DGIdb - IL5RA Gene Record

IL5RA 3568 Druggable Genome

Alternate Names:

3568
INTERLEUKIN 5 RECEPTOR SUBUNIT ALPHA
IL5RA
CD125
CDw125
HSIL5R3
IL5R
147851
6017
ENSG00000091181
OTTHUMG00000090245
IL-5 receptor subunit alpha
Interleukin-5 receptor subunit alpha
CD_antigen=CD125
IL-5R subunit alpha
IL-5R-alpha
IL-5RA
Q01344
Interleukin 5 receptor, α subunit
Interleukin 5 receptor alpha
T90828
1706
BE0003471

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	Type 1 cytokine receptor
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	IL-3 receptor family
GuideToPharmacology Gene Category ID	306

(5 More Sources)

Gene Categories: Category Details

EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Laviolette M et al., 2013, Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia., J Allergy Clin Immunol
Bagnasco D et al., 2017, Anti-Interleukin 5 (IL-5) and IL-5Ra Biological Drugs: Efficacy, Safety, and Future Perspectives in Severe Eosinophilic Asthma., Front Med (Lausanne)
Ghazi A et al., 2012, Benralizumab--a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity--a novel approach for the treatment of asthma., Expert Opin Biol Ther

BENRALIZUMAB IL5RA

Interaction Score: 151.48

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Binding

Endogenous Drug? False

Direct Interaction? False

PMIDs:
23866823 28913336 22136436

Sources:
TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Ensembl: ENSG00000091181
- Version: 101_38
Alternate Names:

IL5RA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q01344
- Version: January-2014
Alternate Names:

IL5RA Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Publications:
GuideToPharmacology: 3568
- Version: 29-September-2020
Alternate Names:

6017 HUGO Gene ID

6017 HUGO Gene Symbol

interleukin 5 receptor subunit alpha HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name IL-3 receptor family

GuideToPharmacology Gene Category ID 306

Publications:

DrugBank: BE0003471

Version: 5.1.7

Alternate Names:

IL5RA DrugBank Gene Name

Q01344 UniProt Accession

3568 Entrez Gene Id

Gene Info:

Publications:

Laviolette M et al., 2013, Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia., J Allergy Clin Immunol

Bagnasco D et al., 2017, Anti-Interleukin 5 (IL-5) and IL-5Ra Biological Drugs: Efficacy, Safety, and Future Perspectives in Severe Eosinophilic Asthma., Front Med (Lausanne)

Ghazi A et al., 2012, Benralizumab--a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity--a novel approach for the treatment of asthma., Expert Opin Biol Ther

HingoraniCasas: ENSG00000091181
- Version: 31-May-2017
Alternate Names:

ENSG00000091181 Gene Symbol

IL5RA Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: IL5R
- Version: chembl_23
Alternate Names:

IL5R GENE_SYMBOL

IL5RA GENE_SYMBOL

Interleukin-5 receptor subunit alpha UNIPROT

Gene Info:

Publications:
Pharos: IL5RA
- Version: 03-September-2020
Alternate Names:

Interleukin-5 receptor subunit alpha Gene Name

Q01344 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
GO: IL5RA
- Version: 05-September-2020
Alternate Names:

IL5R GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: Interleukin 5 receptor alpha
- Version: 2020.06.01
Alternate Names:

IL5RA TTD Gene Abbreviation

T90828 TTD Target ID

Gene Info:

Publications:

Specific Action of the Ligand	Binding
Endogenous Drug?	False
Direct Interaction?	False

6017	HUGO Gene ID
6017	HUGO Gene Symbol
interleukin 5 receptor subunit alpha	HUGO Gene Name

IL5RA	DrugBank Gene Name
Q01344	UniProt Accession
3568	Entrez Gene Id

IL5R	GENE_SYMBOL
IL5RA	GENE_SYMBOL
Interleukin-5 receptor subunit alpha	UNIPROT

Interleukin-5 receptor subunit alpha	Gene Name
Q01344	UniProt ID

antibody (inhibitory)
inhibitor (inhibitory)

IL5RA Gene Record

IL5RA 3568 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

BENRALIZUMAB IL5RA

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Binding Endogenous Drug? False Direct Interaction? False

PMIDs: 23866823 28913336 22136436

Sources: TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Ensembl: ENSG00000091181

Alternate Names: IL5RA Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q01344

Alternate Names: IL5RA Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass Type 1 cytokine receptor

Publications:

GuideToPharmacology: 3568

Alternate Names: 6017 HUGO Gene ID 6017 HUGO Gene Symbol interleukin 5 receptor subunit alpha HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name IL-3 receptor family GuideToPharmacology Gene Category ID 306

Publications:

DrugBank: BE0003471

Alternate Names: IL5RA DrugBank Gene Name Q01344 UniProt Accession 3568 Entrez Gene Id

Gene Info:

HingoraniCasas: ENSG00000091181

Alternate Names: ENSG00000091181 Gene Symbol IL5RA Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: IL5R

Alternate Names: IL5R GENE_SYMBOL IL5RA GENE_SYMBOL Interleukin-5 receptor subunit alpha UNIPROT

Gene Info:

Publications:

Pharos: IL5RA

Alternate Names: Interleukin-5 receptor subunit alpha Gene Name Q01344 UniProt ID

Gene Info:

Gene Categories: TRANSCRIPTION FACTOR

Publications:

GO: IL5RA

Alternate Names: IL5R GO Gene Synonym

Gene Info:

Gene Categories: EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

TTD: Interleukin 5 receptor alpha

Alternate Names: IL5RA TTD Gene Abbreviation T90828 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Binding

Endogenous Drug? False

Direct Interaction? False

PMIDs:
23866823 28913336 22136436

Sources:
TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Alternate Names:

IL5RA Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

IL5RA Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Alternate Names:

6017 HUGO Gene ID

6017 HUGO Gene Symbol

interleukin 5 receptor subunit alpha HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name IL-3 receptor family

GuideToPharmacology Gene Category ID 306

Alternate Names:

IL5RA DrugBank Gene Name

Q01344 UniProt Accession

3568 Entrez Gene Id

Alternate Names:

ENSG00000091181 Gene Symbol

IL5RA Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

IL5R GENE_SYMBOL

IL5RA GENE_SYMBOL

Interleukin-5 receptor subunit alpha UNIPROT

Alternate Names:

Interleukin-5 receptor subunit alpha Gene Name

Q01344 UniProt ID

Gene Categories:

TRANSCRIPTION FACTOR

Alternate Names:

IL5R GO Gene Synonym

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

IL5RA TTD Gene Abbreviation

T90828 TTD Target ID