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LIF Gene Record

  • Summary
  • Interactions
  • Claims
  • LIF 3976 Druggable Genome

    Alternate Names:

    3976
    LIF, INTERLEUKIN 6 FAMILY CYTOKINE
    LIF
    CDF
    DIA
    HILDA
    MLPLI
    159540
    6596
    ENSG00000128342
    OTTHUMG00000150910
    LIF INTERLEUKIN 6 FAMILY CYTOKINE

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    DRUGGABLE GENOME

    Publications:

    Sakuma et al., 2000, Differential adaptation of growth and differentiation factor 8/myostatin, fibroblast growth factor 6 and leukemia inhibitory factor in overloaded, regenerating and denervated rat muscles., Biochim. Biophys. Acta
    Boyle et al., 2001, The experimental neuroprotectant leukaemia inhibitory factor (LIF) does not compromise antitumour activity of paclitaxel, cisplatin and carboplatin., Cancer Chemother. Pharmacol.
    Vanderlocht et al., 2006, Effects of IFN-beta, leptin and simvastatin on LIF secretion by T lymphocytes of MS patients and healthy controls., J. Neuroimmunol.
    O'Flaherty et al., 2002, Cytotoxicity of paclitaxel or cisplatin on carcinoma cell lines is not inhibited by leukemia inhibitory factor (LIF)., Growth Factors
    Liu et al., 1999, Mifepristone regulation of leukemia inhibitory factor and uterine receptivity in rabbits., Contraception
    Reinhart et al., 1999, Xeno-oestrogens and phyto-oestrogens induce the synthesis of leukaemia inhibitory factor by human and bovine oviduct cells., Mol. Hum. Reprod.
    Knight et al., 1997, Localization of leukaemia inhibitory factor to airway epithelium and its amplification of contractile responses to tachykinins., Br. J. Pharmacol.
    Weber et al., 1980, Leucocyte migration inhibition factor (LIF) and antithrombin III (AT III)., J Clin Lab Immunol
    López-Karpovitch et al., 2002, Effect of azacytidine in the release of leukemia inhibitory factor, oncostatin m, interleukin (IL)-6, and IL-11 by mononuclear cells of patients with refractory anemia., Cytokine
    Mackiewicz et al., 1993, Leukemia inhibitory factor, interferon gamma and dexamethasone regulate N-glycosylation of alpha 1-protease inhibitor in human hepatoma cells., Eur. J. Cell Biol.
  • BUPIVACAINE   LIF

    Interaction Score: 1.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10838161


    Sources:
    NCI

  • CAPSAICIN   LIF

    Interaction Score: 0.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9138695


    Sources:
    NCI

  • DAIDZEIN   LIF

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10508216


    Sources:
    NCI

  • MIFEPRISTONE   LIF

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10717784


    Sources:
    NCI

  • THROMBIN   LIF

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7007650


    Sources:
    NCI

  • ESTRADIOL   LIF

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10508216


    Sources:
    NCI

  • AZACITIDINE   LIF

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12543079


    Sources:
    NCI

  • SIMVASTATIN   LIF

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16797728


    Sources:
    NCI

  • DEXAMETHASONE   LIF

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8392465


    Sources:
    NCI

  • CISPLATIN   LIF

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12519017 11800022


    Sources:
    NCI

  • PACLITAXEL   LIF

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11800022


    Sources:
    NCI

  • Ensembl: ENSG00000128342

    • Version: 101_38

    Alternate Names:
    LIF Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: LIF

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Reinhart et al., 1999, Xeno-oestrogens and phyto-oestrogens induce the synthesis of leukaemia inhibitory factor by human and bovine oviduct cells., Mol. Hum. Reprod.
    Sano et al., 2000, Interleukin-6 family of cytokines mediate angiotensin II-induced cardiac hypertrophy in rodent cardiomyocytes., J. Biol. Chem.
    Liu et al., 2001, Effects of leukaemia inhibitory factor on endometrial receptivity and its hormonal regulation in rabbits., Cell Biol. Int.

  • HingoraniCasas: ENSG00000128342

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000128342 Gene Symbol
    LIF Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: LIF

    • Version: 01-February-2022

    Alternate Names:
    HILDA GO Gene Synonym

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21