DGIdb - MAOA Gene Record

MAOA 4128 Druggable Genome

Alternate Names:

4128
MONOAMINE OXIDASE A
MAOA
BRNRS
MAO-A
309850
6833
ENSG00000189221
OTTHUMG00000021387
P21397
AOFA_HUMAN
Amine oxidase [flavin-containing] A
Monoamine oxidase type A
AMINE OXIDASE [FLAVIN-CONTAINING] A (EC 1.4.3.4) (MONOAMINE OXIDASE TYPE A) (MAO-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P21397]
T83875

Gene Info:

Target Main Class	Enzymes
Target Subclass	1.4.3.4
Transmembrane Helix Count	1
Target Class	Enzymes
Target Subclass	EC:1.4.3.4
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Interpro Name	Amine oxidase
Interpro Acc	IPR002937
Uniprot Status	Swiss-Prot
Interpro Short Name	Amino_oxidase
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Ulus et al., 2000, Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors., Biochem. Pharmacol.
Sulzer et al., 2005, Mechanisms of neurotransmitter release by amphetamines: a review., Prog. Neurobiol.
McIntyre et al., 2006, The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms., Expert Opin Drug Saf
MacKenzie et al., 2008, Phenelzine causes an increase in brain ornithine that is prevented by prior monoamine oxidase inhibition., Neurochem. Res.
Nolen, 2003, [Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression]., Ned Tijdschr Geneeskd
Volz et al., 1998, Monoamine oxidase inhibitors. A perspective on their use in the elderly., Drugs Aging
Wooters et al., 2007, The monoamine oxidase inhibitor phenelzine enhances the discriminative stimulus effect of nicotine in rats., Behav Pharmacol
Chiche et al., 2009, Antidepressant phenelzine alters differentiation of cultured human and mouse preadipocytes., Mol. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Pickar et al., 1982, Selective and nonselective monoamine oxidase inhibitors: behavioral disturbances during their administration to depressed patients., Arch. Gen. Psychiatry
Chenu et al., 2009, Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area., Int. J. Neuropsychopharmacol.
Patkar et al., 2006, Transdermal selegiline: the new generation of monoamine oxidase inhibitors., CNS Spectr
Lee et al., 2007, Transdermal selegiline for the treatment of major depressive disorder., Neuropsychiatr Dis Treat
Azzaro et al., 2007, Pharmacokinetics and absolute bioavailability of selegiline following treatment of healthy subjects with the selegiline transdermal system (6 mg/24 h): a comparison with oral selegiline capsules., J Clin Pharmacol
Baker et al., 2007, Amine oxidases and their inhibitors: what can they tell us about neuroprotection and the development of drugs for neuropsychiatric disorders?, J Psychiatry Neurosci
Jagrat et al., 2011, Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies., Bioorg. Med. Chem. Lett.
Booysen HP et al., 2011, Thio- and aminocaffeine analogues as inhibitors of human monoamine oxidase., Bioorg Med Chem
Kettler et al., 1990, Comparison of monoamine oxidase-A inhibition by moclobemide in vitro and ex vivo in rats., Acta Psychiatr Scand Suppl
Thase et al., 1995, MAOIs in the contemporary treatment of depression., Neuropsychopharmacology
Wichitnithad W et al., 2011, Time-dependent slowly-reversible inhibition of monoamine oxidase A by N-substituted 1,2,3,6-tetrahydropyridines., Bioorg Med Chem
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Fulton et al., 1996, Moclobemide. An update of its pharmacological properties and therapeutic use., Drugs
Berlin et al., 1990, Comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase-A inhibitors moclobemide and toloxatone, and assessment of their effect on psychometric performance in healthy subjects., Br J Clin Pharmacol
Bonnet U, 2003, Moclobemide: therapeutic use and clinical studies., CNS Drug Rev
Finberg et al., 2002, Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, reserpine reversal, serotonergic and dopaminergic behaviours., Neuropharmacology
Todd et al., 1995, GABA-elevating effects of the antidepressant/antipanic drug phenelzine in brain: effects of pretreatment with tranylcypromine, (-)-deprenyl and clorgyline., J Affect Disord
Wiest et al., 1999, 3H[2-(2-benzofuranyl)-2-imidazoline] (BFI) binding in human platelets: modulation by tranylcypromine., Naunyn Schmiedebergs Arch. Pharmacol.
Löscher et al., 1999, Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy., J. Pharmacol. Exp. Ther.
Salsali et al., 2004, Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6., Cell. Mol. Neurobiol.
Cohen et al., 1999, Reduction of oral ethanol self-administration in rats by monoamine oxidase inhibitors., Pharmacol. Biochem. Behav.
Shioda et al., 2010, Mirtazapine abolishes hyperthermia in an animal model of serotonin syndrome., Neurosci. Lett.
Gatch et al., 2006, Effects of monoamine oxidase inhibitors on cocaine discrimination in rats., Behav Pharmacol
Shioda et al., 2004, Extracellular serotonin, dopamine and glutamate levels are elevated in the hypothalamus in a serotonin syndrome animal model induced by tranylcypromine and fluoxetine., Prog. Neuropsychopharmacol. Biol. Psychiatry
Lang et al., 2004, Liquid chromatographic and tandem mass spectrometric assay for evaluation of in vivo inhibition of rat brain monoamine oxidases (MAO) A and B following a single dose of MAO inhibitors: application of biomarkers in drug discovery., Anal. Biochem.
Strydom B et al., 2010, Inhibition of monoamine oxidase by 8-benzyloxycaffeine analogues., Bioorg Med Chem
Coelho Cerqueira E et al., 2011, Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO., Bioorg Med Chem
Manley-King CI et al., 2011, Inhibition of monoamine oxidase by C5-substituted phthalimide analogues., Bioorg Med Chem
Okaecwe T et al., 2012, Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives., Bioorg Med Chem
Manley-King CI et al., 2011, Inhibition of monoamine oxidase by selected C5- and C6-substituted isatin analogues., Bioorg Med Chem

