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MAOB Gene Record

  • Summary
  • Interactions
  • Claims
  • MAOB 4129 Druggable GenomeDrug Resistance

    Alternate Names:

    4129
    MONOAMINE OXIDASE B
    MAOB
    309860
    6834
    ENSG00000069535
    OTTHUMG00000021388
    P27338
    MA0B
    AMINE OXIDASE [FLAVIN-CONTAINING] B (EC 1.4.3.4) (MONOAMINE OXIDASE TYPE B) (MAO-B). [SOURCE:UNIPROT/SWISSPROT;ACC:P27338]
    AOFB_HUMAN
    BE0002196
    Monoamine oxidase type B
    MAO-B
    Amine oxidase [flavin-containing] B
    2490
    T83011
    NM_000898
    NP_000889

    Gene Info:

    Target Class Enzymes
    Target Subclass EC:1.4.3
    Target Subclass EC:1.4.3.4
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Interpro Acc IPR002937
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Amine oxidase
    Interpro Short Name Amino_oxidase
    Uniprot Status Swiss-Prot
    Target Main Class Enzymes
    Transmembrane Helix Count 1
    Target Subclass 1.4.3
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Catecholamine turnover
    GuideToPharmacology Gene Category ID 766
    (10 More Sources)

    Gene Categories: Category Details

    DRUG RESISTANCE
    DRUGGABLE GENOME
    ENZYME

    Publications:

    Nolen, 2003, [Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression]., Ned Tijdschr Geneeskd
    Volz et al., 1998, Monoamine oxidase inhibitors. A perspective on their use in the elderly., Drugs Aging
    Wooters et al., 2007, The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats., Behav Pharmacol
    Chenu et al., 2009, Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area., Int. J. Neuropsychopharmacol.
    McIntyre et al., 2006, The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms., Expert Opin Drug Saf
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Chiche et al., 2009, Antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes., Mol. Pharmacol.
    Pickar et al., 1982, Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients., Arch. Gen. Psychiatry
    Clarke et al., 1982, A comparison of cardiac and vascular clorgyline-resistant amine oxidase and monoamine oxidase. Inhibition by amphetamine, mexiletine and other drugs., Biochem. Pharmacol.
    Egashira et al., 1999, The inhibition of monoamine oxidase activity by various antidepressants: differences found in various mammalian species., Jpn. J. Pharmacol.
    Ulus et al., 2000, Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors., Biochem. Pharmacol.
    Sulzer et al., 2005, Mechanisms of neurotransmitter release by amphetamines: a review., Prog. Neurobiol.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Youdim et al., 2001, Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]., Cell. Mol. Neurobiol.
    Naoi et al., 2009, Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson's disease., Expert Rev Neurother
    Uzun et al., Investigation of oral selegiline and rasagiline administration on QT interval in conscious rabbits., Eur Rev Med Pharmacol Sci
    Chau et al., 2010, Rasagiline protects against alpha-synuclein induced sensitivity to oxidative stress in dopaminergic cells., Neurochem. Int.
    Chen et al., 2007, Comprehensive review of rasagiline, a second-generation monoamine oxidase inhibitor, for the treatment of Parkinson's disease., Clin Ther
    Youdim et al., Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition., J. Neurosci. Res.
    Weinreb et al., 2010, Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity., Prog. Neurobiol.
    Leegwater-Kim et al., 2010, The role of rasagiline in the treatment of Parkinson's disease., Clin Interv Aging
    Hovevey-Sion et al., 1989, Effects of monoamine oxidase inhibitors on levels of catechols and homovanillic acid in striatum and plasma., Neuropharmacology
    Kettler et al., 1990, Comparison of monoamine oxidase-A inhibition by moclobemide in vitro and ex vivo in rats., Acta Psychiatr Scand Suppl
    Mason, 1985, Chronic administration of type A monoamine oxidase inhibitors increases duration of thiopentone anaesthesia in the rat., Physiol. Behav.
    Heinonen et al., 1994, Pharmacokinetic aspects of l-deprenyl (selegiline) and its metabolites., Clin. Pharmacol. Ther.
    Deleu et al., 2002, Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson's disease., Clin Pharmacokinet
    Jagrat et al., 2011, Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies., Bioorg. Med. Chem. Lett.
    Stössel A et al., 2013, Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones., J Med Chem
    Lee et al., 2007, Transdermal selegiline for the treatment of major depressive disorder., Neuropsychiatr Dis Treat
    Magyar et al., Pharmacokinetic aspects of deprenyl effects., Pol J Pharmacol Pharm
    Patkar et al., 2006, Transdermal selegiline: the new generation of monoamine oxidase inhibitors., CNS Spectr
    Heinonen et al., 1998, Safety of selegiline (deprenyl) in the treatment of Parkinson's disease., Drug Saf
    Azzaro et al., 2007, Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules., J Clin Pharmacol
    Chrisp et al., 1991, Selegiline. A review of its pharmacology, symptomatic benefits and protective potential in Parkinson's disease., Drugs Aging
    2002, Selegiline: a second look. Six years later: too risky in Parkinson's disease., Prescrire Int
    Baker et al., 2007, Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders?, J Psychiatry Neurosci
    Macleod et al., 2005, Monoamine oxidase B inhibitors for early Parkinson's disease., Cochrane Database Syst Rev
    Okaecwe T et al., 2012, Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives., Bioorg Med Chem
    Adams et al., 1994, Chronic treatment with levodopa and/or selegiline does not affect behavioral recovery induced by fetal ventral mesencephalic grafts in unilaterally 6-hydroxydopamine-lesioned rats., Exp. Neurol.
    Baraczka et al., 1983, Changes in dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in human cerebrospinal fluid after L-dopa and deprenyl administration., J. Neural Transm.
    2004, Safinamide: FCE 26743, NW 1015, PNU 151774, PNU 151774E., Drugs R D
    Marzo et al., 2004, Pharmacokinetics and pharmacodynamics of safinamide, a neuroprotectant with antiparkinsonian and anticonvulsant activity., Pharmacol. Res.
    Mertens MD et al., 2014, Alkynyl-coumarinyl ethers as MAO-B inhibitors., Bioorg Med Chem
    Finberg et al., 2002, Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, reserpine reversal, serotonergic and dopaminergic behaviours., Neuropharmacology
    Gatch et al., 2006, Effects of monoamine oxidase inhibitors on cocaine discrimination in rats., Behav Pharmacol
    Wiest et al., 1999, 3H[2-(2-benzofuranyl)-2-imidazoline] (BFI) binding in human platelets: modulation by tranylcypromine., Naunyn Schmiedebergs Arch. Pharmacol.
    Lang et al., 2004, Liquid chromatographic and tandem mass spectrometric assay for evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors: application of biomarkers in drug discovery., Anal. Biochem.
    Cohen et al., 1999, Reduction of oral ethanol self-administration in rats by monoamine oxidase inhibitors., Pharmacol. Biochem. Behav.
    Salsali et al., 2004, Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6., Cell. Mol. Neurobiol.
    Shioda et al., 2010, Mirtazapine abolishes hyperthermia in an animal model of serotonin syndrome., Neurosci. Lett.
    Shioda et al., 2004, Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine., Prog. Neuropsychopharmacol. Biol. Psychiatry
    Todd et al., 1995, GABA-elevating effects of the antidepressant/antipanic drug phenelzine in brain: effects of pretreatment with tranylcypromine, (-)-deprenyl and clorgyline., J Affect Disord
    Löscher et al., 1999, Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy., J. Pharmacol. Exp. Ther.
    Green et al., 1980, p-Methoxyamphetamine, a potent reversible inhibitor of type-A monoamine oxidase in vitro and in vivo., J. Pharm. Pharmacol.
    Ask et al., 1983, Selective inhibition of monoamine oxidase in monoaminergic neurons in the rat brain., Naunyn Schmiedebergs Arch. Pharmacol.
    Manley-King CI et al., 2011, Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues., Bioorg Med Chem
    Rothman, 1999, Does phentermine inhibit monoamine oxidase?, Lancet
    Nandigama et al., 2002, Phentermine inhibition of recombinant human liver monoamine oxidases A and B., Biochem. Pharmacol.
    Kilpatrick et al., 2001, Monoamine oxidase inhibition is unlikely to be relevant to the risks associated with phentermine and fenfluramine: a comparison with their abilities to evoke monoamine release., Int. J. Obes. Relat. Metab. Disord.
    Rothman, 1999, Is phentermine an inhibitor of monoamine oxidase? A critical appraisal., Synapse
    Bonnet U, 2003, Moclobemide: therapeutic use and clinical studies., CNS Drug Rev
    Manley-King CI et al., 2011, Inhibition of monoamine oxidase by C5-substituted phthalimide analogues., Bioorg Med Chem
    Strydom B et al., 2010, Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues., Bioorg Med Chem
    Tang et al., 1998, Enhanced glial cell line-derived neurotrophic factor mRNA expression upon (-)-deprenyl and melatonin treatments., J. Neurosci. Res.
    Fang et al., 1995, Inhibition of monoamine oxidases by haloperidol and its metabolites: pharmacological implications for the chemotherapy of schizophrenia., Psychopharmacology (Berl.)
    Booysen HP et al., 2011, Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase., Bioorg Med Chem
    Villeneuve et al., 2009, Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells., Am. J. Physiol. Heart Circ. Physiol.
    Huang M et al., 2015, Multifunctional coumarin derivatives: monoamine oxidase B (MAO-B) inhibition, anti-β-amyloid (Aβ) aggregation and metal chelation properties against Alzheimer's disease., Bioorg Med Chem Lett
    Fuentes et al., 1979, Central mediation of the antihypertensive effect of pargyline in spontaneously hypertensive rats., Eur. J. Pharmacol.
    Murphy et al., 1998, Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgyline) or MAO-B (selegiline and pargyline)., J. Neural Transm. Suppl.
    Milczek EM et al., 2008, Structural and mechanistic studies of mofegiline inhibition of recombinant human monoamine oxidase B., J Med Chem
    Coelho Cerqueira E et al., 2011, Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO., Bioorg Med Chem
    Murata et al., 2001, Zonisamide has beneficial effects on Parkinson's disease patients., Neurosci. Res.
    Okada, 1994, [Effects of carbamazepine and zonisamide on dopaminergic system in rat striatum and hippocampus]., Nihon Shinkei Seishin Yakurigaku Zasshi
    Sonsalla et al., 2010, The antiepileptic drug zonisamide inhibits MAO-B and attenuates MPTP toxicity in mice: clinical relevance., Exp. Neurol.
    Okada et al., 1995, Effects of zonisamide on dopaminergic system., Epilepsy Res.
    Murata, 2004, Novel therapeutic effects of the anti-convulsant, zonisamide, on Parkinson's disease., Curr. Pharm. Des.
    Farooq et al., 2008, Therapeutic role of zonisamide in neuropsychiatric disorders., Mini Rev Med Chem
    Murata, 2010, Zonisamide: a new drug for Parkinson's disease., Drugs Today
    Nag S et al., 2012, Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B)., Bioorg Med Chem
    Binda C et al., 2011, Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs., ACS Med Chem Lett
    Binda C et al., 2003, Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures., Proc Natl Acad Sci U S A
    Vermeiren C et al., 2018, The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases., Mov Disord
    Sterling J et al., 1998, (R)(+)-N-propargyl-1-aminoindan (rasagiline) and derivatives: highly selective and potent inhibitors of monoamine oxidase B., J Neural Transm Suppl
  • PARGYLINE   MAOB

