DGIdb - IL1B Gene Record

IL1B 3553 Druggable Genome

Alternate Names:

3553
INTERLEUKIN 1 BETA
IL1B
IL-1
IL1-BETA
IL1F2
147720
5992
ENSG00000125538
OTTHUMG00000131344
IL-1 beta
Interleukin-1 beta
Catabolin
P01584
IL1B_HUMAN
PA29808
INTERLEUKIN-1
IL-1-beta
T42000
IL1
T95488
IL1beta

Gene Info:

Target Subclass	Cytokine
Target Main Class	Other
Target Subclass	Ligand
Target Class	Miscellaneous
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

KINASE
DRUGGABLE GENOME

Publications:

Bacon et al., 1989, Potent and specific inhibition of IL-8-, IL-1 alpha- and IL-1 beta-induced in vitro human lymphocyte migration by calcium channel antagonists., Biochem. Biophys. Res. Commun.
Takeshita et al., 1989, Immunological and anti-inflammatory effects of clarithromycin: inhibition of interleukin 1 production of murine peritoneal macrophages., Drugs Exp Clin Res
Ma et al., 2005, Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis., Inflamm. Res.
Tran et al., 2013, Role of interleukin-1 inhibitors in the management of gout., Pharmacotherapy
Cronstein et al., 2013, Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis., J Clin Rheumatol
Shiotani A et al., 2009, The preventive factors for aspirin-induced peptic ulcer: aspirin ulcer and corpus atrophy., J Gastroenterol
Hettmannsperger et al., 1992, Cytokine-stimulated human dermal microvascular endothelial cells produce interleukin 6--inhibition by hydrocortisone, dexamethasone, and calcitriol., J. Invest. Dermatol.
Schmitt et al., 1987, Systemic administration of etretin increases epidermal interleukin I in the rat., Br. J. Dermatol.
Corral-Gudino L et al., 2006, -511 C/T IL1B gene polymorphism is associated to resistance to bisphosphonates treatment in Paget disease of bone., Bone
Zhang L et al., 2010, The effect of cytochrome P2C19 and interleukin-1 polymorphisms on H. pylori eradication rate of 1-week triple therapy with omeprazole or rabeprazole, amoxycillin and clarithromycin in Chinese people., J Clin Pharm Ther
Sugimoto et al., 2006, Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy., Clin. Pharmacol. Ther.
Take S et al., 2003, Interleukin-1beta genetic polymorphism influences the effect of cytochrome P 2C19 genotype on the cure rate of 1-week triple therapy for Helicobacter pylori infection., Am J Gastroenterol
Nakane et al., 1990, Effects of IL-1 and cortisol on beta-adrenergic receptors, cell proliferation, and differentiation in cultured human A549 lung tumor cells., J. Immunol.
Roche et al., 1988, Interleukin-1 production by antibiotic-treated human monocytes., J. Antimicrob. Chemother.
Gogusev et al., Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21)., Anticancer Res.
Loft ND et al., 2018, Associations between functional polymorphisms and response to biological treatment in Danish patients with psoriasis., Pharmacogenomics J
Gao et al., 1997, Characterization and cytokine-stimulating activities of acidic heteroglycans from Tremella fuciformis., Planta Med.
Somogyi AA et al., 2016, Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain., Pain
Rajasekaran K et al., 2011, A swell in the armamentarium of antiepileptic drug targets., Epilepsy Curr
Ikeda et al., 1991, Interleukin-1 suppresses mesangial cell growth via inhibition of Ca2+ entry., Cytokine
Church et al., 2009, Canakinumab, a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders., Curr. Opin. Mol. Ther.
Cheung et al., 2003, Interleukin-6 (IL-6), IL-1, receptor activator of nuclear factor kappaB ligand (RANKL) and osteoprotegerin production by human osteoblastic cells: comparison of the effects of 17-beta oestradiol and raloxifene., J. Endocrinol.
Hadjiminas et al., 1994, Enhanced survival from cecal ligation and puncture with pentoxifylline is associated with altered neutrophil trafficking and reduced interleukin-1 beta expression but not inhibition of tumor necrosis factor synthesis., Surgery
Yamashita et al., 1989, Interleukin-1 inhibits thyrotrophin-induced human thyroglobulin gene expression., J. Endocrinol.
Colinas et al., 1995, The effects of interleukin-1 beta and tumor necrosis factor-alpha on in vitro colony formation by human hematopoietic progenitor cells exposed to doxorubicin or hydroquinone., Exp. Hematol.
Elsässer-Beile et al., 1996, Cytokine production in leukocyte cultures during therapy with Echinacea extract., J. Clin. Lab. Anal.
Lacruz-Guzmán D et al., 2013, Influence of polymorphisms and TNF and IL1β serum concentration on the infliximab response in Crohn's disease and ulcerative colitis., Eur J Clin Pharmacol
Lehtimäki T et al., 2003, Interleukin-1B genotype modulates the improvement of coronary artery reactivity by lipid-lowering therapy with pravastatin: a placebo-controlled positron emission tomography study in young healthy men., Pharmacogenetics
Morrey et al., 1994, Activation of human monocytes by the pineal hormone melatonin., J. Immunol.
Abdul Hamied et al., 1987, Effects of adriamycin, 4-hydroperoxycyclophosphamide and ASTA Z 7557 (INN mafosfamide) on the release of IL-2 and IL-1 in vitro., Int. J. Immunopharmacol.
Quay et al., Effect of pentamidine on cytokine (IL-1 beta, TNF alpha, IL-6) production by human alveolar macrophages in vitro., Exp. Lung Res.

CANAKINUMAB IL1B

Interaction Score: 10.03

Interaction Types & Directionality:

antibody (inhibitory)

binder

inhibitor (inhibitory)

Interaction Info:

Trial Name Canakinumab

Novel drug target Established target

Mechanism of Interaction Interleukin-1 beta inhibitor

PMIDs:
19169963

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions TEND TTD
TT-301 IL1B

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22131899

Sources:
TTD
GEVOKIZUMAB IL1B

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Interleukin-1 beta negative allosteric modulator

Direct Interaction yes

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
RILONACEPT IL1B

Interaction Score: 3.34

Interaction Types & Directionality:

binder

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-1 beta inhibitor

Direct Interaction yes

PMIDs:
23553601 23319019

Sources:
ChemblInteractions TTD
PENTAMIDINE IL1B

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8370344

Sources:
NCI
GLUCOSAMINE IL1B

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TILUDRONIC ACID IL1B

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16257277

Sources:
PharmGKB
THYROGLOBULIN IL1B

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2788696

Sources:
NCI
MAFOSFAMIDE IL1B

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3497116

Sources:
NCI
ECHINACEA, UNSPECIFIED IL1B

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8951617

Sources:
NCI
RISEDRONIC ACID IL1B

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16257277

Sources:
PharmGKB
RABEPRAZOLE IL1B

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21054464 16815316 14638340

Sources:
PharmGKB
CELASTROL IL1B

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DIACEREIN IL1B

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AC-201

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
USTEKINUMAB IL1B

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28696418

Sources:
PharmGKB
CLODRONIC ACID IL1B

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16257277

Sources:
PharmGKB
LANSOPRAZOLE IL1B

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21054464 16815316 14638340

Sources:
NCI PharmGKB
ACITRETIN IL1B

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1431212 2954576

Sources:
NCI
OFLOXACIN IL1B

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3260587

Sources:
NCI
NICARDIPINE IL1B

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1888883

Sources:
NCI
CEFACLOR IL1B

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3260587

Sources:
NCI
IBUDILAST IL1B

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
OMEPRAZOLE IL1B

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21054464 16815316 14638340

Sources:
PharmGKB
HYDROQUINONE IL1B

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7589278

Sources:
NCI
ALTEPLASE IL1B

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8615653

Sources:
NCI
ERYTHROMYCIN IL1B

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2534682

Sources:
NCI
INFLIXIMAB IL1B

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22960943

Sources:
PharmGKB
MELATONIN IL1B

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8077674

Sources:
NCI
RALOXIFENE IL1B

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12773123

Sources:
NCI
MORPHINE IL1B

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27649267

Sources:
PharmGKB
PENTOXIFYLLINE IL1B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8048000

Sources:
NCI
VERAPAMIL IL1B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2686646

Sources:
NCI
PRAVASTATIN IL1B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14515062

Sources:
PharmGKB
HYDROCORTISONE IL1B

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2162889

Sources:
NCI
LITHIUM IL1B

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9342951

Sources:
NCI
RESVERATROL IL1B

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16389574

Sources:
NCI
ASPIRIN IL1B

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19448967

Sources:
PharmGKB

Ensembl: ENSG00000125538
- Version: 101_38
Alternate Names:

IL1B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P01584
- Version: January-2014
Alternate Names:

IL1B Gene Symbol

Gene Info:

Target Subclass Cytokine

Target Class Miscellaneous

Target Subclass Ligand

Publications:
TEND: P01584
- Version: 01-August-2011
Alternate Names:

3553 Entrez Gene Id

IL1B Gene Symbol

IL1B_HUMAN Uniprot Id

Gene Info:

Target Subclass Cytokine

Target Main Class Other

Target Subclass Ligand

Publications:

PharmGKB: IL1B

Version: 18-August-2020

Alternate Names:

PA29808 PharmGKB ID

Gene Info:

Publications:

Sugimoto et al., 2006, Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy., Clin. Pharmacol. Ther.

