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ITGB3 3690 Druggable Genome
Alternate Names:
3690 INTEGRIN SUBUNIT BETA 3 ITGB3 BDPLT16 BDPLT2 CD61 GP3A GPIIIa GT 173470 6156 ENSG00000259207 ENSG00000259753 OTTHUMG00000171956 OTTHUMG00000171957 ITB3_HUMAN P05106 CD_antigen=CD61 Platelet membrane glycoprotein IIIa Integrin beta-3 PA205 ENSG00000056345 INTEGRIN BETA-3 PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IIIA) (GPIIIA) (CD61 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P05106] AC068234.1 BDPLT24 GT2 Gene Info:
Target Subclass Integrin Target Main Class Receptors Target Subclass Other_receptors Transmembrane Helix Count 1 Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level Interpro Type Domain Uniprot Status Swiss-Prot Interpro Acc IPR002369 Interpro Short Name Integrin_bsu_N Interpro Name Integrin beta subunit, N-terminal Target Class Receptors Target Subclass Receptors Gene Biotype PROTEIN_CODING Gene Categories: Category Details
CELL SURFACE DRUGGABLE GENOME Publications:
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Interaction Score: 10.6
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Trial Name eptifibatide,Integrilin Novel drug target Established target Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor -
Interaction Types & Directionality:
antibody (inhibitory) antagonist (inhibitory) inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor Direct Interaction yes Trial Name abciximab, c7E3,ReoPro -
Interaction Score: 4.42
Interaction Types & Directionality:
antagonist (inhibitory) inhibitor (inhibitory) Interaction Info:
Trial Name cilengitide. EMD-121974 Novel drug target Established target Mechanism of Interaction Integrin alpha-V/beta-3 antagonist -
Interaction Score: 2.21
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor Direct Interaction yes -
Interaction Score: 2.21
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Integrin alpha-IIb/beta-3 antagonist Direct Interaction yes -
Interaction Score: 2.21
Interaction Types & Directionality:
n/a Interaction Info:
Novel drug target Established target Trial Name YM-028, gantofiban -
Interaction Score: 1.77
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Direct Interaction yes Mechanism of Interaction Integrin alpha-V/beta-3 antagonist Trial Name CNTO-95 -
Interaction Score: 1.55
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Interaction Score: 1.1
Interaction Types & Directionality:
antibody (inhibitory) antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Integrin alpha-V/beta-3 antagonist Direct Interaction yes -
Interaction Score: 0.88
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Integrin alpha-V/beta-3 inhibitor Direct Interaction yes -
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name GLPG0187 Novel drug target Established target
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- Version: 101_38
Alternate Names:
AC068234.1 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 101_38
Alternate Names:
ITGB3 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: January-2014
Alternate Names:
ITGB3 Gene Symbol Gene Info:
Target Subclass Integrin Target Class Receptors Target Subclass Receptors Publications:
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Alternate Names:
ITGB3 Gene Symbol ITB3_HUMAN Uniprot Id 3690 Entrez Gene Id Gene Info:
Target Subclass Integrin Target Main Class Receptors Target Subclass Other_receptors Publications:
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- Version: 11-September-2012
Alternate Names:
3690 Entrez Gene Id INTEGRIN BETA-3 Uniprot Protein Name ENSG00000259207 Ensembl Gene Id Gene Info:
Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level Interpro Type Domain Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 26-July-2011
Alternate Names:
INTEGRIN BETA-3 PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IIIA) (GPIIIA) (CD61 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P05106] Description ITGB3 Display Id ENSG00000056345 Ensembl Gene Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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Alternate Names:
PA205 PharmGKB ID Gene Info:
Publications:
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Alternate Names:
Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000259207 Gene Symbol ITGB3 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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Alternate Names:
ITGB3 Gene Symbol Gene Info:
Publications:
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- Version: chembl_23
Alternate Names:
GP3A GENE_SYMBOL ITGB3 GENE_SYMBOL Integrin beta-3 UNIPROT Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000259753 Gene Symbol Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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Alternate Names:
GP3A GO Gene Synonym Gene Info:
Gene Categories:
CELL SURFACE Publications: