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IL1B Gene Record

  • Summary
  • Interactions
  • Claims
  • IL1B 3553 Druggable Genome

    Alternate Names:

    3553
    INTERLEUKIN 1 BETA
    IL1B
    IL-1
    IL1-BETA
    IL1F2
    147720
    5992
    ENSG00000125538
    OTTHUMG00000131344
    IL-1 beta
    Interleukin-1 beta
    Catabolin
    P01584
    IL1B_HUMAN
    PA29808
    INTERLEUKIN-1
    IL-1-beta
    T42000
    IL1
    T95488
    IL1beta

    Gene Info:

    Target Subclass Cytokine
    Target Main Class Other
    Target Subclass Ligand
    Target Class Miscellaneous
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUGGABLE GENOME

    Publications:

    Bacon et al., 1989, Potent and specific inhibition of IL-8-, IL-1 alpha- and IL-1 beta-induced in vitro human lymphocyte migration by calcium channel antagonists., Biochem. Biophys. Res. Commun.
    Takeshita et al., 1989, Immunological and anti-inflammatory effects of clarithromycin: inhibition of interleukin 1 production of murine peritoneal macrophages., Drugs Exp Clin Res
    Ma et al., 2005, Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis., Inflamm. Res.
    Tran et al., 2013, Role of interleukin-1 inhibitors in the management of gout., Pharmacotherapy
    Cronstein et al., 2013, Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis., J Clin Rheumatol
    Shiotani A et al., 2009, The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy., J Gastroenterol
    Hettmannsperger et al., 1992, Cytokine-stimulated human dermal microvascular endothelial cells produce interleukin 6--inhibition by hydrocortisone, dexamethasone, and calcitriol., J. Invest. Dermatol.
    Schmitt et al., 1987, Systemic administration of etretin increases epidermal interleukin I in the rat., Br. J. Dermatol.
    Corral-Gudino L et al., 2006, -511 C/T IL1B gene polymorphism is associated to resistance to bisphosphonates treatment in Paget disease of bone., Bone
    Zhang L et al., 2010, The effect of cytochrome P2C19 and interleukin-1 polymorphisms on H. pylori eradication rate of 1-week triple therapy with omeprazole or rabeprazole, amoxycillin and clarithromycin in Chinese people., J Clin Pharm Ther
    Sugimoto et al., 2006, Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy., Clin. Pharmacol. Ther.
    Take S et al., 2003, Interleukin-1beta genetic polymorphism influences the effect of cytochrome P 2C19 genotype on the cure rate of 1-week triple therapy for Helicobacter pylori infection., Am J Gastroenterol
    Nakane et al., 1990, Effects of IL-1 and cortisol on beta-adrenergic receptors, cell proliferation, and differentiation in cultured human A549 lung tumor cells., J. Immunol.
    Roche et al., 1988, Interleukin-1 production by antibiotic-treated human monocytes., J. Antimicrob. Chemother.
    Gogusev et al., Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21)., Anticancer Res.
    Loft ND et al., 2018, Associations between functional polymorphisms and response to biological treatment in Danish patients with psoriasis., Pharmacogenomics J
    Gao et al., 1997, Characterization and cytokine-stimulating activities of acidic heteroglycans from Tremella fuciformis., Planta Med.
    Somogyi AA et al., 2016, Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain., Pain
    Rajasekaran K et al., 2011, A swell in the armamentarium of antiepileptic drug targets., Epilepsy Curr
    Ikeda et al., 1991, Interleukin-1 suppresses mesangial cell growth via inhibition of Ca2+ entry., Cytokine
    Church et al., 2009, Canakinumab, a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders., Curr. Opin. Mol. Ther.
    Cheung et al., 2003, Interleukin-6 (IL-6), IL-1, receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin production by human osteoblastic cells: comparison of the effects of 17-beta oestradiol and raloxifene., J. Endocrinol.
    Hadjiminas et al., 1994, Enhanced survival from cecal ligation and puncture with pentoxifylline is associated with altered neutrophil trafficking and reduced interleukin-1 beta expression but not inhibition of tumor necrosis factor synthesis., Surgery
    Yamashita et al., 1989, Interleukin-1 inhibits thyrotrophin-induced human thyroglobulin gene expression., J. Endocrinol.
    Colinas et al., 1995, The effects of interleukin-1 beta and tumor necrosis factor-alpha on in vitro colony formation by human hematopoietic progenitor cells exposed to doxorubicin or hydroquinone., Exp. Hematol.
    Elsässer-Beile et al., 1996, Cytokine production in leukocyte cultures during therapy with Echinacea extract., J. Clin. Lab. Anal.
    Lacruz-Guzmán D et al., 2013, Influence of polymorphisms and TNF and IL1β serum concentration on the infliximab response in Crohn's disease and ulcerative colitis., Eur J Clin Pharmacol
    Lehtimäki T et al., 2003, Interleukin-1B genotype modulates the improvement of coronary artery reactivity by lipid-lowering therapy with pravastatin: a placebo-controlled positron emission tomography study in young healthy men., Pharmacogenetics
    Morrey et al., 1994, Activation of human monocytes by the pineal hormone melatonin., J. Immunol.
    Abdul Hamied et al., 1987, Effects of adriamycin, 4-hydroperoxycyclophosphamide and ASTA Z 7557 (INN mafosfamide) on the release of IL-2 and IL-1 in vitro., Int. J. Immunopharmacol.
    Quay et al., Effect of pentamidine on cytokine (IL-1 beta, TNF alpha, IL-6) production by human alveolar macrophages in vitro., Exp. Lung Res.
  • CANAKINUMAB   IL1B

    Interaction Score: 10.03

    Interaction Types & Directionality:
    antibody (inhibitory)
    binder
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Canakinumab
    Novel drug target Established target
    Mechanism of Interaction Interleukin-1 beta inhibitor

    PMIDs:
    19169963


    Sources:
    MyCancerGenome TdgClinicalTrial ChemblInteractions TEND TTD

  • TT-301   IL1B

    Interaction Score: 3.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22131899


    Sources:
    TTD

  • GEVOKIZUMAB   IL1B

    Interaction Score: 3.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Interleukin-1 beta negative allosteric modulator
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • RILONACEPT   IL1B

    Interaction Score: 3.34

    Interaction Types & Directionality:
    binder
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interleukin-1 beta inhibitor
    Direct Interaction yes

    PMIDs:
    23553601 23319019


    Sources:
    ChemblInteractions TTD

  • PENTAMIDINE   IL1B

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8370344


    Sources:
    NCI

  • GLUCOSAMINE   IL1B

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TILUDRONIC ACID   IL1B

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16257277


    Sources:
    PharmGKB

  • THYROGLOBULIN   IL1B

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2788696


    Sources:
    NCI

  • MAFOSFAMIDE   IL1B

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3497116


    Sources:
    NCI

  • ECHINACEA, UNSPECIFIED   IL1B

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8951617


    Sources:
    NCI

  • RISEDRONIC ACID   IL1B

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16257277


    Sources:
    PharmGKB

  • RABEPRAZOLE   IL1B

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21054464 16815316 14638340


    Sources:
    PharmGKB

  • CELASTROL   IL1B

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DIACEREIN   IL1B

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AC-201
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • USTEKINUMAB   IL1B

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28696418


    Sources:
    PharmGKB

  • CLODRONIC ACID   IL1B

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16257277


    Sources:
    PharmGKB

  • LANSOPRAZOLE   IL1B

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21054464 16815316 14638340


    Sources:
    NCI PharmGKB

  • ACITRETIN   IL1B

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1431212 2954576


    Sources:
    NCI

  • OFLOXACIN   IL1B

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3260587


    Sources:
    NCI

  • NICARDIPINE   IL1B

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1888883


    Sources:
    NCI

  • CEFACLOR   IL1B

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3260587


    Sources:
    NCI

  • IBUDILAST   IL1B

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OMEPRAZOLE   IL1B

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21054464 16815316 14638340


    Sources:
    PharmGKB

  • HYDROQUINONE   IL1B

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7589278


    Sources:
    NCI

  • ALTEPLASE   IL1B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8615653


    Sources:
    NCI

  • ERYTHROMYCIN   IL1B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2534682


    Sources:
    NCI

  • INFLIXIMAB   IL1B

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22960943


    Sources:
    PharmGKB

  • MELATONIN   IL1B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8077674


    Sources:
    NCI

  • RALOXIFENE   IL1B

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12773123


    Sources:
    NCI

  • MORPHINE   IL1B

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27649267


    Sources:
    PharmGKB

  • PENTOXIFYLLINE   IL1B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8048000


    Sources:
    NCI

  • VERAPAMIL   IL1B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2686646


    Sources:
    NCI

  • PRAVASTATIN   IL1B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14515062


    Sources:
    PharmGKB

  • HYDROCORTISONE   IL1B

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2162889


    Sources:
    NCI

  • LITHIUM   IL1B

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9342951


    Sources:
    NCI

  • RESVERATROL   IL1B

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16389574


    Sources:
    NCI

  • ASPIRIN   IL1B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19448967


    Sources:
    PharmGKB

  • Ensembl: ENSG00000125538

    • Version: 101_38

    Alternate Names:
    IL1B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P01584

    • Version: January-2014

    Alternate Names:
    IL1B Gene Symbol

    Gene Info:
    Target Subclass Cytokine
    Target Class Miscellaneous
    Target Subclass Ligand

    Publications:

  • TEND: P01584

    • Version: 01-August-2011

    Alternate Names:
    3553 Entrez Gene Id
    IL1B Gene Symbol
    IL1B_HUMAN Uniprot Id

    Gene Info:
    Target Subclass Cytokine
    Target Main Class Other
    Target Subclass Ligand

    Publications:

  • PharmGKB: IL1B

    • Version: 18-August-2020

    Alternate Names:
    PA29808 PharmGKB ID

    Gene Info:

    Publications:
    Sugimoto et al., 2006, Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy., Clin. Pharmacol. Ther.
    Zhang L et al., 2010, The effect of cytochrome P2C19 and interleukin-1 polymorphisms on H. pylori eradication rate of 1-week triple therapy with omeprazole or rabeprazole, amoxycillin and clarithromycin in Chinese people., J Clin Pharm Ther
    Take S et al., 2003, Interleukin-1beta genetic polymorphism influences the effect of cytochrome P 2C19 genotype on the cure rate of 1-week triple therapy for Helicobacter pylori infection., Am J Gastroenterol

  • TTD: Interleukin-1 beta

    • Version: 2020.06.01

    Alternate Names:
    IL1B TTD Gene Abbreviation
    T42000 TTD Target ID

    Gene Info:

    Publications:
    Rajasekaran K et al., 2011, A swell in the armamentarium of antiepileptic drug targets., Epilepsy Curr

  • NCI: IL1B

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Bacon et al., 1989, Potent and specific inhibition of IL-8-, IL-1 alpha- and IL-1 beta-induced in vitro human lymphocyte migration by calcium channel antagonists., Biochem. Biophys. Res. Commun.
    Takeshita et al., 1989, Immunological and anti-inflammatory effects of clarithromycin: inhibition of interleukin 1 production of murine peritoneal macrophages., Drugs Exp Clin Res
    Ma et al., 2005, Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis., Inflamm. Res.

  • ChemblInteractions: IL1F2

    • Version: chembl_23

    Alternate Names:
    IL1F2 GENE_SYMBOL
    IL1B GENE_SYMBOL
    Interleukin-1 beta UNIPROT

    Gene Info:

    Publications:

  • MyCancerGenome: IL1B

    • Version: 20-Jun-2017

    Alternate Names:
    3553 Entrez Gene Id
    IL1B MyCancerGenome Gene Symbol
    IL-1-beta MyCancerGenome Reported Gene Name

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000125538

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000125538 Gene Symbol
    IL1B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Interleukin-1

    • Version: 2020.06.01

    Alternate Names:
    IL1 TTD Gene Abbreviation
    T95488 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: IL1B

    • Version: 01-February-2022

    Alternate Names:
    Interleukin-1 beta Gene Name
    P01584 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21