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IL2RA Gene Record

  • Summary
  • Interactions
  • Claims
  • IL2RA 3559 Druggable Genome

    Alternate Names:

    3559
    INTERLEUKIN 2 RECEPTOR SUBUNIT ALPHA
    IL2RA
    CD25
    IDDM10
    IL2R
    IMD41
    TCGFR
    p55
    147730
    6008
    ENSG00000134460
    OTTHUMG00000017616
    P01589
    IL2RA_HUMAN
    IL-2 receptor subunit alpha
    CD_antigen=CD25
    TAC antigen
    Interleukin-2 receptor subunit alpha
    IL-2R subunit alpha
    IL-2-RA
    IL2-RA
    P42701
    IL12RB1
    PA29828
    Interleukin 2 receptor
    T20710
    Interleukin 2 receptor alpha
    T03313

    Gene Info:

    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Type 1 cytokine receptor
    Target Subclass CytokineR
    Target Main Class Receptors
    Transmembrane Helix Count 1
    Target Subclass IG
    Target Subclass Type1
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Garcia et al., Plasmapheresis for recurrent posttransplant focal segmental glomerulosclerosis., Transplant. Proc.
    Monti et al., 2009, Disengaging the IL-2 receptor with daclizumab enhances IL-7-mediated proliferation of CD4(+) and CD8(+) T cells., Am. J. Transplant.
    Shamsi et al., 2005, Allogeneic peripheral blood stem cell transplant (PBSCT) using anti-IL2 receptor antibody Daclizumab for the prevention of acute graft versus host disease in steroid refractory Diamond Blackfan anaemia: a case report., J Pak Med Assoc
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Krouwels et al., 1996, Glucocorticosteroids affect functions of airway- and blood-derived human T-cell clones, favoring the Th1 profile through two mechanisms., Am. J. Respir. Cell Mol. Biol.
    Przepiorka et al., 2000, Daclizumab, a humanized anti-interleukin-2 receptor alpha chain antibody, for treatment of acute graft-versus-host disease., Blood
    Patlolla et al., 2007, Efficacy of anti-IL-2 receptor antibodies compared to no induction and to antilymphocyte antibodies in renal transplantation., Am. J. Transplant.
    Dornand et al., 1992, Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line., J. Cell. Physiol.
    Elias et al., 1993, Effect of propylthiouracil and methimazole on serum levels of interleukin-2 receptors in patients with psoriasis., Int. J. Dermatol.
    Gessl et al., 1995, Activated naive CD4+ peripheral blood T cells in autoimmune thyroid disease., Thyroid
    Balázs, 1991, Increased level of soluble interleukin-2 receptor in sera of patients with Graves' disease., Biomed. Pharmacother.
    Liu et al., 1998, Similarities between the sensitivity to 2-chlorodeoxyadenosine of lymphocytes from CLL patients and bryostatin 1-treated WSU-CLL cells: an infrared spectroscopic study., Cancer Lett.
    Kovarik et al., 1998, Disposition and immunodynamics of basiliximab in liver allograft recipients., Clin. Pharmacol. Ther.
    Berard et al., 1999, A review of interleukin-2 receptor antagonists in solid organ transplantation., Pharmacotherapy
    Choy et al., 2003, IL2-receptor antagonist (basiliximab) induction therapy is associated with lower morbidity and mortality in renal transplant recipients., Transplant. Proc.
    Mentré et al., 1999, Constructing a prediction interval for time to reach a threshold concentration based on a population pharmacokinetic analysis: an application to basiliximab in renal transplantation., J Pharmacokinet Biopharm
    Messingham et al., 2001, Testosterone receptor blockade restores cellular immunity in male mice after burn injury., J. Endocrinol.
    Nakase et al., 1997, Clinical importance of interleukin-2 receptor alpha-chain expression in acute leukemia. The Japan Cooperative Group of Leukemia/Lymphoma., Cancer Detect. Prev.
    Bleeker et al., T-cell evaluation in patients with colon cancer: dinitrochlorobenzene skin testing versus plasma levels of sIL-2r and sCD8., Ann. Surg. Oncol.
    Liu et al., 2006, [Screening of short peptides binding to cell surface interleukin-2 receptor alpha chain]., Nan Fang Yi Ke Da Xue Xue Bao
    Ouyang et al., 1999, Phospholipase A2 inhibitors p-bromophenacyl bromide and arachidonyl trifluoromethyl ketone suppressed interleukin-2 (IL-2) expression in murine primary splenocytes., Arch. Toxicol.
    Recchia et al., 2003, Low dose interleukin-2 and 13-cis-retinoic acid as maintenance therapy in patients with solid tumors responsive to chemotherapy., J. Exp. Clin. Cancer Res.
    Waldmann, 2007, Daclizumab (anti-Tac, Zenapax) in the treatment of leukemia/lymphoma., Oncogene
    Waldmann, 2007, Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: a 25-year personal odyssey., J. Clin. Immunol.
    Vlad et al., 2007, Anti-CD25 treatment and FOXP3-positive regulatory T cells in heart transplantation., Transpl. Immunol.
    Sugita et al., 1992, [Analysis of lymphocyte surface markers in childhood acute lymphoblastic leukemia during maintenance chemotherapy]., Gan To Kagaku Ryoho
    Kos et al., 2000, Protective role of IL-2 during activation of T cells with bryostatin 1., Int. J. Immunopharmacol.
    Mantzavinos et al., 1996, Serum markers of immune activation in women undergoing in-vitro fertilization and embryo transfer., Hum. Reprod.
    Attanasio et al., 2002, Immunomodulatory effects of estrogen and progesterone replacement in a nonhuman primate model., J. Clin. Immunol.
    Goebel et al., 2006, Tubulin polymerization modulates interleukin-2 receptor signal transduction in human T cells., J. Recept. Signal Transduct. Res.
    Balaji et al., 1997, Effect of 5-fluorouracil on interleukin-1 and interleukin-2 receptor expression., Biochem. Mol. Biol. Int.
    Wan, 1998, [Effects of lentinan of peripheral blood mononuclear cell expression of interleukin-2 receptor in patients with chronic hepatitis B in vivo and in vitro]., Hunan Yi Ke Da Xue Xue Bao
    Zwirska-Korczala et al., 2004, Influence of thyroxine on serum soluble interleukin-2 receptor alpha levels in thyroid disorders., J Clin Pharm Ther
    Walz et al., 1989, Similar effects of cyclosporine and verapamil on lymphokine, interleukin 2 receptor, and proto-oncogene expression., Transplantation
    Goebel et al., 2005, Atorvastatin affects interleukin-2 signaling by altering the lipid raft enrichment of the interleukin-2 receptor beta chain., J. Investig. Med.
    Duvic et al., 2008, Optimizing denileukin diftitox (Ontak) therapy., Future Oncol
    Kiyokawa et al., 1989, Cytotoxicity of interleukin 2-toxin toward lymphocytes from patients with adult T-cell leukemia., Cancer Res.
    Turturro, 2007, Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders., Expert Rev Anticancer Ther
    Murphy et al., 1988, Interleukin 2 toxin: a step toward selective immunomodulation., Am. J. Kidney Dis.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Colić et al., 2000, Garlic extracts stimulate proliferation of rat lymphocytes in vitro by increasing IL-2 and IL-4 production., Immunopharmacol Immunotoxicol
    Hancock et al., 1988, Recombinant granulocyte-macrophage colony-stimulating factor down-regulates expression of IL-2 receptor on human mononuclear phagocytes by induction of prostaglandin E., J. Immunol.
    Forrest et al., 2005, Daclizumab therapy in kidney transplantation-different mechanisms of action in- versus ex-vivo?, Transpl. Immunol.
    Caproni et al., 1995, Pharmacologic modulation by cetirizine of some adhesion molecules expression in psoriatic skin lesions., Int. J. Dermatol.
    Reddy et al., 1991, Evaluation of HIV P24 antigen, beta 2-microglobulin, neopterin, soluble CD4, soluble CD8, and soluble interleukin-2 receptor levels in patients with AIDS or AIDS-related complex treated with 2',3'-dideoxyinosine (ddI)., J. Clin. Lab. Anal.
  • BASILIXIMAB   IL2RA

    Interaction Score: 7.11

    Interaction Types & Directionality:
    antibody (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interleukin-2 receptor inhibitor
    Direct Interaction yes
    Trial Name basiliximab,Simulect

    PMIDs:
    9695721 10512062 12591363 16908318 11752352 10567956


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • ALDESLEUKIN   IL2RA

    Interaction Score: 5.33

    Interaction Types & Directionality:
    agonist (activating)
    modulator

    Interaction Info:
    Novel drug target Established target
    Trial Name Proleukin IL-2
    Mechanism of Interaction Interleukin-2 receptor agonist

    PMIDs:
    16864089 10207608 16767920 11752352 17530023 17216565 17584597


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DACLIZUMAB   IL2RA

    Interaction Score: 5.33

    Interaction Types & Directionality:
    antibody (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interleukin-2 receptor inhibitor
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    16908318 19788505 16304857 11752352 8600944 10607689 17564638


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DENILEUKIN DIFTITOX   IL2RA

    Interaction Score: 4.26

    Interaction Types & Directionality:
    binder

    Interaction Info:
    Mechanism of Interaction Interleukin-2 receptor binding agent
    Direct Interaction yes

    PMIDs:
    18684057 2786749 17187516 3124610 11752352 17016423 17139284


    Sources:
    ChemblInteractions

  • LENTINAN   IL2RA

    Interaction Score: 4.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10681809


