IRAK4 Gene Record

  • IRAK4 51135 Druggable Genome

    Alternate Names:

    51135
    INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4
    IRAK4
    IPD1
    IRAK-4
    NY-REN-64
    REN64
    606883
    17967
    ENSG00000198001
    OTTHUMG00000169425
    2045
    Q9NWZ3
    NP_001107654
    NM_001114182
    INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE-4 (EC 2.7.1.37) (IRAK-4) (NY- REN-64 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NWZ3]
    Renal carcinoma antigen NY-REN-64
    T55398
    IMD67
    Interleukin-1 receptor-associated kinase 4

    Gene Info:

    GuideToPharmacology Gene Category Name Interleukin-1 receptor-associated kinase (IRAK) family
    GuideToPharmacology Gene Category ID 579
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    DRUGGABLE GENOME
    ENZYME

    Publications:

  • PF-06650833   IRAK4

    Interaction Score: 3.36

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL535331   IRAK4

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LAUROGUADINE   IRAK4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SNS-314   IRAK4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GO-6976   IRAK4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW441756X   IRAK4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL225519   IRAK4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GEFITINIB   IRAK4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TOZASERTIB   IRAK4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LINIFANIB   IRAK4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DASATINIB   IRAK4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • R-406   IRAK4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RG-1530   IRAK4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SP-600125   IRAK4

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYC-116   IRAK4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TAE-684   IRAK4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   IRAK4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ILORASERTIB   IRAK4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CENISERTIB   IRAK4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000198001

    • Version: 101_38

    Alternate Names:
    IRAK4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000198001

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000198001 Ensembl Gene Id
    IRAK4 Display Id
    INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE-4 (EC 2.7.1.37) (IRAK-4) (NY- REN-64 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:Q9NWZ3] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 51135

    • Version: 29-September-2020

    Alternate Names:
    17967 HUGO Gene ID
    17967 HUGO Gene Symbol
    interleukin 1 receptor associated kinase 4 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Interleukin-1 receptor-associated kinase (IRAK) family
    GuideToPharmacology Gene Category ID 579

    Gene Categories:
    ENZYME

    Publications:

  • NCI: IRAK4

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Qin et al., 2004, IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness., J. Biol. Chem.

  • HingoraniCasas: ENSG00000198001

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000198001 Gene Symbol
    IRAK4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: IRAK4

    • Version: 19.3

    Alternate Names:
    ENSG00000198001 Ensembl Gene ID
    NY-REN-64 Human Protein Atlas Gene Synonym
    Interleukin 1 receptor associated kinase 4 Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • dGene: IRAK4

    • Version: 27-Jun-2013

    Alternate Names:
    51135 Gene ID
    IPD1 dGene Synonym
    IRAK-4 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: Renal carcinoma antigen NY-REN-64

    • Version: 2020.06.01

    Alternate Names:
    IRAK-4 TTD Gene Abbreviation
    T55398 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: IRAK4

    • Version: 01-May-2021

    Alternate Names:
    Interleukin-1 receptor-associated kinase 4 Gene Name
    Q9NWZ3 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • DTC: IRAK4

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:

  • GO: IRAK4

    • Version: 01-May-2021

    Alternate Names:

    Gene Info:

    Gene Categories:
    SERINE THREONINE KINASE

    Publications: