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IKZF1 Gene Record

  • Summary
  • Interactions
  • Claims
  • IKZF1 10320 Clinically Actionable

    Alternate Names:

    10320
    IKAROS FAMILY ZINC FINGER 1
    IKZF1
    CVID13
    Hs.54452
    IK1
    IKAROS
    LYF1
    LyF-1
    PPP1R92
    PRO0758
    ZNFN1A1
    603023
    13176
    ENSG00000185811
    OTTHUMG00000155907
    73
    Q13422
    DNA-binding protein Ikaros

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Krönke et al., 2014, Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells., Science
    Yeoh AEJ et al., 2018, Intensifying Treatment of Childhood B-Lymphoblastic Leukemia With IKZF1 Deletion Reduces Relapse and Improves Overall Survival: Results of Malaysia-Singapore ALL 2010 Study., J Clin Oncol
  • LENALIDOMIDE   IKZF1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type multiple myeloma
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    24292625


    Sources:
    JAX-CKB

  • FLUDARABINE   IKZF1

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30044693


    Sources:
    CIViC

  • CYTARABINE   IKZF1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30044693


    Sources:
    CIViC

  • IMATINIB   IKZF1

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30044693


    Sources:
    CIViC

  • DAUNORUBICIN   IKZF1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30044693


    Sources:
    CIViC

  • METHOTREXATE   IKZF1

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30044693


    Sources:
    CIViC

  • Ensembl: ENSG00000185811

    • Version: 101_38

    Alternate Names:
    IKZF1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • JAX-CKB: IKZF1

    • Version: 27-September-2017

    Alternate Names:
    10320 CKB Entrez Id
    IKZF1 CKB Gene Synonym
    CVID13 CKB Gene Synonym

    Gene Info:

    Publications:
    Jia et al., 2014, The impact of IKZF1 deletion on the prognosis of acute lymphoblastic leukemia: an updated meta-analysis., Cancer Biomark
    Yao et al., 2016, Prognostic impact of IKZF1 deletion in adults with common B-cell acute lymphoblastic leukemia., BMC Cancer
    Ribera et al., 2015, Prognostic significance of copy number alterations in adolescent and adult patients with precursor B acute lymphoblastic leukemia enrolled in PETHEMA protocols., Cancer

  • CIViC: IKZF1

    • Version: 14-September-2020

    Alternate Names:
    10320 Entrez Gene ID
    73 CIViC Gene ID

    Gene Info:

    Publications:
    Yeoh AEJ et al., 2018, Intensifying Treatment of Childhood B-Lymphoblastic Leukemia With IKZF1 Deletion Reduces Relapse and Improves Overall Survival: Results of Malaysia-Singapore ALL 2010 Study., J Clin Oncol

  • Tempus: IKZF1

    • Version: 11-November-2018

    Alternate Names:
    IKZF1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: IKZF1

    • Version: 01-February-2022

    Alternate Names:
    DNA-binding protein Ikaros Gene Name
    Q13422 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

  • MskImpact: IKZF1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: IKZF1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: IKZF1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21