DGIdb - KCNA5 Gene Record

KCNA5 3741 Druggable Genome

Alternate Names:

3741
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5
KCNA5
ATFB7
HCK1
HK2
HPCN1
KV1.5
PCN1
176267
6224
ENSG00000130037
OTTHUMG00000168232
Voltage-gated potassium channel subunit Kv1.5
Voltage-gated potassium channel HK2
P22460
KCNA5_HUMAN
BE0004717
542
K<SUB>v</SUB>1.5
NM_002234
NP_002225
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV1.5) (HK2) (HPCN1). [SOURCE:UNIPROT/SWISSPROT;ACC:P22460]
Voltage-gated potassium channel Kv1.5
T17569

Gene Info:

Initial Gene Query	Kv1.5
Counted Citations from 1950-2000	725
GuideToPharmacology Gene Category Name	Voltage-gated potassium channels
GuideToPharmacology Gene Category ID	81
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ion_trans_dom
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Name	Ion transport domain
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	ION CHANNEL
Interpro Acc	IPR005821
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

CELL SURFACE
ION CHANNEL
DRUGGABLE GENOME

Publications:

Lacerda et al., 1997, Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart., Mol. Pharmacol.
Judge et al., 2006, Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment., Pharmacol. Ther.
Yang et al., 1995, Mechanism of block of a human cardiac potassium channel by terfenadine racemate and enantiomers., Br. J. Pharmacol.
Drici et al., 1996, Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart., Circulation
Keirns J et al., 2017, QT Interval Shortening With Isavuconazole: In Vitro and In Vivo Effects on Cardiac Repolarization., Clin Pharmacol Ther
Eldstrom J et al., 2007, The molecular basis of high-affinity binding of the antiarrhythmic compound vernakalant (RSD1235) to Kv1.5 channels., Mol Pharmacol

BMS-394136 KCNA5

Interaction Score: 2.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BMS-919373 KCNA5

Interaction Score: 2.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL178707 KCNA5

Interaction Score: 1.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
VERNAKALANT KCNA5

Interaction Score: 1.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

PMIDs:
17872968

Sources:
DrugBank
RESINIFERATOXIN KCNA5

Interaction Score: 0.9

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CLOFILIUM KCNA5

Interaction Score: 0.68

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ISAVUCONAZOLE KCNA5

Interaction Score: 0.6

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
28074556

Sources:
DrugBank
LORATADINE KCNA5

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9271355

Sources:
NCI
TERFENADINE KCNA5

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7670728

Sources:
NCI
FLECAINIDE KCNA5

Interaction Score: 0.27

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
DALFAMPRIDINE KCNA5

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Pore blocker

Endogenous Drug? False

Direct Interaction? False

PMIDs:
16472864

Sources:
DrugBank GuideToPharmacology ChemblInteractions
PROPAFENONE KCNA5

Interaction Score: 0.25

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
None found

Sources:
GuideToPharmacology
ANDROSTANOLONE KCNA5

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8823008

Sources:
NCI
DILTIAZEM KCNA5

Interaction Score: 0.23

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Pore blocker

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
BUPIVACAINE KCNA5

Interaction Score: 0.21

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
DRONEDARONE KCNA5

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Whole cell patch clamp experiment using HEK293 cells expressing human Kv1.5.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology
QUINIDINE KCNA5

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
TEDISAMIL KCNA5

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GUANIDINE HYDROCHLORIDE KCNA5

Interaction Score: 0.07

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated potassium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions
NERISPIRDINE KCNA5

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NIFEDIPINE KCNA5

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Ensembl: ENSG00000130037
- Version: 101_38
Alternate Names:

KCNA5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000130037

Version: 26-July-2011

Alternate Names:

KCNA5 Display Id

ENSG00000130037 Ensembl Gene Id

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV1.5) (HK2) (HPCN1). [SOURCE:UNIPROT/SWISSPROT;ACC:P22460] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P22460
- Version: 11-September-2012
Alternate Names:

ENSG00000130037 Ensembl Gene Id

P22460 Uniprot Accession

KCNA5_HUMAN Uniprot Id

Gene Info:

Interpro Short Name Ion_trans_dom

Interpro Type Domain

Human Readable Name DRUGGABLE GENOME

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
BaderLabGenes: KCNA5
- Version: February-2014
Alternate Names:

3741 Entrez Gene ID

Gene Info:

Initial Gene Query Kv1.5

Counted Citations from 1950-2000 725

Gene Categories:

ION CHANNEL

Publications:
GuideToPharmacology: 3741
- Version: 29-September-2020
Alternate Names:

6224 HUGO Gene ID

6224 HUGO Gene Symbol

potassium voltage-gated channel subfamily A member 5 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Voltage-gated potassium channels

GuideToPharmacology Gene Category ID 81

Gene Categories:

ION CHANNEL

Publications:

DrugBank: BE0004717

Version: 5.1.7

Alternate Names:

KCNA5 DrugBank Gene Name

P22460 UniProt Accession

3741 Entrez Gene Id

Gene Info:

Publications:

Eldstrom J et al., 2007, The molecular basis of high-affinity binding of the antiarrhythmic compound vernakalant (RSD1235) to Kv1.5 channels., Mol Pharmacol

Judge et al., 2006, Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment., Pharmacol. Ther.

Keirns J et al., 2017, QT Interval Shortening With Isavuconazole: In Vitro and In Vivo Effects on Cardiac Repolarization., Clin Pharmacol Ther

NCI: KCNA5

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Drici et al., 1996, Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart., Circulation

Nishiyama et al., 1997, Effects of thyroid and glucocorticoid hormones on Kv1.5 potassium channel gene expression in the rat left ventricle., Biochem. Biophys. Res. Commun.

Lacerda et al., 1997, Interactions of the nonsedating antihistamine loratadine with a Kv1.5-type potassium channel cloned from human heart., Mol. Pharmacol.

ChemblInteractions: KCNA5
- Version: chembl_23
Alternate Names:

KCNA5 GENE_SYMBOL

Potassium voltage-gated channel subfamily A member 5 UNIPROT

HPCN1 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000130037
- Version: 31-May-2017
Alternate Names:

ENSG00000130037 Gene Symbol

KCNA5 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: KCNA5
- Version: 03-September-2020
Alternate Names:

Potassium voltage-gated channel subfamily A member 5 Gene Name

P22460 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:
TTD: Voltage-gated potassium channel Kv1.5
- Version: 2020.06.01
Alternate Names:

KCNA5 TTD Gene Abbreviation

T17569 TTD Target ID

Gene Info:

Publications:
GO: KCNA5
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE

Publications:

Specific Action of the Ligand	Pore blocker
Endogenous Drug?	False
Direct Interaction?	False

Details of the Assay for Interaction	Whole cell patch clamp experiment using HEK293 cells expressing human Kv1.5.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Mechanism of Interaction	Voltage-gated potassium channel blocker
Direct Interaction	yes

KCNA5	Display Id
ENSG00000130037	Ensembl Gene Id
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV1.5) (HK2) (HPCN1). [SOURCE:UNIPROT/SWISSPROT;ACC:P22460]	Description

6224	HUGO Gene ID
6224	HUGO Gene Symbol
potassium voltage-gated channel subfamily A member 5	HUGO Gene Name

KCNA5	DrugBank Gene Name
P22460	UniProt Accession
3741	Entrez Gene Id

KCNA5	GENE_SYMBOL
Potassium voltage-gated channel subfamily A member 5	UNIPROT
HPCN1	UNIPROT

Potassium voltage-gated channel subfamily A member 5	Gene Name
P22460	UniProt ID

antagonist (inhibitory)
blocker (inhibitory)

KCNA5 Gene Record

KCNA5 3741 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info:

PMIDs: 17872968

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand None Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand None Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 28074556

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9271355

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7670728

Sources: NCI

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand None Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory) blocker (inhibitory)

Interaction Info: Specific Action of the Ligand Pore blocker Endogenous Drug? False Direct Interaction? False

PMIDs: 16472864

Sources: DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand None

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8823008

Sources: NCI

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand Pore blocker Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand None Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Whole cell patch clamp experiment using HEK293 cells expressing human Kv1.5. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: TTD GuideToPharmacology

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Specific Action of the Ligand None Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated potassium channel blocker

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

blocker (inhibitory)

PMIDs:
17872968

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
28074556

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9271355

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7670728

Sources:
NCI

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Pore blocker

Endogenous Drug? False

Direct Interaction? False

PMIDs:
16472864

Sources:
DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
8823008

Sources:
NCI

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand Pore blocker

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Whole cell patch clamp experiment using HEK293 cells expressing human Kv1.5.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated potassium channel blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Alternate Names:

KCNA5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

KCNA5 Display Id

ENSG00000130037 Ensembl Gene Id

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 5 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV1.5) (HK2) (HPCN1). [SOURCE:UNIPROT/SWISSPROT;ACC:P22460] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME