DGIdb - LPL Gene Record

LPL 4023 Druggable Genome

Alternate Names:

4023
LIPOPROTEIN LIPASE
LPL
HDLCQ11
LIPD
609708
6677
ENSG00000175445
OTTHUMG00000036645
P06858
LIPL_HUMAN
LIPOPROTEIN LIPASE PRECURSOR (EC 3.1.1.34) (LPL). [SOURCE:UNIPROT/SWISSPROT;ACC:P06858]
PA232
T28692

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Human Readable Name	LIPASE
Interpro Type	Family
Interpro Short Name	Lipase
Interpro Name	Lipase
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000734
Target Class	Enzymes
Target Subclass	EC:3.1.1.34
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

CELL SURFACE
PHOSPHOLIPASE
DRUGGABLE GENOME
LIPASE

Publications:

Noguchi et al., 1996, Role of insulin resistance in decreasing lipoprotein lipase activity in tumor-bearing rats., Surg. Today
Malczewska-Malec et al., 2004, Analysis of candidate genes in Polish families with obesity., Clin. Chem. Lab. Med.
Paulin et al., 1991, Beta-adrenergic blockade and lipoprotein lipase activity in rat tissues after acute exercise., Am. J. Physiol.
Picard et al., 1996, Postprandial serum lipids and tissue lipoprotein lipase are acutely altered in rats by the alpha-glucosidase inhibitor acarbose., Horm. Metab. Res.
Chien KL et al., 2009, Common sequence variant in lipoprotein lipase gene conferring triglyceride response to fibrate treatment., Pharmacogenomics
Hoogerbrugge et al., 1997, Transient hyperlipidemia during treatment of ALL with L-asparaginase is related to decreased lipoprotein lipase activity., Leukemia
Pulinilkunnil et al., 2003, Circulating triglyceride lipolysis facilitates lipoprotein lipase translocation from cardiomyocyte to myocardial endothelial lining., Cardiovasc. Res.
Müller et al., 1994, Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport., J. Cell Biol.
Nakayama et al., 2000, Effect of the lipoprotein lipase activator NO-1886 on adriamycin-induced nephrotic syndrome in rats., Metab. Clin. Exp.
Hylander et al., 1985, Effects of long-term therapy with labetalol on lipoprotein metabolism in patients with mild hypertension., Acta Med Scand
Medh et al., 1996, Lipoprotein lipase binds to low density lipoprotein receptors and induces receptor-mediated catabolism of very low density lipoproteins in vitro., J. Biol. Chem.
Heinroth et al., 1980, [Effect of antihypertensives on the activity of lipoprotein lipase of cardiac tissue in rabbits, and normotonic and spontaneously hypertensive rats]., Acta Biol. Med. Ger.
Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
Tan, 1985, Is the glucocorticoid-induced hypertriglyceridemia in uremic rats caused by decreased tissue lipoprotein lipase activity?, Horm. Metab. Res.
Bershad et al., 1985, Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne., N. Engl. J. Med.

IBROLIPIM LPL

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NADOLOL LPL

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1681747

Sources:
NCI
ACARBOSE LPL

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8886823

Sources:
NCI
ISOTRETINOIN LPL

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2931603

Sources:
NCI
LABETALOL LPL

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
4050551

Sources:
NCI
DIAZOXIDE LPL

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14499880

Sources:
NCI
INOSITOL LPL

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8063863

Sources:
NCI
ASPARAGINASE LPL

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9264396

Sources:
NCI
ORLISTAT LPL

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name orlistat,Xenical

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ADRIAMYCIN LPL

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10831167

Sources:
NCI
GEMFIBROZIL LPL

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TRIAMCINOLONE LPL

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
4077022

Sources:
NCI
RESERPINE LPL

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7282227

Sources:
NCI
FENOFIBRATE LPL

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19207029

Sources:
PharmGKB
CLOFIBRATE LPL

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
INSULIN LPL

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8727949 15202783

Sources:
NCI
PRAVASTATIN LPL

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16103896

Sources:
PharmGKB
LOVASTATIN LPL

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8663292

Sources:
NCI

Ensembl: ENSG00000175445
- Version: 101_38
Alternate Names:

LPL Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P06858
- Version: January-2014
Alternate Names:

LPL Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.1.34

Publications:
HopkinsGroom: P06858
- Version: 11-September-2012
Alternate Names:

ENSG00000175445 Ensembl Gene Id

4023 Entrez Gene Id

P06858 Uniprot Accession

Gene Info:

Human Readable Name LIPASE

Human Readable Name DRUGGABLE GENOME

Interpro Type Family

Gene Categories:

DRUGGABLE GENOME, LIPASE

Publications:
RussLampel: ENSG00000175445
- Version: 26-July-2011
Alternate Names:

LIPOPROTEIN LIPASE PRECURSOR (EC 3.1.1.34) (LPL). [SOURCE:UNIPROT/SWISSPROT;ACC:P06858] Description

LPL Display Id

ENSG00000175445 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: LPL

Version: 18-August-2020

Alternate Names:

PA232 PharmGKB ID

Gene Info:

Publications:

Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J

Chien KL et al., 2009, Common sequence variant in lipoprotein lipase gene conferring triglyceride response to fibrate treatment., Pharmacogenomics

NCI: LPL

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Malczewska-Malec et al., 2004, Analysis of candidate genes in Polish families with obesity., Clin. Chem. Lab. Med.

Noguchi et al., 1996, Role of insulin resistance in decreasing lipoprotein lipase activity in tumor-bearing rats., Surg. Today

Paulin et al., 1991, Beta-adrenergic blockade and lipoprotein lipase activity in rat tissues after acute exercise., Am. J. Physiol.

HingoraniCasas: ENSG00000175445
- Version: 31-May-2017
Alternate Names:

ENSG00000175445 Gene Symbol

LPL Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: LPL
- Version: 01-February-2022
Alternate Names:

LIPD GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, PHOSPHOLIPASE

Publications:
TTD: Lipoprotein lipase
- Version: 2020.06.01
Alternate Names:

LPL TTD Gene Abbreviation

T28692 TTD Target ID

Gene Info:

Publications:

Trial Name	orlistat,Xenical
Novel drug target	Established target

ENSG00000175445	Ensembl Gene Id
4023	Entrez Gene Id
P06858	Uniprot Accession

LIPOPROTEIN LIPASE PRECURSOR (EC 3.1.1.34) (LPL). [SOURCE:UNIPROT/SWISSPROT;ACC:P06858]	Description
LPL	Display Id
ENSG00000175445	Ensembl Gene Id

LPL Gene Record

LPL 4023 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1681747

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8886823

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2931603

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 4050551

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14499880

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8063863

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9264396

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Trial Name orlistat,Xenical Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10831167

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 4077022

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7282227

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19207029

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8727949 15202783

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16103896

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8663292

Sources: NCI

Ensembl: ENSG00000175445

Alternate Names: LPL Ensembl Gene Name

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
1681747

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8886823

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2931603

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
4050551

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14499880

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8063863

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9264396

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name orlistat,Xenical

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
10831167

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
4077022

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7282227

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
19207029

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
8727949 15202783

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16103896

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
8663292

Sources:
NCI

Alternate Names:

LPL Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

LPL Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.1.1.34

Alternate Names:

ENSG00000175445 Ensembl Gene Id

4023 Entrez Gene Id

P06858 Uniprot Accession

Gene Info:

Human Readable Name LIPASE

Human Readable Name DRUGGABLE GENOME

Interpro Type Family

Gene Categories:

DRUGGABLE GENOME, LIPASE

Alternate Names:

LIPOPROTEIN LIPASE PRECURSOR (EC 3.1.1.34) (LPL). [SOURCE:UNIPROT/SWISSPROT;ACC:P06858] Description

LPL Display Id

ENSG00000175445 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA232 PharmGKB ID

Publications:

Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J

Chien KL et al., 2009, Common sequence variant in lipoprotein lipase gene conferring triglyceride response to fibrate treatment., Pharmacogenomics

Alternate Names:

ENSG00000175445 Gene Symbol

LPL Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

LIPD GO Gene Synonym

Gene Categories:

CELL SURFACE, PHOSPHOLIPASE

Alternate Names:

LPL TTD Gene Abbreviation

T28692 TTD Target ID