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IL2 Gene Record

  • Summary
  • Interactions
  • Claims
  • IL2 3558 Druggable GenomeClinically Actionable

    Alternate Names:

    3558
    INTERLEUKIN 2
    IL2
    IL-2
    TCGF
    lymphokine
    147680
    6001
    ENSG00000109471
    OTTHUMG00000133075
    PA195
    Interleukin-2
    T61698

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Nagler et al., 2004, Suppression of hepatocellular carcinoma growth in mice by the alkaloid coccidiostat halofuginone., Eur. J. Cancer
    Peng et al., 2004, Effect of catecholamines on IL-2 production and NK cytotoxicity of rats in vitro., Acta Pharmacol. Sin.
    Figueroa et al., 1993, [Pharmacological modification of prolactinemia. Effects on cellular immune function in normal subjects]., Rev Med Chil
    Bygbjerg et al., 1987, Effect of antimalarial drugs on stimulation and interleukin 2 production of human lymphocytes., Int. J. Immunopharmacol.
    Dos Reis et al., 1988, Stage-specific distinctions in potassium channel blocker control of T-lymphocyte activation., Int. J. Immunopharmacol.
    Van Gool et al., 1995, Accessory signalling by B7-1 for T cell activation induced by anti-CD2: evidence for IL-2-independent CTL generation and CsA-resistant cytokine production., Scand. J. Immunol.
    Ma et al., 2002, The role of Ras in T lymphocyte activation., Cell. Signal.
    Di Marco et al., 1993, The effect of cefepime on some immune parameters in vitro: lack of interference with mitogen-induced lymphoproliferation, immunoglobulin synthesis, IFN-gamma and IL-2 secretion and IL-2 receptor expression., J Chemother
    Márquez A et al., 2013, IL2/IL21 region polymorphism influences response to rituximab in systemic lupus erythematosus patients., Mol Biol Rep
    Bessler et al., 2005, In vitro effect of statins on cytokine production and mitogen response of human peripheral blood mononuclear cells., Clin. Immunol.
    Alex et al., 1995, Compatibility and activity of aldesleukin (recombinant interleukin-2) in presence of selected drugs during simulated Y-site administration: evaluation of three methods., Am J Health Syst Pharm
    Biglino et al., 1990, Effects of ofloxacin on cell-mediated immune response and lymphokine production., J. Antimicrob. Chemother.
    Hammer et al., 2005, Sex steroid metabolism in human peripheral blood mononuclear cells changes with aging., J. Clin. Endocrinol. Metab.
    Anderson et al., 1992, Biological activity of recombinant interleukin-2 in intravenous admixtures containing antibiotic, morphine sulfate, or total parenteral nutrient solution., Am J Hosp Pharm
    Puc et al., 1998, Mitochondrial activity after cold preservation of pancreatic islet cells treated with pefloxacin (PFX)., Ann. Transplant.
    Sireci et al., 1999, Effects of glyburide-cyclosporin A interaction on interleukin-2 production in rats., Immunopharmacol Immunotoxicol
    Haq, 1986, 1,25-Dihydroxyvitamin D3 (calcitriol) suppresses IL-2 induced murine thymocyte proliferation., Thymus
    Konno et al., 1992, Influences of roxithromycin on cell-mediated immune responses., Life Sci.
    Szuster-Ciesielska et al., Neuroleptics modulate cytokine and reactive oxygen species production in blood leukocytes of healthy volunteers., Arch. Immunol. Ther. Exp. (Warsz.)
    Baba et al., 2006, Effects of N-acyl-2-hydroxymethyl aziridines on in vitro proliferative responses of human lymphocytes stimulated by mitogens., Gen. Physiol. Biophys.
    Schmidt et al., Effect of corticosteroids, cyclosporin A, and methotrexate on cytokine release from monocytes and T-cell subsets., Immunopharmacology
    Cools et al., 1992, Lack of immunosuppression by ketoconazole and itraconazole., Int. J. Immunopharmacol.
    Pasqui et al., 1995, Imipenem and immune response: in vitro and in vivo studies., Drugs Exp Clin Res
    Bernand et al., 2000, Multifocal fixed drug eruption to paracetamol, tropisetron and ondansetron induced by interleukin 2., Dermatology (Basel)
    Abdul Hamied et al., 1987, Effects of adriamycin, 4-hydroperoxycyclophosphamide and ASTA Z 7557 (INN mafosfamide) on the release of IL-2 and IL-1 in vitro., Int. J. Immunopharmacol.
    Hall et al., Long-term exposure to methotrexate induces immunophenotypic changes, decreased methotrexate uptake and increased dihydrofolate gene copy number in Jurkat T cells., Int. J. Immunopharmacol.
    Colić et al., 2000, Garlic extracts stimulate proliferation of rat lymphocytes in vitro by increasing IL-2 and IL-4 production., Immunopharmacol Immunotoxicol
  • IMIPENEM   IL2

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7796708


    Sources:
    NCI

  • AZIRIDINE   IL2

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17197726


    Sources:
    NCI

  • CEFEPIME   IL2

    Interaction Score: 3.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8106902


    Sources:
    NCI

  • THYMOCTONAN   IL2

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TICARCILLIN   IL2

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1598936


    Sources:
    NCI

  • PEFLOXACIN   IL2

    Interaction Score: 1.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9869897


    Sources:
    NCI

  • QUININE   IL2

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3497888 2846451


    Sources:
    NCI

  • PERFOSFAMIDE   IL2

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3497116


    Sources:
    NCI

  • HALOFUGINONE   IL2

    Interaction Score: 0.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15177499


    Sources:
    NCI

  • TROPISETRON   IL2

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11053919


    Sources:
    NCI

  • ALDESLEUKIN   IL2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ROXITHROMYCIN   IL2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1513198


    Sources:
    NCI

  • DACLIZUMAB   IL2

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • GARLIC   IL2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10737264


    Sources:
    NCI

  • PYRIMETHAMINE   IL2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3497888


    Sources:
    NCI

  • ITRACONAZOLE   IL2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1330944


    Sources:
    NCI

  • CALCITRIOL   IL2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3492067


    Sources:
    NCI

  • OFLOXACIN   IL2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2115511


    Sources:
    NCI

  • METYROSINE   IL2

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15456539


    Sources:
    NCI

  • BECLOMETHASONE   IL2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8071057


    Sources:
    NCI

  • METOCLOPRAMIDE   IL2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8191163


    Sources:
    NCI

  • RITUXIMAB   IL2

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23645042


    Sources:
    PharmGKB

  • GLYBURIDE   IL2

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10466081


    Sources:
    NCI

  • BROMOCRIPTINE   IL2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8191163


    Sources:
    NCI

  • PRASTERONE   IL2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16091484


    Sources:
    NCI

  • GENTAMICIN   IL2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1598936


    Sources:
    NCI

  • PROCHLORPERAZINE   IL2

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8564607


    Sources:
    NCI

  • PRAVASTATIN   IL2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16051523


    Sources:
    NCI

  • ACETAMINOPHEN   IL2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11053919


    Sources:
    NCI

  • CYCLOSPORINE   IL2

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7529939 12135706


    Sources:
    NCI

  • CLOZAPINE   IL2

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15053234


    Sources:
    NCI

  • METHOTREXATE   IL2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9669212


    Sources:
    NCI

  • Ensembl: ENSG00000109471

    • Version: 101_38

    Alternate Names:
    IL2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: IL2

    • Version: 18-August-2020

    Alternate Names:
    PA195 PharmGKB ID

    Gene Info:

    Publications:
    Márquez A et al., 2013, IL2/IL21 region polymorphism influences response to rituximab in systemic lupus erythematosus patients., Mol Biol Rep

  • TTD: Interleukin-2

    • Version: 2020.06.01

    Alternate Names:
    IL2 TTD Gene Abbreviation
    T61698 TTD Target ID

    Gene Info:

    Publications:
    Hoyos V et al., 2012, Genetic modification of human T lymphocytes for the treatment of hematologic malignancies., Haematologica

  • NCI: IL2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Bygbjerg et al., 1987, Effect of antimalarial drugs on stimulation and interleukin 2 production of human lymphocytes., Int. J. Immunopharmacol.
    Dos Reis et al., 1988, Stage-specific distinctions in potassium channel blocker control of T-lymphocyte activation., Int. J. Immunopharmacol.
    Alex et al., 1995, Compatibility and activity of aldesleukin (recombinant interleukin-2) in presence of selected drugs during simulated Y-site administration: evaluation of three methods., Am J Health Syst Pharm

  • HingoraniCasas: ENSG00000109471

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000109471 Gene Symbol
    IL2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • CarisMolecularIntelligence: IL2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • GO: IL2

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21