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KCNQ1 Gene Record

  • Summary
  • Interactions
  • Claims
  • KCNQ1 3784 Druggable Genome

    Alternate Names:

    3784
    POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY Q MEMBER 1
    KCNQ1
    ATFB1
    ATFB3
    JLNS1
    KCNA8
    KCNA9
    KVLQT1
    Kv1.9
    Kv7.1
    LQT
    LQT1
    RWS
    SQT2
    WRS
    607542
    6294
    ENSG00000053918
    OTTHUMG00000009900
    Voltage-gated potassium channel subunit Kv7.1
    KQT-like 1
    IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
    Potassium voltage-gated channel subfamily KQT member 1
    P51787
    KCNQ1_HUMAN
    PA223
    POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV7.1) (IKS PRODUCING SLOW VOLTAGE-GATED POTASSIUM CHANNEL ALPHA SUBUNIT KVLQT1) (KQT-LIKE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P51787]
    Voltage-gated potassium channel Kv7.1
    T49526

    Gene Info:

    Initial Gene Query Kv7.1
    Counted Citations from 1950-2000 1149
    Human Readable Name ION CHANNEL
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Ion_trans_dom
    Interpro Name Ion transport domain
    Interpro Acc IPR005821
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Target Subclass Potassium_channels
    Target Subclass Channels
    Transmembrane Helix Count 6
    Target Subclass Voltage_gated_ion_channels
    Target Main Class Transporters
    Target Class Transporters
    Target Subclass TC:1.A.1.15.6
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

    Li et al., 2001, Functional consequences of the arrhythmogenic G306R KvLQT1 K+ channel mutant probed by viral gene transfer in cardiomyocytes., J. Physiol. (Lond.)
    Ohya et al., 2002, Molecular and functional characterization of ERG, KCNQ, and KCNE subtypes in rat stomach smooth muscle., Am. J. Physiol. Gastrointest. Liver Physiol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Chouabe et al., Effects of calcium channel blockers on cloned cardiac K+ channels IKr and IKs., Therapie
    Yumoto et al., 2004, Bepridil block of recombinant human cardiac IKs current shows a time-dependent unblock., J. Cardiovasc. Pharmacol.
    Chouabe et al., 1998, HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers., Mol. Pharmacol.
    Lengyel et al., 2007, Diabetes mellitus attenuates the repolarization reserve in mammalian heart., Cardiovasc. Res.
    Kuryshev et al., 2000, Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels., J. Pharmacol. Exp. Ther.
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
    Dai XP et al., 2012, KCNQ1 gene polymorphisms are associated with the therapeutic efficacy of repaglinide in Chinese type 2 diabetic patients., Clin Exp Pharmacol Physiol
    Tavira B et al., 2011, KCNQ1 gene variants and risk of new-onset diabetes in tacrolimus-treated renal-transplanted patients., Clin Transplant
  • INDAPAMIDE   KCNQ1

    Interaction Score: 7.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    11351021 11804849 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • BEPRIDIL   KCNQ1

    Interaction Score: 2.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10860024 14716203 9765513


    Sources:
    TdgClinicalTrial TEND

  • EZOGABINE   KCNQ1

    Interaction Score: 1.9

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Trial Name retigabine, ezogabine,Potiga
    Novel drug target Established target
    Mechanism of Interaction KCNQ (Kv7) potassium channel blocker

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • DOLASETRON   KCNQ1

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11046096


    Sources:
    NCI

  • REPAGLINIDE   KCNQ1

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22414228


    Sources:
    PharmGKB

  • TACROLIMUS   KCNQ1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21355884


    Sources:
    PharmGKB

  • INSULIN   KCNQ1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17182020


    Sources:
    NCI

  • CELECOXIB   KCNQ1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22336956


    Sources:
    PharmGKB

  • INDOMETHACIN   KCNQ1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name Indaflex

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • GUANIDINE HYDROCHLORIDE   KCNQ1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated potassium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TEDISAMIL   KCNQ1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated potassium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DALFAMPRIDINE   KCNQ1

    Interaction Score: 0.11

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated potassium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NERISPIRDINE   KCNQ1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated potassium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000053918

    • Version: 101_38

    Alternate Names:
    KCNQ1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P51787

    • Version: 11-September-2012

    Alternate Names:
    3784 Entrez Gene Id
    ENSG00000053918 Ensembl Gene Id
    P51787 Uniprot Accession

    Gene Info:
    Human Readable Name ION CHANNEL
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    ION CHANNEL, DRUGGABLE GENOME

    Publications:

  • TEND: P51787

    • Version: 01-August-2011

    Alternate Names:
    3784 Entrez Gene Id
    KCNQ1_HUMAN Uniprot Id
    P51787 Uniprot Accession

    Gene Info:
    Target Subclass Potassium_channels
    Target Subclass Channels
    Transmembrane Helix Count 6

    Publications:

  • BaderLabGenes: KCNQ1

    • Version: February-2014

    Alternate Names:
    3784 Entrez Gene ID

    Gene Info:
    Initial Gene Query Kv7.1
    Counted Citations from 1950-2000 1149

    Gene Categories:
    ION CHANNEL

    Publications:

  • TdgClinicalTrial: P51787

    • Version: January-2014

    Alternate Names:
    KCNQ1 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.1.15.6

    Publications:

  • RussLampel: ENSG00000053918

    • Version: 26-July-2011

    Alternate Names:
    KCNQ1 Display Id
    ENSG00000053918 Ensembl Gene Id
    POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV7.1) (IKS PRODUCING SLOW VOLTAGE-GATED POTASSIUM CHANNEL ALPHA SUBUNIT KVLQT1) (KQT-LIKE 1). [SOURCE:UNIPROT/SWISSPROT;ACC:P51787] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: KCNQ1

    • Version: 18-August-2020

    Alternate Names:
    PA223 PharmGKB ID

    Gene Info:

    Publications:
    Dai XP et al., 2012, KCNQ1 gene polymorphisms are associated with the therapeutic efficacy of repaglinide in Chinese type 2 diabetic patients., Clin Exp Pharmacol Physiol
    Gong L et al., 2012, Celecoxib pathways: pharmacokinetics and pharmacodynamics., Pharmacogenet Genomics
    Tavira B et al., 2011, KCNQ1 gene variants and risk of new-onset diabetes in tacrolimus-treated renal-transplanted patients., Clin Transplant

  • NCI: KCNQ1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Lengyel et al., 2007, Diabetes mellitus attenuates the repolarization reserve in mammalian heart., Cardiovasc. Res.
    Kuryshev et al., 2000, Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels., J. Pharmacol. Exp. Ther.

  • HingoraniCasas: ENSG00000053918

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000053918 Gene Symbol
    KCNQ1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: KCNA8

    • Version: chembl_23

    Alternate Names:
    KCNA9 GENE_SYMBOL
    KVLQT1 GENE_SYMBOL
    KCNQ1 GENE_SYMBOL

    Gene Info:

    Publications:

  • GO: KCNQ1

    • Version: 01-February-2022

    Alternate Names:
    KCNA8 GO Gene Synonym
    KCNA9 GO Gene Synonym
    KVLQT1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

  • TTD: Voltage-gated potassium channel Kv7.1

    • Version: 2020.06.01

    Alternate Names:
    KCNQ1 TTD Gene Abbreviation
    T49526 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: KCNQ1

    • Version: 01-February-2022

    Alternate Names:
    Potassium voltage-gated channel subfamily KQT member 1 Gene Name
    P51787 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21