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KCNJ1 Gene Record

  • Summary
  • Interactions
  • Claims
  • KCNJ1 3758 Druggable Genome

    Alternate Names:

    3758
    POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY J MEMBER 1
    KCNJ1
    KIR1.1
    ROMK
    ROMK1
    600359
    6255
    ENSG00000151704
    OTTHUMG00000048247
    P48048
    IRK1_HUMAN
    429
    K<sub>ir</sub>1.1
    BE0004905
    ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 1 (POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 1) (ATP-REGULATED POTASSIUM CHANNEL ROM-K) (KIR1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P48048]
    BE0000644
    NP_722448|NP_000211
    NM_153764|NM_000220
    PA213
    Inward rectifier potassium channel Kir1.1
    T78710
    ATP-sensitive inward rectifier potassium channel 1
    potassium inwardly rectifying channel subfamily J member 1

    Gene Info:

    Target Class Transporters
    Target Subclass TC:1.A.2.1.1
    Transmembrane Helix Count 2
    Target Main Class Transporters
    Target Subclass Voltage_gated_ion_channels
    Target Subclass Channels
    Target Subclass InwardlyRectifyingKchannel
    Human Readable Name DRUGGABLE GENOME
    GuideToPharmacology Gene Category Name Inwardly rectifying potassium channels
    GuideToPharmacology Gene Category ID 74
    Initial Gene Query Kir1.1
    Counted Citations from 1950-2000 387
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

    Plant et al., 1990, Phentolamine and yohimbine inhibit ATP-sensitive K+ channels in mouse pancreatic beta-cells., Br. J. Pharmacol.
    Lu et al., 2006, CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney., J. Clin. Invest.
    Pondugula et al., 2006, Glucocorticoid regulation of genes in the amiloride-sensitive sodium transport pathway by semicircular canal duct epithelium of neonatal rat., Physiol. Genomics
    Serrano-Martín et al., 2006, Glibenclamide, a blocker of K+(ATP) channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis., Antimicrob. Agents Chemother.
    Greeley et al., 2010, Neonatal diabetes mellitus: a model for personalized medicine., Trends Endocrinol. Metab.
    Guirgis et al., 1976, Comparative study of the hypoglycaemic and antilipolytic effects of four antidiabetic agents administered i.v., Arzneimittelforschung
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Bataille, 2002, [Molecular mechanisms of insulin secretion]., Diabetes Metab.
    Proks et al., 2002, Sulfonylurea stimulation of insulin secretion., Diabetes
    Tanemoto M et al., 2000, Rat homolog of sulfonylurea receptor 2B determines glibenclamide sensitivity of ROMK2 in Xenopus laevis oocyte., Am J Physiol Renal Physiol
    Bednarczyk P et al., 2018, Evidence for a mitochondrial ATP-regulated potassium channel in human dermal fibroblasts., Biochim Biophys Acta Bioenerg
    Konstas AA et al., 2002, Intrinsic sensitivity of Kir1.1 (ROMK) to glibenclamide in the absence of SUR2B. Implications for the identity of the renal ATP-regulated secretory K+ channel., J Biol Chem
    Bkaily et al., 1988, Bethanidine increases one type of potassium current and relaxes aortic muscle., Can. J. Physiol. Pharmacol.
    Bkaily, 1990, Bethanidine, nitroprusside and atrial natriuretic factor open a cGMP-sensitive K+ channel in aortic muscle., Prog. Clin. Biol. Res.
    Shepherd et al., 1996, Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: implications for stimulus-response coupling of insulin release., Br. J. Pharmacol.
    Kirsten et al., 1998, Clinical pharmacokinetics of vasodilators. Part I., Clin Pharmacokinet
    Bray et al., 1992, A specific binding site for K+ channel openers in rat aorta., J. Biol. Chem.
    Evans et al., 2005, Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function., J. Exp. Biol.
    Löffler-Walz et al., 1998, Binding of K(ATP) channel modulators in rat cardiac membranes., Br. J. Pharmacol.
    Black et al., 2008, Different effects of KCa and KATP agonists on brain tumor permeability between syngeneic and allogeneic rat models., Brain Res.
    Liu et al., 1999, ATP-dependent activation of K(Ca) and ROMK-type K(ATP) channels in human submandibular gland ductal cells., J. Biol. Chem.
    Smith et al., 1998, Inhibition of the ATP-sensitive potassium channel from mouse pancreatic beta-cells by surfactants., Br. J. Pharmacol.
    Proks et al., 2001, Interaction of stilbene disulphonates with cloned K(ATP) channels., Br. J. Pharmacol.
    Karnes JH et al., 2013, Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment., Pharmacogenomics J
    Winkelman DL et al., 2005, Inhibition of the A-type K+ channels of dorsal root ganglion neurons by the long-duration anesthetic butamben., J Pharmacol Exp Ther
  • GLYMIDINE   KCNJ1

    Interaction Score: 10.52

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16470247 16263802 17015627 20434356 134717 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • ACETOHEXAMIDE   KCNJ1

    Interaction Score: 8.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10751228 17139284 17016423 29458000 11927600


    Sources:
    TEND TdgClinicalTrial DrugBank

  • GLIMEPIRIDE   KCNJ1

    Interaction Score: 2.76

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name rosiglitazone + glimepiride,Avandaryl
    Novel drug target Established target
    Trial Name glimepiride ,Amaryl

    PMIDs:
    12703060 17139284 17016423 12475777


    Sources:
    TEND TdgClinicalTrial DrugBank

  • MINOXIDIL   KCNJ1

    Interaction Score: 2.43

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    9646008 1601843 16169954 9579735 18602898 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • TOLBUTAMIDE   KCNJ1

    Interaction Score: 2.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10455193 9647478 11226127


    Sources:
    TEND TdgClinicalTrial DrugBank

  • MK-7145   KCNJ1

    Interaction Score: 1.58

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Measured using a Tl<sup>+</sup> flux assay.
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BETHANIDINE   KCNJ1

    Interaction Score: 1.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    3167688 2157221


    Sources:
    DrugBank

  • TOLAZAMIDE   KCNJ1

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • AGMATINE   KCNJ1

    Interaction Score: 0.9

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8922740


    Sources:
    DrugBank

  • GLICLAZIDE   KCNJ1

    Interaction Score: 0.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • BUTAMBEN   KCNJ1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15923341


    Sources:
    DrugBank

  • GLIPIZIDE   KCNJ1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • CHLORPROPAMIDE   KCNJ1

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • YOHIMBINE   KCNJ1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    2282453


    Sources:
    DrugBank

  • NATEGLINIDE   KCNJ1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • GLYBURIDE   KCNJ1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • REPAGLINIDE   KCNJ1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • HYDROCHLOROTHIAZIDE   KCNJ1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22907731


    Sources:
    PharmGKB

  • Ensembl: ENSG00000151704

    • Version: 101_38

    Alternate Names:
    KCNJ1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P48048

    • Version: January-2014

    Alternate Names:
    KCNJ1 Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass TC:1.A.2.1.1

    Publications:

  • BaderLabGenes: KCNJ1

    • Version: February-2014

    Alternate Names:
    3758 Entrez Gene ID

    Gene Info:
    Initial Gene Query Kir1.1
    Counted Citations from 1950-2000 387

    Gene Categories:
    ION CHANNEL

    Publications:

  • TEND: P48048

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000151704 Ensembl Gene Id
    IRK1_HUMAN Uniprot Id
    P48048 Uniprot Accession

    Gene Info:
    Transmembrane Helix Count 2
    Target Main Class Transporters
    Target Subclass Voltage_gated_ion_channels

    Publications:

  • RussLampel: ENSG00000151704

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000151704 Ensembl Gene Id
    KCNJ1 Display Id
    ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 1 (POTASSIUM CHANNEL, INWARDLY RECTIFYING, SUBFAMILY J, MEMBER 1) (ATP-REGULATED POTASSIUM CHANNEL ROM-K) (KIR1.1). [SOURCE:UNIPROT/SWISSPROT;ACC:P48048] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 3758

    • Version: 29-September-2020

    Alternate Names:
    6255 HUGO Gene ID
    6255 HUGO Gene Symbol
    potassium inwardly rectifying channel subfamily J member 1 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Inwardly rectifying potassium channels
    GuideToPharmacology Gene Category ID 74

    Gene Categories:
    ION CHANNEL

    Publications:

  • PharmGKB: KCNJ1

    • Version: 18-August-2020

    Alternate Names:
    PA213 PharmGKB ID

    Gene Info:

    Publications:
    Karnes JH et al., 2013, Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment., Pharmacogenomics J

  • DrugBank: BE0004905

    • Version: 5.1.7

    Alternate Names:
    KCNJ1 DrugBank Gene Name
    P48048 UniProt Accession
    3758 Entrez Gene Id

    Gene Info:

    Publications:
    Plant et al., 1990, Phentolamine and yohimbine inhibit ATP-sensitive K+ channels in mouse pancreatic beta-cells., Br. J. Pharmacol.
    Winkelman DL et al., 2005, Inhibition of the A-type K+ channels of dorsal root ganglion neurons by the long-duration anesthetic butamben., J Pharmacol Exp Ther

  • DrugBank: BE0000644

    • Version: 5.1.7

    Alternate Names:
    KCNJ1 DrugBank Gene Name
    P48048 UniProt Accession
    3758 Entrez Gene Id

    Gene Info:

    Publications:
    Bataille, 2002, [Molecular mechanisms of insulin secretion]., Diabetes Metab.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • HingoraniCasas: ENSG00000151704

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000151704 Gene Symbol
    KCNJ1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: KCNJ1

    • Version: 03-September-2020

    Alternate Names:
    ATP-sensitive inward rectifier potassium channel 1 Gene Name
    P48048 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications:

  • TTD: Inward rectifier potassium channel Kir1.1

    • Version: 2020.06.01

    Alternate Names:
    KCNJ1 TTD Gene Abbreviation
    T78710 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21