DGIdb - KCNJ11 Gene Record

KCNJ11 3767 Druggable GenomeDrug Resistance

Alternate Names:

3767
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY J MEMBER 11
KCNJ11
BIR
HHF2
IKATP
KIR6.2
MODY13
PHHI
TNDM3
600937
6257
ENSG00000187486
OTTHUMG00000165914
Q14654
IRK11_HUMAN
POTASSIUM INWARDLY-RECTIFYING CHANNEL, SUBFAMILY J, MEMBER 11 (KCNJ11), MRNA [SOURCE:REFSEQ_DNA;ACC:NM_000525]
NM_000525.3
BE0000708
PA217
Inward rectifier K(+) channel Kir6.2
ATP-sensitive inward rectifier potassium channel 11
Potassium channel, inwardly rectifying subfamily J member 11
442
NP_000516
NM_000525
K<sub>ir</sub>6.2
BE0004923
potassium inwardly rectifying channel subfamily J member 11

Gene Info:

Transmembrane Helix Count	2
Target Subclass	Channels
Target Main Class	Transporters
Target Subclass	InwardlyRectifyingKchannel
Target Subclass	Voltage_gated_ion_channels
Human Readable Name	DRUGGABLE GENOME
Initial Gene Query	Kir6.2
Counted Citations from 1950-2000	1209
GuideToPharmacology Gene Category Name	Inwardly rectifying potassium channels
GuideToPharmacology Gene Category ID	74
Target Class	Transporters
Target Subclass	TC:1.A.2.1
Gene Biotype	PROTEIN_CODING

(11 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUG RESISTANCE
DRUGGABLE GENOME

Publications:

Klen J et al., 2014, CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients., Eur J Clin Pharmacol
Sesti G et al., 2006, The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes., J Clin Endocrinol Metab
Gloyn AL et al., 2001, Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)., Diabet Med
Javorsky M et al., 2012, KCNJ11 gene E23K variant and therapeutic response to sulfonylureas., Eur J Intern Med
Li Q et al., 2014, KCNJ11 E23K variant is associated with the therapeutic effect of sulphonylureas in Chinese type 2 diabetic patients., Clin Exp Pharmacol Physiol
Yildiz, 2007, Vasodilating mechanisms of levosimendan: involvement of K+ channels., J. Pharmacol. Sci.
Jabůrek et al., 1998, State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate., J. Biol. Chem.
Pearson ER et al., 2006, Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations., N Engl J Med
Sakura et al., 1999, Altered functional properties of KATP channel conferred by a novel splice variant of SUR1., J. Physiol. (Lond.)
de Lonlay et al., 2002, Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases., Eur. J. Pediatr.
Russ et al., 2003, Binding and effect of K ATP channel openers in the absence of Mg2+., Br. J. Pharmacol.
Shindo et al., 2000, MCC-134, a novel vascular relaxing agent, is an inverse agonist for the pancreatic-type ATP-sensitive K(+) channel., J. Pharmacol. Exp. Ther.
D'hahan et al., 1999, Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP., Proc. Natl. Acad. Sci. U.S.A.
Darendeliler F et al., 2002, ABCC8 (SUR1) and KCNJ11 (KIR6.2) mutations in persistent hyperinsulinemic hypoglycemia of infancy and evaluation of different therapeutic measures., J Pediatr Endocrinol Metab
Ohkubo K et al., 2005, Genotypes of the pancreatic beta-cell K-ATP channel and clinical phenotypes of Japanese patients with persistent hyperinsulinaemic hypoglycaemia of infancy., Clin Endocrinol (Oxf)
Lawrence et al., 2002, Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K(ATP) channels., Br. J. Pharmacol.
Bataille, 2002, [Molecular mechanisms of insulin secretion]., Diabetes Metab.
Song et al., 2001, Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels., Br. J. Pharmacol.
Tsutsumi et al., 2000, Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes., Anesthesiology
Eguchi et al., 2005, [Effects of propofol and thiamylal on nicorandil induced ATP-sensitive potassium channel activities in cultured rat aortic smooth muscle cells]., Masui
Kawano et al., 2004, Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels., Anesthesiology
Yu M et al., 2010, KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes., Clin Pharmacol Ther
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Ninomiya T et al., 2003, Verapamil, a Ca2+ entry blocker, targets the pore-forming subunit of cardiac type KATP channel (Kir6.2)., J Cardiovasc Pharmacol
Shigeto et al., 2007, Nateglinide and mitiglinide, but not sulfonylureas, induce insulin secretion through a mechanism mediated by calcium release from endoplasmic reticulum., J. Pharmacol. Exp. Ther.
Yamada et al., 2006, Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant., J. Physiol. (Lond.)
Li et al., 2000, [Effects of glibenclamide on mRNA level of ATP-sensitive potassium channels of heart in normal and streptozotocin-induced diabetic rats]., Zhonghua Yi Xue Za Zhi
Jin et al., 2007, Uncoupling by (--)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP., Pharmacol. Res.
Foster et al., 1997, Ibutilide. A review of its pharmacological properties and clinical potential in the acute management of atrial flutter and fibrillation., Drugs
Doggrell et al., 2005, Ibutilide--recent molecular insights and accumulating evidence for use in atrial flutter and fibrillation., Expert Opin Investig Drugs
Proks et al., 1997, Phentolamine block of KATP channels is mediated by Kir6.2., Proc. Natl. Acad. Sci. U.S.A.
Bian X et al., 2006, Synthesis and antihyperglycemic evaluation of various protoberberine derivatives., Bioorg Med Chem Lett
Yunoki et al., 2001, The effects of flecainide on ATP-sensitive K(+) channels in pig urethral myocytes., Br. J. Pharmacol.
Tavira B et al., 2012, Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus., Mol Genet Metab
Keirns J et al., 2017, QT Interval Shortening With Isavuconazole: In Vitro and In Vivo Effects on Cardiac Repolarization., Clin Pharmacol Ther

GLIMEPIRIDE KCNJ11

Interaction Score: 3.11

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

Trial Name glimepiride,Amaryl

PMIDs:
12086984 24442125 12703060 16595597 11318841 22385882 25115353 11325810

Sources:
NCI TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions
THIAMYLAL KCNJ11

Interaction Score: 2.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10754636 15852621 14739809

Sources:
TEND TdgClinicalTrial DrugBank
GLIQUIDONE KCNJ11

Interaction Score: 1.78

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24442125 16359864 16595597 11318841 22385882 25115353

Sources:
DTC PharmGKB
GLIPIZIDE KCNJ11

Interaction Score: 1.55

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
24442125 16595597 11318841 22385882 25115353

Sources:
PharmGKB ChemblInteractions
GLICLAZIDE KCNJ11

Interaction Score: 1.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24442125 16595597 11318841 22385882 25115353

Sources:
PharmGKB
LEVOSIMENDAN KCNJ11

Interaction Score: 1.33

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name Levosimendan

Novel drug target Established target

PMIDs:
17452812

Sources:
TdgClinicalTrial DrugBank
DIAZOXIDE KCNJ11

Interaction Score: 1.15

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 11 opener

Direct Interaction yes

PMIDs:
16885550 10581306 11808879 12770942 10604939 10518593 12199344 15807877

Sources:
PharmGKB DrugBank ChemblInteractions
GLYBURIDE KCNJ11

Interaction Score: 0.93

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
24442125 16595597 11318841 9593694 22385882 25115353

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
BERBERRUBINE KCNJ11

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16359864

Sources:
DTC
TOLBUTAMIDE SODIUM, STERILE KCNJ11

Interaction Score: 0.89

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ACETOHEXAMIDE KCNJ11

Interaction Score: 0.59

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IBUTILIDE KCNJ11

Interaction Score: 0.48

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
9257085 15926871

Sources:
DrugBank
BERBERINE CHLORIDE KCNJ11

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16359864

Sources:
DTC
SARAKALIM KCNJ11

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Sulfonylurea receptors; K-ATP channels opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TOLBUTAMIDE KCNJ11

Interaction Score: 0.44

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

Specific Action of the Ligand None

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
NAMINIDIL KCNJ11

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Sulfonylurea receptors; K-ATP channels opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MITIGLINIDE KCNJ11

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
REPAGLINIDE KCNJ11

Interaction Score: 0.44

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
20054294

Sources:
TEND PharmGKB ChemblInteractions
PINACIDIL KCNJ11

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener

PMIDs:
None found

Sources:
ChemblInteractions
ISAVUCONAZOLE KCNJ11

Interaction Score: 0.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
28074556

Sources:
DrugBank
FLECAINIDE KCNJ11

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11429398

Sources:
NCI
NICORANDIL KCNJ11

Interaction Score: 0.36

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
None found

Sources:
GuideToPharmacology
NATEGLINIDE KCNJ11

Interaction Score: 0.32

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
None found

Sources:
TEND ChemblInteractions
PHENTOLAMINE KCNJ11

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9326676

Sources:
NCI
MINOXIDIL KCNJ11

Interaction Score: 0.27

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
TOLAZAMIDE KCNJ11

Interaction Score: 0.25

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VERAPAMIL KCNJ11

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11752352 12883317 17409272 17038430

Sources:
DrugBank
CHLORPROPAMIDE KCNJ11

Interaction Score: 0.16

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
EPIGALOCATECHIN GALLATE KCNJ11

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17656102

Sources:
NCI
TACROLIMUS KCNJ11

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22264780

Sources:
PharmGKB
METFORMIN KCNJ11

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16595597

Sources:
PharmGKB
STREPTOZOCIN KCNJ11

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11798815

Sources:
NCI

Ensembl: ENSG00000187486
- Version: 101_38
Alternate Names:

KCNJ11 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: Q14654
- Version: 01-August-2011
Alternate Names:

ENSG00000187486 Ensembl Gene Id

Q14654 Uniprot Accession

KCNJ11 Gene Symbol

Gene Info:

Transmembrane Helix Count 2

Target Subclass Channels

Target Main Class Transporters

Publications:
RussLampel: ENSG00000187486
- Version: 26-July-2011
Alternate Names:

POTASSIUM INWARDLY-RECTIFYING CHANNEL, SUBFAMILY J, MEMBER 11 (KCNJ11), MRNA [SOURCE:REFSEQ_DNA;ACC:NM_000525] Description

NM_000525.3 Display Id

ENSG00000187486 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
BaderLabGenes: KCNJ11
- Version: February-2014
Alternate Names:

3767 Entrez Gene ID

Gene Info:

Initial Gene Query Kir6.2

Counted Citations from 1950-2000 1209

Gene Categories:

ION CHANNEL

Publications:
TdgClinicalTrial: Q14654
- Version: January-2014
Alternate Names:

KCNJ11 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.2.1

Publications:
GuideToPharmacology: 3767
- Version: 29-September-2020
Alternate Names:

6257 HUGO Gene ID

6257 HUGO Gene Symbol

potassium inwardly rectifying channel subfamily J member 11 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Inwardly rectifying potassium channels

GuideToPharmacology Gene Category ID 74

Gene Categories:

ION CHANNEL

Publications:

PharmGKB: KCNJ11

Version: 18-August-2020

Alternate Names:

PA217 PharmGKB ID

Gene Info:

Publications:

Klen J et al., 2014, CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients., Eur J Clin Pharmacol

Sesti G et al., 2006, The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes., J Clin Endocrinol Metab

Gloyn AL et al., 2001, Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)., Diabet Med

DrugBank: BE0000708

Version: 5.1.7

Alternate Names:

KCNJ11 DrugBank Gene Name

Q14654 UniProt Accession

3767 Entrez Gene Id

Gene Info:

Publications:

Lawrence et al., 2002, Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K(ATP) channels., Br. J. Pharmacol.

Bataille, 2002, [Molecular mechanisms of insulin secretion]., Diabetes Metab.

Song et al., 2001, Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels., Br. J. Pharmacol.

DrugBank: BE0004923
- Version: 5.1.7
Alternate Names:

KCNJ11 DrugBank Gene Name

Q14654 UniProt Accession

3767 Entrez Gene Id

Gene Info:

Publications:

Jabůrek et al., 1998, State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate., J. Biol. Chem.

NCI: KCNJ11

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Jin et al., 2007, Uncoupling by (--)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP., Pharmacol. Res.

Li et al., 2000, [Effects of glibenclamide on mRNA level of ATP-sensitive potassium channels of heart in normal and streptozotocin-induced diabetic rats]., Zhonghua Yi Xue Za Zhi

Proks et al., 1997, Phentolamine block of KATP channels is mediated by Kir6.2., Proc. Natl. Acad. Sci. U.S.A.

DTC: KCNJ11
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Bian X et al., 2006, Synthesis and antihyperglycemic evaluation of various protoberberine derivatives., Bioorg Med Chem Lett
HingoraniCasas: ENSG00000187486
- Version: 31-May-2017
Alternate Names:

ENSG00000187486 Gene Symbol

KCNJ11 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: KCNJ11
- Version: chembl_23
Alternate Names:

KCNJ11 GENE_SYMBOL

ATP-sensitive inward rectifier potassium channel 11 UNIPROT

IKATP UNIPROT

Gene Info:

Publications:
Pharos: KCNJ11
- Version: 03-September-2020
Alternate Names:

ATP-sensitive inward rectifier potassium channel 11 Gene Name

Q14654 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:
GO: KCNJ11
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

Mechanism of Interaction	Sulfonylurea receptor 1, Kir6.2 blocker
Direct Interaction	yes
Trial Name	glimepiride,Amaryl

Mechanism of Interaction	Potassium channel, inwardly rectifying, subfamily J, member 11 opener
Direct Interaction	yes

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	None

Mechanism of Interaction	Sulfonylurea receptors; K-ATP channels opener
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Sulfonylurea receptor 2, Kir6.2 opener

ENSG00000187486	Ensembl Gene Id
Q14654	Uniprot Accession
KCNJ11	Gene Symbol

POTASSIUM INWARDLY-RECTIFYING CHANNEL, SUBFAMILY J, MEMBER 11 (KCNJ11), MRNA [SOURCE:REFSEQ_DNA;ACC:NM_000525]	Description
NM_000525.3	Display Id
ENSG00000187486	Ensembl Gene Id

6257	HUGO Gene ID
6257	HUGO Gene Symbol
potassium inwardly rectifying channel subfamily J member 11	HUGO Gene Name

KCNJ11	DrugBank Gene Name
Q14654	UniProt Accession
3767	Entrez Gene Id

KCNJ11	GENE_SYMBOL
ATP-sensitive inward rectifier potassium channel 11	UNIPROT
IKATP	UNIPROT

blocker (inhibitory)
inhibitor (inhibitory)

Trial Name	-
Novel drug target	Established target

Trial Name	Levosimendan
Novel drug target	Established target

blocker (inhibitory)
inhibitor (inhibitory)

ATP-sensitive inward rectifier potassium channel 11	Gene Name
Q14654	UniProt ID

KCNJ11 Gene Record

KCNJ11 3767 Druggable GenomeDrug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker Direct Interaction yes Trial Name glimepiride,Amaryl

PMIDs: 12086984 24442125 12703060 16595597 11318841 22385882 25115353 11325810

Sources: NCI TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10754636 15852621 14739809

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24442125 16359864 16595597 11318841 22385882 25115353

Sources: DTC PharmGKB

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker Direct Interaction yes

PMIDs: 24442125 16595597 11318841 22385882 25115353

Sources: PharmGKB ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24442125 16595597 11318841 22385882 25115353

Sources: PharmGKB

Interaction Types & Directionality: inducer (activating)

Interaction Info: Trial Name Levosimendan Novel drug target Established target

PMIDs: 17452812

Sources: TdgClinicalTrial DrugBank

Interaction Types & Directionality: inducer (activating)

Interaction Info: Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 11 opener Direct Interaction yes

PMIDs: 16885550 10581306 11808879 12770942 10604939 10518593 12199344 15807877

Sources: PharmGKB DrugBank ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand None

PMIDs: 24442125 16595597 11318841 9593694 22385882 25115353

Sources: TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16359864

Sources: DTC

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 9257085 15926871

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16359864

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Sulfonylurea receptors; K-ATP channels opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker Direct Interaction yes Specific Action of the Ligand None

PMIDs: None found

Sources: GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Sulfonylurea receptors; K-ATP channels opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker Direct Interaction yes

PMIDs: 20054294

Sources: TEND PharmGKB ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Direct Interaction yes Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

Trial Name glimepiride,Amaryl

PMIDs:
12086984 24442125 12703060 16595597 11318841 22385882 25115353 11325810

Sources:
NCI TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10754636 15852621 14739809

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
24442125 16359864 16595597 11318841 22385882 25115353

Sources:
DTC PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
24442125 16595597 11318841 22385882 25115353

Sources:
PharmGKB ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
24442125 16595597 11318841 22385882 25115353

Sources:
PharmGKB

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name Levosimendan

Novel drug target Established target

PMIDs:
17452812

Sources:
TdgClinicalTrial DrugBank

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 11 opener

Direct Interaction yes

PMIDs:
16885550 10581306 11808879 12770942 10604939 10518593 12199344 15807877

Sources:
PharmGKB DrugBank ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
24442125 16595597 11318841 9593694 22385882 25115353

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16359864

Sources:
DTC

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
9257085 15926871

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16359864

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Sulfonylurea receptors; K-ATP channels opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

Specific Action of the Ligand None

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Sulfonylurea receptors; K-ATP channels opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
20054294

Sources:
TEND PharmGKB ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
28074556

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
11429398

Sources:
NCI

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
None found

Sources:
GuideToPharmacology