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INSR Gene Record

  • Summary
  • Interactions
  • Claims
  • INSR 3643 Druggable GenomeClinically Actionable

    Alternate Names:

    3643
    INSULIN RECEPTOR
    INSR
    CD220
    HHF5
    147670
    6091
    ENSG00000171105
    OTTHUMG00000181992
    P06213
    INSR_HUMAN
    IR
    Insulin receptor subunit alpha
    CD_antigen=CD220
    Insulin receptor subunit beta
    INSULIN RECEPTOR PRECURSOR (EC 2.7.1.112) (IR) (CD220 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P06213]
    PA202
    T85435

    Gene Info:

    Target Main Class Receptors
    Target Subclass Kinase
    Transmembrane Helix Count 1
    Target Subclass InsR
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001245
    Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom
    Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain
    Human Readable Name KINASE
    Target Class Receptors
    Target Subclass EC:2.7.10.1
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    KINASE
    TYROSINE KINASE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME
    TRANSCRIPTION FACTOR

    Publications:

    Chen J et al., 2013, LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor., J Med Chem
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Li QS et al., 2016, A candidate-gene association study of topiramate-induced weight loss in obese patients with and without type 2 diabetes mellitus., Pharmacogenet Genomics
  • INSULIN SUSP ISOPHANE PURIFIED PORK   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN ZINC SUSP EXTENDED RECOMBINANT HUMAN   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN PORK   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN ZINC SUSP PROMPT BEEF   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN ZINC SUSP PURIFIED BEEF/PORK   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN PURIFIED PORK   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN DETEMIR   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN SUSP ISOPHANE PURIFIED BEEF   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN SUSP PROTAMINE ZINC PURIFIED BEEF   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN SUSP ISOPHANE BEEF   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RECOMBINANT HUMAN KALLIKREIN-1   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • INSULIN ZINC SUSP PURIFIED BEEF   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN SUSP ISOPHANE BEEF/PORK   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN PURIFIED BEEF   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN ZINC SUSP PROMPT PURIFIED PORK   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN SUSP ISOPHANE SEMISYNTHETIC PURIFIED HUMAN   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN ZINC SUSP EXTENDED BEEF   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN ASPART PROTAMINE RECOMBINANT   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN ZINC SUSP SEMISYNTHETIC PURIFIED HUMAN   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN GLULISINE   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN ZINC SUSP EXTENDED PURIFIED BEEF   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN SUSP PROTAMINE ZINC BEEF/PORK   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN LISPRO   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN DEGLUDEC   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN LISPRO PROTAMINE RECOMBINANT   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN ZINC SUSP PURIFIED PORK   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN SUSP ISOPHANE RECOMBINANT HUMAN   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN ASPART   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN ZINC SUSP BEEF   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN SUSP PROTAMINE ZINC PURIFIED PORK   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN ZINC SUSP RECOMBINANT HUMAN   INSR

    Interaction Score: 1.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MITOGLITAZONE   INSR

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • KW-2450   INSR

    Interaction Score: 0.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Insulin receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN PEGLISPRO   INSR

    Interaction Score: 0.52

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INSULIN GLARGINE   INSR

    Interaction Score: 0.52

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Insulin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TESOFENSINE   INSR

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LINSITINIB   INSR

    Interaction Score: 0.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Insulin receptor inhibitor
    Direct Interaction yes
    Notes

    PMIDs:
    None found


    Sources:
    TALC ChemblInteractions

  • CERITINIB   INSR

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    23837797


    Sources:
    DTC

  • AEW-541   INSR

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BMS-754807   INSR

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Mechanism of Interaction Insulin receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TALC ChemblInteractions

  • METHAZOLAMIDE   INSR

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • INSULIN   INSR

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Insulin receptor agonist
    Trial Name TPM-02/Insulin

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • TOPIRAMATE   INSR

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26524290


    Sources:
    PharmGKB

  • EPIRUBICIN   INSR

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • HESPERADIN   INSR

    Interaction Score: 0.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • GO-6976   INSR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GW441756X   INSR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LINIFANIB   INSR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TOZASERTIB   INSR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYCLOPHOSPHAMIDE   INSR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • R-406   INSR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RG-1530   INSR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DOVITINIB   INSR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • SP-600125   INSR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYC-116   INSR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TAE-684   INSR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PF-00562271   INSR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ILORASERTIB   INSR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FLUOROURACIL   INSR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CENISERTIB   INSR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000171105

    • Version: 101_38

    Alternate Names:
    INSR Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000171105

    • Version: 26-July-2011

    Alternate Names:
    INSULIN RECEPTOR PRECURSOR (EC 2.7.1.112) (IR) (CD220 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P06213] Description
    ENSG00000171105 Ensembl Gene Id
    INSR Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P06213

    • Version: January-2014

    Alternate Names:
    INSR Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass EC:2.7.10.1

    Publications:

  • TEND: P06213

    • Version: 01-August-2011

    Alternate Names:
    P06213 Uniprot Accession
    ENSG00000171105 Ensembl Gene Id
    INSR Gene Symbol

    Gene Info:
    Target Main Class Receptors
    Target Subclass Kinase
    Transmembrane Helix Count 1

    Publications:

  • HopkinsGroom: P06213

    • Version: 11-September-2012

    Alternate Names:
    INSR_HUMAN Uniprot Id
    3643 Entrez Gene Id
    ENSG00000171105 Ensembl Gene Id

    Gene Info:
    Uniprot Status Swiss-Prot
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain

    Gene Categories:
    KINASE, DRUGGABLE GENOME

    Publications:

  • PharmGKB: INSR

    • Version: 18-August-2020

    Alternate Names:
    PA202 PharmGKB ID

    Gene Info:

    Publications:
    Li QS et al., 2016, A candidate-gene association study of topiramate-induced weight loss in obese patients with and without type 2 diabetes mellitus., Pharmacogenet Genomics

  • TTD: Insulin receptor

    • Version: 2020.06.01

    Alternate Names:
    INSR TTD Gene Abbreviation
    T85435 TTD Target ID

    Gene Info:

    Publications:
    Heinemann L et al., 2012, Ultrafast-acting insulins: state of the art., J Diabetes Sci Technol
    González-Ortiz M et al., 2012, Effect of metformin glycinate on glycated hemoglobin A1C concentration and insulin sensitivity in drug-naive adult patients with type 2 diabetes mellitus., Diabetes Technol Ther

  • DTC: INSR

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
    Chen J et al., 2013, LDK378: a promising anaplastic lymphoma kinase (ALK) inhibitor., J Med Chem

  • HingoraniCasas: ENSG00000171105

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000171105 Gene Symbol
    INSR Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: INSR

    • Version: chembl_23

    Alternate Names:
    INSR GENE_SYMBOL
    Insulin receptor UNIPROT
    Insulin receptor subunit alpha UNIPROT

    Gene Info:

    Publications:

  • TALC: IR

    • Version: 12-May-2016

    Alternate Names:
    IR Gene Symbol

    Gene Info:

    Publications:

  • dGene: INSR

    • Version: 27-Jun-2013

    Alternate Names:
    3643 Gene ID
    CD220 dGene Synonym
    HHF5 dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, TYROSINE KINASE

    Publications:

  • Pharos: INSR

    • Version: 01-February-2022

    Alternate Names:
    Insulin receptor Gene Name
    P06213 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER, KINASE, ENZYME, TRANSCRIPTION FACTOR

    Publications:

  • MskImpact: INSR

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • GO: INSR

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    TYROSINE KINASE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • CarisMolecularIntelligence: INSR

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21