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ITGA2B 3674 Druggable Genome
Alternate Names:
3674 INTEGRIN SUBUNIT ALPHA 2B ITGA2B BDPLT16 BDPLT2 CD41 CD41B GP2B GPIIb GT GTA HPA3 PPP1R93 607759 6138 ENSG00000005961 OTTHUMG00000177935 PA29938 CD_antigen=CD41 Integrin alpha-IIb light chain, form 1 Integrin alpha-IIb heavy chain Integrin alpha-IIb light chain, form 2 Integrin alpha-IIb GPalpha IIb ITGAB Platelet membrane glycoprotein IIb ITA2B_HUMAN P08514 INTEGRIN ALPHA-IIB PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IIB) (GPALPHA IIB) (GPIIB) (CD41 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P08514] GT1 Gene Info:
Target Class Receptors Target Subclass Receptors Target Subclass Integrin Target Main Class Receptors Transmembrane Helix Count 1 Target Subclass Other_receptors Human Readable Name DRUGGABLE GENOME Uniprot Status Swiss-Prot Interpro Acc IPR000413 Interpro Name Integrin alpha chain Uniprot Evidence 1: Evidence at protein level Interpro Short Name Integrin_alpha Interpro Type Family Gene Biotype PROTEIN_CODING Gene Categories: Category Details
CELL SURFACE EXTERNAL SIDE OF PLASMA MEMBRANE DRUGGABLE GENOME Publications:
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Interaction Types & Directionality:
antibody (inhibitory) antagonist (inhibitory) inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor Direct Interaction yes Trial Name abciximab, c7E3,ReoPro
Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB -
Interaction Score: 5.5
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Trial Name eptifibatide,Integrilin Novel drug target Established target Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor -
Interaction Score: 4.58
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Interaction Score: 3.43
Interaction Types & Directionality:
n/a Interaction Info:
Trial Name YM-028, gantofiban Novel drug target Established target -
Interaction Score: 3.43
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Mechanism of Interaction Integrin alpha-IIb/beta-3 antagonist Direct Interaction yes -
Interaction Score: 3.43
Interaction Types & Directionality:
inhibitor (inhibitory) Interaction Info:
Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor Direct Interaction yes
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- Version: 101_38
Alternate Names:
ITGA2B Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
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- Version: 26-July-2011
Alternate Names:
ITGA2B Display Id ENSG00000005961 Ensembl Gene Id INTEGRIN ALPHA-IIB PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IIB) (GPALPHA IIB) (GPIIB) (CD41 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P08514] Description Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: 11-September-2012
Alternate Names:
ITGA2B Uniprot Gene Name P08514 Uniprot Accession INTEGRIN ALPHA-IIB LIGHT CHAIN, FORM 1 Uniprot Protein Name Gene Info:
Uniprot Status Swiss-Prot Interpro Acc IPR000413 Interpro Name Integrin alpha chain Gene Categories:
DRUGGABLE GENOME Publications:
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Alternate Names:
3674 Entrez Gene Id ITA2B_HUMAN Uniprot Id ITGA2B Gene Symbol Gene Info:
Target Subclass Integrin Target Main Class Receptors Transmembrane Helix Count 1 Publications:
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- Version: January-2014
Alternate Names:
ITGA2B Gene Symbol Gene Info:
Target Class Receptors Target Subclass Receptors Target Subclass Integrin Publications:
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Alternate Names:
PA29938 PharmGKB ID Gene Info:
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Alternate Names:
Gene Info:
Publications:
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- Version: 31-May-2017
Alternate Names:
ENSG00000005961 Gene Symbol ITGA2B Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
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- Version: chembl_23
Alternate Names:
ITGAB GENE_SYMBOL ITGA2B GENE_SYMBOL Integrin alpha-IIb UNIPROT Gene Info:
Publications:
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Alternate Names:
GP2B GO Gene Synonym ITGAB GO Gene Synonym Gene Info:
Gene Categories:
CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE Publications: