DGIdb - LYN Gene Record

LYN 4067 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

4067
LYN PROTO-ONCOGENE, SRC FAMILY TYROSINE KINASE
LYN
JTK8
p53Lyn
p56Lyn
165120
6735
ENSG00000254087
OTTHUMG00000044345
V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
Tyrosine-protein kinase Lyn
Lck/Yes-related novel protein tyrosine kinase
P07948
LYN_HUMAN
ENSG00000147507
TYROSINE-PROTEIN KINASE LYN (EC 2.7.1.112). [SOURCE:UNIPROT/SWISSPROT;ACC:P07948]
T68163
3359

Gene Info:

Target Class	Enzymes
Target Subclass	EC:2.7.10.2
Human Readable Name	DRUGGABLE GENOME
Initial Gene Query	LYN
Counted Citations from 1950-2000	1494
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Uniprot Evidence	1: Evidence at protein level
Interpro Type	Domain
Interpro Acc	IPR001245
Human Readable Name	KINASE
Uniprot Status	Swiss-Prot
Gene Biotype	PROTEIN_CODING

(15 More Sources)

Gene Categories: Category Details

KINASE
TYROSINE KINASE
DRUG RESISTANCE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Hilberg et al., 2008, BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy., Cancer Res.
Wind S et al., 2019, Clinical Pharmacokinetics and Pharmacodynamics of Nintedanib., Clin Pharmacokinet
McDonald O et al., 2006, Aza-stilbenes as potent and selective c-RAF inhibitors., Bioorg Med Chem Lett
Puig de la Bellacasa R et al., 2014, 4-Amino-2-arylamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-(8H)-ones as BCR kinase inhibitors for B lymphoid malignancies., Eur J Med Chem
Deguchi Y et al., 2008, Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinib-resistant cell lines., Leuk Res
Graham Robinett R et al., 2007, The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors., Bioorg Med Chem Lett
Kneidinger M et al., 2008, The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils., Blood

GW459057A LYN

Interaction Score: 1.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16890436

Sources:
DTC
BAFETINIB LYN

Interaction Score: 1.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase Lyn inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions TTD
GW559768X LYN

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17884497

Sources:
DTC
JNJ-26483327 LYN

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase Lyn inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
NILOTINIB LYN

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18191450

Sources:
CIViC
BOSUTINIB LYN

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase Lyn inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IBRUTINIB LYN

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
25222877

Sources:
DTC
MASITINIB LYN

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name masitinib, AB1010

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial MyCancerGenomeClinicalTrial
NINTEDANIB LYN

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
18559524 31016670

Sources:
TALC
TG100-801 LYN

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
XL-228 LYN

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DORAMAPIMOD LYN

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IMATINIB LYN

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18191450

Sources:
DTC CIViC
AZD-1152-HQPA LYN

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL578061 LYN

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENMD-981693 LYN

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MLN-8054 LYN

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SB-220025 LYN

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DASATINIB LYN

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
18180381

Sources:
ChemblInteractions
CENISERTIB LYN

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC DTC MyCancerGenome
R-406 LYN

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25222877

Sources:
DTC
OSI-632 LYN

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 LYN

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CEDIRANIB LYN

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KENPAULLONE LYN

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ERLOTINIB LYN

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALSTERPAULLONE LYN

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB LYN

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
DTC ChemblInteractions
ENTRECTINIB LYN

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW441756X LYN

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GEFITINIB LYN

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LINIFANIB LYN

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB LYN

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SORAFENIB LYN

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 LYN

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOVITINIB LYN

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 LYN

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 LYN

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 LYN

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 LYN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000254087
- Version: 101_38
Alternate Names:

LYN Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P07948
- Version: January-2014
Alternate Names:

LYN Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.10.2

Publications:
BaderLabGenes: LYN
- Version: February-2014
Alternate Names:

4067 Entrez Gene ID

Gene Info:

Initial Gene Query LYN

Counted Citations from 1950-2000 1494

Gene Categories:

KINASE

Publications:
HopkinsGroom: P07948
- Version: 11-September-2012
Alternate Names:

P07948 Uniprot Accession

LYN_HUMAN Uniprot Id

ENSG00000254087 Ensembl Gene Id

Gene Info:

Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom

Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain

Human Readable Name DRUGGABLE GENOME

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000147507
- Version: 26-July-2011
Alternate Names:

LYN Display Id

TYROSINE-PROTEIN KINASE LYN (EC 2.7.1.112). [SOURCE:UNIPROT/SWISSPROT;ACC:P07948] Description

ENSG00000147507 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
CIViC: LYN
- Version: 14-September-2020
Alternate Names:

4067 Entrez Gene ID

3359 CIViC Gene ID

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Deguchi Y et al., 2008, Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinib-resistant cell lines., Leuk Res

DTC: LYN

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Puig de la Bellacasa R et al., 2014, 4-Amino-2-arylamino-6-(2,6-dichlorophenyl)-pyrido[2,3-d]pyrimidin-7-(8H)-ones as BCR kinase inhibitors for B lymphoid malignancies., Eur J Med Chem

Graham Robinett R et al., 2007, The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors., Bioorg Med Chem Lett

McDonald O et al., 2006, Aza-stilbenes as potent and selective c-RAF inhibitors., Bioorg Med Chem Lett

TALC: LYN
- Version: 12-May-2016
Alternate Names:

LYN Gene Symbol

Gene Info:

Publications:
ChemblInteractions: JTK8
- Version: chembl_23
Alternate Names:

JTK8 GENE_SYMBOL

LYN GENE_SYMBOL

Tyrosine-protein kinase Lyn UNIPROT

Gene Info:

Publications:
MyCancerGenome: LYN
- Version: 20-Jun-2017
Alternate Names:

4067 Entrez Gene Id

LYN MyCancerGenome Gene Symbol

LYN MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000254087
- Version: 31-May-2017
Alternate Names:

ENSG00000254087 Gene Symbol

LYN Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: LYN
- Version: 19.3
Alternate Names:

ENSG00000254087 Ensembl Gene ID

JTK8 Human Protein Atlas Gene Synonym

LYN proto-oncogene, Src family tyrosine kinase Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

ENZYME

Publications:
GO: LYN
- Version: 01-February-2022
Alternate Names:

JTK8 GO Gene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
Tempus: LYN
- Version: 11-November-2018
Alternate Names:

LYN Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: LYN
- Version: 27-Jun-2013
Alternate Names:

4067 Gene ID

JTK8 dGene Synonym

p53Lyn dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
TTD: Tyrosine-protein kinase Lyn
- Version: 2020.06.01
Alternate Names:

JTK8 TTD Gene Abbreviation

T68163 TTD Target ID

Gene Info:

Publications:
Pharos: LYN
- Version: 01-February-2022
Alternate Names:

Tyrosine-protein kinase Lyn Gene Name

P07948 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MyCancerGenomeClinicalTrial: LYN
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: LYN
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Tyrosine-protein kinase Lyn inhibitor
Direct Interaction	yes

P07948	Uniprot Accession
LYN_HUMAN	Uniprot Id
ENSG00000254087	Ensembl Gene Id

LYN	Display Id
TYROSINE-PROTEIN KINASE LYN (EC 2.7.1.112). [SOURCE:UNIPROT/SWISSPROT;ACC:P07948]	Description
ENSG00000147507	Ensembl Gene Id

JTK8	GENE_SYMBOL
LYN	GENE_SYMBOL
Tyrosine-protein kinase Lyn	UNIPROT

4067	Entrez Gene Id
LYN	MyCancerGenome Gene Symbol
LYN	MyCancerGenome Reported Gene Name

Trial Name	masitinib, AB1010
Novel drug target	Novel Target

LYN Gene Record

LYN 4067 Druggable GenomeClinically ActionableDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16890436

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosine-protein kinase Lyn inhibitor Direct Interaction yes

PMIDs: None found

Sources: MyCancerGenome ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17884497

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosine-protein kinase Lyn inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18191450

Sources: CIViC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosine-protein kinase Lyn inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 25222877

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name masitinib, AB1010 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial MyCancerGenomeClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes

PMIDs: 18559524 31016670

Sources: TALC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction SRC inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction SRC inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18191450

Sources: DTC CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction SRC inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction SRC inhibitor Direct Interaction yes

Interaction Types & Directionality:

n/a

PMIDs:
16890436

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase Lyn inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
MyCancerGenome ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
17884497

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase Lyn inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
18191450

Sources:
CIViC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase Lyn inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
25222877

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name masitinib, AB1010

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
18559524 31016670

Sources:
TALC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18191450

Sources:
DTC CIViC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction SRC inhibitor

Direct Interaction yes

PMIDs:
18180381

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC DTC MyCancerGenome

Interaction Types & Directionality:

n/a

PMIDs:
25222877

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a