DGIdb - ITGA2 Gene Record

ITGA2 3673 Druggable Genome

Alternate Names:

3673
INTEGRIN SUBUNIT ALPHA 2
ITGA2
BR
CD49B
GPIa
HPA-5
VLA-2
VLAA2
192974
6137
ENSG00000164171
OTTHUMG00000131165
CD49 antigen-like family member B
Collagen receptor
VLA-2 subunit alpha
Platelet membrane glycoprotein Ia
Integrin alpha-2
CD_antigen=CD49b
INTEGRIN ALPHA-2 PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IA) (GPIA) (COLLAGEN RECEPTOR) (VLA-2 ALPHA CHAIN) (CD49B). [SOURCE:UNIPROT/SWISSPROT;ACC:P17301]
ITA2_HUMAN
P17301
PA204
T55293

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000413
Uniprot Status	Swiss-Prot
Interpro Short Name	Integrin_alpha
Interpro Name	Integrin alpha chain
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Verschuren JJ et al., 2013, Value of platelet pharmacogenetics in common clinical practice of patients with ST-segment elevation myocardial infarction., Int J Cardiol
Giusti B et al., 2008, Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment., Atherosclerosis
Lepäntalo A et al., 2006, Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients., Thromb Haemost
Angiolillo DJ et al., 2005, Variability in platelet aggregation following sustained aspirin and clopidogrel treatment in patients with coronary heart disease and influence of the 807 C/T polymorphism of the glycoprotein Ia gene., Am J Cardiol
Angiolillo DJ et al., 2004, 807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment., Blood Coagul Fibrinolysis

VATELIZUMAB ITGA2

Interaction Score: 15.46

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-2 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
E-7820 ITGA2

Interaction Score: 15.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CLOPIDOGREL ITGA2

Interaction Score: 4.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22940005 17157856 16493486 16214444 15205592

Sources:
PharmGKB
ASPIRIN ITGA2

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22940005 17157856 16493486 16214444 15205592

Sources:
PharmGKB

Ensembl: ENSG00000164171
- Version: 101_38
Alternate Names:

ITGA2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P17301
- Version: 11-September-2012
Alternate Names:

ITGA2 Uniprot Gene Name

P17301 Uniprot Accession

ITA2_HUMAN Uniprot Id

Gene Info:

Interpro Type Family

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR000413

Gene Categories:

DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000164171

Version: 26-July-2011

Alternate Names:

ITGA2 Display Id

ENSG00000164171 Ensembl Gene Id

INTEGRIN ALPHA-2 PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IA) (GPIA) (COLLAGEN RECEPTOR) (VLA-2 ALPHA CHAIN) (CD49B). [SOURCE:UNIPROT/SWISSPROT;ACC:P17301] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: ITGA2

Version: 18-August-2020

Alternate Names:

PA204 PharmGKB ID

Gene Info:

Publications:

Giusti B et al., 2008, Role of glycoprotein Ia gene polymorphisms in determining platelet function in myocardial infarction patients undergoing percutaneous coronary intervention on dual antiplatelet treatment., Atherosclerosis

Lepäntalo A et al., 2006, Polymorphisms of COX-1 and GPVI associate with the antiplatelet effect of aspirin in coronary artery disease patients., Thromb Haemost

Angiolillo DJ et al., 2004, 807 C/T Polymorphism of the glycoprotein Ia gene and pharmacogenetic modulation of platelet response to dual antiplatelet treatment., Blood Coagul Fibrinolysis

ChemblInteractions: CD49B
- Version: chembl_23
Alternate Names:

CD49B GENE_SYMBOL

ITGA2 GENE_SYMBOL

Integrin alpha-2 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000164171
- Version: 31-May-2017
Alternate Names:

ENSG00000164171 Gene Symbol

ITGA2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: ITGA2
- Version: 01-February-2022
Alternate Names:

CD49B GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: Integrin alpha-2
- Version: 2020.06.01
Alternate Names:

ITGA2 TTD Gene Abbreviation

T55293 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Integrin alpha-2 antagonist
Direct Interaction	yes

ITGA2	Uniprot Gene Name
P17301	Uniprot Accession
ITA2_HUMAN	Uniprot Id

ITGA2	Display Id
ENSG00000164171	Ensembl Gene Id
INTEGRIN ALPHA-2 PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IA) (GPIA) (COLLAGEN RECEPTOR) (VLA-2 ALPHA CHAIN) (CD49B). [SOURCE:UNIPROT/SWISSPROT;ACC:P17301]	Description

ITGA2	TTD Gene Abbreviation
T55293	TTD Target ID

ITGA2 Gene Record

ITGA2 3673 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

VATELIZUMAB ITGA2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Integrin alpha-2 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

E-7820 ITGA2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

CLOPIDOGREL ITGA2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22940005 17157856 16493486 16214444 15205592

Sources: PharmGKB

ASPIRIN ITGA2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22940005 17157856 16493486 16214444 15205592

Sources: PharmGKB

Ensembl: ENSG00000164171

Alternate Names: ITGA2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P17301

Alternate Names: ITGA2 Uniprot Gene Name P17301 Uniprot Accession ITA2_HUMAN Uniprot Id

Gene Info: Interpro Type Family Uniprot Evidence 1: Evidence at protein level Interpro Acc IPR000413

Gene Categories: DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000164171

Alternate Names: ITGA2 Display Id ENSG00000164171 Ensembl Gene Id INTEGRIN ALPHA-2 PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IA) (GPIA) (COLLAGEN RECEPTOR) (VLA-2 ALPHA CHAIN) (CD49B). [SOURCE:UNIPROT/SWISSPROT;ACC:P17301] Description

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

PharmGKB: ITGA2

Alternate Names: PA204 PharmGKB ID

Gene Info:

ChemblInteractions: CD49B

Alternate Names: CD49B GENE_SYMBOL ITGA2 GENE_SYMBOL Integrin alpha-2 UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000164171

Alternate Names: ENSG00000164171 Gene Symbol ITGA2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: ITGA2

Alternate Names: CD49B GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

TTD: Integrin alpha-2

Alternate Names: ITGA2 TTD Gene Abbreviation T55293 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Integrin alpha-2 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
22940005 17157856 16493486 16214444 15205592

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22940005 17157856 16493486 16214444 15205592

Sources:
PharmGKB

Alternate Names:

ITGA2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ITGA2 Uniprot Gene Name

P17301 Uniprot Accession

ITA2_HUMAN Uniprot Id

Gene Info:

Interpro Type Family

Uniprot Evidence 1: Evidence at protein level

Interpro Acc IPR000413

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ITGA2 Display Id

ENSG00000164171 Ensembl Gene Id

INTEGRIN ALPHA-2 PRECURSOR (PLATELET MEMBRANE GLYCOPROTEIN IA) (GPIA) (COLLAGEN RECEPTOR) (VLA-2 ALPHA CHAIN) (CD49B). [SOURCE:UNIPROT/SWISSPROT;ACC:P17301] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA204 PharmGKB ID

Alternate Names:

CD49B GENE_SYMBOL

ITGA2 GENE_SYMBOL

Integrin alpha-2 UNIPROT

Alternate Names:

ENSG00000164171 Gene Symbol

ITGA2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

CD49B GO Gene Synonym

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

ITGA2 TTD Gene Abbreviation

T55293 TTD Target ID