DGIdb - IL12B Gene Record

IL12B 3593 Druggable Genome

Alternate Names:

3593
INTERLEUKIN 12B
IL12B
CLMF
CLMF2
IL-12B
IMD28
IMD29
NKSF
NKSF2
161561
5970
ENSG00000113302
OTTHUMG00000130307
P29460
IL12B_HUMAN
Cytotoxic lymphocyte maturation factor 40 kDa subunit
IL-12 subunit p40
NK cell stimulatory factor chain 2
CLMF p40
Interleukin-12 subunit beta
PA29785
Interleukin-12 beta
T95385

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	Type 1 cytokine receptor
Target Class	Other
Target Main Class	Other
Target Subclass	Ligand
Target Subclass	Cytokine
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

GROWTH FACTOR
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Khanna et al., 2016, The Next Wave of Biological Agents for the Treatment of IBD: Evidence from Cochrane Reviews., Inflamm. Bowel Dis.
Engel et al., 2016, Ustekinumab in Crohn's disease: evidence to date and place in therapy., Ther Adv Chronic Dis
van den Reek JMPA et al., 2017, Polymorphisms in CD84, IL12B and TNFAIP3 are associated with response to biologics in patients with psoriasis., Br J Dermatol
Wittig, 2007, Drug evaluation: CNTO-1275, a mAb against IL-12/IL-23p40 for the potential treatment of inflammatory diseases., Curr Opin Investig Drugs
Reddy et al., 2007, Modulation of CLA, IL-12R, CD40L, and IL-2Ralpha expression and inhibition of IL-12- and IL-23-induced cytokine secretion by CNTO 1275., Cell. Immunol.
Ovejero-Benito MC et al., 2018, Polymorphisms associated with adalimumab and infliximab response in moderate-to-severe plaque psoriasis., Pharmacogenomics
Ovejero-Benito MC et al., 2017, Polymorphisms associated with etanercept response in moderate-to-severe plaque psoriasis., Pharmacogenomics

USTEKINUMAB IL12B

Interaction Score: 12.37

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-12 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
27306074 27433311 27564082 17979029 17761156

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB FDA
BRIAKINUMAB IL12B

Interaction Score: 12.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Briakinumab

Novel drug target Established target

Mechanism of Interaction Interleukin-23 inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
ETANERCEPT IL12B

Interaction Score: 1.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28470127

Sources:
PharmGKB
INFLIXIMAB IL12B

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29192552

Sources:
PharmGKB
ISOPROTERENOL IL12B

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000113302
- Version: 101_38
Alternate Names:

IL12B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P29460
- Version: 01-August-2011
Alternate Names:

ENSG00000113302 Ensembl Gene Id

IL12B Gene Symbol

P29460 Uniprot Accession

Gene Info:

Target Main Class Other

Target Subclass Ligand

Target Subclass Cytokine

Publications:
TdgClinicalTrial: P29460
- Version: January-2014
Alternate Names:

IL12B Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Publications:

PharmGKB: IL12B

Version: 18-August-2020

Alternate Names:

PA29785 PharmGKB ID

Gene Info:

Publications:

van den Reek JMPA et al., 2017, Polymorphisms in CD84, IL12B and TNFAIP3 are associated with response to biologics in patients with psoriasis., Br J Dermatol

Ovejero-Benito MC et al., 2017, Polymorphisms associated with etanercept response in moderate-to-severe plaque psoriasis., Pharmacogenomics

Prieto-Pérez R et al., 2018, New polymorphisms associated with response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis., Pharmacogenomics J

TTD: Interleukin-12 beta
- Version: 2020.06.01
Alternate Names:

IL12B TTD Gene Abbreviation

T95385 TTD Target ID

Gene Info:

Publications:

Lasek W et al., 2014, Interleukin 12: still a promising candidate for tumor immunotherapy?, Cancer Immunol Immunother
ChemblInteractions: NKSF2
- Version: chembl_23
Alternate Names:

NKSF2 GENE_SYMBOL

IL12B GENE_SYMBOL

Interleukin-12 subunit beta UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000113302
- Version: 31-May-2017
Alternate Names:

ENSG00000113302 Gene Symbol

IL12B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: IL12B
- Version: 01-February-2022
Alternate Names:

NKSF2 GO Gene Synonym

Gene Info:

Gene Categories:

GROWTH FACTOR, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
ClearityFoundationClinicalTrial: IL-12B
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
FDA: IL12B
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:

Mechanism of Interaction	Interleukin-12 inhibitor
Direct Interaction	yes
Trial Name	-

Trial Name	Briakinumab
Novel drug target	Established target
Mechanism of Interaction	Interleukin-23 inhibitor

ENSG00000113302	Ensembl Gene Id
IL12B	Gene Symbol
P29460	Uniprot Accession

NKSF2	GENE_SYMBOL
IL12B	GENE_SYMBOL
Interleukin-12 subunit beta	UNIPROT

antibody (inhibitory)
inhibitor (inhibitory)

IL12B Gene Record

IL12B 3593 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

USTEKINUMAB IL12B

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-12 inhibitor Direct Interaction yes Trial Name -

PMIDs: 27306074 27433311 27564082 17979029 17761156

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB FDA

BRIAKINUMAB IL12B

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Briakinumab Novel drug target Established target Mechanism of Interaction Interleukin-23 inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

ETANERCEPT IL12B

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28470127

Sources: PharmGKB

INFLIXIMAB IL12B

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29192552

Sources: PharmGKB

ISOPROTERENOL IL12B

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Ensembl: ENSG00000113302

Alternate Names: IL12B Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P29460

Alternate Names: ENSG00000113302 Ensembl Gene Id IL12B Gene Symbol P29460 Uniprot Accession

Gene Info: Target Main Class Other Target Subclass Ligand Target Subclass Cytokine

Publications:

TdgClinicalTrial: P29460

Alternate Names: IL12B Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass Type 1 cytokine receptor

Publications:

PharmGKB: IL12B

Alternate Names: PA29785 PharmGKB ID

Gene Info:

TTD: Interleukin-12 beta

Alternate Names: IL12B TTD Gene Abbreviation T95385 TTD Target ID

Gene Info:

Publications: Lasek W et al., 2014, Interleukin 12: still a promising candidate for tumor immunotherapy?, Cancer Immunol Immunother

ChemblInteractions: NKSF2

Alternate Names: NKSF2 GENE_SYMBOL IL12B GENE_SYMBOL Interleukin-12 subunit beta UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000113302

Alternate Names: ENSG00000113302 Gene Symbol IL12B Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: IL12B

Alternate Names: NKSF2 GO Gene Synonym

Gene Info:

Gene Categories: GROWTH FACTOR, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

ClearityFoundationClinicalTrial: IL-12B

Alternate Names:

Gene Info:

Publications:

FDA: IL12B

Alternate Names:

Gene Info:

Publications:

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-12 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
27306074 27433311 27564082 17979029 17761156

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB FDA

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Briakinumab

Novel drug target Established target

Mechanism of Interaction Interleukin-23 inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
28470127

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
29192552

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

IL12B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000113302 Ensembl Gene Id

IL12B Gene Symbol

P29460 Uniprot Accession

Gene Info:

Target Main Class Other

Target Subclass Ligand

Target Subclass Cytokine

Alternate Names:

IL12B Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Alternate Names:

PA29785 PharmGKB ID

Alternate Names:

IL12B TTD Gene Abbreviation

T95385 TTD Target ID

Publications:

Lasek W et al., 2014, Interleukin 12: still a promising candidate for tumor immunotherapy?, Cancer Immunol Immunother

Alternate Names:

NKSF2 GENE_SYMBOL

IL12B GENE_SYMBOL

Interleukin-12 subunit beta UNIPROT

Alternate Names:

ENSG00000113302 Gene Symbol

IL12B Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

NKSF2 GO Gene Synonym

Gene Categories:

GROWTH FACTOR, EXTERNAL SIDE OF PLASMA MEMBRANE