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IL10 Gene Record

  • Summary
  • Interactions
  • Claims
  • IL10 3586 Druggable GenomeClinically Actionable

    Alternate Names:

    3586
    INTERLEUKIN 10
    IL10
    CSIF
    GVHDS
    IL-10
    IL10A
    TGIF
    124092
    5962
    ENSG00000136634
    OTTHUMG00000036386
    Interleukin-10
    Cytokine synthesis inhibitory factor
    PA29778
    T09092

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE

    Publications:

    Zhang X et al., 2011, Impact of interleukin-10 gene polymorphisms on tacrolimus dosing requirements in Chinese liver transplant patients during the early posttransplantation period., Eur J Clin Pharmacol
    Brzozowska et al., 2004, Healing of chronic gastric ulcers in diabetic rats treated with native aspirin, nitric oxide (NO)-derivative of aspirin and cyclooxygenase (COX)-2 inhibitor., J. Physiol. Pharmacol.
    Nepomuceno et al., 2003, Rapamycin inhibits the interleukin 10 signal transduction pathway and the growth of Epstein Barr virus B-cell lymphomas., Cancer Res.
    Sam WJ et al., 2011, Associations of ABCB1 3435C>T and IL-10-1082G>A polymorphisms with long-term sirolimus dose requirements in renal transplant patients., Transplantation
    Sugimoto et al., 2006, Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy., Clin. Pharmacol. Ther.
    Santucci et al., 2005, Different sensitivity of lamina propria T-cell subsets to nitric oxide-induced apoptosis explains immunomodulatory activity of a nitric oxide-releasing derivative of mesalamine in rodent colitis., Gastroenterology
    Rodrigues Rde O et al., 2014, Interleukin-10 gene polymorphism (-1082G/A) and allergy to efavirenz in patients infected with human immunodeficiency virus., Braz J Infect Dis
    Visani et al., 1996, All-trans retinoic acid and in vitro cytokine production by acute promyelocytic leukemia cells., Eur. J. Haematol.
    Grinyó J et al., 2008, Association of four DNA polymorphisms with acute rejection after kidney transplantation., Transpl Int
    Wei et al., 2006, Expression of cytokines IL-2, IL-10 and TNF-alpha in mice with herpes simplex viral encephalitis., J. Huazhong Univ. Sci. Technol. Med. Sci.
    Epeldegui M et al., 2016, Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial)., Clin Cancer Res
    Kang et al., 1999, Modulation of ex vivo cytokine production by splenocytes using in vitro combined therapeutics in murine retroviral model., DNA Cell Biol.
    van Furth et al., 1997, Effect of lisofylline and pentoxifylline on the bacterial-stimulated production of TNF-alpha, IL-1 beta IL-10 by human leucocytes., Immunology
  • LISOFYLLINE   IL10

    Interaction Score: 3.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9227316


    Sources:
    NCI

  • PEGILODECAKIN   IL10

    Interaction Score: 3.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SCH-708980   IL10

    Interaction Score: 3.64

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interleukin-10 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ILODECAKIN   IL10

    Interaction Score: 3.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ACYCLOVIR   IL10

    Interaction Score: 1.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16961277


    Sources:
    NCI

  • ROFECOXIB   IL10

    Interaction Score: 1.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15613743


    Sources:
    NCI

  • RABEPRAZOLE   IL10

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16815316


    Sources:
    NCI

  • CLARITHROMYCIN   IL10

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16815316


    Sources:
    NCI

  • RITUXIMAB   IL10

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26384320


    Sources:
    PharmGKB

  • AMOXICILLIN   IL10

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16815316


    Sources:
    NCI

  • MESALAMINE   IL10

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15887108


    Sources:
    NCI

  • EFAVIRENZ   IL10

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24819158


    Sources:
    PharmGKB

  • SIROLIMUS   IL10

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12907620 22094953


    Sources:
    NCI PharmGKB

  • TRETINOIN   IL10

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8982293


    Sources:
    NCI

  • ZIDOVUDINE   IL10

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10433557


    Sources:
    NCI

  • TACROLIMUS   IL10

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21359536


    Sources:
    PharmGKB

  • CYCLOSPORINE   IL10

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18444945


    Sources:
    PharmGKB

  • Ensembl: ENSG00000136634

    • Version: 101_38

    Alternate Names:
    IL10 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: IL10

    • Version: 18-August-2020

    Alternate Names:
    PA29778 PharmGKB ID

    Gene Info:

    Publications:
    Rodrigues Rde O et al., 2014, Interleukin-10 gene polymorphism (-1082G/A) and allergy to efavirenz in patients infected with human immunodeficiency virus., Braz J Infect Dis
    Ferreira Vasconcelos LM et al., 2018, Polymorphism of IL10, IL4, CTLA4, and DAO Genes in Cross-Reactive Nonsteroidal Anti-inflammatory Drug Hypersensitivity., J Clin Pharmacol
    Grinyó J et al., 2008, Association of four DNA polymorphisms with acute rejection after kidney transplantation., Transpl Int

  • NCI: IL10

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    van Furth et al., 1997, Effect of lisofylline and pentoxifylline on the bacterial-stimulated production of TNF-alpha, IL-1 beta IL-10 by human leucocytes., Immunology
    Takaono et al., 2002, Effects of intravenous anesthetics on interleukin (IL)-6 and IL-10 production by lipopolysaccharide-stimulated mononuclear cells from healthy volunteers., Acta Anaesthesiol Scand
    Dorsey et al., 2002, Immunotherapy with interleukin-10 depends on the CXC chemokines inducible protein-10 and monokine induced by IFN-gamma., Cancer Res.

  • HingoraniCasas: ENSG00000136634

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000136634 Gene Symbol
    IL10 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: IL10

    • Version: chembl_23

    Alternate Names:
    IL10 GENE_SYMBOL
    Interleukin-10 UNIPROT
    Cytokine synthesis inhibitory factor UNIPROT

    Gene Info:

    Publications:

  • TTD: Interleukin-10

    • Version: 2020.06.01

    Alternate Names:
    IL10 TTD Gene Abbreviation
    T09092 TTD Target ID

    Gene Info:

    Publications:

  • MskImpact: IL10

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • GO: IL10

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    GROWTH FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21