DGIdb - IRAK4 Gene Record

IRAK4 51135 Druggable Genome

Alternate Names:

51135
INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4
IRAK4
IPD1
IRAK-4
NY-REN-64
REN64
606883
17967
ENSG00000198001
OTTHUMG00000169425
2045
Q9NWZ3
NP_001107654
interleukin-1 receptor-associated kinase 4
NM_001114182
INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE-4 (EC 2.7.1.37) (IRAK-4) (NY- REN-64 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NWZ3]
BE0004344
Renal carcinoma antigen NY-REN-64
T55398

Gene Info:

GuideToPharmacology Gene Category Name	Interleukin-1 receptor-associated kinase (IRAK) family
GuideToPharmacology Gene Category ID	579
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME

Publications:

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

CHEMBL1236126 IRAK4

Interaction Score: 5.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
PF-06650833 IRAK4

Interaction Score: 2.71

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
CHEMBL535331 IRAK4

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LAUROGUADINE IRAK4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SNS-314 IRAK4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 IRAK4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW441756X IRAK4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL225519 IRAK4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GEFITINIB IRAK4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB IRAK4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LINIFANIB IRAK4

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DASATINIB IRAK4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 IRAK4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 IRAK4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 IRAK4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 IRAK4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 IRAK4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 IRAK4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB IRAK4

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB IRAK4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FOSTAMATINIB IRAK4

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000198001
- Version: 101_38
Alternate Names:

IRAK4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000198001

Version: 26-July-2011

Alternate Names:

ENSG00000198001 Ensembl Gene Id

IRAK4 Display Id

INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE-4 (EC 2.7.1.37) (IRAK-4) (NY- REN-64 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NWZ3] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 51135
- Version: 29-September-2020
Alternate Names:

17967 HUGO Gene ID

17967 HUGO Gene Symbol

interleukin 1 receptor associated kinase 4 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Interleukin-1 receptor-associated kinase (IRAK) family

GuideToPharmacology Gene Category ID 579

Gene Categories:

ENZYME

Publications:

DrugBank: BE0004344

Version: 5.1.7

Alternate Names:

IRAK4 DrugBank Gene Name

Q9NWZ3 UniProt Accession

51135 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

NCI: IRAK4
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Qin et al., 2004, IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness., J. Biol. Chem.
HingoraniCasas: ENSG00000198001
- Version: 31-May-2017
Alternate Names:

ENSG00000198001 Gene Symbol

IRAK4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: IRAK4
- Version: 19.3
Alternate Names:

ENSG00000198001 Ensembl Gene ID

NY-REN-64 Human Protein Atlas Gene Synonym

Interleukin 1 receptor associated kinase 4 Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: IRAK4
- Version: 03-September-2020
Alternate Names:

Interleukin-1 receptor-associated kinase 4 Gene Name

Q9NWZ3 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
dGene: IRAK4
- Version: 27-Jun-2013
Alternate Names:

51135 Gene ID

IPD1 dGene Synonym

IRAK-4 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Renal carcinoma antigen NY-REN-64
- Version: 2020.06.01
Alternate Names:

IRAK-4 TTD Gene Abbreviation

T55398 TTD Target ID

Gene Info:

Publications:
DTC: IRAK4
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:
GO: IRAK4
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

ENSG00000198001	Ensembl Gene Id
IRAK4	Display Id
INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE-4 (EC 2.7.1.37) (IRAK-4) (NY- REN-64 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NWZ3]	Description

17967	HUGO Gene ID
17967	HUGO Gene Symbol
interleukin 1 receptor associated kinase 4	HUGO Gene Name

IRAK4	DrugBank Gene Name
Q9NWZ3	UniProt Accession
51135	Entrez Gene Id

Interleukin-1 receptor-associated kinase 4	Gene Name
Q9NWZ3	UniProt ID

IRAK4 Gene Record

IRAK4 51135 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26516587

Sources:
DrugBank

Alternate Names:

IRAK4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000198001 Ensembl Gene Id

IRAK4 Display Id

INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE-4 (EC 2.7.1.37) (IRAK-4) (NY- REN-64 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NWZ3] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

17967 HUGO Gene ID

17967 HUGO Gene Symbol

interleukin 1 receptor associated kinase 4 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Interleukin-1 receptor-associated kinase (IRAK) family

GuideToPharmacology Gene Category ID 579

Gene Categories:

ENZYME

Alternate Names:

IRAK4 DrugBank Gene Name

Q9NWZ3 UniProt Accession

51135 Entrez Gene Id

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

Publications:

Qin et al., 2004, IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness., J. Biol. Chem.

Alternate Names:

ENSG00000198001 Gene Symbol

IRAK4 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000198001 Ensembl Gene ID

NY-REN-64 Human Protein Atlas Gene Synonym

Interleukin 1 receptor associated kinase 4 Human Protein Atlas Gene Description

Gene Categories:

ENZYME

Alternate Names:

Interleukin-1 receptor-associated kinase 4 Gene Name

Q9NWZ3 UniProt ID