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ITGA2B Gene Record

  • Summary
  • Interactions
  • Claims
  • ITGA2B 3674 Druggable Genome

    Alternate Names:

    3674
    INTEGRIN SUBUNIT ALPHA 2B
    ITGA2B
    BDPLT16
    BDPLT2
    CD41
    CD41B
    GP2B
    GPIIb
    GT
    GTA
    HPA3
    PPP1R93
    607759
    6138
    ENSG00000005961
    OTTHUMG00000177935
    PA29938
    CD_antigen=CD41
    Integrin alpha-IIb light chain, form 1
    Integrin alpha-IIb heavy chain
    Integrin alpha-IIb light chain, form 2
    Integrin alpha-IIb
    GPalpha IIb
    ITGAB
    Platelet membrane glycoprotein IIb
    ITA2B_HUMAN
    P08514
    INTEGRIN ALPHA-IIB PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IIB) (GPALPHA IIB) (GPIIB) (CD41 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P08514]
    GT1

    Gene Info:

    Target Class Receptors
    Target Subclass Receptors
    Target Subclass Integrin
    Target Main Class Receptors
    Transmembrane Helix Count 1
    Target Subclass Other_receptors
    Human Readable Name DRUGGABLE GENOME
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000413
    Interpro Name Integrin alpha chain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name Integrin_alpha
    Interpro Type Family
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Mazzaferri et al., 2008, Abciximab: a review and update for clinicians., Expert Rev Cardiovasc Ther
    Gibbs, 2009, Point-of-care assessment of antiplatelet agents in the perioperative period: a review., Anaesth Intensive Care
    Ibbotson et al., 2003, Abciximab: an updated review of its therapeutic use in patients with ischaemic heart disease undergoing percutaneous coronary revascularisation., Drugs
    Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics
    Juwana et al., 2010, Tirofiban for myocardial infarction., Expert Opin Pharmacother
    Roffi et al., 2002, Impact of different platelet glycoprotein IIb/IIIa receptor inhibitors among diabetic patients undergoing percutaneous coronary intervention: : Do Tirofiban and ReoPro Give Similar Efficacy Outcomes Trial (TARGET) 1-year follow-up., Circulation
    Kondo et al., 2002, Clinical pharmacokinetics of tirofiban, a nonpeptide glycoprotein IIb/IIIa receptor antagonist: comparison with the monoclonal antibody abciximab., Clin Pharmacokinet
    Dickfeld et al., 2001, Differential antiplatelet effects of various glycoprotein IIb-IIIa antagonists., Thromb. Res.
    von Segesser et al., 2001, Alternatives to unfractionated heparin for anticoagulation in cardiopulmonary bypass., Perfusion
    Théroux et al., 2000, Glycoprotein IIb/IIIa receptor blockade improves outcomes in diabetic patients presenting with unstable angina/non-ST-elevation myocardial infarction: results from the Platelet Receptor Inhibition in Ischemic Syndrome Management in Patients Limited by Unstable Signs and Symptoms (PRISM-PLUS) study., Circulation
    Pumiglia et al., 1993, Thrombin and thrombin receptor agonist peptide induce tyrosine phosphorylation and tyrosine kinases in the platelet cytoskeleton. Translocation of pp60c-src and integrin alpha IIb beta 3 (glycoprotein IIb/IIIa) is not required for aggregation, but is dependent on formation of large aggregate structures., Biochem. J.
    Derhaschnig et al., 2003, Blockade of GPIIb/IIIa by eptifibatide and tirofiban does not alter tissue factor induced thrombin generation in human endotoxemia., Thromb. Haemost.
    Mousa et al., 2001, Comparison of the effect of different platelet GPIIb/IIa antagonists on the dynamics of platelet/fibrin-mediated clot strength induced using thromboelastography., Thromb. Res.
    Weksler, 2000, Antiplatelet agents in stroke prevention. combination therapy: present and future., Cerebrovasc. Dis.
    Hong et al., 2003, Glycoprotein IIb/IIIa receptor antagonist (2S)-2-[(2-Naphthyl-sulfonyl)amino]-3-[[2-([4-(4-piperidinyl)-2-[2-(4-piperidinyl)ethyl] butanoyl]amino)acetyl]amino]propanoic acid dihydrochloride (CRL42796), in combination with aspirin and/or enoxaparin, prevents coronary artery rethrombosis after successful thrombolytic treatment by recombinant tissue plasminogen activator., J. Pharmacol. Exp. Ther.
  • TIROFIBAN   ITGA2B

