DGIdb - INSR Gene Record

INSR 3643 Druggable GenomeClinically Actionable

Alternate Names:

3643
INSULIN RECEPTOR
INSR
CD220
HHF5
147670
6091
ENSG00000171105
OTTHUMG00000181992
P06213
INSR_HUMAN
1800
NP_000199
NM_000208
IR
Insulin receptor subunit alpha
CD_antigen=CD220
Insulin receptor subunit beta
INSULIN RECEPTOR PRECURSOR (EC 2.7.1.112) (IR) (CD220 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P06213]
BE0000033
PA202
T85435

Gene Info:

GuideToPharmacology Gene Category Name	Type II RTKs: Insulin receptor family
GuideToPharmacology Gene Category ID	321
Target Main Class	Receptors
Target Subclass	Kinase
Transmembrane Helix Count	1
Target Subclass	InsR
Uniprot Status	Swiss-Prot
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR001245
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Human Readable Name	KINASE
Target Class	Receptors
Target Subclass	EC:2.7.10.1
Gene Biotype	PROTEIN_CODING

(14 More Sources)

Gene Categories: Category Details

TRANSPORTER
KINASE
TYROSINE KINASE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME
TRANSCRIPTION FACTOR

Publications:

Chen J et al., 2013, LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor., J Med Chem
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Li QS et al., 2016, A candidate-gene association study of topiramate-induced weight loss in obese patients with and without type 2 diabetes mellitus., Pharmacogenet Genomics
Rosenbloom, 2009, Mecasermin (recombinant human insulin-like growth factor I)., Adv Ther
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

INSULIN SUSP ISOPHANE PURIFIED PORK INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN ZINC SUSP EXTENDED RECOMBINANT HUMAN INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN PORK INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN ZINC SUSP PROMPT BEEF INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN ZINC SUSP PURIFIED BEEF/PORK INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN PURIFIED PORK INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN DETEMIR INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN SUSP ISOPHANE PURIFIED BEEF INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN SUSP PROTAMINE ZINC PURIFIED BEEF INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN SUSP ISOPHANE BEEF INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RECOMBINANT HUMAN KALLIKREIN-1 INSR

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
INSULIN ZINC SUSP PURIFIED BEEF INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN SUSP ISOPHANE BEEF/PORK INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN PURIFIED BEEF INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN ZINC SUSP PROMPT PURIFIED PORK INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN SUSP ISOPHANE SEMISYNTHETIC PURIFIED HUMAN INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN ZINC SUSP EXTENDED BEEF INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHROMIC CHLORIDE INSR

Interaction Score: 0.86

Interaction Types & Directionality:

activator (activating)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
INSULIN ASPART PROTAMINE RECOMBINANT INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN ZINC SUSP SEMISYNTHETIC PURIFIED HUMAN INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN GLULISINE INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN ZINC SUSP EXTENDED PURIFIED BEEF INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN SUSP PROTAMINE ZINC BEEF/PORK INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN LISPRO INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN DEGLUDEC INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN LISPRO PROTAMINE RECOMBINANT INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN ZINC SUSP PURIFIED PORK INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN SUSP ISOPHANE RECOMBINANT HUMAN INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN ASPART INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN ZINC SUSP BEEF INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN SUSP PROTAMINE ZINC PURIFIED PORK INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN ZINC SUSP RECOMBINANT HUMAN INSR

Interaction Score: 0.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER INSR

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
MECASERMIN INSR

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19198769

Sources:
DrugBank
MITOGLITAZONE INSR

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
KW-2450 INSR

Interaction Score: 0.43

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Insulin receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN PEGLISPRO INSR

Interaction Score: 0.43

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
INSULIN GLARGINE INSR

Interaction Score: 0.43

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LINSITINIB INSR

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TALC ChemblInteractions GuideToPharmacology
CHEMBL401930 INSR

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
TESOFENSINE INSR

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CERITINIB INSR

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
23837797

Sources:
DTC GuideToPharmacology
BRIGATINIB INSR

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

binder

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
DrugBank GuideToPharmacology
AEW-541 INSR

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BMS-754807 INSR

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Insulin receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC ChemblInteractions
METHAZOLAMIDE INSR

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
INSULIN INSR

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

Trial Name TPM-02/Insulin

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology
TOPIRAMATE INSR

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26524290

Sources:
PharmGKB
EPIRUBICIN INSR

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
HESPERADIN INSR

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
GO-6976 INSR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOVITINIB INSR

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
DTC GuideToPharmacology
GW441756X INSR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LINIFANIB INSR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB INSR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLOPHOSPHAMIDE INSR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
R-406 INSR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 INSR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 INSR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 INSR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 INSR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 INSR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUOROURACIL INSR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ILORASERTIB INSR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB INSR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FOSTAMATINIB INSR

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000171105
- Version: 101_38
Alternate Names:

INSR Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000171105
- Version: 26-July-2011
Alternate Names:

INSULIN RECEPTOR PRECURSOR (EC 2.7.1.112) (IR) (CD220 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P06213] Description

ENSG00000171105 Ensembl Gene Id

INSR Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P06213
- Version: January-2014
Alternate Names:

INSR Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass EC:2.7.10.1

Publications:
TEND: P06213
- Version: 01-August-2011
Alternate Names:

P06213 Uniprot Accession

ENSG00000171105 Ensembl Gene Id

INSR Gene Symbol

Gene Info:

Target Main Class Receptors

Target Subclass Kinase

Transmembrane Helix Count 1

Publications:
HopkinsGroom: P06213
- Version: 11-September-2012
Alternate Names:

INSR_HUMAN Uniprot Id

3643 Entrez Gene Id

ENSG00000171105 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Interpro Type Domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 3643
- Version: 29-September-2020
Alternate Names:

6091 HUGO Gene ID

6091 HUGO Gene Symbol

insulin receptor HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Type II RTKs: Insulin receptor family

GuideToPharmacology Gene Category ID 321

Publications:
PharmGKB: INSR
- Version: 18-August-2020
Alternate Names:

PA202 PharmGKB ID

Gene Info:

Publications:

Li QS et al., 2016, A candidate-gene association study of topiramate-induced weight loss in obese patients with and without type 2 diabetes mellitus., Pharmacogenet Genomics

DrugBank: BE0000033

Version: 5.1.7

Alternate Names:

INSR DrugBank Gene Name

P06213 UniProt Accession

3643 Entrez Gene Id

Gene Info:

Publications:

Bell, 2007, Insulin therapy in diabetes mellitus: how can the currently available injectable insulins be most prudently and efficaciously utilised?, Drugs

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Chen et al., 2002, Acidic residues on the N-terminus of proinsulin C-Peptide are important for the folding of insulin precursor., J. Biochem.

TTD: Insulin receptor

Version: 2020.06.01

Alternate Names:

INSR TTD Gene Abbreviation

T85435 TTD Target ID

Gene Info:

Publications:

Heinemann L et al., 2012, Ultrafast-acting insulins: state of the art., J Diabetes Sci Technol

González-Ortiz M et al., 2012, Effect of metformin glycinate on glycated hemoglobin A1C concentration and insulin sensitivity in drug-naive adult patients with type 2 diabetes mellitus., Diabetes Technol Ther

DTC: INSR

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

Chen J et al., 2013, LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor., J Med Chem

HingoraniCasas: ENSG00000171105
- Version: 31-May-2017
Alternate Names:

ENSG00000171105 Gene Symbol

INSR Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: INSR
- Version: chembl_23
Alternate Names:

INSR GENE_SYMBOL

Insulin receptor UNIPROT

Insulin receptor subunit alpha UNIPROT

Gene Info:

Publications:
TALC: IR
- Version: 12-May-2016
Alternate Names:

IR Gene Symbol

Gene Info:

Publications:
Pharos: INSR
- Version: 03-September-2020
Alternate Names:

Insulin receptor Gene Name

P06213 UniProt ID

Gene Info:

Gene Categories:

ENZYME, KINASE, TRANSCRIPTION FACTOR, TRANSPORTER

Publications:
dGene: INSR
- Version: 27-Jun-2013
Alternate Names:

3643 Gene ID

CD220 dGene Synonym

HHF5 dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
MskImpact: INSR
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: INSR
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
GO: INSR
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

TYROSINE KINASE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Mechanism of Interaction	Insulin receptor agonist
Direct Interaction	yes

Mechanism of Interaction	Insulin receptor inhibitor
Direct Interaction	yes

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Notes
Mechanism of Interaction	Insulin receptor inhibitor
Direct Interaction	yes

INSULIN RECEPTOR PRECURSOR (EC 2.7.1.112) (IR) (CD220 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P06213]	Description
ENSG00000171105	Ensembl Gene Id
INSR	Display Id

P06213	Uniprot Accession
ENSG00000171105	Ensembl Gene Id
INSR	Gene Symbol

INSR_HUMAN	Uniprot Id
3643	Entrez Gene Id
ENSG00000171105	Ensembl Gene Id

6091	HUGO Gene ID
6091	HUGO Gene Symbol
insulin receptor	HUGO Gene Name

INSR	DrugBank Gene Name
P06213	UniProt Accession
3643	Entrez Gene Id

INSR	GENE_SYMBOL
Insulin receptor	UNIPROT
Insulin receptor subunit alpha	UNIPROT

INSR Gene Record

INSR 3643 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Insulin receptor agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Insulin receptor agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: activator (activating)

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Insulin receptor agonist Direct Interaction yes

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

activator (activating)

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Insulin receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Insulin receptor agonist

Direct Interaction yes