Amine oxidase [flavin-containing] B UNIPROT

Monoamine oxidase type B UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000069535
- Version: 31-May-2017
Alternate Names:

ENSG00000069535 Gene Symbol

MAOB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: MAOB
- Version: 03-September-2020
Alternate Names:

P27338 UniProt ID

Amine oxidase [flavin-containing] B Gene Name

Gene Info:

Gene Categories:

ENZYME

Publications:
TTD: Monoamine oxidase type B
- Version: 2020.06.01
Alternate Names:

MAO-B TTD Gene Abbreviation

T83011 TTD Target ID

Gene Info:

Publications:
GO: MAOB
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Trial Name	-
Novel drug target	Established target
Specific Action of the Ligand	Inhibition

Trial Name	rasagiline mesylate, TVP-1012,Agilect
Novel drug target	Established target
Specific Action of the Ligand	Inhibition

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Direct Interaction	yes
Mechanism of Interaction	Monoamine oxidase inhibitor
Trial Name	-

Mechanism of Interaction	Monoamine oxidase B inhibitor
Direct Interaction	yes

MAOB	Uniprot Gene Name
P27338	Uniprot Accession
4129	Entrez Gene Id

AMINE OXIDASE [FLAVIN-CONTAINING] B (EC 1.4.3.4) (MONOAMINE OXIDASE TYPE B) (MAO-B). [SOURCE:UNIPROT/SWISSPROT;ACC:P27338]	Description
ENSG00000069535	Ensembl Gene Id
MAOB	Display Id

6834	HUGO Gene ID
6834	HUGO Gene Symbol
monoamine oxidase B	HUGO Gene Name

MAOB	DrugBank Gene Name
P27338	UniProt Accession
4129	Entrez Gene Id

MAOB	GENE_SYMBOL
Amine oxidase [flavin-containing] B	UNIPROT
Monoamine oxidase type B	UNIPROT

antagonist (inhibitory)
inhibitor (inhibitory)

P27338	UniProt ID
Amine oxidase [flavin-containing] B	Gene Name

MAOB Gene Record

MAOB 4129 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19542488 7995016 11978145 25542589 477738 19300583 9564606 6441926 16641841 9673855 17715422 1794016 12199263 17823646 16034956

Sources: DTC TTD DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Specific Action of the Ligand Inhibition

PMIDs: 12504917 16495723 14574774 9829163 10494892 15351283 10548268 15049511 20655983 15276688 11752352 8749840 10027835

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name rasagiline mesylate, TVP-1012,Agilect Novel drug target Established target Specific Action of the Ligand Inhibition

PMIDs: 12043833 19673610 19499843 20624440 18035186 15573406 20600573 11752352 20517484

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 9564630 10592235

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 7995016 11978145 21680183 23631427 19300583 6441926 16641841 9673855 11752352 17715422 1794016 12199263 17823646 16034956

Sources: TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: ligand

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22436387

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Monoamine oxidase inhibitor Trial Name -

PMIDs: 2248058 4070383

Sources: TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: 21680183 12595913

Sources: DTC DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22055712

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19053775

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22055712

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19542488 7995016 11978145 25542589 477738 19300583 9564606 6441926 16641841 9673855 17715422 1794016 12199263 17823646 16034956

Sources:
DTC TTD DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
12504917 16495723 14574774 9829163 10494892 15351283 10548268 15049511 20655983 15276688 11752352 8749840 10027835

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name rasagiline mesylate, TVP-1012,Agilect

Novel drug target Established target

Specific Action of the Ligand Inhibition

PMIDs:
12043833 19673610 19499843 20624440 18035186 15573406 20600573 11752352 20517484

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
9564630 10592235

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
7995016 11978145 21680183 23631427 19300583 6441926 16641841 9673855 11752352 17715422 1794016 12199263 17823646 16034956

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

ligand

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
22436387

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Monoamine oxidase inhibitor

Trial Name -

PMIDs:
2248058 4070383

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
21680183 12595913

Sources:
DTC DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
22055712

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19053775

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
22055712

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
20093036

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20093036

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21778064

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
21134756

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22705191