    Sources:
    NCI

  • DINITROCHLOROBENZENE   IL2RA

    Interaction Score: 4.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9607619


    Sources:
    NCI

  • LMB-2   IL2RA

    Interaction Score: 4.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Interleukin-2 receptor alpha chain binding agent

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • INOLIMOMAB   IL2RA

    Interaction Score: 4.26

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Interleukin-2 receptor alpha chain antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • CETIRIZINE   IL2RA

    Interaction Score: 0.85

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7591422


    Sources:
    NCI

  • METHIMAZOLE   IL2RA

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8340196 7647571 1760523


    Sources:
    NCI

  • GARLIC   IL2RA

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10737264


    Sources:
    NCI

  • DECITABINE   IL2RA

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15814281


    Sources:
    NCI

  • DIDANOSINE   IL2RA

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1774603


    Sources:
    NCI

  • THYROXINE   IL2RA

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15068404


    Sources:
    NCI

  • BRYOSTATIN   IL2RA

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10988359


    Sources:
    NCI

  • METHYLPREDNISOLONE   IL2RA

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8981122


    Sources:
    NCI

  • CLADRIBINE   IL2RA

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9619876


    Sources:
    NCI

  • PROPYLTHIOURACIL   IL2RA

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8340196


    Sources:
    NCI

  • ALDESLEUKIN   IL2RA

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name IRX-2
    Novel drug target Established target

    PMIDs:
    9167045


    Sources:
    TdgClinicalTrial NCI

  • FLUTAMIDE   IL2RA

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11312147


    Sources:
    NCI

  • THEOPHYLLINE   IL2RA

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3129507


    Sources:
    NCI

  • CAFFEINE   IL2RA

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3129507


    Sources:
    NCI

  • STAUROSPORINE   IL2RA

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1560050


    Sources:
    NCI

  • VERAPAMIL   IL2RA

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2645720


    Sources:
    NCI

  • MERCAPTOPURINE   IL2RA

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1580639


    Sources:
    NCI

  • ATORVASTATIN   IL2RA

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16207471


    Sources:
    NCI

  • PROGESTERONE   IL2RA

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12405159


    Sources:
    NCI

  • PACLITAXEL   IL2RA

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16595340


    Sources:
    NCI

  • FLUOROURACIL   IL2RA

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9238541


    Sources:
    NCI

  • Ensembl: ENSG00000134460

    • Version: 101_38

    Alternate Names:
    IL2RA Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P42701

    • Version: January-2014

    Alternate Names:
    IL12RB1 Gene Symbol
    IL2RA Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Type 1 cytokine receptor

    Publications:

  • TEND: P01589

    • Version: 01-August-2011

    Alternate Names:
    P01589 Uniprot Accession
    3559 Entrez Gene Id
    IL2RA Gene Symbol

    Gene Info:
    Target Subclass CytokineR
    Target Main Class Receptors
    Transmembrane Helix Count 1

    Publications:

  • TdgClinicalTrial: P01589

    • Version: January-2014

    Alternate Names:
    IL2RA Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass Receptor
    Target Subclass Type 1 cytokine receptor

    Publications:

  • NCI: IL2RA

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Dornand et al., 1992, Contrasting effects of the protein kinase C inhibitor staurosporine on the interleukin-1 and phorbol ester activation pathways in the EL4-6.1 thymoma cell line., J. Cell. Physiol.
    Messingham et al., 2001, Testosterone receptor blockade restores cellular immunity in male mice after burn injury., J. Endocrinol.
    Bleeker et al., T-cell evaluation in patients with colon cancer: dinitrochlorobenzene skin testing versus plasma levels of sIL-2r and sCD8., Ann. Surg. Oncol.

  • ChemblInteractions: IL2RA

    • Version: chembl_23

    Alternate Names:
    p55 UNIPROT
    IL2RA GENE_SYMBOL
    Interleukin-2 receptor subunit alpha UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000134460

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000134460 Gene Symbol
    IL2RA Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: IL2RA

    • Version: 18-August-2020

    Alternate Names:
    PA29828 PharmGKB ID

    Gene Info:

    Publications:

  • Tempus: IL2RA

    • Version: 11-November-2018

    Alternate Names:
    IL2RA Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: Interleukin 2 receptor

    • Version: 2020.06.01

    Alternate Names:
    IL2R TTD Gene Abbreviation
    T20710 TTD Target ID

    Gene Info:

    Publications:

  • TTD: Interleukin 2 receptor alpha

    • Version: 2020.06.01

    Alternate Names:
    IL2RA TTD Gene Abbreviation
    T03313 TTD Target ID

    Gene Info:

    Publications:

  • FDA: IL2RA

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

  • GO: IL2RA

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21