    Interaction Score: 7.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19542488 7995016 11978145 25542589 477738 19300583 9564606 6441926 16641841 9673855 17715422 1794016 12199263 17823646 16034956


    Sources:
    DTC TTD DrugBank

  • TRANYLCYPROMINE   MAOB

    Interaction Score: 5.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Inhibition

    PMIDs:
    12504917 16495723 14574774 9829163 10494892 15351283 10548268 15049511 20655983 15276688 11752352 8749840 10027835


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • RASAGILINE   MAOB

    Interaction Score: 3.9

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name rasagiline mesylate, TVP-1012,Agilect
    Novel drug target Established target
    Specific Action of the Ligand Inhibition

    PMIDs:
    12043833 19673610 19499843 20624440 18035186 15573406 20600573 11752352 20517484


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • AZILECT   MAOB

    Interaction Score: 2.51

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    9564630 10592235


    Sources:
    DrugBank

  • SELEGILINE   MAOB

    Interaction Score: 1.95

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    7995016 11978145 21680183 23631427 19300583 6441926 16641841 9673855 11752352 17715422 1794016 12199263 17823646 16034956


    Sources:
    TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • CHEMBL371428   MAOB

    Interaction Score: 1.67

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL436947   MAOB

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL239507   MAOB

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL1233960   MAOB

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • CHEMBL239508   MAOB

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • [18F]FLUORORASAGILINE   MAOB

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22436387


    Sources:
    DTC

  • ISOCARBOXAZID   MAOB

    Interaction Score: 1.67

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Monoamine oxidase inhibitor
    Trial Name -

    PMIDs:
    2248058 4070383


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • MOCLOBEMIDE   MAOB

    Interaction Score: 1.04

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    21680183 12595913


    Sources:
    DTC DrugBank GuideToPharmacology

  • BUDIPINE   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL1927670   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22055712


    Sources:
    DTC

  • MOFEGILINE   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19053775


    Sources:
    DTC

  • LAZABEMIDE   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL1927684   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22055712


    Sources:
    DTC

  • INDELOXAZINE   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL602466   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20093036


    Sources:
    DTC

  • CHEMBL602260   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20093036


    Sources:
    DTC

  • CHEMBL1813518   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21778064


    Sources:
    DTC

  • SULPHADOXINE   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHEMBL1642672   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21134756


    Sources:
    DTC

  • CHEMBL2088301   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22705191


    Sources:
    DTC

  • CHEMBL221877   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SAFINAMIDE MESYLATE   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Monoamine oxidase B inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RASAGILINE MESYLATE   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Monoamine oxidase B inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL2088303   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22705191


    Sources:
    DTC

  • GUAIACOL HYDROCHLORIDE   MAOB

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PHENTERMINE   MAOB

    Interaction Score: 0.72

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    10799660 10218558 11911838 11673765 10231134


    Sources:
    DrugBank

  • PHENELZINE   MAOB

    Interaction Score: 0.64

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Irreversible inhibition

    PMIDs:
    14574774 9829163 17912044 18700056 16370964 11752352 19201819 7092487


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • FLORTAUCIPIR F 18   MAOB

    Interaction Score: 0.56

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    29278274


    Sources:
    DrugBank

  • SAFINAMIDE   MAOB

    Interaction Score: 0.56

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    15563241 15082032 23631427 24560738


    Sources:
    DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • FARNESOL   MAOB

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    DrugBank

  • 4-HYDROXYBENZALDEHYDE   MAOB

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ISATIN   MAOB

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • SELEGILINE HYDROCHLORIDE   MAOB

    Interaction Score: 0.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Monoamine oxidase B inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ANISALDEHYDE   MAOB

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PARGYLINE HYDROCHLORIDE   MAOB

    Interaction Score: 0.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Monoamine oxidase inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZIMELDINE   MAOB

    Interaction Score: 0.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    10580379


    Sources:
    DrugBank

  • PIPERONAL   MAOB

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PARA-METHOXYAMPHETAMINE   MAOB

    Interaction Score: 0.36

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    6103055 6646243


    Sources:
    DrugBank

  • NAPHTHOQUINONE   MAOB

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22071524


    Sources:
    DTC

  • CHEMBL1233973   MAOB

    Interaction Score: 0.28

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    12913124 10592235


    Sources:
    DrugBank

  • LADOSTIGIL   MAOB

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NIALAMIDE   MAOB

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2506486


    Sources:
    DrugBank

  • CHEMBL126506   MAOB

    Interaction Score: 0.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    15955613


    Sources:
    DrugBank

  • NOMIFENSINE   MAOB

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10580379


    Sources:
    DrugBank

  • EPHEDRA   MAOB

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    10799660 15955613


    Sources:
    DrugBank

  • INDANTADOL   MAOB

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name V3381
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • ZONISAMIDE   MAOB

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11755227 7856330 19948168 8991786 14965331 18782051 20502722


    Sources:
    DrugBank

  • EUGENOL   MAOB

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • METHAMPHETAMINE   MAOB

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name low dose intravenous methamphetamine

    PMIDs:
    10799660 15955613


    Sources:
    TdgClinicalTrial DrugBank

  • LINEZOLID   MAOB

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PHENELZINE SULFATE   MAOB

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Monoamine oxidase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PSORALEN   MAOB

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PIOGLITAZONE   MAOB

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22282722


    Sources:
    DrugBank

  • FLAVANONE   MAOB

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • AMPHETAMINE   MAOB

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    7059347


    Sources:
    DrugBank

  • TRYPTAMINE   MAOB

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LEVODOPA   MAOB

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7867755 6420516


    Sources:
    NCI

  • PIPERINE   MAOB

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MENADIONE   MAOB

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22071524


    Sources:
    DTC

  • MELATONIN   MAOB

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9726430


    Sources:
    NCI

  • RALFINAMIDE   MAOB

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Monoamine oxidase B inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FLAVIN ADENIN DINUCLEOTIDE   MAOB

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • HALOPERIDOL   MAOB

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7617809


    Sources:
    NCI

  • Ensembl: ENSG00000069535

    • Version: 101_38

    Alternate Names:
    MAOB Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P27338

    • Version: January-2014

    Alternate Names:
    MA0B Gene Symbol
    MAOB Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.4.3
    Target Subclass EC:1.4.3.4

    Publications:

  • HopkinsGroom: P27338

    • Version: 11-September-2012

    Alternate Names:
    MAOB Uniprot Gene Name
    P27338 Uniprot Accession
    4129 Entrez Gene Id

    Gene Info:
    Interpro Type Domain
    Interpro Acc IPR002937
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P27338

    • Version: 01-August-2011

    Alternate Names:
    4129 Entrez Gene Id
    P27338 Uniprot Accession
    MAOB Gene Symbol

    Gene Info:
    Target Main Class Enzymes
    Transmembrane Helix Count 1
    Target Subclass 1.4.3

    Publications:

  • RussLampel: ENSG00000069535

    • Version: 26-July-2011

    Alternate Names:
    AMINE OXIDASE [FLAVIN-CONTAINING] B (EC 1.4.3.4) (MONOAMINE OXIDASE TYPE B) (MAO-B). [SOURCE:UNIPROT/SWISSPROT;ACC:P27338] Description
    ENSG00000069535 Ensembl Gene Id
    MAOB Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 4129

    • Version: 29-September-2020

    Alternate Names:
    6834 HUGO Gene ID
    6834 HUGO Gene Symbol
    monoamine oxidase B HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Catecholamine turnover
    GuideToPharmacology Gene Category ID 766

    Gene Categories:
    ENZYME

    Publications:

  • DrugBank: BE0002196

    • Version: 5.1.7

    Alternate Names:
    MAOB DrugBank Gene Name
    P27338 UniProt Accession
    4129 Entrez Gene Id

    Gene Info:

    Publications:
    Clarke et al., 1982, A comparison of cardiac and vascular clorgyline-resistant amine oxidase and monoamine oxidase. Inhibition by amphetamine, mexiletine and other drugs., Biochem. Pharmacol.
    Ulus et al., 2000, Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors., Biochem. Pharmacol.
    Rothman, 1999, Does phentermine inhibit monoamine oxidase?, Lancet

  • NCI: MAOB

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Fang et al., 1995, Inhibition of monoamine oxidases by haloperidol and its metabolites: pharmacological implications for the chemotherapy of schizophrenia., Psychopharmacology (Berl.)
    Quitkin et al., 1984, l-Deprenyl in atypical depressives., Arch. Gen. Psychiatry
    Adams et al., 1994, Chronic treatment with levodopa and/or selegiline does not affect behavioral recovery induced by fetal ventral mesencephalic grafts in unilaterally 6-hydroxydopamine-lesioned rats., Exp. Neurol.

  • DTC: MAOB

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Manley-King CI et al., 2011, Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues., Bioorg Med Chem
    Okaecwe T et al., 2012, Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives., Bioorg Med Chem
    Manley-King CI et al., 2011, Inhibition of monoamine oxidase by C5-substituted phthalimide analogues., Bioorg Med Chem

  • ChemblInteractions: MAOB

    • Version: chembl_23

    Alternate Names:
    MAOB GENE_SYMBOL
    Amine oxidase [flavin-containing] B UNIPROT
    Monoamine oxidase type B UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000069535

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000069535 Gene Symbol
    MAOB Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: MAOB

    • Version: 03-September-2020

    Alternate Names:
    P27338 UniProt ID
    Amine oxidase [flavin-containing] B Gene Name

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • TTD: Monoamine oxidase type B

    • Version: 2020.06.01

    Alternate Names:
    MAO-B TTD Gene Abbreviation
    T83011 TTD Target ID

    Gene Info:

    Publications:

  • GO: MAOB

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21