• ITGB7 3695 Druggable Genome

    Alternate Names:

    3695
    INTEGRIN SUBUNIT BETA 7
    ITGB7
    147559
    6162
    ENSG00000139626
    OTTHUMG00000169775
    INTEGRIN BETA-7 PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P26010]
    P26010
    ITB7_HUMAN
    INTEGRIN BETA-7
    Gut homing receptor beta subunit
    T14065
    2461
    integrin, beta 7 subunit
    NM_000889
    NP_000880

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Receptors
    Target Subclass Receptors
    Target Subclass Integrin
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002369
    Interpro Type Domain
    Interpro Name Integrin beta subunit, N-terminal
    Interpro Short Name Integrin_bsu_N
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Integrins
    GuideToPharmacology Gene Category ID 760
    (5 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    DRUGGABLE GENOME
  • Interaction Score: 19.14

    Interaction Types & Directionality:
    antibody (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Novel Target
    Trial Name vedolizumab, MLN-02
    Mechanism of Interaction Integrin alpha-4/beta-7 inhibitor

  • Interaction Score: 12.76

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin beta-7 antagonist
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 6.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Interaction Score: 4.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-4/beta-7 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


  • Interaction Score: 4.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Integrin alpha-4/beta-7 antagonist

    PMIDs:
    None found


    • Version: 101_38

    Alternate Names:
    ITGB7 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000139626 Ensembl Gene Id
    INTEGRIN BETA-7 PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P26010] Description
    ITGB7 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: 11-September-2012

    Alternate Names:
    ITGB7 Uniprot Gene Name
    ITB7_HUMAN Uniprot Id
    P26010 Uniprot Accession

    Gene Info:
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002369

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: January-2014

    Alternate Names:
    ITGB7 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptors
    Target Subclass Integrin

    Publications:

    • Version: 29-September-2020

    Alternate Names:
    6162 HUGO Gene ID
    6162 HUGO Gene Symbol
    integrin subunit beta 7 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Integrins
    GuideToPharmacology Gene Category ID 760

    Publications:

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000139626 Gene Symbol
    ITGB7 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

    • Version: chembl_23

    Alternate Names:
    ITGB7 GENE_SYMBOL
    Integrin beta-7 UNIPROT
    Gut homing receptor beta subunit UNIPROT

    Gene Info:

    Publications:

    • Version: 2020.06.01

    Alternate Names:
    ITGB7 TTD Gene Abbreviation
    T14065 TTD Target ID

    Gene Info:

    Publications:

    • Version: 01-May-2021

    Alternate Names:

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications: