DGIdb - IL2 Gene Record

IL2 3558 Druggable GenomeClinically Actionable

Alternate Names:

3558
INTERLEUKIN 2
IL2
IL-2
TCGF
lymphokine
147680
6001
ENSG00000109471
OTTHUMG00000133075
PA195
Interleukin-2
T61698

Gene Info:

Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

GROWTH FACTOR
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Nagler et al., 2004, Suppression of hepatocellular carcinoma growth in mice by the alkaloid coccidiostat halofuginone., Eur. J. Cancer
Peng et al., 2004, Effect of catecholamines on IL-2 production and NK cytotoxicity of rats in vitro., Acta Pharmacol. Sin.
Figueroa et al., 1993, [Pharmacological modification of prolactinemia. Effects on cellular immune function in normal subjects]., Rev Med Chil
Bygbjerg et al., 1987, Effect of antimalarial drugs on stimulation and interleukin 2 production of human lymphocytes., Int. J. Immunopharmacol.
Dos Reis et al., 1988, Stage-specific distinctions in potassium channel blocker control of T-lymphocyte activation., Int. J. Immunopharmacol.
Van Gool et al., 1995, Accessory signalling by B7-1 for T cell activation induced by anti-CD2: evidence for IL-2-independent CTL generation and CsA-resistant cytokine production., Scand. J. Immunol.
Ma et al., 2002, The role of Ras in T lymphocyte activation., Cell. Signal.
Di Marco et al., 1993, The effect of cefepime on some immune parameters in vitro: lack of interference with mitogen-induced lymphoproliferation, immunoglobulin synthesis, IFN-gamma and IL-2 secretion and IL-2 receptor expression., J Chemother
Márquez A et al., 2013, IL2/IL21 region polymorphism influences response to rituximab in systemic lupus erythematosus patients., Mol Biol Rep
Bessler et al., 2005, In vitro effect of statins on cytokine production and mitogen response of human peripheral blood mononuclear cells., Clin. Immunol.
Alex et al., 1995, Compatibility and activity of aldesleukin (recombinant interleukin-2) in presence of selected drugs during simulated Y-site administration: evaluation of three methods., Am J Health Syst Pharm
Biglino et al., 1990, Effects of ofloxacin on cell-mediated immune response and lymphokine production., J. Antimicrob. Chemother.
Hammer et al., 2005, Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging., J. Clin. Endocrinol. Metab.
Anderson et al., 1992, Biological activity of recombinant interleukin-2 in intravenous admixtures containing antibiotic, morphine sulfate, or total parenteral nutrient solution., Am J Hosp Pharm
Puc et al., 1998, Mitochondrial activity after cold preservation of pancreatic islet cells treated with pefloxacin (PFX)., Ann. Transplant.
Sireci et al., 1999, Effects of glyburide-cyclosporin A interaction on interleukin-2 production in rats., Immunopharmacol Immunotoxicol
Haq, 1986, 1,25-Dihydroxyvitamin D3 (calcitriol) suppresses IL-2 induced murine thymocyte proliferation., Thymus
Konno et al., 1992, Influences of roxithromycin on cell-mediated immune responses., Life Sci.
Szuster-Ciesielska et al., Neuroleptics modulate cytokine and reactive oxygen species production in blood leukocytes of healthy volunteers., Arch. Immunol. Ther. Exp. (Warsz.)
Baba et al., 2006, Effects of N-acyl-2-hydroxymethyl aziridines on in vitro proliferative responses of human lymphocytes stimulated by mitogens., Gen. Physiol. Biophys.
Schmidt et al., Effect of corticosteroids, cyclosporin A, and methotrexate on cytokine release from monocytes and T-cell subsets., Immunopharmacology
Cools et al., 1992, Lack of immunosuppression by ketoconazole and itraconazole., Int. J. Immunopharmacol.
Pasqui et al., 1995, Imipenem and immune response: in vitro and in vivo studies., Drugs Exp Clin Res
Bernand et al., 2000, Multifocal fixed drug eruption to paracetamol, tropisetron and ondansetron induced by interleukin 2., Dermatology (Basel)
Abdul Hamied et al., 1987, Effects of adriamycin, 4-hydroperoxycyclophosphamide and ASTA Z 7557 (INN mafosfamide) on the release of IL-2 and IL-1 in vitro., Int. J. Immunopharmacol.
Hall et al., Long-term exposure to methotrexate induces immunophenotypic changes, decreased methotrexate uptake and increased dihydrofolate gene copy number in Jurkat T cells., Int. J. Immunopharmacol.
Colić et al., 2000, Garlic extracts stimulate proliferation of rat lymphocytes in vitro by increasing IL-2 and IL-4 production., Immunopharmacol Immunotoxicol

IMIPENEM IL2

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7796708

Sources:
NCI
AZIRIDINE IL2

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17197726

Sources:
NCI
CEFEPIME IL2

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8106902

Sources:
NCI
THYMOCTONAN IL2

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TICARCILLIN IL2

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1598936

Sources:
NCI
PEFLOXACIN IL2

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9869897

Sources:
NCI
QUININE IL2

Interaction Score: 0.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3497888 2846451

Sources:
NCI
PERFOSFAMIDE IL2

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3497116

Sources:
NCI
HALOFUGINONE IL2

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15177499

Sources:
NCI
TROPISETRON IL2

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11053919

Sources:
NCI
ALDESLEUKIN IL2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ROXITHROMYCIN IL2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1513198

Sources:
NCI
DACLIZUMAB IL2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GARLIC IL2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10737264

Sources:
NCI
PYRIMETHAMINE IL2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3497888

Sources:
NCI
ITRACONAZOLE IL2

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1330944

Sources:
NCI
CALCITRIOL IL2

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3492067

Sources:
NCI
OFLOXACIN IL2

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2115511

Sources:
NCI
METYROSINE IL2

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15456539

Sources:
NCI
BECLOMETHASONE IL2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8071057

Sources:
NCI
METOCLOPRAMIDE IL2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8191163

Sources:
NCI
RITUXIMAB IL2

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23645042

Sources:
PharmGKB
GLYBURIDE IL2

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10466081

Sources:
NCI
BROMOCRIPTINE IL2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8191163

Sources:
NCI
PRASTERONE IL2

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16091484

Sources:
NCI
GENTAMICIN IL2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1598936

Sources:
NCI
PROCHLORPERAZINE IL2

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8564607

Sources:
NCI
PRAVASTATIN IL2

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16051523

Sources:
NCI
ACETAMINOPHEN IL2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11053919

Sources:
NCI
CYCLOSPORINE IL2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7529939 12135706

Sources:
NCI
CLOZAPINE IL2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15053234

Sources:
NCI
METHOTREXATE IL2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9669212

Sources:
NCI

Ensembl: ENSG00000109471
- Version: 101_38
Alternate Names:

IL2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
PharmGKB: IL2
- Version: 18-August-2020
Alternate Names:

PA195 PharmGKB ID

Gene Info:

Publications:

Márquez A et al., 2013, IL2/IL21 region polymorphism influences response to rituximab in systemic lupus erythematosus patients., Mol Biol Rep
TTD: Interleukin-2
- Version: 2020.06.01
Alternate Names:

IL2 TTD Gene Abbreviation

T61698 TTD Target ID

Gene Info:

Publications:

Hoyos V et al., 2012, Genetic modification of human T lymphocytes for the treatment of hematologic malignancies., Haematologica

NCI: IL2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Bygbjerg et al., 1987, Effect of antimalarial drugs on stimulation and interleukin 2 production of human lymphocytes., Int. J. Immunopharmacol.

Dos Reis et al., 1988, Stage-specific distinctions in potassium channel blocker control of T-lymphocyte activation., Int. J. Immunopharmacol.

Alex et al., 1995, Compatibility and activity of aldesleukin (recombinant interleukin-2) in presence of selected drugs during simulated Y-site administration: evaluation of three methods., Am J Health Syst Pharm

HingoraniCasas: ENSG00000109471
- Version: 31-May-2017
Alternate Names:

ENSG00000109471 Gene Symbol

IL2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
CarisMolecularIntelligence: IL2
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
GO: IL2
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

GROWTH FACTOR

Publications:

IL2 Gene Record

IL2 3558 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7796708

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17197726

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8106902

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1598936

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9869897

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3497888 2846451

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3497116

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15177499

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11053919

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1513198

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10737264

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3497888

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1330944

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3492067

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2115511

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
7796708

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17197726

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8106902

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
1598936

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9869897

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3497888 2846451

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3497116

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15177499

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11053919

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
1513198

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
10737264

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3497888

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1330944

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3492067

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2115511

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15456539

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8071057

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8191163

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23645042

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
10466081

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8191163

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16091484

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1598936

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8564607