TRANYLCYPROMINE MAOA

Interaction Score: 19.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12504917 8749840 10494892 10027835 14574774 15049511 9829163 11752352 10548268 20655983 16495723 15276688 15351283

Sources:
TdgClinicalTrial TEND TTD
ISOCARBOXAZID MAOA

Interaction Score: 5.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Monoamine oxidase inhibitor

Trial Name -

PMIDs:
2248058 7612154 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
MOCLOBEMIDE MAOA

Interaction Score: 5.35

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name moclobemide ,Aurorix

Novel drug target Established target

PMIDs:
8875133 1705137 11752352 21680183 12595913

Sources:
DTC TdgClinicalTrial TEND TTD
1-PHENETHYLPIPERIDINE MAOA

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22078410

Sources:
DTC
PHENELZINE MAOA

Interaction Score: 3.27

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16370964 17768678 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources:
TdgClinicalTrial TEND
CHEMBL602260 MAOA

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20093036

Sources:
DTC
CHEMBL1642672 MAOA

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21134756

Sources:
DTC
CHEMBL1927684 MAOA

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22055712

Sources:
DTC
CHEMBL2088301 MAOA

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22705191

Sources:
DTC
CHEMBL2088303 MAOA

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22705191

Sources:
DTC
CHEMBL1813518 MAOA

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21778064

Sources:
DTC
CHEMBL602466 MAOA

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20093036

Sources:
DTC
CHEMBL1927670 MAOA

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22055712

Sources:
DTC
CLORGILINE MAOA

Interaction Score: 1.9

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22078410 10592235

Sources:
DTC TTD
SELEGILINE MAOA

Interaction Score: 1.59

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
16641841 19300583 17715422 17823646 21680183

Sources:
DTC
PARGYLINE HYDROCHLORIDE MAOA

Interaction Score: 1.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NAPHTHOQUINONE MAOA

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22071524

Sources:
DTC
INDANTADOL MAOA

Interaction Score: 0.79

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase A inhibitor

Direct Interaction yes

Trial Name V3381

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
LADOSTIGIL MAOA

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TRYPTAMINE MAOA

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PHENELZINE SULFATE MAOA

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HARMINE MAOA

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
TTD
PSORALEN MAOA

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
METHAMPHETAMINE MAOA

Interaction Score: 0.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name low dose intravenous methamphetamine

Novel drug target Established target

PMIDs:
10799660 15955613

Sources:
TdgClinicalTrial
PIPERINE MAOA

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MENADIONE MAOA

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22071524

Sources:
DTC

Ensembl: ENSG00000189221
- Version: 101_38
Alternate Names:

MAOA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P21397
- Version: 01-August-2011
Alternate Names:

P21397 Uniprot Accession

4128 Entrez Gene Id

AOFA_HUMAN Uniprot Id

Gene Info:

Target Main Class Enzymes

Target Subclass 1.4.3.4

Transmembrane Helix Count 1

Publications:

RussLampel: ENSG00000189221

Version: 26-July-2011

Alternate Names:

MAOA Display Id

ENSG00000189221 Ensembl Gene Id

AMINE OXIDASE [FLAVIN-CONTAINING] A (EC 1.4.3.4) (MONOAMINE OXIDASE TYPE A) (MAO-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P21397] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P21397
- Version: 11-September-2012
Alternate Names:

AMINE OXIDASE [FLAVIN-CONTAINING] A Uniprot Protein Name

P21397 Uniprot Accession

4128 Entrez Gene Id

Gene Info:

Interpro Name Amine oxidase

Human Readable Name DRUGGABLE GENOME

Interpro Acc IPR002937

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P21397
- Version: January-2014
Alternate Names:

MAOA Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.4.3.4

Publications:

DTC: MAOA

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Coelho Cerqueira E et al., 2011, Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO., Bioorg Med Chem

Jagrat et al., 2011, Pyrazoline based MAO inhibitors: synthesis, biological evaluation and SAR studies., Bioorg. Med. Chem. Lett.

Okaecwe T et al., 2012, Inhibition of monoamine oxidase by 8-phenoxymethylcaffeine derivatives., Bioorg Med Chem

ChemblInteractions: MAOA
- Version: chembl_23
Alternate Names:

MAOA GENE_SYMBOL

Amine oxidase [flavin-containing] A UNIPROT

Monoamine oxidase type A UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000189221
- Version: 31-May-2017
Alternate Names:

ENSG00000189221 Gene Symbol

MAOA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Monoamine oxidase type A
- Version: 2020.06.01
Alternate Names:

MAO-A TTD Gene Abbreviation

T83875 TTD Target ID

Gene Info:

Publications:
Pharos: MAOA
- Version: 01-February-2022
Alternate Names:

Amine oxidase [flavin-containing] A Gene Name

P21397 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Direct Interaction	yes
Mechanism of Interaction	Monoamine oxidase inhibitor
Trial Name	-

Trial Name	moclobemide ,Aurorix
Novel drug target	Established target

Mechanism of Interaction	Monoamine oxidase A inhibitor
Direct Interaction	yes
Trial Name	V3381

Trial Name	low dose intravenous methamphetamine
Novel drug target	Established target

P21397	Uniprot Accession
4128	Entrez Gene Id
AOFA_HUMAN	Uniprot Id

MAOA	Display Id
ENSG00000189221	Ensembl Gene Id
AMINE OXIDASE [FLAVIN-CONTAINING] A (EC 1.4.3.4) (MONOAMINE OXIDASE TYPE A) (MAO-A). [SOURCE:UNIPROT/SWISSPROT;ACC:P21397]	Description

AMINE OXIDASE [FLAVIN-CONTAINING] A	Uniprot Protein Name
P21397	Uniprot Accession
4128	Entrez Gene Id

MAOA	GENE_SYMBOL
Amine oxidase [flavin-containing] A	UNIPROT
Monoamine oxidase type A	UNIPROT

Amine oxidase [flavin-containing] A	Gene Name
P21397	UniProt ID

antagonist (inhibitory)
inhibitor (inhibitory)

antagonist (inhibitory)
inhibitor (inhibitory)

MAOA Gene Record

MAOA 4128 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12504917 8749840 10494892 10027835 14574774 15049511 9829163 11752352 10548268 20655983 16495723 15276688 15351283

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Monoamine oxidase inhibitor Trial Name -

PMIDs: 2248058 7612154 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name moclobemide ,Aurorix Novel drug target Established target

PMIDs: 8875133 1705137 11752352 21680183 12595913

Sources: DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22078410

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16370964 17768678 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20093036

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21134756

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22055712

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22705191

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22705191

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21778064

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20093036

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22055712

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 22078410 10592235

Sources: DTC TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 16641841 19300583 17715422 17823646 21680183

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Monoamine oxidase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22071524

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Monoamine oxidase A inhibitor Direct Interaction yes Trial Name V3381

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12504917 8749840 10494892 10027835 14574774 15049511 9829163 11752352 10548268 20655983 16495723 15276688 15351283

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Monoamine oxidase inhibitor

Trial Name -

PMIDs:
2248058 7612154 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name moclobemide ,Aurorix

Novel drug target Established target

PMIDs:
8875133 1705137 11752352 21680183 12595913

Sources:
DTC TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
22078410

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16370964 17768678 14574774 9829163 17912044 19201819 11752352 7092487 18700056

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
20093036

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21134756

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22055712

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22705191

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22705191

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21778064

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20093036

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22055712

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
22078410 10592235

Sources:
DTC TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
16641841 19300583 17715422 17823646 21680183

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22071524

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase A inhibitor

Direct Interaction yes

Trial Name V3381

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Monoamine oxidase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name low dose intravenous methamphetamine

Novel drug target Established target

PMIDs:
10799660 15955613

Sources:
TdgClinicalTrial