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LPL Gene Record

  • Summary
  • Interactions
  • Claims
  • LPL 4023 Druggable Genome

    Alternate Names:

    4023
    LIPOPROTEIN LIPASE
    LPL
    HDLCQ11
    LIPD
    609708
    6677
    ENSG00000175445
    OTTHUMG00000036645
    P06858
    LIPL_HUMAN
    LIPOPROTEIN LIPASE PRECURSOR (EC 3.1.1.34) (LPL). [SOURCE:UNIPROT/SWISSPROT;ACC:P06858]
    PA232
    T28692

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Human Readable Name LIPASE
    Interpro Type Family
    Interpro Short Name Lipase
    Interpro Name Lipase
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000734
    Target Class Enzymes
    Target Subclass EC:3.1.1.34
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    PHOSPHOLIPASE
    DRUGGABLE GENOME
    LIPASE

    Publications:

    Noguchi et al., 1996, Role of insulin resistance in decreasing lipoprotein lipase activity in tumor-bearing rats., Surg. Today
    Malczewska-Malec et al., 2004, Analysis of candidate genes in Polish families with obesity., Clin. Chem. Lab. Med.
    Paulin et al., 1991, Beta-adrenergic blockade and lipoprotein lipase activity in rat tissues after acute exercise., Am. J. Physiol.
    Picard et al., 1996, Postprandial serum lipids and tissue lipoprotein lipase are acutely altered in rats by the alpha-glucosidase inhibitor acarbose., Horm. Metab. Res.
    Chien KL et al., 2009, Common sequence variant in lipoprotein lipase gene conferring triglyceride response to fibrate treatment., Pharmacogenomics
    Hoogerbrugge et al., 1997, Transient hyperlipidemia during treatment of ALL with L-asparaginase is related to decreased lipoprotein lipase activity., Leukemia
    Pulinilkunnil et al., 2003, Circulating triglyceride lipolysis facilitates lipoprotein lipase translocation from cardiomyocyte to myocardial endothelial lining., Cardiovasc. Res.
    Müller et al., 1994, Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport., J. Cell Biol.
    Nakayama et al., 2000, Effect of the lipoprotein lipase activator NO-1886 on adriamycin-induced nephrotic syndrome in rats., Metab. Clin. Exp.
    Hylander et al., 1985, Effects of long-term therapy with labetalol on lipoprotein metabolism in patients with mild hypertension., Acta Med Scand
    Medh et al., 1996, Lipoprotein lipase binds to low density lipoprotein receptors and induces receptor-mediated catabolism of very low density lipoproteins in vitro., J. Biol. Chem.
    Heinroth et al., 1980, [Effect of antihypertensives on the activity of lipoprotein lipase of cardiac tissue in rabbits, and normotonic and spontaneously hypertensive rats]., Acta Biol. Med. Ger.
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
    Tan, 1985, Is the glucocorticoid-induced hypertriglyceridemia in uremic rats caused by decreased tissue lipoprotein lipase activity?, Horm. Metab. Res.
    Bershad et al., 1985, Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne., N. Engl. J. Med.
  • IBROLIPIM   LPL

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NADOLOL   LPL

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1681747


    Sources:
    NCI

  • ACARBOSE   LPL

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8886823


    Sources:
    NCI

  • ISOTRETINOIN   LPL

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2931603


    Sources:
    NCI

  • LABETALOL   LPL

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    4050551


    Sources:
    NCI

  • DIAZOXIDE   LPL

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14499880


    Sources:
    NCI

  • INOSITOL   LPL

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8063863


    Sources:
    NCI

  • ASPARAGINASE   LPL

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9264396


    Sources:
    NCI

  • ORLISTAT   LPL

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name orlistat,Xenical
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ADRIAMYCIN   LPL

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10831167


    Sources:
    NCI

  • GEMFIBROZIL   LPL

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TRIAMCINOLONE   LPL

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    4077022


    Sources:
    NCI

  • RESERPINE   LPL

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7282227


    Sources:
    NCI

  • FENOFIBRATE   LPL

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19207029


    Sources:
    PharmGKB

  • CLOFIBRATE   LPL

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • INSULIN   LPL

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8727949 15202783


    Sources:
    NCI

  • PRAVASTATIN   LPL

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16103896


    Sources:
    PharmGKB

  • LOVASTATIN   LPL

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8663292


    Sources:
    NCI

  • Ensembl: ENSG00000175445

    • Version: 101_38

    Alternate Names:
    LPL Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P06858

    • Version: January-2014

    Alternate Names:
    LPL Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:3.1.1.34

    Publications:

  • HopkinsGroom: P06858

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000175445 Ensembl Gene Id
    4023 Entrez Gene Id
    P06858 Uniprot Accession

    Gene Info:
    Human Readable Name LIPASE
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family

    Gene Categories:
    DRUGGABLE GENOME, LIPASE

    Publications:

  • RussLampel: ENSG00000175445

    • Version: 26-July-2011

    Alternate Names:
    LIPOPROTEIN LIPASE PRECURSOR (EC 3.1.1.34) (LPL). [SOURCE:UNIPROT/SWISSPROT;ACC:P06858] Description
    LPL Display Id
    ENSG00000175445 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: LPL

    • Version: 18-August-2020

    Alternate Names:
    PA232 PharmGKB ID

    Gene Info:

    Publications:
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
    Chien KL et al., 2009, Common sequence variant in lipoprotein lipase gene conferring triglyceride response to fibrate treatment., Pharmacogenomics

  • NCI: LPL

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Malczewska-Malec et al., 2004, Analysis of candidate genes in Polish families with obesity., Clin. Chem. Lab. Med.
    Noguchi et al., 1996, Role of insulin resistance in decreasing lipoprotein lipase activity in tumor-bearing rats., Surg. Today
    Paulin et al., 1991, Beta-adrenergic blockade and lipoprotein lipase activity in rat tissues after acute exercise., Am. J. Physiol.

  • HingoraniCasas: ENSG00000175445

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000175445 Gene Symbol
    LPL Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: LPL

    • Version: 01-February-2022

    Alternate Names:
    LIPD GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, PHOSPHOLIPASE

    Publications:

  • TTD: Lipoprotein lipase

    • Version: 2020.06.01

    Alternate Names:
    LPL TTD Gene Abbreviation
    T28692 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21