DGIdb - IGF2 Gene Record

IGF2 3481 Druggable GenomeClinically Actionable

Alternate Names:

3481
INSULIN LIKE GROWTH FACTOR 2
IGF2
C11orf43
GRDF
IGF-II
PP9974
147470
5466
ENSG00000129965
ENSG00000167244
OTTHUMG00000009395
T3M-11-derived growth factor
Insulin-like growth factor II
Insulin-like growth factor II Ala-25 Del
Preptin
Somatomedin-A
PP1446
P01344
60
PA29699
Insulin-like growth factor-II
T90572

Gene Info:

Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

GROWTH FACTOR
HORMONE ACTIVITY
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

Vidal et al., 2015, A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer., Cancer Cell
Ferrari et al., 2002, Short-term effects of anastrozole treatment on insulin-like growth factor system in postmenopausal advanced breast cancer patients., J. Steroid Biochem. Mol. Biol.
Desbois-Mouthon et al., 2006, Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib., Int. J. Cancer
Lund et al., 2004, Autocrine inhibition of chemotherapy response in human liver tumor cells by insulin-like growth factor-II., Cancer Lett.
Sterle et al., 1998, Insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein-2 and pregnancy-associated glycoprotein mRNA in pigs with somatotropin-enhanced fetal growth., J. Endocrinol.
Meng et al., 2004, Insulin-like growth factor-2 activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases., J. Gastrointest. Surg.
Aberdeen et al., 1999, Developmental expression of and effect of betamethasone on the messenger ribonucleic acid levels for peptide growth factors in the baboon fetal adrenal gland., J. Endocrinol.
Lauterio et al., 1993, Fluoxetine induced insulin-like growth factor II (IGF-II) changes in hypothalami of normal, exercised and food restricted rats., Regul. Pept.
McCaffery I et al., 2013, Putative predictive biomarkers of survival in patients with metastatic pancreatic adenocarcinoma treated with gemcitabine and ganitumab, an IGF1R inhibitor., Clin Cancer Res
Beltran PJ et al., 2014, Ganitumab (AMG 479) inhibits IGF-II-dependent ovarian cancer growth and potentiates platinum-based chemotherapy., Clin Cancer Res

GANITUMAB IGF2

Interaction Score: 6.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23741071 24727326

Sources:
CIViC
DUSIGITUMAB IGF2

Interaction Score: 4.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Insulin-like growth factor II inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
XENTUZUMAB IGF2

Interaction Score: 2.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
HUMAN GROWTH HORMONE IGF2

Interaction Score: 1.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9834461

Sources:
NCI
LINSITINIB IGF2

Interaction Score: 1.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25670080

Sources:
CIViC
BETAMETHASONE IGF2

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10495414

Sources:
NCI
GLUTAMINE IGF2

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14746834

Sources:
NCI
ANASTROZOLE IGF2

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11983488

Sources:
NCI
CABAZITAXEL IGF2

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25670080

Sources:
CIViC
FLUOXETINE IGF2

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8265809

Sources:
NCI
ETOPOSIDE IGF2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15019164

Sources:
NCI
GEFITINIB IGF2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16988945

Sources:
NCI
GEMCITABINE IGF2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23741071

Sources:
CIViC
DOCETAXEL IGF2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25670080

Sources:
CIViC

Ensembl: ENSG00000167244
- Version: 101_38
Alternate Names:

IGF2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
PharmGKB: IGF2
- Version: 18-August-2020
Alternate Names:

PA29699 PharmGKB ID

Gene Info:

Publications:

Zeng Y et al., 2019, Polymorphisms in IGF2/H19 gene locus are associated with platinum-based chemotherapeutic response in Chinese patients with epithelial ovarian cancer., Pharmacogenomics

CIViC: IGF2

Version: 14-September-2020

Alternate Names:

3481 Entrez Gene ID

60 CIViC Gene ID

Gene Info:

Publications:

McCaffery I et al., 2013, Putative predictive biomarkers of survival in patients with metastatic pancreatic adenocarcinoma treated with gemcitabine and ganitumab, an IGF1R inhibitor., Clin Cancer Res

Beltran PJ et al., 2014, Ganitumab (AMG 479) inhibits IGF-II-dependent ovarian cancer growth and potentiates platinum-based chemotherapy., Clin Cancer Res

Vidal et al., 2015, A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer., Cancer Cell

NCI: IGF2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Meng et al., 2004, Insulin-like growth factor-2 activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases., J. Gastrointest. Surg.

Kasperk et al., 1990, Studies of the mechanism by which androgens enhance mitogenesis and differentiation in bone cells., J. Clin. Endocrinol. Metab.

Skrtic et al., 1997, Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells., Endocrinology

HingoraniCasas: ENSG00000167244
- Version: 31-May-2017
Alternate Names:

ENSG00000167244 Gene Symbol

IGF2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: IGF2
- Version: chembl_23
Alternate Names:

IGF2 GENE_SYMBOL

Insulin-like growth factor II UNIPROT

Insulin-like growth factor II Ala-25 Del UNIPROT

Gene Info:

Publications:
Pharos: IGF2
- Version: 03-September-2020
Alternate Names:

Insulin-like growth factor II Gene Name

P01344 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:
GO: IGF2
- Version: 05-September-2020
Alternate Names:

PP1446 GO Gene Synonym

Gene Info:

Gene Categories:

GROWTH FACTOR, HORMONE ACTIVITY

Publications:
TTD: Insulin-like growth factor-II
- Version: 2020.06.01
Alternate Names:

IGF2 TTD Gene Abbreviation

T90572 TTD Target ID

Gene Info:

Publications:
MskImpact: IGF2
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Insulin-like growth factor II inhibitor
Direct Interaction	yes

IGF2	GENE_SYMBOL
Insulin-like growth factor II	UNIPROT
Insulin-like growth factor II Ala-25 Del	UNIPROT

IGF2 Gene Record

IGF2 3481 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23741071 24727326

Sources: CIViC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Insulin-like growth factor II inhibitor Direct Interaction yes

PMIDs: None found

Sources: TTD ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9834461

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25670080

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10495414

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14746834

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11983488

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25670080

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8265809

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15019164

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16988945

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23741071

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25670080

Sources: CIViC

Ensembl: ENSG00000167244

Alternate Names: IGF2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: IGF2

Alternate Names: PA29699 PharmGKB ID

Gene Info:

Publications: Zeng Y et al., 2019, Polymorphisms in IGF2/H19 gene locus are associated with platinum-based chemotherapeutic response in Chinese patients with epithelial ovarian cancer., Pharmacogenomics

CIViC: IGF2

Alternate Names: 3481 Entrez Gene ID 60 CIViC Gene ID

Gene Info:

NCI: IGF2

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000167244

Alternate Names: ENSG00000167244 Gene Symbol IGF2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Interaction Types & Directionality:

n/a

PMIDs:
23741071 24727326

Sources:
CIViC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Insulin-like growth factor II inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
9834461

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
25670080

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
10495414

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14746834

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11983488

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
25670080

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
8265809

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15019164

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16988945

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23741071

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
25670080

Sources:
CIViC

Alternate Names:

IGF2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA29699 PharmGKB ID

Publications:

Zeng Y et al., 2019, Polymorphisms in IGF2/H19 gene locus are associated with platinum-based chemotherapeutic response in Chinese patients with epithelial ovarian cancer., Pharmacogenomics

Alternate Names:

3481 Entrez Gene ID

60 CIViC Gene ID

Alternate Names:

ENSG00000167244 Gene Symbol

IGF2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

IGF2 GENE_SYMBOL

Insulin-like growth factor II UNIPROT

Insulin-like growth factor II Ala-25 Del UNIPROT

Alternate Names:

Insulin-like growth factor II Gene Name

P01344 UniProt ID

Gene Categories:

TRANSCRIPTION FACTOR

Alternate Names:

PP1446 GO Gene Synonym

Gene Categories:

GROWTH FACTOR, HORMONE ACTIVITY

Alternate Names:

IGF2 TTD Gene Abbreviation

T90572 TTD Target ID

Gene Categories:

CLINICALLY ACTIONABLE