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LIPC Gene Record

  • Summary
  • Interactions
  • Claims
  • LIPC 3990 Druggable Genome

    Alternate Names:

    3990
    LIPASE C, HEPATIC TYPE
    LIPC
    HDLCQ12
    HL
    HTGL
    LIPH
    151670
    6619
    ENSG00000166035
    OTTHUMG00000132632
    LIPC_HUMAN
    P11150
    HEPATIC TRIACYLGLYCEROL LIPASE PRECURSOR (EC 3.1.1.3) (HEPATIC LIPASE) (HL). [SOURCE:UNIPROT/SWISSPROT;ACC:P11150]
    HEPATIC TRIACYLGLYCEROL LIPASE
    PA230

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR000734
    Interpro Name Lipase
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Lipase
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Human Readable Name LIPASE
    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    PHOSPHOLIPASE
    DRUGGABLE GENOME
    LIPASE
    ENZYME

    Publications:

    Mordasini et al., 1982, [Alcohol and plasma lipoproteins in acute and long-term studies]., Schweiz Med Wochenschr
    Lahoz C et al., 2005, The -514C/T polymorphism of the hepatic lipase gene significantly modulates the HDL-cholesterol response to statin treatment., Atherosclerosis
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
    Barrowcliffe et al., 1986, Anticoagulant activities of pentosan polysulphate (Hémoclar) due to release of hepatic triglyceride lipase (HTGL)., Thromb. Haemost.
    Berk-Planken et al., 2003, Atorvastatin dose-dependently decreases hepatic lipase activity in type 2 diabetes: effect of sex and the LIPC promoter variant., Diabetes Care
    Harenberg et al., 1985, Anticoagulant and lipolytic effects of a low molecular weight heparin fraction., Thromb. Res.
    Eckel et al., 1988, Plasma lipolytic activity. Relationship to postheparin lipolytic activity and evidence for metabolic regulation., Diabetes
  • PENTOSAN POLYSULFATE SODIUM   LIPC

    Interaction Score: 8.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2433786


    Sources:
    NCI

  • HEPARIN   LIPC

    Interaction Score: 0.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    4082106 3360217


    Sources:
    NCI

  • FLUVASTATIN   LIPC

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16103896


    Sources:
    PharmGKB

  • PRAVASTATIN   LIPC

    Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16115483 16103896


    Sources:
    PharmGKB

  • SIMVASTATIN   LIPC

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16103896


    Sources:
    PharmGKB

  • ATORVASTATIN   LIPC

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12547874


    Sources:
    NCI

  • ALCOHOL   LIPC

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7163806


    Sources:
    NCI

  • Ensembl: ENSG00000166035

    • Version: 101_38

    Alternate Names:
    LIPC Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000166035

    • Version: 26-July-2011

    Alternate Names:
    LIPC Display Id
    HEPATIC TRIACYLGLYCEROL LIPASE PRECURSOR (EC 3.1.1.3) (HEPATIC LIPASE) (HL). [SOURCE:UNIPROT/SWISSPROT;ACC:P11150] Description
    ENSG00000166035 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P11150

    • Version: 11-September-2012

    Alternate Names:
    HEPATIC TRIACYLGLYCEROL LIPASE Uniprot Protein Name
    LIPC_HUMAN Uniprot Id
    ENSG00000166035 Ensembl Gene Id

    Gene Info:
    Interpro Acc IPR000734
    Interpro Name Lipase
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    DRUGGABLE GENOME, LIPASE

    Publications:

  • PharmGKB: LIPC

    • Version: 18-August-2020

    Alternate Names:
    PA230 PharmGKB ID

    Gene Info:

    Publications:
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
    Lahoz C et al., 2005, The -514C/T polymorphism of the hepatic lipase gene significantly modulates the HDL-cholesterol response to statin treatment., Atherosclerosis

  • NCI: LIPC

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Mordasini et al., 1982, [Alcohol and plasma lipoproteins in acute and long-term studies]., Schweiz Med Wochenschr
    Barrowcliffe et al., 1986, Anticoagulant activities of pentosan polysulphate (Hémoclar) due to release of hepatic triglyceride lipase (HTGL)., Thromb. Haemost.
    Berk-Planken et al., 2003, Atorvastatin dose-dependently decreases hepatic lipase activity in type 2 diabetes: effect of sex and the LIPC promoter variant., Diabetes Care

  • HingoraniCasas: ENSG00000166035

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000166035 Gene Symbol
    LIPC Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: LIPC

    • Version: 19.3

    Alternate Names:
    ENSG00000166035 Ensembl Gene ID
    HL Human Protein Atlas Gene Synonym
    HTGL Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • GO: LIPC

    • Version: 01-February-2022

    Alternate Names:
    HTGL GO Gene Synonym

    Gene Info:

    Gene Categories:
    PHOSPHOLIPASE

    Publications:

  • Pharos: LIPC

    • Version: 01-February-2022

    Alternate Names:
    Hepatic triacylglycerol lipase Gene Name
    P11150 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21