• ITK 3702 Druggable GenomeClinically Actionable

    Alternate Names:

    3702
    IL2 INDUCIBLE T-CELL KINASE
    ITK
    EMT
    LPFS1
    LYK
    PSCTK2
    186973
    6171
    ENSG00000113263
    OTTHUMG00000130245
    Interleukin-2-inducible T-cell kinase
    Kinase EMT
    Tyrosine-protein kinase Lyk
    T-cell-specific kinase
    IL-2-inducible T-cell kinase
    Tyrosine-protein kinase ITK/TSK
    2046
    Q08881
    NP_005537
    NM_005546
    ITK_HUMAN
    TYROSINE-PROTEIN KINASE ITK/TSK (EC 2.7.1.112) (T-CELL-SPECIFIC KINASE) (TYROSINE-PROTEIN KINASE LYK) (KINASE EMT). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08881]
    IL2 inducible T cell kinase
    T91761

    Gene Info:

    GuideToPharmacology Gene Category Name Tec family
    GuideToPharmacology Gene Category ID 629
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Human Readable Name KINASE
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Interpro Acc IPR001245
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    KINASE
    TYROSINE KINASE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
  • Interaction Score: 6.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23098091


    Sources:
    DTC

  • Interaction Score: 1.68

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


  • Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.31

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase ITK/TSK inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

    • Version: 101_38

    Alternate Names:
    ITK Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000113263 Ensembl Gene Id
    ITK_HUMAN Uniprot Id
    3702 Entrez Gene Id

    Gene Info:
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Human Readable Name KINASE
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ITK Display Id
    ENSG00000113263 Ensembl Gene Id
    TYROSINE-PROTEIN KINASE ITK/TSK (EC 2.7.1.112) (T-CELL-SPECIFIC KINASE) (TYROSINE-PROTEIN KINASE LYK) (KINASE EMT). [SOURCE:UNIPROT/SWISSPROT;ACC:Q08881] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    6171 HUGO Gene ID
    6171 HUGO Gene Symbol
    IL2 inducible T cell kinase HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Tec family
    GuideToPharmacology Gene Category ID 629

    Gene Categories:
    ENZYME

    Publications:

    • Version: 2020.06.01
  • DTC: ITK

    • Version: 02-September-2020
    • Version: 31-May-2017

    Alternate Names:
    ENSG00000113263 Gene Symbol
    ITK Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    LYK GENE_SYMBOL
    ITK GENE_SYMBOL
    Tyrosine-protein kinase ITK/TSK UNIPROT

    Gene Info:

    Publications:

    • Version: 19.3

    Alternate Names:
    ENSG00000113263 Ensembl Gene ID
    EMT Human Protein Atlas Gene Synonym
    LYK Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

    • Version: 27-Jun-2013

    Alternate Names:
    3702 Gene ID
    EMT dGene Synonym
    LYK dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, TYROSINE KINASE

    Publications:

  • GO: ITK

    • Version: 01-May-2021

    Alternate Names:
    EMT GO Gene Synonym
    LYK GO Gene Synonym

    Gene Info:

    Gene Categories:
    TYROSINE KINASE

    Publications:

    • Version: 01-May-2021

    Alternate Names:
    Tyrosine-protein kinase ITK/TSK Gene Name
    Q08881 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications: