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IGF2 Gene Record

  • Summary
  • Interactions
  • Claims
  • IGF2 3481 Druggable GenomeClinically Actionable

    Alternate Names:

    3481
    INSULIN LIKE GROWTH FACTOR 2
    IGF2
    C11orf43
    GRDF
    IGF-II
    PP9974
    147470
    5466
    ENSG00000129965
    ENSG00000167244
    OTTHUMG00000009395
    T3M-11-derived growth factor
    Insulin-like growth factor II
    Insulin-like growth factor II Ala-25 Del
    Preptin
    Somatomedin-A
    60
    PA29699
    Insulin-like growth factor-II
    T90572
    SRS3
    PP1446
    P01344

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    GROWTH FACTOR
    HORMONE ACTIVITY
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Vidal et al., 2015, A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer., Cancer Cell
    Ferrari et al., 2002, Short-term effects of anastrozole treatment on insulin-like growth factor system in postmenopausal advanced breast cancer patients., J. Steroid Biochem. Mol. Biol.
    Desbois-Mouthon et al., 2006, Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib., Int. J. Cancer
    Lund et al., 2004, Autocrine inhibition of chemotherapy response in human liver tumor cells by insulin-like growth factor-II., Cancer Lett.
    Sterle et al., 1998, Insulin-like growth factor (IGF)-I, IGF-II, IGF-binding protein-2 and pregnancy-associated glycoprotein mRNA in pigs with somatotropin-enhanced fetal growth., J. Endocrinol.
    Meng et al., 2004, Insulin-like growth factor-2 activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases., J. Gastrointest. Surg.
    Aberdeen et al., 1999, Developmental expression of and effect of betamethasone on the messenger ribonucleic acid levels for peptide growth factors in the baboon fetal adrenal gland., J. Endocrinol.
    Lauterio et al., 1993, Fluoxetine induced insulin-like growth factor II (IGF-II) changes in hypothalami of normal, exercised and food restricted rats., Regul. Pept.
    McCaffery I et al., 2013, Putative predictive biomarkers of survival in patients with metastatic pancreatic adenocarcinoma treated with gemcitabine and ganitumab, an IGF1R inhibitor., Clin Cancer Res
    Beltran PJ et al., 2014, Ganitumab (AMG 479) inhibits IGF-II-dependent ovarian cancer growth and potentiates platinum-based chemotherapy., Clin Cancer Res
  • GANITUMAB   IGF2

    Interaction Score: 6.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23741071 24727326


    Sources:
    CIViC

  • DUSIGITUMAB   IGF2

    Interaction Score: 4.42

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Insulin-like growth factor II inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • HUMAN GROWTH HORMONE   IGF2

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9834461


    Sources:
    NCI

  • XENTUZUMAB   IGF2

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • GLUTAMINE   IGF2

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14746834


    Sources:
    NCI

  • LINSITINIB   IGF2

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25670080


    Sources:
    CIViC

  • BETAMETHASONE   IGF2

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10495414


    Sources:
    NCI

  • ANASTROZOLE   IGF2

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11983488


    Sources:
    NCI

  • CABAZITAXEL   IGF2

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25670080


    Sources:
    CIViC

  • FLUOXETINE   IGF2

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8265809


    Sources:
    NCI

  • ETOPOSIDE   IGF2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15019164


    Sources:
    NCI

  • GEFITINIB   IGF2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16988945


    Sources:
    NCI

  • DOCETAXEL   IGF2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25670080


    Sources:
    CIViC

  • GEMCITABINE   IGF2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23741071


    Sources:
    CIViC

  • Ensembl: ENSG00000167244

    • Version: 101_38

    Alternate Names:
    IGF2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: IGF2

    • Version: 18-August-2020

    Alternate Names:
    PA29699 PharmGKB ID

    Gene Info:

    Publications:
    Zeng Y et al., 2019, Polymorphisms in IGF2/H19 gene locus are associated with platinum-based chemotherapeutic response in Chinese patients with epithelial ovarian cancer., Pharmacogenomics

  • CIViC: IGF2

    • Version: 14-September-2020

    Alternate Names:
    3481 Entrez Gene ID
    60 CIViC Gene ID

    Gene Info:

    Publications:
    McCaffery I et al., 2013, Putative predictive biomarkers of survival in patients with metastatic pancreatic adenocarcinoma treated with gemcitabine and ganitumab, an IGF1R inhibitor., Clin Cancer Res
    Beltran PJ et al., 2014, Ganitumab (AMG 479) inhibits IGF-II-dependent ovarian cancer growth and potentiates platinum-based chemotherapy., Clin Cancer Res
    Vidal et al., 2015, A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer., Cancer Cell

  • NCI: IGF2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Meng et al., 2004, Insulin-like growth factor-2 activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases., J. Gastrointest. Surg.
    Kasperk et al., 1990, Studies of the mechanism by which androgens enhance mitogenesis and differentiation in bone cells., J. Clin. Endocrinol. Metab.
    Skrtic et al., 1997, Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells., Endocrinology

  • HingoraniCasas: ENSG00000167244

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000167244 Gene Symbol
    IGF2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: IGF2

    • Version: chembl_23

    Alternate Names:
    IGF2 GENE_SYMBOL
    Insulin-like growth factor II UNIPROT
    Insulin-like growth factor II Ala-25 Del UNIPROT

    Gene Info:

    Publications:

  • GO: IGF2

    • Version: 01-February-2022

    Alternate Names:
    PP1446 GO Gene Synonym

    Gene Info:

    Gene Categories:
    GROWTH FACTOR, HORMONE ACTIVITY

    Publications:

  • TTD: Insulin-like growth factor-II

    • Version: 2020.06.01

    Alternate Names:
    IGF2 TTD Gene Abbreviation
    T90572 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: IGF2

    • Version: 01-February-2022

    Alternate Names:
    Insulin-like growth factor II Gene Name
    P01344 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

  • MskImpact: IGF2

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21