• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

ITGA2 Gene Record

  • Summary
  • Interactions
  • Claims
  • ITGA2 3673 Druggable Genome

    Alternate Names:

    3673
    INTEGRIN SUBUNIT ALPHA 2
    ITGA2
    BR
    CD49B
    GPIa
    HPA-5
    VLA-2
    VLAA2
    192974
    6137
    ENSG00000164171
    OTTHUMG00000131165
    CD49 antigen-like family member B
    Collagen receptor
    VLA-2 subunit alpha
    Platelet membrane glycoprotein Ia
    Integrin alpha-2
    CD_antigen=CD49b
    INTEGRIN ALPHA-2 PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IA) (GPIA) (COLLAGEN RECEPTOR) (VLA-2 ALPHA CHAIN) (CD49B). [SOURCE:UNIPROT/SWISSPROT;ACC:P17301]
    ITA2_HUMAN
    P17301
    PA204
    T55293

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000413
    Uniprot Status Swiss-Prot
    Interpro Short Name Integrin_alpha
    Interpro Name Integrin alpha chain
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Verschuren JJ et al., 2013, Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction., Int J Cardiol
    Giusti B et al., 2008, Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment., Atherosclerosis
    Lepäntalo A et al., 2006, Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients., Thromb Haemost
    Angiolillo DJ et al., 2005, Variability in platelet aggregation following sustained aspirin and clopidogrel treatment in patients with coronary heart disease and influence of the 807 C/T polymorphism of the glycoprotein Ia gene., Am J Cardiol
    Angiolillo DJ et al., 2004, 807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment., Blood Coagul Fibrinolysis
  • VATELIZUMAB   ITGA2

    Interaction Score: 15.46

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Integrin alpha-2 antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • E-7820   ITGA2

    Interaction Score: 15.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CLOPIDOGREL   ITGA2

    Interaction Score: 4.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22940005 17157856 16493486 16214444 15205592


    Sources:
    PharmGKB

  • ASPIRIN   ITGA2

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22940005 17157856 16493486 16214444 15205592


    Sources:
    PharmGKB

  • Ensembl: ENSG00000164171

    • Version: 101_38

    Alternate Names:
    ITGA2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P17301

    • Version: 11-September-2012

    Alternate Names:
    ITGA2 Uniprot Gene Name
    P17301 Uniprot Accession
    ITA2_HUMAN Uniprot Id

    Gene Info:
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR000413

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000164171

    • Version: 26-July-2011

    Alternate Names:
    ITGA2 Display Id
    ENSG00000164171 Ensembl Gene Id
    INTEGRIN ALPHA-2 PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IA) (GPIA) (COLLAGEN RECEPTOR) (VLA-2 ALPHA CHAIN) (CD49B). [SOURCE:UNIPROT/SWISSPROT;ACC:P17301] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: ITGA2

    • Version: 18-August-2020

    Alternate Names:
    PA204 PharmGKB ID

    Gene Info:

    Publications:
    Giusti B et al., 2008, Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment., Atherosclerosis
    Lepäntalo A et al., 2006, Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients., Thromb Haemost
    Angiolillo DJ et al., 2004, 807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment., Blood Coagul Fibrinolysis

  • ChemblInteractions: CD49B

    • Version: chembl_23

    Alternate Names:
    CD49B GENE_SYMBOL
    ITGA2 GENE_SYMBOL
    Integrin alpha-2 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000164171

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000164171 Gene Symbol
    ITGA2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: ITGA2

    • Version: 01-February-2022

    Alternate Names:
    CD49B GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • TTD: Integrin alpha-2

    • Version: 2020.06.01

    Alternate Names:
    ITGA2 TTD Gene Abbreviation
    T55293 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21