LTK Gene Record

  • LTK 4058 Druggable GenomeClinically Actionable

    Alternate Names:

    4058
    LEUKOCYTE RECEPTOR TYROSINE KINASE
    LTK
    TYK1
    151520
    6721
    ENSG00000062524
    OTTHUMG00000130339
    P29376
    LEUKOCYTE TYROSINE KINASE RECEPTOR
    LTK_HUMAN
    LEUKOCYTE TYROSINE KINASE RECEPTOR PRECURSOR (EC 2.7.1.112) (PROTEIN TYROSINE KINASE-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P29376]
    1838
    NP_001129157
    NM_001135685

    Gene Info:

    Human Readable Name KINASE
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Interpro Acc IPR001245
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Initial Gene Query LTK
    Counted Citations from 1950-2000 246
    GuideToPharmacology Gene Category Name Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family
    GuideToPharmacology Gene Category ID 329
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    KINASE
    TYROSINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

  • CHEMBL399530   LTK

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GILTERITINIB   LTK

    Interaction Score: 0.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL202721   LTK

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • AST-487   LTK

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HESPERADIN   LTK

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • ALISERTIB   LTK

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL1997335   LTK

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PAZOPANIB   LTK

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • OSI-632   LTK

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL379975   LTK

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DACTOLISIB   LTK

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CEDIRANIB   LTK

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PD-0166285   LTK

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ERLOTINIB   LTK

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • VANDETANIB   LTK

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SOTRASTAURIN   LTK

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ENTRECTINIB   LTK

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TOZASERTIB   LTK

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LINIFANIB   LTK

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RG-1530   LTK

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYC-116   LTK

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   LTK

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ILORASERTIB   LTK

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CENISERTIB   LTK

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000062524

    • Version: 101_38

    Alternate Names:
    LTK Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000062524

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000062524 Ensembl Gene Id
    LEUKOCYTE TYROSINE KINASE RECEPTOR PRECURSOR (EC 2.7.1.112) (PROTEIN TYROSINE KINASE-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P29376] Description
    LTK Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: LTK

    • Version: February-2014

    Alternate Names:
    4058 Entrez Gene ID

    Gene Info:
    Initial Gene Query LTK
    Counted Citations from 1950-2000 246

    Gene Categories:
    KINASE

    Publications:

  • HopkinsGroom: P29376

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000062524 Ensembl Gene Id
    LTK Uniprot Gene Name
    LTK_HUMAN Uniprot Id

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Interpro Acc IPR001245

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 4058

    • Version: 29-September-2020

    Alternate Names:
    6721 HUGO Gene ID
    6721 HUGO Gene Symbol
    leukocyte receptor tyrosine kinase HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Type XIX RTKs: Leukocyte tyrosine kinase (LTK) receptor family
    GuideToPharmacology Gene Category ID 329

    Publications:

  • DTC: LTK

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

  • HingoraniCasas: ENSG00000062524

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000062524 Gene Symbol
    LTK Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • IDG: LTK

    • Version: 15-July-2019

    Alternate Names:
    LTK Gene Symbol

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • HumanProteinAtlas: LTK

    • Version: 19.3

    Alternate Names:
    ENSG00000062524 Ensembl Gene ID
    TYK1 Human Protein Atlas Gene Synonym
    Leukocyte receptor tyrosine kinase Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • dGene: LTK

    • Version: 27-Jun-2013

    Alternate Names:
    4058 Gene ID
    TYK1 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, TYROSINE KINASE

    Publications:

  • GO: LTK

    • Version: 01-May-2021

    Alternate Names:
    TYK1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TYROSINE KINASE

    Publications:

  • Pharos: LTK

    • Version: 01-May-2021

    Alternate Names:
    Leukocyte tyrosine kinase receptor Gene Name
    P29376 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • FoundationOneGenes: LTK

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: