DGIdb - KCNQ1 Gene Record

KCNQ1 3784 Druggable Genome

Alternate Names:

3784
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY Q MEMBER 1
KCNQ1
ATFB1
ATFB3
JLNS1
KCNA8
KCNA9
KVLQT1
Kv1.9
Kv7.1
LQT
LQT1
RWS
SQT2
WRS
607542
6294
ENSG00000053918
OTTHUMG00000009900
Voltage-gated potassium channel subunit Kv7.1
KQT-like 1
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
Potassium voltage-gated channel subfamily KQT member 1
P51787
KCNQ1_HUMAN
PA223
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV7.1) (IKS PRODUCING SLOW VOLTAGE-GATED POTASSIUM CHANNEL ALPHA SUBUNIT KVLQT1) (KQT-LIKE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P51787]
Voltage-gated potassium channel Kv7.1
T49526

Gene Info:

Initial Gene Query	Kv7.1
Counted Citations from 1950-2000	1149
Human Readable Name	ION CHANNEL
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Ion_trans_dom
Interpro Name	Ion transport domain
Interpro Acc	IPR005821
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Target Subclass	Potassium_channels
Target Subclass	Channels
Transmembrane Helix Count	6
Target Subclass	Voltage_gated_ion_channels
Target Main Class	Transporters
Target Class	Transporters
Target Subclass	TC:1.A.1.15.6
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

CELL SURFACE
ION CHANNEL
DRUGGABLE GENOME

Publications:

Li et al., 2001, Functional consequences of the arrhythmogenic G306R KvLQT1 K+ channel mutant probed by viral gene transfer in cardiomyocytes., J. Physiol. (Lond.)
Ohya et al., 2002, Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle., Am. J. Physiol. Gastrointest. Liver Physiol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Chouabe et al., Effects of calcium channel blockers on cloned cardiac K+ channels IKr and IKs., Therapie
Yumoto et al., 2004, Bepridil block of recombinant human cardiac IKs current shows a time-dependent unblock., J. Cardiovasc. Pharmacol.
Chouabe et al., 1998, HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers., Mol. Pharmacol.
Lengyel et al., 2007, Diabetes mellitus attenuates the repolarization reserve in mammalian heart., Cardiovasc. Res.
Kuryshev et al., 2000, Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels., J. Pharmacol. Exp. Ther.
Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
Dai XP et al., 2012, KCNQ1 gene polymorphisms are associated with the therapeutic efficacy of repaglinide in Chinese type 2 diabetic patients., Clin Exp Pharmacol Physiol
Tavira B et al., 2011, KCNQ1 gene variants and risk of new-onset diabetes in tacrolimus-treated renal-transplanted patients., Clin Transplant

INDAPAMIDE KCNQ1

Interaction Score: 7.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11351021 11804849 11752352

Sources:
TdgClinicalTrial TEND TTD
BEPRIDIL KCNQ1

Interaction Score: 2.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10860024 14716203 9765513

Sources:
TdgClinicalTrial TEND
EZOGABINE KCNQ1

Interaction Score: 1.9

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Trial Name retigabine, ezogabine,Potiga

Novel drug target Established target

Mechanism of Interaction KCNQ (Kv7) potassium channel blocker

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
DOLASETRON KCNQ1

Interaction Score: 1.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11046096

Sources:
NCI
REPAGLINIDE KCNQ1

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22414228

Sources:
PharmGKB
TACROLIMUS KCNQ1

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21355884

Sources:
PharmGKB
INSULIN KCNQ1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17182020

Sources:
NCI
CELECOXIB KCNQ1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22336956

Sources:
PharmGKB
INDOMETHACIN KCNQ1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Indaflex

PMIDs:
None found

Sources:
TdgClinicalTrial
GUANIDINE HYDROCHLORIDE KCNQ1

Interaction Score: 0.12

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TEDISAMIL KCNQ1

Interaction Score: 0.12

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DALFAMPRIDINE KCNQ1

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NERISPIRDINE KCNQ1

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000053918
- Version: 101_38
Alternate Names:

KCNQ1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P51787
- Version: 11-September-2012
Alternate Names:

3784 Entrez Gene Id

ENSG00000053918 Ensembl Gene Id

P51787 Uniprot Accession

Gene Info:

Human Readable Name ION CHANNEL

Uniprot Status Swiss-Prot

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
TEND: P51787
- Version: 01-August-2011
Alternate Names:

3784 Entrez Gene Id

KCNQ1_HUMAN Uniprot Id

P51787 Uniprot Accession

Gene Info:

Target Subclass Potassium_channels

Target Subclass Channels

Transmembrane Helix Count 6

Publications:
BaderLabGenes: KCNQ1
- Version: February-2014
Alternate Names:

3784 Entrez Gene ID

Gene Info:

Initial Gene Query Kv7.1

Counted Citations from 1950-2000 1149

Gene Categories:

ION CHANNEL

Publications:
TdgClinicalTrial: P51787
- Version: January-2014
Alternate Names:

KCNQ1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.15.6

Publications:

RussLampel: ENSG00000053918

Version: 26-July-2011

Alternate Names:

KCNQ1 Display Id

ENSG00000053918 Ensembl Gene Id

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV7.1) (IKS PRODUCING SLOW VOLTAGE-GATED POTASSIUM CHANNEL ALPHA SUBUNIT KVLQT1) (KQT-LIKE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P51787] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: KCNQ1

Version: 18-August-2020

Alternate Names:

PA223 PharmGKB ID

Gene Info:

Publications:

Dai XP et al., 2012, KCNQ1 gene polymorphisms are associated with the therapeutic efficacy of repaglinide in Chinese type 2 diabetic patients., Clin Exp Pharmacol Physiol

Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics

Tavira B et al., 2011, KCNQ1 gene variants and risk of new-onset diabetes in tacrolimus-treated renal-transplanted patients., Clin Transplant

NCI: KCNQ1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Lengyel et al., 2007, Diabetes mellitus attenuates the repolarization reserve in mammalian heart., Cardiovasc. Res.

Kuryshev et al., 2000, Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels., J. Pharmacol. Exp. Ther.

HingoraniCasas: ENSG00000053918
- Version: 31-May-2017
Alternate Names:

ENSG00000053918 Gene Symbol

KCNQ1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: KCNA8
- Version: chembl_23
Alternate Names:

KCNA9 GENE_SYMBOL

KVLQT1 GENE_SYMBOL

KCNQ1 GENE_SYMBOL

Gene Info:

Publications:
GO: KCNQ1
- Version: 01-February-2022
Alternate Names:

KCNA8 GO Gene Synonym

KCNA9 GO Gene Synonym

KVLQT1 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
TTD: Voltage-gated potassium channel Kv7.1
- Version: 2020.06.01
Alternate Names:

KCNQ1 TTD Gene Abbreviation

T49526 TTD Target ID

Gene Info:

Publications:
Pharos: KCNQ1
- Version: 01-February-2022
Alternate Names:

Potassium voltage-gated channel subfamily KQT member 1 Gene Name

P51787 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Trial Name	retigabine, ezogabine,Potiga
Novel drug target	Established target
Mechanism of Interaction	KCNQ (Kv7) potassium channel blocker

Mechanism of Interaction	Voltage-gated potassium channel blocker
Direct Interaction	yes

3784	Entrez Gene Id
ENSG00000053918	Ensembl Gene Id
P51787	Uniprot Accession

KCNQ1	Display Id
ENSG00000053918	Ensembl Gene Id
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV7.1) (IKS PRODUCING SLOW VOLTAGE-GATED POTASSIUM CHANNEL ALPHA SUBUNIT KVLQT1) (KQT-LIKE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P51787]	Description

KCNA8	GO Gene Synonym
KCNA9	GO Gene Synonym
KVLQT1	GO Gene Synonym

Potassium voltage-gated channel subfamily KQT member 1	Gene Name
P51787	UniProt ID

KCNQ1 Gene Record

KCNQ1 3784 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11351021 11804849 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10860024 14716203 9765513

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Trial Name retigabine, ezogabine,Potiga Novel drug target Established target Mechanism of Interaction KCNQ (Kv7) potassium channel blocker

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11046096

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22414228

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21355884

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17182020

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22336956

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name Indaflex

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000053918

Alternate Names: KCNQ1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P51787

Alternate Names: 3784 Entrez Gene Id ENSG00000053918 Ensembl Gene Id P51787 Uniprot Accession

Gene Info: Human Readable Name ION CHANNEL Uniprot Status Swiss-Prot Uniprot Evidence 1: Evidence at protein level

Gene Categories: ION CHANNEL, DRUGGABLE GENOME

Publications:

TEND: P51787

Alternate Names: 3784 Entrez Gene Id KCNQ1_HUMAN Uniprot Id P51787 Uniprot Accession

Gene Info: Target Subclass Potassium_channels Target Subclass Channels Transmembrane Helix Count 6

Publications:

BaderLabGenes: KCNQ1

Alternate Names: 3784 Entrez Gene ID

Gene Info: Initial Gene Query Kv7.1 Counted Citations from 1950-2000 1149

Gene Categories: ION CHANNEL

Publications:

TdgClinicalTrial: P51787

Alternate Names: KCNQ1 Gene Symbol

Gene Info: Target Class Transporters Target Subclass TC:1.A.1.15.6

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11351021 11804849 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10860024 14716203 9765513

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Trial Name retigabine, ezogabine,Potiga

Novel drug target Established target

Mechanism of Interaction KCNQ (Kv7) potassium channel blocker

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
11046096

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22414228

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21355884

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17182020

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22336956

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Indaflex

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

KCNQ1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

3784 Entrez Gene Id

ENSG00000053918 Ensembl Gene Id

P51787 Uniprot Accession

Gene Info:

Human Readable Name ION CHANNEL

Uniprot Status Swiss-Prot

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Alternate Names:

3784 Entrez Gene Id

KCNQ1_HUMAN Uniprot Id

P51787 Uniprot Accession

Gene Info:

Target Subclass Potassium_channels

Target Subclass Channels

Transmembrane Helix Count 6

Alternate Names:

3784 Entrez Gene ID

Gene Info:

Initial Gene Query Kv7.1

Counted Citations from 1950-2000 1149

Gene Categories:

ION CHANNEL

Alternate Names:

KCNQ1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.15.6

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA223 PharmGKB ID

Publications:

Lengyel et al., 2007, Diabetes mellitus attenuates the repolarization reserve in mammalian heart., Cardiovasc. Res.

Kuryshev et al., 2000, Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels., J. Pharmacol. Exp. Ther.

Alternate Names:

ENSG00000053918 Gene Symbol

KCNQ1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

KCNA9 GENE_SYMBOL

KVLQT1 GENE_SYMBOL

KCNQ1 GENE_SYMBOL

Alternate Names:

KCNA8 GO Gene Synonym

KCNA9 GO Gene Synonym

KVLQT1 GO Gene Synonym

Gene Categories:

CELL SURFACE

Alternate Names:

KCNQ1 TTD Gene Abbreviation

T49526 TTD Target ID

Alternate Names:

Potassium voltage-gated channel subfamily KQT member 1 Gene Name

P51787 UniProt ID

Gene Categories:

ION CHANNEL