• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

LEP Gene Record

  • Summary
  • Interactions
  • Claims
  • LEP 3952 Druggable Genome

    Alternate Names:

    3952
    LEPTIN
    LEP
    LEPD
    OB
    OBS
    164160
    6553
    ENSG00000174697
    OTTHUMG00000157564
    PA228

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    TUMOR SUPPRESSOR
    HORMONE ACTIVITY
    DRUGGABLE GENOME

    Publications:

    Kraus et al., 2002, Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine., Pharmacopsychiatry
    Leonhardt et al., 1999, Immunoreactive leptin and leptin mRNA expression are increased in rat hypo- but not hyperthyroidism., J. Endocrinol.
    Doknic et al., 2002, Dopaminergic tone and obesity: an insight from prolactinomas treated with bromocriptine., Eur. J. Endocrinol.
    Hung et al., 1999, Effects of lovastatin and gemfibrozil in subjects with high ratios of total cholesterol to high-density lipoprotein cholesterol., J. Formos. Med. Assoc.
    Housová et al., 2005, Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment., Physiol Res
    Cartmill et al., 2003, Effects of dexamethasone, glucose infusion, adrenocorticotropin, and propylthiouracil on plasma leptin concentrations in horses., Domest. Anim. Endocrinol.
    Hryniewicz et al., 2003, Partial reversal of cachexia by beta-adrenergic receptor blocker therapy in patients with chronic heart failure., J. Card. Fail.
    Atmaca et al., 2003, Serum leptin and triglyceride levels in patients on treatment with atypical antipsychotics., J Clin Psychiatry
    Dos Santos-Júnior A et al., 2016, Pharmacogenetics of Risperidone and Cardiovascular Risk in Children and Adolescents., Int J Endocrinol
    Nurmi EL et al., 2013, Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies., Transl Psychiatry
    Gregoor JG et al., 2011, Polymorphisms of the LEP, LEPR and HTR2C gene: obesity and BMI change in patients using antipsychotic medication in a naturalistic setting., Pharmacogenomics
    Calarge CA et al., 2009, Leptin gene -2548G/A variants predict risperidone-associated weight gain in children and adolescents., Psychiatr Genet
    Törüner et al., 2004, Effects of PPARgamma and PPARalpha agonists on serum leptin levels in diet-induced obese rats., Horm. Metab. Res.
    Selimoglu et al., 2005, Is leptin a predictive factor in the end of therapy response in chronic hepatitis B?, Pediatr Int
    Fogari et al., 2005, Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients., Hypertens. Res.
    Murata et al., 2000, Stimulation by eicosapentaenoic acids of leptin mRNA expression and its secretion in mouse 3T3-L1 adipocytes in vitro., Biochem. Biophys. Res. Commun.
    Stumvoll et al., 2000, Leptin levels in humans are acutely suppressed by isoproterenol despite acipimox-induced inhibition of lipolysis, but not by free fatty acids., Metab. Clin. Exp.
    Srivastava V et al., 2008, Genetic correlates of olanzapine-induced weight gain in schizophrenia subjects from north India: role of metabolic pathway genes., Pharmacogenomics
  • SOYBEAN OIL   LEP

    Interaction Score: 1.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10726911


    Sources:
    NCI

  • GEMFIBROZIL   LEP

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15114521 10083765


    Sources:
    NCI

  • FELODIPINE   LEP

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16097363


    Sources:
    NCI

  • RISPERIDONE   LEP

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12755665 26880915 23799528 21510767 19873684


    Sources:
    NCI PharmGKB

  • BROMOCRIPTINE   LEP

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12088923


    Sources:
    NCI

  • PROPYLTHIOURACIL   LEP

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12450621


    Sources:
    NCI

  • CARVEDILOL   LEP

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14966787


    Sources:
    NCI

  • METHIMAZOLE   LEP

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10495413


    Sources:
    NCI

  • MIRTAZAPINE   LEP

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12518269


    Sources:
    NCI

  • TROGLITAZONE   LEP

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10753628


    Sources:
    NCI

  • LAMIVUDINE   LEP

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16091072


    Sources:
    NCI

  • METHADONE   LEP

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15717844


    Sources:
    NCI

  • LOVASTATIN   LEP

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10083765


    Sources:
    NCI

  • CLOZAPINE   LEP

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12755665


    Sources:
    NCI

  • OLANZAPINE   LEP

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18681781


    Sources:
    PharmGKB

  • Ensembl: ENSG00000174697

    • Version: 101_38

    Alternate Names:
    LEP Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: LEP

    • Version: 18-August-2020

    Alternate Names:
    PA228 PharmGKB ID

    Gene Info:

    Publications:
    Srivastava V et al., 2008, Genetic correlates of olanzapine-induced weight gain in schizophrenia subjects from north India: role of metabolic pathway genes., Pharmacogenomics
    Calarge CA et al., 2009, Leptin gene -2548G/A variants predict risperidone-associated weight gain in children and adolescents., Psychiatr Genet
    Gregoor JG et al., 2011, Polymorphisms of the LEP, LEPR and HTR2C gene: obesity and BMI change in patients using antipsychotic medication in a naturalistic setting., Pharmacogenomics

  • NCI: LEP

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Leonhardt et al., 1999, Immunoreactive leptin and leptin mRNA expression are increased in rat hypo- but not hyperthyroidism., J. Endocrinol.
    Housová et al., 2005, Adipocyte-derived hormones in heroin addicts: the influence of methadone maintenance treatment., Physiol Res
    Selimoglu et al., 2005, Is leptin a predictive factor in the end of therapy response in chronic hepatitis B?, Pediatr Int

  • HingoraniCasas: ENSG00000174697

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000174697 Gene Symbol
    LEP Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: LEP

    • Version: 01-February-2022

    Alternate Names:
    OB GO Gene Synonym
    OBS GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR, HORMONE ACTIVITY

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21