DGIdb - KCNA1 Gene Record

KCNA1 3736 Druggable Genome

Alternate Names:

3736
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 1
KCNA1
AEMK
EA1
HBK1
HUK1
KV1.1
MBK1
MK1
RBK1
176260
6218
ENSG00000111262
OTTHUMG00000044398
Voltage-gated K(+) channel HuKI
Voltage-gated potassium channel HBK1
Voltage-gated potassium channel subunit Kv1.1
Q09470
POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 1 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV1.1) (HUKI) (HBK1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q09470]
KCNA1_HUMAN

Gene Info:

Target Class	Transporters
Target Subclass	TC:1.A.1.2.12
Initial Gene Query	Kv1.1
Counted Citations from 1950-2000	758
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	ION CHANNEL
Interpro Name	Ion transport domain
Interpro Acc	IPR005821
Interpro Short Name	Ion_trans_dom
Target Main Class	Transporters
Target Subclass	Voltage_gated_ion_channels
Target Subclass	Channels
Transmembrane Helix Count	6
Target Subclass	Potassium_channels
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

CELL SURFACE
ION CHANNEL
DRUGGABLE GENOME

Publications:

Nilsson et al., 2003, Local anesthetic block of Kv channels: role of the S6 helix and the S5-S6 linker for bupivacaine action., Mol. Pharmacol.
Judge et al., 2006, Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment., Pharmacol. Ther.
Matchett et al., 2009, Neuroprotective effect of volatile anesthetic agents: molecular mechanisms., Neurol. Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Lecomte et al., 2000, Maurotoxin and the Kv1.1 channel: voltage-dependent binding upon enantiomerization of the scorpion toxin disulfide bridge Cys31-Cys34., J. Pept. Res.
Pan Y et al., 2008, Cortisone dissociates the Shaker family K+ channels from their beta subunits., Nat Chem Biol

CORTISONE KCNA1

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18806782

Sources:
DTC
BUPIVACAINE KCNA1

Interaction Score: 1.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12761353

Sources:
NCI
ISOFLURANE KCNA1

Interaction Score: 1.0

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
19298752 17016423 17139284

Sources:
TdgClinicalTrial TEND
DESFLURANE KCNA1

Interaction Score: 0.94

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19298752 17016423 17139284

Sources:
TdgClinicalTrial TEND
SEVOFLURANE KCNA1

Interaction Score: 0.68

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
ENFLURANE KCNA1

Interaction Score: 0.54

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19298752

Sources:
TdgClinicalTrial TEND
DALFAMPRIDINE KCNA1

Interaction Score: 0.54

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Voltage-gated potassium channel blocker

PMIDs:
16472864

Sources:
TdgClinicalTrial ChemblInteractions TEND
TEDISAMIL KCNA1

Interaction Score: 0.14

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GUANIDINE HYDROCHLORIDE KCNA1

Interaction Score: 0.14

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NERISPIRDINE KCNA1

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METHOTREXATE KCNA1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10727107

Sources:
NCI

Ensembl: ENSG00000111262
- Version: 101_38
Alternate Names:

KCNA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q09470
- Version: January-2014
Alternate Names:

KCNA1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.2.12

Publications:
BaderLabGenes: KCNA1
- Version: February-2014
Alternate Names:

3736 Entrez Gene ID

Gene Info:

Initial Gene Query Kv1.1

Counted Citations from 1950-2000 758

Gene Categories:

ION CHANNEL

Publications:
HopkinsGroom: Q09470
- Version: 11-September-2012
Alternate Names:

KCNA1 Uniprot Gene Name

KCNA1_HUMAN Uniprot Id

ENSG00000111262 Ensembl Gene Id

Gene Info:

Interpro Type Domain

Uniprot Status Swiss-Prot

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000111262

Version: 26-July-2011

Alternate Names:

ENSG00000111262 Ensembl Gene Id

KCNA1 Display Id

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 1 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV1.1) (HUKI) (HBK1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q09470] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TEND: Q09470
- Version: 01-August-2011
Alternate Names:

KCNA1 Gene Symbol

Q09470 Uniprot Accession

3736 Entrez Gene Id

Gene Info:

Target Main Class Transporters

Target Subclass Voltage_gated_ion_channels

Target Subclass Channels

Publications:

NCI: KCNA1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Nilsson et al., 2003, Local anesthetic block of Kv channels: role of the S6 helix and the S5-S6 linker for bupivacaine action., Mol. Pharmacol.

Wang et al., 2000, Role of K(+) channel expression in polyamine-dependent intestinal epithelial cell migration., Am. J. Physiol., Cell Physiol.

Lecomte et al., 2000, Maurotoxin and the Kv1.1 channel: voltage-dependent binding upon enantiomerization of the scorpion toxin disulfide bridge Cys31-Cys34., J. Pept. Res.

DTC: KCNA1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Pan Y et al., 2008, Cortisone dissociates the Shaker family K+ channels from their beta subunits., Nat Chem Biol
HingoraniCasas: ENSG00000111262
- Version: 31-May-2017
Alternate Names:

ENSG00000111262 Gene Symbol

KCNA1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: KCNA1
- Version: chembl_23
Alternate Names:

KCNA1 GENE_SYMBOL

Potassium voltage-gated channel subfamily A member 1 UNIPROT

Voltage-gated K(+) channel HuKI UNIPROT

Gene Info:

Publications:
Pharos: KCNA1
- Version: 01-February-2022
Alternate Names:

Potassium voltage-gated channel subfamily A member 1 Gene Name

Q09470 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:
GO: KCNA1
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE

Publications:

Novel drug target	Established target
Trial Name	-
Mechanism of Interaction	Voltage-gated potassium channel blocker

Mechanism of Interaction	Voltage-gated potassium channel blocker
Direct Interaction	yes

KCNA1	Uniprot Gene Name
KCNA1_HUMAN	Uniprot Id
ENSG00000111262	Ensembl Gene Id

KCNA1	GENE_SYMBOL
Potassium voltage-gated channel subfamily A member 1	UNIPROT
Voltage-gated K(+) channel HuKI	UNIPROT

Potassium voltage-gated channel subfamily A member 1	Gene Name
Q09470	UniProt ID

antagonist (inhibitory)
blocker (inhibitory)

KCNA1 Gene Record

KCNA1 3736 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18806782

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12761353

Sources: NCI

Interaction Types & Directionality: inducer (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 19298752 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inducer (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 19298752 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inducer (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inducer (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 19298752

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory) blocker (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Voltage-gated potassium channel blocker

PMIDs: 16472864

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated potassium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10727107

Sources: NCI

Ensembl: ENSG00000111262

Alternate Names: KCNA1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q09470

Alternate Names: KCNA1 Gene Symbol

Gene Info: Target Class Transporters Target Subclass TC:1.A.1.2.12

Publications:

BaderLabGenes: KCNA1

Alternate Names: 3736 Entrez Gene ID

Gene Info: Initial Gene Query Kv1.1 Counted Citations from 1950-2000 758

Gene Categories: ION CHANNEL

Publications:

HopkinsGroom: Q09470

Alternate Names: KCNA1 Uniprot Gene Name KCNA1_HUMAN Uniprot Id ENSG00000111262 Ensembl Gene Id

Gene Info: Interpro Type Domain Uniprot Status Swiss-Prot Uniprot Evidence 1: Evidence at protein level

Gene Categories: ION CHANNEL, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000111262

Alternate Names: ENSG00000111262 Ensembl Gene Id KCNA1 Display Id POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 1 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV1.1) (HUKI) (HBK1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q09470] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: Q09470

Alternate Names: KCNA1 Gene Symbol Q09470 Uniprot Accession 3736 Entrez Gene Id

Gene Info: Target Main Class Transporters Target Subclass Voltage_gated_ion_channels Target Subclass Channels

Publications:

NCI: KCNA1

Alternate Names:

Gene Info:

Interaction Types & Directionality:

n/a

PMIDs:
18806782

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12761353

Sources:
NCI

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
19298752 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19298752 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
19298752

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Voltage-gated potassium channel blocker

PMIDs:
16472864

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated potassium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
10727107

Sources:
NCI

Alternate Names:

KCNA1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

KCNA1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.2.12

Alternate Names:

3736 Entrez Gene ID

Gene Info:

Initial Gene Query Kv1.1

Counted Citations from 1950-2000 758

Gene Categories:

ION CHANNEL

Alternate Names:

KCNA1 Uniprot Gene Name

KCNA1_HUMAN Uniprot Id

ENSG00000111262 Ensembl Gene Id

Gene Info:

Interpro Type Domain

Uniprot Status Swiss-Prot

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Alternate Names:

ENSG00000111262 Ensembl Gene Id

KCNA1 Display Id

POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 1 (VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV1.1) (HUKI) (HBK1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q09470] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

KCNA1 Gene Symbol

Q09470 Uniprot Accession

3736 Entrez Gene Id

Gene Info:

Target Main Class Transporters

Target Subclass Voltage_gated_ion_channels

Target Subclass Channels

Publications:

Pan Y et al., 2008, Cortisone dissociates the Shaker family K+ channels from their beta subunits., Nat Chem Biol

Alternate Names:

ENSG00000111262 Gene Symbol

KCNA1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

KCNA1 GENE_SYMBOL

Potassium voltage-gated channel subfamily A member 1 UNIPROT

Voltage-gated K(+) channel HuKI UNIPROT

Alternate Names:

Potassium voltage-gated channel subfamily A member 1 Gene Name

Q09470 UniProt ID

Gene Categories:

ION CHANNEL

Gene Categories:

CELL SURFACE