    Interaction Score: 13.74

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    20210689 12057986 11929319 11342206 11565896 11076818 20938371


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • ABCIXIMAB   ITGA2B

    Interaction Score: 9.16

    Interaction Types & Directionality:
    antibody (inhibitory)
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor
    Direct Interaction yes
    Trial Name abciximab, c7E3,ReoPro

    PMIDs:
    18510478 19499855 12749745 20938371


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB

  • EPTIFIBATIDE   ITGA2B

    Interaction Score: 5.5

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name eptifibatide,Integrilin
    Novel drug target Established target
    Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor

    PMIDs:
    20938371


    Sources:
    TdgClinicalTrial ChemblInteractions PharmGKB

  • ENOXAPARIN   ITGA2B

    Interaction Score: 4.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12734394


    Sources:
    NCI

  • GANTOFIBAN   ITGA2B

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name YM-028, gantofiban
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • TADOCIZUMAB   ITGA2B

    Interaction Score: 3.43

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-IIb/beta-3 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TIROFIBAN HYDROCHLORIDE   ITGA2B

    Interaction Score: 3.43

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-IIb/beta-3 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • THROMBIN   ITGA2B

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7689831 14652636


    Sources:
    NCI

  • ASPIRIN   ITGA2B

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11583738 11096182


    Sources:
    NCI

  • Ensembl: ENSG00000005961

    • Version: 101_38

    Alternate Names:
    ITGA2B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000005961

    • Version: 26-July-2011

    Alternate Names:
    ITGA2B Display Id
    ENSG00000005961 Ensembl Gene Id
    INTEGRIN ALPHA-IIB PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IIB) (GPALPHA IIB) (GPIIB) (CD41 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P08514] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P08514

    • Version: 11-September-2012

    Alternate Names:
    ITGA2B Uniprot Gene Name
    P08514 Uniprot Accession
    INTEGRIN ALPHA-IIB LIGHT CHAIN, FORM 1 Uniprot Protein Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000413
    Interpro Name Integrin alpha chain

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P08514

    • Version: 01-August-2011

    Alternate Names:
    3674 Entrez Gene Id
    ITA2B_HUMAN Uniprot Id
    ITGA2B Gene Symbol

    Gene Info:
    Target Subclass Integrin
    Target Main Class Receptors
    Transmembrane Helix Count 1

    Publications:

  • TdgClinicalTrial: P08514

    • Version: January-2014

    Alternate Names:
    ITGA2B Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptors
    Target Subclass Integrin

    Publications:

  • PharmGKB: ITGA2B

    • Version: 18-August-2020

    Alternate Names:
    PA29938 PharmGKB ID

    Gene Info:

    Publications:
    Sangkuhl K et al., 2011, Platelet aggregation pathway., Pharmacogenet Genomics

  • NCI: ITGA2B

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Derhaschnig et al., 2003, Blockade of GPIIb/IIIa by eptifibatide and tirofiban does not alter tissue factor induced thrombin generation in human endotoxemia., Thromb. Haemost.
    Pumiglia et al., 1993, Thrombin and thrombin receptor agonist peptide induce tyrosine phosphorylation and tyrosine kinases in the platelet cytoskeleton. Translocation of pp60c-src and integrin alpha IIb beta 3 (glycoprotein IIb/IIIa) is not required for aggregation, but is dependent on formation of large aggregate structures., Biochem. J.
    Trikha et al., 2002, Multiple roles for platelet GPIIb/IIIa and alphavbeta3 integrins in tumor growth, angiogenesis, and metastasis., Cancer Res.

  • HingoraniCasas: ENSG00000005961

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000005961 Gene Symbol
    ITGA2B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: GP2B

    • Version: chembl_23

    Alternate Names:
    ITGAB GENE_SYMBOL
    ITGA2B GENE_SYMBOL
    Integrin alpha-IIb UNIPROT

    Gene Info:

    Publications:

  • GO: ITGA2B

    • Version: 01-February-2022

    Alternate Names:
    GP2B GO Gene Synonym
    ITGAB GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21