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KCNJ11 Gene Record

  • Summary
  • Interactions
  • Claims
  • KCNJ11 3767 Druggable GenomeDrug Resistance

    Alternate Names:

    3767
    POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY J MEMBER 11
    KCNJ11
    BIR
    HHF2
    IKATP
    KIR6.2
    MODY13
    PHHI
    TNDM3
    600937
    6257
    ENSG00000187486
    OTTHUMG00000165914
    Q14654
    IRK11_HUMAN
    POTASSIUM INWARDLY-RECTIFYING CHANNEL, SUBFAMILY J, MEMBER 11 (KCNJ11), MRNA [SOURCE:REFSEQ_DNA;ACC:NM_000525]
    NM_000525.3
    BE0000708
    PA217
    Inward rectifier K(+) channel Kir6.2
    ATP-sensitive inward rectifier potassium channel 11
    Potassium channel, inwardly rectifying subfamily J member 11
    442
    NP_000516
    NM_000525
    K<sub>ir</sub>6.2
    BE0004923
    potassium inwardly rectifying channel subfamily J member 11

    Gene Info:

    Transmembrane Helix Count 2
    Target Subclass Channels
    Target Main Class Transporters
    Target Subclass InwardlyRectifyingKchannel
    Target Subclass Voltage_gated_ion_channels
    Human Readable Name DRUGGABLE GENOME
    Initial Gene Query Kir6.2
    Counted Citations from 1950-2000 1209
    GuideToPharmacology Gene Category Name Inwardly rectifying potassium channels
    GuideToPharmacology Gene Category ID 74
    Target Class Transporters
    Target Subclass TC:1.A.2.1
    Gene Biotype PROTEIN_CODING
    (11 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUG RESISTANCE
    DRUGGABLE GENOME

    Publications:

    Klen J et al., 2014, CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients., Eur J Clin Pharmacol
    Sesti G et al., 2006, The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes., J Clin Endocrinol Metab
    Gloyn AL et al., 2001, Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)., Diabet Med
    Javorsky M et al., 2012, KCNJ11 gene E23K variant and therapeutic response to sulfonylureas., Eur J Intern Med
    Li Q et al., 2014, KCNJ11 E23K variant is associated with the therapeutic effect of sulphonylureas in Chinese type 2 diabetic patients., Clin Exp Pharmacol Physiol
    Yildiz, 2007, Vasodilating mechanisms of levosimendan: involvement of K+ channels., J. Pharmacol. Sci.
    Jabůrek et al., 1998, State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate., J. Biol. Chem.
    Pearson ER et al., 2006, Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations., N Engl J Med
    Sakura et al., 1999, Altered functional properties of KATP channel conferred by a novel splice variant of SUR1., J. Physiol. (Lond.)
    de Lonlay et al., 2002, Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases., Eur. J. Pediatr.
    Russ et al., 2003, Binding and effect of K ATP channel openers in the absence of Mg2+., Br. J. Pharmacol.
    Shindo et al., 2000, MCC-134, a novel vascular relaxing agent, is an inverse agonist for the pancreatic-type ATP-sensitive K(+) channel., J. Pharmacol. Exp. Ther.
    D'hahan et al., 1999, Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP., Proc. Natl. Acad. Sci. U.S.A.
    Darendeliler F et al., 2002, ABCC8 (SUR1) and KCNJ11 (KIR6.2) mutations in persistent hyperinsulinemic hypoglycemia of infancy and evaluation of different therapeutic measures., J Pediatr Endocrinol Metab
    Ohkubo K et al., 2005, Genotypes of the pancreatic beta-cell K-ATP channel and clinical phenotypes of Japanese patients with persistent hyperinsulinaemic hypoglycaemia of infancy., Clin Endocrinol (Oxf)
    Lawrence et al., 2002, Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K(ATP) channels., Br. J. Pharmacol.
    Bataille, 2002, [Molecular mechanisms of insulin secretion]., Diabetes Metab.
    Song et al., 2001, Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels., Br. J. Pharmacol.
    Tsutsumi et al., 2000, Blockade of adenosine triphosphate-sensitive potassium channels by thiamylal in rat ventricular myocytes., Anesthesiology
    Eguchi et al., 2005, [Effects of propofol and thiamylal on nicorandil induced ATP-sensitive potassium channel activities in cultured rat aortic smooth muscle cells]., Masui
    Kawano et al., 2004, Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels., Anesthesiology
    Yu M et al., 2010, KCNJ11 Lys23Glu and TCF7L2 rs290487(C/T) polymorphisms affect therapeutic efficacy of repaglinide in Chinese patients with type 2 diabetes., Clin Pharmacol Ther
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Ninomiya T et al., 2003, Verapamil, a Ca2+ entry blocker, targets the pore-forming subunit of cardiac type KATP channel (Kir6.2)., J Cardiovasc Pharmacol
    Shigeto et al., 2007, Nateglinide and mitiglinide, but not sulfonylureas, induce insulin secretion through a mechanism mediated by calcium release from endoplasmic reticulum., J. Pharmacol. Exp. Ther.
    Yamada et al., 2006, Protection conferred by myocardial ATP-sensitive K+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant., J. Physiol. (Lond.)
    Li et al., 2000, [Effects of glibenclamide on mRNA level of ATP-sensitive potassium channels of heart in normal and streptozotocin-induced diabetic rats]., Zhonghua Yi Xue Za Zhi
    Jin et al., 2007, Uncoupling by (--)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP., Pharmacol. Res.
    Foster et al., 1997, Ibutilide. A review of its pharmacological properties and clinical potential in the acute management of atrial flutter and fibrillation., Drugs
    Doggrell et al., 2005, Ibutilide--recent molecular insights and accumulating evidence for use in atrial flutter and fibrillation., Expert Opin Investig Drugs
    Proks et al., 1997, Phentolamine block of KATP channels is mediated by Kir6.2., Proc. Natl. Acad. Sci. U.S.A.
    Bian X et al., 2006, Synthesis and antihyperglycemic evaluation of various protoberberine derivatives., Bioorg Med Chem Lett
    Yunoki et al., 2001, The effects of flecainide on ATP-sensitive K(+) channels in pig urethral myocytes., Br. J. Pharmacol.
    Tavira B et al., 2012, Association between a common KCNJ11 polymorphism (rs5219) and new-onset posttransplant diabetes in patients treated with Tacrolimus., Mol Genet Metab
    Keirns J et al., 2017, QT Interval Shortening With Isavuconazole: In Vitro and In Vivo Effects on Cardiac Repolarization., Clin Pharmacol Ther
  • GLIMEPIRIDE   KCNJ11