Zhang L et al., 2010, The effect of cytochrome P2C19 and interleukin-1 polymorphisms on H. pylori eradication rate of 1-week triple therapy with omeprazole or rabeprazole, amoxycillin and clarithromycin in Chinese people., J Clin Pharm Ther

Take S et al., 2003, Interleukin-1beta genetic polymorphism influences the effect of cytochrome P 2C19 genotype on the cure rate of 1-week triple therapy for Helicobacter pylori infection., Am J Gastroenterol

TTD: Interleukin-1 beta
- Version: 2020.06.01
Alternate Names:

IL1B TTD Gene Abbreviation

T42000 TTD Target ID

Gene Info:

Publications:

Rajasekaran K et al., 2011, A swell in the armamentarium of antiepileptic drug targets., Epilepsy Curr

NCI: IL1B

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Bacon et al., 1989, Potent and specific inhibition of IL-8-, IL-1 alpha- and IL-1 beta-induced in vitro human lymphocyte migration by calcium channel antagonists., Biochem. Biophys. Res. Commun.

Takeshita et al., 1989, Immunological and anti-inflammatory effects of clarithromycin: inhibition of interleukin 1 production of murine peritoneal macrophages., Drugs Exp Clin Res

Ma et al., 2005, Effect of resveratrol on peritoneal macrophages in rats with severe acute pancreatitis., Inflamm. Res.

ChemblInteractions: IL1F2
- Version: chembl_23
Alternate Names:

IL1F2 GENE_SYMBOL

IL1B GENE_SYMBOL

Interleukin-1 beta UNIPROT

Gene Info:

Publications:
MyCancerGenome: IL1B
- Version: 20-Jun-2017
Alternate Names:

3553 Entrez Gene Id

IL1B MyCancerGenome Gene Symbol

IL-1-beta MyCancerGenome Reported Gene Name

Gene Info:

Publications:
HingoraniCasas: ENSG00000125538
- Version: 31-May-2017
Alternate Names:

ENSG00000125538 Gene Symbol

IL1B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Interleukin-1
- Version: 2020.06.01
Alternate Names:

IL1 TTD Gene Abbreviation

T95488 TTD Target ID

Gene Info:

Publications:
Pharos: IL1B
- Version: 01-February-2022
Alternate Names:

Interleukin-1 beta Gene Name

P01584 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:

Trial Name	Canakinumab
Novel drug target	Established target
Mechanism of Interaction	Interleukin-1 beta inhibitor

Mechanism of Interaction	Interleukin-1 beta negative allosteric modulator
Direct Interaction	yes
Novel drug target	Established target

3553	Entrez Gene Id
IL1B	MyCancerGenome Gene Symbol
IL-1-beta	MyCancerGenome Reported Gene Name

antibody (inhibitory)
binder
inhibitor (inhibitory)

binder
inhibitor (inhibitory)

IL1B Gene Record

IL1B 3553 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antibody (inhibitory) binder inhibitor (inhibitory)

Interaction Info: Trial Name Canakinumab Novel drug target Established target Mechanism of Interaction Interleukin-1 beta inhibitor

PMIDs: 19169963

Sources: MyCancerGenome TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22131899

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Interleukin-1 beta negative allosteric modulator Direct Interaction yes Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: binder inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-1 beta inhibitor Direct Interaction yes

PMIDs: 23553601 23319019

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8370344

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16257277

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2788696

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3497116

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8951617

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16257277

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21054464 16815316 14638340

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name AC-201 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28696418

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16257277

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21054464 16815316 14638340

Sources: NCI PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1431212 2954576

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

antibody (inhibitory)

binder

inhibitor (inhibitory)

Interaction Info:

Trial Name Canakinumab

Novel drug target Established target

Mechanism of Interaction Interleukin-1 beta inhibitor

PMIDs:
19169963

Sources:
MyCancerGenome TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
22131899

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Interleukin-1 beta negative allosteric modulator

Direct Interaction yes

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

binder

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-1 beta inhibitor

Direct Interaction yes

PMIDs:
23553601 23319019

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
8370344

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
16257277

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
2788696

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3497116

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8951617

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16257277

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21054464 16815316 14638340

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AC-201

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
28696418

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16257277

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21054464 16815316 14638340

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
1431212 2954576

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3260587

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1888883

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3260587

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
21054464 16815316 14638340

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
7589278

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8615653

Sources:
NCI

Interaction Types & Directionality:

n/a