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KIF6 Gene Record

  • Summary
  • Interactions
  • Claims
  • KIF6 221458

    Alternate Names:

    221458
    KINESIN FAMILY MEMBER 6
    KIF6
    C6orf102
    dJ1043E3.1
    dJ137F1.4
    dJ188D3.1
    613919
    21202
    ENSG00000164627
    OTTHUMG00000014648
    PA134920075

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    Publications:

    Ruiz-Iruela C et al., 2018, KIF6 gene as a pharmacogenetic marker for lipid-lowering effect in statin treatment., PLoS One
    Shiffman D et al., 2010, Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial., Am J Cardiol
    Iakoubova OA et al., 2010, KIF6 Trp719Arg polymorphism and the effect of statin therapy in elderly patients: results from the PROSPER study., Eur J Cardiovasc Prev Rehabil
    Iakoubova OA et al., 2008, Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study., J Am Coll Cardiol
    Iakoubova OA et al., 2008, Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials., J Am Coll Cardiol
    Hopewell JC et al., 2011, No impact of KIF6 genotype on vascular risk and statin response among 18,348 randomized patients in the heart protection study., J Am Coll Cardiol
  • ROSUVASTATIN   KIF6

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30304062


    Sources:
    PharmGKB

  • PRAVASTATIN   KIF6

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20403483 20215968 18222355 18222353


    Sources:
    PharmGKB

  • ATORVASTATIN   KIF6

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30304062 20403483 20215968 18222355 18222353


    Sources:
    PharmGKB

  • SIMVASTATIN   KIF6

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30304062 21458191


    Sources:
    PharmGKB

  • Ensembl: ENSG00000164627

    • Version: 101_38

    Alternate Names:
    KIF6 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: KIF6

    • Version: 18-August-2020

    Alternate Names:
    PA134920075 PharmGKB ID

    Gene Info:

    Publications:
    Shiffman D et al., 2010, Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial., Am J Cardiol
    Iakoubova OA et al., 2008, Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials., J Am Coll Cardiol
    Iakoubova OA et al., 2008, Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study., J Am Coll Cardiol

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21