    Interaction Score: 3.11

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker
    Direct Interaction yes
    Trial Name glimepiride,Amaryl

    PMIDs:
    12086984 24442125 12703060 16595597 11318841 22385882 25115353 11325810


    Sources:
    NCI TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

  • THIAMYLAL   KCNJ11

    Interaction Score: 2.66

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10754636 15852621 14739809


    Sources:
    TEND TdgClinicalTrial DrugBank

  • GLIQUIDONE   KCNJ11

    Interaction Score: 1.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24442125 16359864 16595597 11318841 22385882 25115353


    Sources:
    DTC PharmGKB

  • GLIPIZIDE   KCNJ11

    Interaction Score: 1.55

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker
    Direct Interaction yes

    PMIDs:
    24442125 16595597 11318841 22385882 25115353


    Sources:
    PharmGKB ChemblInteractions

  • GLICLAZIDE   KCNJ11

    Interaction Score: 1.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24442125 16595597 11318841 22385882 25115353


    Sources:
    PharmGKB

  • LEVOSIMENDAN   KCNJ11

    Interaction Score: 1.33

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:
    Trial Name Levosimendan
    Novel drug target Established target

    PMIDs:
    17452812


    Sources:
    TdgClinicalTrial DrugBank

  • DIAZOXIDE   KCNJ11

    Interaction Score: 1.15

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:
    Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 11 opener
    Direct Interaction yes

    PMIDs:
    16885550 10581306 11808879 12770942 10604939 10518593 12199344 15807877


    Sources:
    PharmGKB DrugBank ChemblInteractions

  • GLYBURIDE   KCNJ11

    Interaction Score: 0.93

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand None

    PMIDs:
    24442125 16595597 11318841 9593694 22385882 25115353


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • BERBERRUBINE   KCNJ11

    Interaction Score: 0.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16359864


    Sources:
    DTC

  • TOLBUTAMIDE SODIUM, STERILE   KCNJ11

    Interaction Score: 0.89

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ACETOHEXAMIDE   KCNJ11

    Interaction Score: 0.59

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IBUTILIDE   KCNJ11

    Interaction Score: 0.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    9257085 15926871


    Sources:
    DrugBank

  • BERBERINE CHLORIDE   KCNJ11

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16359864


    Sources:
    DTC

  • SARAKALIM   KCNJ11

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptors; K-ATP channels opener
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TOLBUTAMIDE   KCNJ11

    Interaction Score: 0.44

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker
    Direct Interaction yes
    Specific Action of the Ligand None

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • NAMINIDIL   KCNJ11

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptors; K-ATP channels opener
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MITIGLINIDE   KCNJ11

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • REPAGLINIDE   KCNJ11

    Interaction Score: 0.44

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker
    Direct Interaction yes

    PMIDs:
    20054294


    Sources:
    TEND PharmGKB ChemblInteractions

  • PINACIDIL   KCNJ11

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Sulfonylurea receptor 2, Kir6.2 opener

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ISAVUCONAZOLE   KCNJ11

    Interaction Score: 0.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    28074556


    Sources:
    DrugBank

  • FLECAINIDE   KCNJ11

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11429398


    Sources:
    NCI

  • NICORANDIL   KCNJ11

    Interaction Score: 0.36

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand None

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • NATEGLINIDE   KCNJ11

    Interaction Score: 0.32

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TEND ChemblInteractions

  • PHENTOLAMINE   KCNJ11

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9326676


    Sources:
    NCI

  • MINOXIDIL   KCNJ11

    Interaction Score: 0.27

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Specific Action of the Ligand None
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • TOLAZAMIDE   KCNJ11

    Interaction Score: 0.25

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VERAPAMIL   KCNJ11

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11752352 12883317 17409272 17038430


    Sources:
    DrugBank

  • CHLORPROPAMIDE   KCNJ11

    Interaction Score: 0.16

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • EPIGALOCATECHIN GALLATE   KCNJ11

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17656102


    Sources:
    NCI

  • TACROLIMUS   KCNJ11

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22264780


    Sources:
    PharmGKB

  • METFORMIN   KCNJ11

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16595597


    Sources:
    PharmGKB

  • STREPTOZOCIN   KCNJ11

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11798815


    Sources:
    NCI

  • Ensembl: ENSG00000187486

    • Version: 101_38

    Alternate Names:
    KCNJ11 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: Q14654

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000187486 Ensembl Gene Id
    Q14654 Uniprot Accession
    KCNJ11 Gene Symbol

    Gene Info:
    Transmembrane Helix Count 2
    Target Subclass Channels
    Target Main Class Transporters

    Publications:

  • RussLampel: ENSG00000187486

    • Version: 26-July-2011

    Alternate Names:
    POTASSIUM INWARDLY-RECTIFYING CHANNEL, SUBFAMILY J, MEMBER 11 (KCNJ11), MRNA [SOURCE:REFSEQ_DNA;ACC:NM_000525] Description
    NM_000525.3 Display Id
    ENSG00000187486 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • BaderLabGenes: KCNJ11

    • Version: February-2014

    Alternate Names:
    3767 Entrez Gene ID

    Gene Info:
    Initial Gene Query Kir6.2
    Counted Citations from 1950-2000 1209

    Gene Categories:
    ION CHANNEL

    Publications:

  • TdgClinicalTrial: Q14654

    • Version: January-2014

    Alternate Names:
    KCNJ11 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.2.1

    Publications:

  • GuideToPharmacology: 3767

    • Version: 29-September-2020

    Alternate Names:
    6257 HUGO Gene ID
    6257 HUGO Gene Symbol
    potassium inwardly rectifying channel subfamily J member 11 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Inwardly rectifying potassium channels
    GuideToPharmacology Gene Category ID 74

    Gene Categories:
    ION CHANNEL

    Publications:

  • PharmGKB: KCNJ11

    • Version: 18-August-2020

    Alternate Names:
    PA217 PharmGKB ID

    Gene Info:

    Publications:
    Klen J et al., 2014, CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients., Eur J Clin Pharmacol
    Sesti G et al., 2006, The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes., J Clin Endocrinol Metab
    Gloyn AL et al., 2001, Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)., Diabet Med

  • DrugBank: BE0000708

    • Version: 5.1.7

    Alternate Names:
    KCNJ11 DrugBank Gene Name
    Q14654 UniProt Accession
    3767 Entrez Gene Id

    Gene Info:

    Publications:
    Lawrence et al., 2002, Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K(ATP) channels., Br. J. Pharmacol.
    Bataille, 2002, [Molecular mechanisms of insulin secretion]., Diabetes Metab.
    Song et al., 2001, Glimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channels., Br. J. Pharmacol.

  • DrugBank: BE0004923

    • Version: 5.1.7

    Alternate Names:
    KCNJ11 DrugBank Gene Name
    Q14654 UniProt Accession
    3767 Entrez Gene Id

    Gene Info:

    Publications:
    Jabůrek et al., 1998, State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate., J. Biol. Chem.

  • NCI: KCNJ11

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Jin et al., 2007, Uncoupling by (--)-epigallocatechin-3-gallate of ATP-sensitive potassium channels from phosphatidylinositol polyphosphates and ATP., Pharmacol. Res.
    Li et al., 2000, [Effects of glibenclamide on mRNA level of ATP-sensitive potassium channels of heart in normal and streptozotocin-induced diabetic rats]., Zhonghua Yi Xue Za Zhi
    Proks et al., 1997, Phentolamine block of KATP channels is mediated by Kir6.2., Proc. Natl. Acad. Sci. U.S.A.

  • DTC: KCNJ11

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Bian X et al., 2006, Synthesis and antihyperglycemic evaluation of various protoberberine derivatives., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000187486

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000187486 Gene Symbol
    KCNJ11 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: KCNJ11

    • Version: chembl_23

    Alternate Names:
    KCNJ11 GENE_SYMBOL
    ATP-sensitive inward rectifier potassium channel 11 UNIPROT
    IKATP UNIPROT

    Gene Info:

    Publications:

  • Pharos: KCNJ11

    • Version: 03-September-2020

    Alternate Names:
    ATP-sensitive inward rectifier potassium channel 11 Gene Name
    Q14654 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

  • GO: KCNJ11

    • Version: 05-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21