DGIdb - KCNJ1 Gene Record

KCNJ1 3758 Druggable Genome

Alternate Names:

3758
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY J MEMBER 1
KCNJ1
KIR1.1
ROMK
ROMK1
600359
6255
ENSG00000151704
OTTHUMG00000048247
P48048
IRK1_HUMAN
429
K<sub>ir</sub>1.1
BE0004905
ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 1 (POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 1) (ATP-REGULATED POTASSIUM CHANNEL ROM-K) (KIR1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P48048]
BE0000644
NP_722448\|NP_000211
NM_153764\|NM_000220
PA213
Inward rectifier potassium channel Kir1.1
T78710
ATP-sensitive inward rectifier potassium channel 1
potassium inwardly rectifying channel subfamily J member 1

Gene Info:

Target Class	Transporters
Target Subclass	TC:1.A.2.1.1
Transmembrane Helix Count	2
Target Main Class	Transporters
Target Subclass	Voltage_gated_ion_channels
Target Subclass	Channels
Target Subclass	InwardlyRectifyingKchannel
Human Readable Name	DRUGGABLE GENOME
GuideToPharmacology Gene Category Name	Inwardly rectifying potassium channels
GuideToPharmacology Gene Category ID	74
Initial Gene Query	Kir1.1
Counted Citations from 1950-2000	387
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

ION CHANNEL
DRUGGABLE GENOME

Publications:

Plant et al., 1990, Phentolamine and yohimbine inhibit ATP-sensitive K+ channels in mouse pancreatic beta-cells., Br. J. Pharmacol.
Lu et al., 2006, CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney., J. Clin. Invest.
Pondugula et al., 2006, Glucocorticoid regulation of genes in the amiloride-sensitive sodium transport pathway by semicircular canal duct epithelium of neonatal rat., Physiol. Genomics
Serrano-Martín et al., 2006, Glibenclamide, a blocker of K+(ATP) channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis., Antimicrob. Agents Chemother.
Greeley et al., 2010, Neonatal diabetes mellitus: a model for personalized medicine., Trends Endocrinol. Metab.
Guirgis et al., 1976, Comparative study of the hypoglycaemic and antilipolytic effects of four antidiabetic agents administered i.v., Arzneimittelforschung
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Bataille, 2002, [Molecular mechanisms of insulin secretion]., Diabetes Metab.
Proks et al., 2002, Sulfonylurea stimulation of insulin secretion., Diabetes
Tanemoto M et al., 2000, Rat homolog of sulfonylurea receptor 2B determines glibenclamide sensitivity of ROMK2 in Xenopus laevis oocyte., Am J Physiol Renal Physiol
Bednarczyk P et al., 2018, Evidence for a mitochondrial ATP-regulated potassium channel in human dermal fibroblasts., Biochim Biophys Acta Bioenerg
Konstas AA et al., 2002, Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. Implications for the identity of the renal ATP-regulated secretory K+ channel., J Biol Chem
Bkaily et al., 1988, Bethanidine increases one type of potassium current and relaxes aortic muscle., Can. J. Physiol. Pharmacol.
Bkaily, 1990, Bethanidine, nitroprusside and atrial natriuretic factor open a cGMP-sensitive K+ channel in aortic muscle., Prog. Clin. Biol. Res.
Shepherd et al., 1996, Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: implications for stimulus-response coupling of insulin release., Br. J. Pharmacol.
Kirsten et al., 1998, Clinical pharmacokinetics of vasodilators. Part I., Clin Pharmacokinet
Bray et al., 1992, A specific binding site for K+ channel openers in rat aorta., J. Biol. Chem.
Evans et al., 2005, Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function., J. Exp. Biol.
Löffler-Walz et al., 1998, Binding of K(ATP) channel modulators in rat cardiac membranes., Br. J. Pharmacol.
Black et al., 2008, Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models., Brain Res.
Liu et al., 1999, ATP-dependent activation of K(Ca) and ROMK-type K(ATP) channels in human submandibular gland ductal cells., J. Biol. Chem.
Smith et al., 1998, Inhibition of the ATP-sensitive potassium channel from mouse pancreatic beta-cells by surfactants., Br. J. Pharmacol.
Proks et al., 2001, Interaction of stilbene disulphonates with cloned K(ATP) channels., Br. J. Pharmacol.
Karnes JH et al., 2013, Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment., Pharmacogenomics J
Winkelman DL et al., 2005, Inhibition of the A-type K+ channels of dorsal root ganglion neurons by the long-duration anesthetic butamben., J Pharmacol Exp Ther

GLYMIDINE KCNJ1

Interaction Score: 10.52

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16470247 16263802 17015627 20434356 134717 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank
ACETOHEXAMIDE KCNJ1

Interaction Score: 8.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10751228 17139284 17016423 29458000 11927600

Sources:
TEND TdgClinicalTrial DrugBank
GLIMEPIRIDE KCNJ1

Interaction Score: 2.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name rosiglitazone + glimepiride,Avandaryl

Novel drug target Established target

Trial Name glimepiride ,Amaryl

PMIDs:
12703060 17139284 17016423 12475777

Sources:
TEND TdgClinicalTrial DrugBank
MINOXIDIL KCNJ1

Interaction Score: 2.43

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9646008 1601843 16169954 9579735 18602898 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank
TOLBUTAMIDE KCNJ1

Interaction Score: 2.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10455193 9647478 11226127

Sources:
TEND TdgClinicalTrial DrugBank
MK-7145 KCNJ1

Interaction Score: 1.58

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Details of the Assay for Interaction Measured using a Tl<sup>+</sup> flux assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
BETHANIDINE KCNJ1

Interaction Score: 1.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
3167688 2157221

Sources:
DrugBank
TOLAZAMIDE KCNJ1

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial
AGMATINE KCNJ1

Interaction Score: 0.9

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
8922740

Sources:
DrugBank
GLICLAZIDE KCNJ1

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial
BUTAMBEN KCNJ1

Interaction Score: 0.79

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
15923341

Sources:
DrugBank
GLIPIZIDE KCNJ1

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial
CHLORPROPAMIDE KCNJ1

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TEND TdgClinicalTrial
YOHIMBINE KCNJ1

Interaction Score: 0.33

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
2282453

Sources:
DrugBank
NATEGLINIDE KCNJ1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
GLYBURIDE KCNJ1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial
REPAGLINIDE KCNJ1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
HYDROCHLOROTHIAZIDE KCNJ1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22907731

Sources:
PharmGKB

Ensembl: ENSG00000151704
- Version: 101_38
Alternate Names:

KCNJ1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P48048
- Version: January-2014
Alternate Names:

KCNJ1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.2.1.1

Publications:
BaderLabGenes: KCNJ1
- Version: February-2014
Alternate Names:

3758 Entrez Gene ID

Gene Info:

Initial Gene Query Kir1.1

Counted Citations from 1950-2000 387

Gene Categories:

ION CHANNEL

Publications:
TEND: P48048
- Version: 01-August-2011
Alternate Names:

ENSG00000151704 Ensembl Gene Id

IRK1_HUMAN Uniprot Id

P48048 Uniprot Accession

Gene Info:

Transmembrane Helix Count 2

Target Main Class Transporters

Target Subclass Voltage_gated_ion_channels

Publications:

RussLampel: ENSG00000151704

Version: 26-July-2011

Alternate Names:

ENSG00000151704 Ensembl Gene Id

KCNJ1 Display Id

ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 1 (POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 1) (ATP-REGULATED POTASSIUM CHANNEL ROM-K) (KIR1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P48048] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 3758
- Version: 29-September-2020
Alternate Names:

6255 HUGO Gene ID

6255 HUGO Gene Symbol

potassium inwardly rectifying channel subfamily J member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Inwardly rectifying potassium channels

GuideToPharmacology Gene Category ID 74

Gene Categories:

ION CHANNEL

Publications:
PharmGKB: KCNJ1
- Version: 18-August-2020
Alternate Names:

PA213 PharmGKB ID

Gene Info:

Publications:

Karnes JH et al., 2013, Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment., Pharmacogenomics J

DrugBank: BE0004905

Version: 5.1.7

Alternate Names:

KCNJ1 DrugBank Gene Name

P48048 UniProt Accession

3758 Entrez Gene Id

Gene Info:

Publications:

Plant et al., 1990, Phentolamine and yohimbine inhibit ATP-sensitive K+ channels in mouse pancreatic beta-cells., Br. J. Pharmacol.

Winkelman DL et al., 2005, Inhibition of the A-type K+ channels of dorsal root ganglion neurons by the long-duration anesthetic butamben., J Pharmacol Exp Ther

DrugBank: BE0000644

Version: 5.1.7

Alternate Names:

KCNJ1 DrugBank Gene Name

P48048 UniProt Accession

3758 Entrez Gene Id

Gene Info:

Publications:

Bataille, 2002, [Molecular mechanisms of insulin secretion]., Diabetes Metab.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

HingoraniCasas: ENSG00000151704
- Version: 31-May-2017
Alternate Names:

ENSG00000151704 Gene Symbol

KCNJ1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: KCNJ1
- Version: 03-September-2020
Alternate Names:

ATP-sensitive inward rectifier potassium channel 1 Gene Name

P48048 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:
TTD: Inward rectifier potassium channel Kir1.1
- Version: 2020.06.01
Alternate Names:

KCNJ1 TTD Gene Abbreviation

T78710 TTD Target ID

Gene Info:

Publications:

Trial Name	rosiglitazone + glimepiride,Avandaryl
Novel drug target	Established target
Trial Name	glimepiride ,Amaryl

Details of the Assay for Interaction	Measured using a Tl<sup>+</sup> flux assay.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

ENSG00000151704	Ensembl Gene Id
IRK1_HUMAN	Uniprot Id
P48048	Uniprot Accession

6255	HUGO Gene ID
6255	HUGO Gene Symbol
potassium inwardly rectifying channel subfamily J member 1	HUGO Gene Name

KCNJ1	DrugBank Gene Name
P48048	UniProt Accession
3758	Entrez Gene Id

ATP-sensitive inward rectifier potassium channel 1	Gene Name
P48048	UniProt ID

KCNJ1 Gene Record

KCNJ1 3758 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: other/unknown

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 16470247 16263802 17015627 20434356 134717 17139284 17016423

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10751228 17139284 17016423 29458000 11927600

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name rosiglitazone + glimepiride,Avandaryl Novel drug target Established target Trial Name glimepiride ,Amaryl

PMIDs: 12703060 17139284 17016423 12475777

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: inducer (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9646008 1601843 16169954 9579735 18602898 17139284 17016423

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10455193 9647478 11226127

Sources: TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Details of the Assay for Interaction Measured using a Tl<sup>+</sup> flux assay. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 3167688 2157221

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TEND TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 8922740

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TEND TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 15923341

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TEND TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: None found

Sources: TEND TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 2282453

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TEND TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22907731

Sources: PharmGKB

Ensembl: ENSG00000151704

Alternate Names: KCNJ1 Ensembl Gene Name

Interaction Types & Directionality:

other/unknown

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
16470247 16263802 17015627 20434356 134717 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10751228 17139284 17016423 29458000 11927600

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name rosiglitazone + glimepiride,Avandaryl

Novel drug target Established target

Trial Name glimepiride ,Amaryl

PMIDs:
12703060 17139284 17016423 12475777

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9646008 1601843 16169954 9579735 18602898 17139284 17016423

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10455193 9647478 11226127

Sources:
TEND TdgClinicalTrial DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Details of the Assay for Interaction Measured using a Tl<sup>+</sup> flux assay.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
3167688 2157221

Sources:
DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
8922740

Sources:
DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
15923341

Sources:
DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TEND TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
2282453

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
22907731

Sources:
PharmGKB

Alternate Names:

KCNJ1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

KCNJ1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.2.1.1

Alternate Names:

3758 Entrez Gene ID

Gene Info:

Initial Gene Query Kir1.1

Counted Citations from 1950-2000 387

Gene Categories:

ION CHANNEL

Alternate Names:

ENSG00000151704 Ensembl Gene Id

IRK1_HUMAN Uniprot Id

P48048 Uniprot Accession

Gene Info:

Transmembrane Helix Count 2

Target Main Class Transporters

Target Subclass Voltage_gated_ion_channels

Alternate Names:

ENSG00000151704 Ensembl Gene Id

KCNJ1 Display Id

ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 1 (POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 1) (ATP-REGULATED POTASSIUM CHANNEL ROM-K) (KIR1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P48048] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

6255 HUGO Gene ID

6255 HUGO Gene Symbol

potassium inwardly rectifying channel subfamily J member 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Inwardly rectifying potassium channels

GuideToPharmacology Gene Category ID 74

Gene Categories:

ION CHANNEL