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ITGB3 Gene Record

  • Summary
  • Interactions
  • Claims
  • ITGB3 3690 Druggable Genome

    Alternate Names:

    3690
    INTEGRIN SUBUNIT BETA 3
    ITGB3
    BDPLT16
    BDPLT2
    CD61
    GP3A
    GPIIIa
    GT
    173470
    6156
    ENSG00000259207
    ENSG00000259753
    OTTHUMG00000171956
    OTTHUMG00000171957
    ITB3_HUMAN
    P05106
    CD_antigen=CD61
    Platelet membrane glycoprotein IIIa
    Integrin beta-3
    PA205
    ENSG00000056345
    INTEGRIN BETA-3 PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IIIA) (GPIIIA) (CD61 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P05106]
    AC068234.1
    BDPLT24
    GT2

    Gene Info:

    Target Subclass Integrin
    Target Main Class Receptors
    Target Subclass Other_receptors
    Transmembrane Helix Count 1
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002369
    Interpro Short Name Integrin_bsu_N
    Interpro Name Integrin beta subunit, N-terminal
    Target Class Receptors
    Target Subclass Receptors
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    DRUGGABLE GENOME

    Publications:

    Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics
    Hall et al., 2007, Characterization and NMR solution structure of a novel cyclic pentapeptide inhibitor of pathogenic hantaviruses., Chem Biol Drug Des
    Ibbotson et al., 2003, Abciximab: an updated review of its therapeutic use in patients with ischaemic heart disease undergoing percutaneous coronary revascularisation., Drugs
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Mazzaferri et al., 2008, Abciximab: a review and update for clinicians., Expert Rev Cardiovasc Ther
    Weber et al., 2002, Low incidence of paradoxical platelet activation by glycoprotein IIb/IIIa inhibitors., Thromb. Res.
    Amoroso et al., 2001, Eptifibatide and abciximab exhibit equivalent antiplatelet efficacy in an experimental model of stenting in both healthy volunteers and patients with coronary artery disease., J. Cardiovasc. Pharmacol.
    Fischer et al., 2005, Synergistic platelet integrin signaling and factor XII activation in poly-N-acetyl glucosamine fiber-mediated hemostasis., Biomaterials
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Schrör et al., 2003, Comparative pharmacology of GP IIb/IIIa antagonists., J. Thromb. Thrombolysis
    Auer et al., 2003, [Platelet glycoprotein IIb/IIIa inhibitors in coronary artery disease]., Herz
    Weber et al., 2002, No evidence for an influence of the human platelet antigen-1 polymorphism on the antiplatelet effects of glycoprotein IIb/IIIa inhibitors., Pharmacogenetics
    Schwarz et al., 2004, Reversibility versus persistence of GPIIb/IIIa blocker-induced conformational change of GPIIb/IIIa (alphaIIbbeta3, CD41/CD61)., J. Pharmacol. Exp. Ther.
    Juwana et al., 2010, Tirofiban for myocardial infarction., Expert Opin Pharmacother
    Floyd CN et al., 2014, The PlA1/A2 polymorphism of glycoprotein IIIa in relation to efficacy of antiplatelet drugs: a systematic review and meta-analysis., Br J Clin Pharmacol
    Cayla G et al., 2011, Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis., JAMA
    Abderrazek F et al., 2010, The GPIIIa PlA polymorphism and the platelet hyperactivity in Tunisian patients with stable coronary artery disease treated with aspirin., Thromb Res
    Lim E et al., 2007, Dose-related efficacy of aspirin after coronary surgery in patients With Pl(A2) polymorphism (NCT00262275)., Ann Thorac Surg
    Dropinski J et al., 2007, Antithrombotic effects of aspirin based on PLA1/A2 glycoprotein IIIa polymorphism in patients with coronary artery disease., Thromb Res
    Lev EI et al., 2007, Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel., Thromb Res
    Lepäntalo A et al., 2006, Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients., Thromb Haemost
    Cooke GE et al., 2006, Effect of platelet antigen polymorphism on platelet inhibition by aspirin, clopidogrel, or their combination., J Am Coll Cardiol
    Morawski W et al., 2005, Prediction of the excessive perioperative bleeding in patients undergoing coronary artery bypass grafting: role of aspirin and platelet glycoprotein IIIa polymorphism., J Thorac Cardiovasc Surg
    Papp E et al., 2005, Glycoprotein IIIA gene (PlA) polymorphism and aspirin resistance: is there any correlation?, Ann Pharmacother
    Undas A et al., 2001, Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury., Circulation
    Szczeklik A et al., 2000, Relationship between bleeding time, aspirin and the PlA1/A2 polymorphism of platelet glycoprotein IIIa., Br J Haematol
    Michelson AD et al., 2000, Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists., Circulation
    Undas A et al., 1999, Platelet glycoprotein IIIa polymorphism, aspirin, and thrombin generation., Lancet
    Monaco A et al., 2013, Synthesis and in vitro evaluation of a novel radioligand for αvβ3 integrin receptor imaging: [18F]FPPA-c(RGDfK)., Bioorg Med Chem Lett
    Motovska Z et al., 2009, High loading dose of clopidogrel is unable to satisfactorily inhibit platelet reactivity in patients with glycoprotein IIIA gene polymorphism: a genetic substudy of PRAGUE-8 trial., Blood Coagul Fibrinolysis
    Simon T et al., 2009, Genetic determinants of response to clopidogrel and cardiovascular events., N Engl J Med
    Angiolillo DJ et al., 2004, PlA polymorphism and platelet reactivity following clopidogrel loading dose in patients undergoing coronary stent implantation., Blood Coagul Fibrinolysis
    Ye Y et al., 2012, Near-infrared fluorescent divalent RGD ligand for integrin αvβ₃-targeted optical imaging., Bioorg Med Chem Lett
  • EPTIFIBATIDE   ITGB3

    Interaction Score: 10.6

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name eptifibatide,Integrilin
    Novel drug target Established target
    Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor

    PMIDs:
    20938371 15860200 10592235 14618072 12928738 12360110 11588534 14617694


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB

  • ABCIXIMAB   ITGB3

    Interaction Score: 8.1

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor
    Direct Interaction yes
    Trial Name abciximab, c7E3,ReoPro

    PMIDs:
    20938371 17441904 12749745 11752352 18510478 12165285 11588534


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB

  • TIROFIBAN   ITGB3

    Interaction Score: 6.18

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    20938371 10592235 20210689 11752352


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • CYPATE   ITGB3

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22871580


    Sources:
    DTC

  • CILENGITIDE   ITGB3

    Interaction Score: 4.42

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name cilengitide. EMD-121974
    Novel drug target Established target
    Mechanism of Interaction Integrin alpha-V/beta-3 antagonist

    PMIDs:
    24095096


    Sources:
    TALC DTC TdgClinicalTrial ChemblInteractions

  • TIROFIBAN HYDROCHLORIDE   ITGB3

    Interaction Score: 2.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TADOCIZUMAB   ITGB3

    Interaction Score: 2.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-IIb/beta-3 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GANTOFIBAN   ITGB3

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name YM-028, gantofiban

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • INTETUMUMAB   ITGB3

    Interaction Score: 1.77

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Integrin alpha-V/beta-3 antagonist
    Trial Name CNTO-95

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • CLOPIDOGREL   ITGB3

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23834376 22028352 19530321 19106083 16458133 15166949


    Sources:
    PharmGKB

  • ETARACIZUMAB   ITGB3

    Interaction Score: 1.1

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-V/beta-3 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ASPIRIN   ITGB3

    Interaction Score: 0.92

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23834376 22028352 20138334 17184645 16675000 16581111 16493486 16458133 16153930 15840736 11723016 11054089 10704169 10459913


    Sources:
    PharmGKB

  • ABITUZUMAB   ITGB3

    Interaction Score: 0.88

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-V/beta-3 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GLPG-0187   ITGB3

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name GLPG0187
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Ensembl: ENSG00000259753

    • Version: 101_38

    Alternate Names:
    AC068234.1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • Ensembl: ENSG00000259207

    • Version: 101_38

    Alternate Names:
    ITGB3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P05106

    • Version: January-2014

    Alternate Names:
    ITGB3 Gene Symbol

    Gene Info:
    Target Subclass Integrin
    Target Class Receptors
    Target Subclass Receptors

    Publications:

  • TEND: P05106

    • Version: 01-August-2011

    Alternate Names:
    ITGB3 Gene Symbol
    ITB3_HUMAN Uniprot Id
    3690 Entrez Gene Id

    Gene Info:
    Target Subclass Integrin
    Target Main Class Receptors
    Target Subclass Other_receptors

    Publications:

  • HopkinsGroom: P05106

    • Version: 11-September-2012

    Alternate Names:
    3690 Entrez Gene Id
    INTEGRIN BETA-3 Uniprot Protein Name
    ENSG00000259207 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Domain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000056345

    • Version: 26-July-2011

    Alternate Names:
    INTEGRIN BETA-3 PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IIIA) (GPIIIA) (CD61 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P05106] Description
    ITGB3 Display Id
    ENSG00000056345 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: ITGB3

    • Version: 18-August-2020

    Alternate Names:
    PA205 PharmGKB ID

    Gene Info:

    Publications:
    Lim E et al., 2007, Dose-related efficacy of aspirin after coronary surgery in patients With Pl(A2) polymorphism (NCT00262275)., Ann Thorac Surg
    Cooke GE et al., 2006, Effect of platelet antigen polymorphism on platelet inhibition by aspirin, clopidogrel, or their combination., J Am Coll Cardiol
    Dropinski J et al., 2007, Antithrombotic effects of aspirin based on PLA1/A2 glycoprotein IIIa polymorphism in patients with coronary artery disease., Thromb Res

  • DTC: ITGB3

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Monaco A et al., 2013, Synthesis and in vitro evaluation of a novel radioligand for αvβ3 integrin receptor imaging: [18F]FPPA-c(RGDfK)., Bioorg Med Chem Lett
    Ye Y et al., 2012, Near-infrared fluorescent divalent RGD ligand for integrin αvβ₃-targeted optical imaging., Bioorg Med Chem Lett

  • HingoraniCasas: ENSG00000259207

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000259207 Gene Symbol
    ITGB3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: ITGB3

    • Version: 12-May-2016

    Alternate Names:
    ITGB3 Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: GP3A

    • Version: chembl_23

    Alternate Names:
    GP3A GENE_SYMBOL
    ITGB3 GENE_SYMBOL
    Integrin beta-3 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000259753

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000259753 Gene Symbol
    Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: ITGB3

    • Version: 01-February-2022

    Alternate Names:
    GP3A GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21