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MAOA Gene Record

  • Summary
  • Interactions
  • Claims
  • MAOA 4128 Druggable Genome

    Alternate Names:

    4128
    MONOAMINE OXIDASE A
    MAOA
    BRNRS
    MAO-A
    309850
    6833
    ENSG00000189221
    OTTHUMG00000021387
    P21397
    AOFA_HUMAN
    Amine oxidase [flavin-containing] A
    Monoamine oxidase type A
    AMINE OXIDASE [FLAVIN-CONTAINING] A (EC 1.4.3.4) (MONOAMINE OXIDASE TYPE A) (MAO-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P21397]
    T83875

    Gene Info:

    Target Main Class Enzymes
    Target Subclass 1.4.3.4
    Transmembrane Helix Count 1
    Target Class Enzymes
    Target Subclass EC:1.4.3.4
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Interpro Name Amine oxidase
    Interpro Acc IPR002937
    Uniprot Status Swiss-Prot
    Interpro Short Name Amino_oxidase
    Uniprot Evidence 1: Evidence at protein level
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Ulus et al., 2000, Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors., Biochem. Pharmacol.
    Sulzer et al., 2005, Mechanisms of neurotransmitter release by amphetamines: a review., Prog. Neurobiol.
    McIntyre et al., 2006, The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms., Expert Opin Drug Saf
    MacKenzie et al., 2008, Phenelzine causes an increase in brain ornithine that is prevented by prior monoamine oxidase inhibition., Neurochem. Res.
    Nolen, 2003, [Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression]., Ned Tijdschr Geneeskd
    Volz et al., 1998, Monoamine oxidase inhibitors. A perspective on their use in the elderly., Drugs Aging
    Wooters et al., 2007, The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats., Behav Pharmacol
    Chiche et al., 2009, Antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes., Mol. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Pickar et al., 1982, Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients., Arch. Gen. Psychiatry
    Chenu et al., 2009, Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area., Int. J. Neuropsychopharmacol.
    Patkar et al., 2006, Transdermal selegiline: the new generation of monoamine oxidase inhibitors., CNS Spectr
    Lee et al., 2007, Transdermal selegiline for the treatment of major depressive disorder., Neuropsychiatr Dis Treat
    Azzaro et al., 2007, Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules., J Clin Pharmacol
    Baker et al., 2007, Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders?, J Psychiatry Neurosci
    Jagrat et al., 2011, Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies., Bioorg. Med. Chem. Lett.
    Booysen HP et al., 2011, Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase., Bioorg Med Chem
    Kettler et al., 1990, Comparison of monoamine oxidase-A inhibition by moclobemide in vitro and ex vivo in rats., Acta Psychiatr Scand Suppl
    Thase et al., 1995, MAOIs in the contemporary treatment of depression., Neuropsychopharmacology
    Wichitnithad W et al., 2011, Time-dependent slowly-reversible inhibition of monoamine oxidase A by N-substituted 1,2,3,6-tetrahydropyridines., Bioorg Med Chem
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Fulton et al., 1996, Moclobemide. An update of its pharmacological properties and therapeutic use., Drugs
    Berlin et al., 1990, Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase-A inhibitors moclobemide and toloxatone, and assessment of their effect on psychometric performance in healthy subjects., Br J Clin Pharmacol
    Bonnet U, 2003, Moclobemide: therapeutic use and clinical studies., CNS Drug Rev
    Finberg et al., 2002, Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, reserpine reversal, serotonergic and dopaminergic behaviours., Neuropharmacology
    Todd et al., 1995, GABA-elevating effects of the antidepressant/antipanic drug phenelzine in brain: effects of pretreatment with tranylcypromine, (-)-deprenyl and clorgyline., J Affect Disord
    Wiest et al., 1999, 3H[2-(2-benzofuranyl)-2-imidazoline] (BFI) binding in human platelets: modulation by tranylcypromine., Naunyn Schmiedebergs Arch. Pharmacol.
    Löscher et al., 1999, Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy., J. Pharmacol. Exp. Ther.
    Salsali et al., 2004, Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6., Cell. Mol. Neurobiol.
    Cohen et al., 1999, Reduction of oral ethanol self-administration in rats by monoamine oxidase inhibitors., Pharmacol. Biochem. Behav.
    Shioda et al., 2010, Mirtazapine abolishes hyperthermia in an animal model of serotonin syndrome., Neurosci. Lett.
    Gatch et al., 2006, Effects of monoamine oxidase inhibitors on cocaine discrimination in rats., Behav Pharmacol
    Shioda et al., 2004, Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine., Prog. Neuropsychopharmacol. Biol. Psychiatry
    Lang et al., 2004, Liquid chromatographic and tandem mass spectrometric assay for evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors: application of biomarkers in drug discovery., Anal. Biochem.
    Strydom B et al., 2010, Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues., Bioorg Med Chem
    Coelho Cerqueira E et al., 2011, Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO., Bioorg Med Chem
    Manley-King CI et al., 2011, Inhibition of monoamine oxidase by C5-substituted phthalimide analogues., Bioorg Med Chem
    Okaecwe T et al., 2012, Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives., Bioorg Med Chem
    Manley-King CI et al., 2011, Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues., Bioorg Med Chem
  • TRANYLCYPROMINE   MAOA

    Interaction Score: 19.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12504917 8749840 10494892 10027835 14574774 15049511 9829163 11752352 10548268 20655983 16495723 15276688 15351283


    Sources:
    TdgClinicalTrial TEND TTD

  • ISOCARBOXAZID   MAOA

    Interaction Score: 5.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Monoamine oxidase inhibitor
    Trial Name -

    PMIDs:
    2248058 7612154 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • MOCLOBEMIDE   MAOA

    Interaction Score: 5.35

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name moclobemide ,Aurorix
    Novel drug target Established target

    PMIDs:
    8875133 1705137 11752352 21680183 12595913


    Sources:
    DTC TdgClinicalTrial TEND TTD

  • 1-PHENETHYLPIPERIDINE   MAOA

    Interaction Score: 4.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22078410


    Sources:
    DTC

  • PHENELZINE   MAOA

    Interaction Score: 3.27

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16370964 17768678 14574774 9829163 17912044 19201819 11752352 7092487 18700056


    Sources:
    TdgClinicalTrial TEND

  • CHEMBL602260   MAOA

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20093036


    Sources:
    DTC

  • CHEMBL1642672   MAOA

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21134756


    Sources:
    DTC

  • CHEMBL1927684   MAOA

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22055712


    Sources:
    DTC

  • CHEMBL2088301   MAOA

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22705191


    Sources:
    DTC

  • CHEMBL2088303   MAOA

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22705191


    Sources:
    DTC

  • CHEMBL1813518   MAOA

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21778064


    Sources:
    DTC

  • CHEMBL602466   MAOA

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20093036


    Sources:
    DTC

  • CHEMBL1927670   MAOA

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22055712


    Sources:
    DTC

  • CLORGILINE   MAOA

    Interaction Score: 1.9

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22078410 10592235


    Sources:
    DTC TTD

  • SELEGILINE   MAOA

    Interaction Score: 1.59

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16641841 19300583 17715422 17823646 21680183


    Sources:
    DTC

  • PARGYLINE HYDROCHLORIDE   MAOA

    Interaction Score: 1.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Monoamine oxidase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NAPHTHOQUINONE   MAOA

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22071524


    Sources:
    DTC

  • INDANTADOL   MAOA

    Interaction Score: 0.79

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Monoamine oxidase A inhibitor
    Direct Interaction yes
    Trial Name V3381

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TTD

  • LADOSTIGIL   MAOA

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TRYPTAMINE   MAOA

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PHENELZINE SULFATE   MAOA

    Interaction Score: 0.34

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Monoamine oxidase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HARMINE   MAOA

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    TTD

  • PSORALEN   MAOA

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • METHAMPHETAMINE   MAOA

    Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name low dose intravenous methamphetamine
    Novel drug target Established target

    PMIDs:
    10799660 15955613


    Sources:
    TdgClinicalTrial

  • PIPERINE   MAOA

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MENADIONE   MAOA

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22071524


    Sources:
    DTC

  • Ensembl: ENSG00000189221

    • Version: 101_38

    Alternate Names:
    MAOA Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P21397

    • Version: 01-August-2011

    Alternate Names:
    P21397 Uniprot Accession
    4128 Entrez Gene Id
    AOFA_HUMAN Uniprot Id

    Gene Info:
    Target Main Class Enzymes
    Target Subclass 1.4.3.4
    Transmembrane Helix Count 1

    Publications:

  • RussLampel: ENSG00000189221

    • Version: 26-July-2011

    Alternate Names:
    MAOA Display Id
    ENSG00000189221 Ensembl Gene Id
    AMINE OXIDASE [FLAVIN-CONTAINING] A (EC 1.4.3.4) (MONOAMINE OXIDASE TYPE A) (MAO-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P21397] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P21397

    • Version: 11-September-2012

    Alternate Names:
    AMINE OXIDASE [FLAVIN-CONTAINING] A Uniprot Protein Name
    P21397 Uniprot Accession
    4128 Entrez Gene Id

    Gene Info:
    Interpro Name Amine oxidase
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR002937

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P21397

    • Version: January-2014

    Alternate Names:
    MAOA Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.4.3.4

    Publications:

  • DTC: MAOA

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Coelho Cerqueira E et al., 2011, Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO., Bioorg Med Chem
    Jagrat et al., 2011, Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies., Bioorg. Med. Chem. Lett.
    Okaecwe T et al., 2012, Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives., Bioorg Med Chem

  • ChemblInteractions: MAOA

    • Version: chembl_23

    Alternate Names:
    MAOA GENE_SYMBOL
    Amine oxidase [flavin-containing] A UNIPROT
    Monoamine oxidase type A UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000189221

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000189221 Gene Symbol
    MAOA Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Monoamine oxidase type A

    • Version: 2020.06.01

    Alternate Names:
    MAO-A TTD Gene Abbreviation
    T83875 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: MAOA

    • Version: 01-February-2022

    Alternate Names:
    Amine oxidase [flavin-containing] A Gene Name
    P21397 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21