DGIdb - JUN Gene Record

JUN 3725 Druggable GenomeClinically Actionable

Alternate Names:

3725
JUN PROTO-ONCOGENE, AP-1 TRANSCRIPTION FACTOR SUBUNIT
JUN
AP-1
AP1
c-Jun
p39
165160
6204
ENSG00000177606
OTTHUMG00000008376
P05412
cJUN
Transcription factor AP-1

Gene Info:

Target Class	Miscellaneous
Target Subclass	Transcription factor
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR COMPLEX
TUMOR SUPPRESSOR
TRANSCRIPTION FACTOR BINDING
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol
Wang Y et al., 2011, A novel monocarbonyl analogue of curcumin, (1E,4E)-1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one, induced cancer cell H460 apoptosis via activation of endoplasmic reticulum stress signaling pathway., J Med Chem
Beutler JA et al., 2009, Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition., J Nat Prod
Liu WK et al., 2008, Involvement of p21 and FasL in induction of cell cycle arrest and apoptosis by neochamaejasmin A in human prostate LNCaP cancer cells., J Nat Prod
Feldman M et al., 2011, Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential., J Nat Prod
Lee SA et al., 2007, The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation., J Biol Chem
Kim H et al., 2008, Synthesis and in vitro biological activity of retinyl retinoate, a novel hybrid retinoid derivative., Bioorg Med Chem
Kang KA et al., 2008, Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect., Bioorg Med Chem

IRISOLIDONE JUN

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17996449

Sources:
DTC
HOLACANTHONE JUN

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19199792

Sources:
DTC
SERGEOLIDE JUN

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19199792

Sources:
DTC
NEOCHAMAEJASMIN A JUN

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18380477

Sources:
DTC
BRUCEANTIN JUN

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19199792

Sources:
DTC
CHEMBL477052 JUN

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21504179

Sources:
DTC
RETINYLRETINOATE JUN

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18511283

Sources:
DTC
SANGIVAMYCIN JUN

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17371872

Sources:
DTC
(-)-CAMPHOR JUN

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CUPRIC CHLORIDE JUN

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BUTINOLINE JUN

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMINEPTINE JUN

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARBOXYMETHYL-TRIMETHYL-ARSONIUM JUN

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SODIUM SELENITE JUN

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
2-MERCAPTOPYRIMIDINE JUN

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CIPROFIBRATE JUN

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
ATOMOXETINE HYDROCHLORIDE JUN

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZENETHIOL JUN

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUINAPRIL HYDROCHLORIDE JUN

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BUPROPION HYDROCHLORIDE JUN

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ANTHRACENE-9-CARBOXYLIC ACID JUN

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CINNARIZINE JUN

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
CHEMBL275260 JUN

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZELASTINE HYDROCHLORIDE JUN

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CRIDANIMOD JUN

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPHENHYDRAMINE HYDROCHLORIDE JUN

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PATULIN JUN

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
NAFRONYL OXALATE JUN

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GEMFIBROZIL JUN

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
MECHLORETHAMINE HYDROCHLORIDE JUN

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIFLUPROMAZINE HYDROCHLORIDE JUN

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ISOLIQUIRITIGENIN JUN

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21866899

Sources:
DTC
ROTENONE JUN

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
TROPISETRON JUN

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZO[B]FLUORANTHENE JUN

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOFIBRATE JUN

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
SERTRALINE JUN

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
FENOFIBRATE JUN

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
LIPOIC ACID, ALPHA JUN

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOTRIMAZOLE JUN

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16680159

Sources:
DTC
VINORELBINE TARTRATE JUN

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHIMAZOLE JUN

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VINBLASTINE SULFATE JUN

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
COLCHICINE JUN

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000177606
- Version: 101_38
Alternate Names:

JUN Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P05412
- Version: January-2014
Alternate Names:

JUN Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Transcription factor

Publications:
NCI: JUN
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Patel et al., 1999, Polyamine depletion is associated with an increase in JunD/AP-1 activity in small intestinal crypt cells., Am. J. Physiol.

DTC: JUN

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Wang Y et al., 2011, A novel monocarbonyl analogue of curcumin, (1E,4E)-1,5-bis(2,3-dimethoxyphenyl)penta-1,4-dien-3-one, induced cancer cell H460 apoptosis via activation of endoplasmic reticulum stress signaling pathway., J Med Chem

Lee SA et al., 2007, The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation., J Biol Chem

MacDonald ML et al., 2006, Identifying off-target effects and hidden phenotypes of drugs in human cells., Nat Chem Biol

HingoraniCasas: ENSG00000177606
- Version: 31-May-2017
Alternate Names:

ENSG00000177606 Gene Symbol

JUN Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Tempus: JUN
- Version: 11-November-2018
Alternate Names:

JUN Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: JUN
- Version: 01-February-2022
Alternate Names:

Transcription factor AP-1 Gene Name

P05412 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
MskImpact: JUN
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: JUN
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: JUN
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
GO: JUN
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX, TUMOR SUPPRESSOR, TRANSCRIPTION FACTOR BINDING

Publications:

JUN Gene Record

JUN 3725 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17996449

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19199792

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19199792

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18380477

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19199792

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21504179

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18511283

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17371872

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16680159

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
17996449

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19199792

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19199792

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18380477

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19199792

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21504179

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18511283

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17371872

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16680159

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16680159