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IFNG Gene Record

  • Summary
  • Interactions
  • Claims
  • IFNG 3458 Druggable Genome

    Alternate Names:

    3458
    INTERFERON GAMMA
    IFNG
    IFG
    IFI
    147570
    5438
    ENSG00000111537
    OTTHUMG00000169113
    P01579
    Immune interferon
    IFN-gamma
    PA29674
    Interferon-gamma
    T77664
    IMD69

    Gene Info:

    Target Class Ligand
    Target Subclass Ligand
    Target Subclass interferon
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Sakurai et al., 2000, Effects of macrophage-colony-stimulating factor on cyclophosphamide-injected mouse NK1.1+ cell activity., Cancer Immunol. Immunother.
    Yagi et al., 1997, [Cytokine-secreting cells in relapsing multiple sclerosis patients treated with high-dose intravenous methylprednisolone]., Rinsho Shinkeigaku
    Zucca et al., 1996, Protective role of the pefloxacin-IFN-gamma association in Leishmania major-infected mice., New Microbiol.
    Kaplon H et al., 2018, Antibodies to watch in 2018., MAbs
    Liu et al., 1991, The effect of suramin, tumor necrosis factor and interferon gamma on human prostate carcinoma., J. Urol.
    Gurujeyalakshmi et al., Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expression., Exp. Lung Res.
    Clark et al., 1994, Effect of interferon gamma and tumour necrosis factor alpha on sensitivity to cisplatin in ovarian carcinoma cell lines., Cancer Immunol. Immunother.
    Di Stefano et al., 1994, Inhibitory effect of melatonin on production of IFN gamma or TNF alpha in peripheral blood mononuclear cells of some blood donors., J. Pineal Res.
    Manusama et al., Toxicity and antitumor activity of interferon gamma alone and in combinations with TNFalpha and melphalan in isolated limb perfusion in the BN175 sarcoma tumor model in rats., Oncol. Rep.
    Hockertz et al., 1996, Treatment of an acute bacterial infection with a combination of acetylsalicylic acid/ibuprofen and interferon gamma., Arzneimittelforschung
    Naldini et al., 1998, Thrombin receptor expression and responsiveness of human monocytic cells to thrombin is linked to interferon-induced cellular differentiation., J. Cell. Physiol.
    Fracchia et al., 2000, Serum interferon gamma in primary biliary cirrhosis: effect of ursodeoxycholic acid and prednisone therapy alone and in combination., Eur J Gastroenterol Hepatol
    Kubera et al., 2000, The effect of repeated amitriptyline and desipramine administration on cytokine release in C57BL/6 mice., Psychoneuroendocrinology
    Parihar et al., 2004, A phase I study of interleukin 12 with trastuzumab in patients with human epidermal growth factor receptor-2-overexpressing malignancies: analysis of sustained interferon gamma production in a subset of patients., Clin. Cancer Res.
    Sesin et al., 1996, New trends in the drug therapy of localized and disseminated Mycobacterium avium complex infection., Am J Health Syst Pharm
    Nie et al., 2002, Effects of theophylline on CD4+ T lymphocyte, interleukin-5, and interferon gamma in induced sputum of asthmatic subjects., Acta Pharmacol. Sin.
  • FONTOLIZUMAB   IFNG

    Interaction Score: 7.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Interferon gamma inhibitor
    Direct Interaction yes
    Trial Name HuZAF

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • PEFLOXACIN   IFNG

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8673851


    Sources:
    NCI

  • AMIKACIN   IFNG

    Interaction Score: 1.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8913387


    Sources:
    NCI

  • EMAPALUMAB   IFNG

    Interaction Score: 0.91

    Interaction Types & Directionality:
    modulator

    Interaction Info:

    PMIDs:
    29300693


    Sources:
    TTD

  • AMITRIPTYLINE   IFNG

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10996474


    Sources:
    NCI

  • METHYLPREDNISOLONE   IFNG

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9396353


    Sources:
    NCI

  • MELPHALAN   IFNG

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9864423


    Sources:
    NCI

  • BLEOMYCIN   IFNG

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8556994


    Sources:
    NCI

  • TRASTUZUMAB   IFNG

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15297404


    Sources:
    NCI

  • THEOPHYLLINE   IFNG

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11918854


    Sources:
    NCI

  • THROMBIN   IFNG

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9731747


    Sources:
    NCI

  • MELATONIN   IFNG

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7722866


    Sources:
    NCI

  • SURAMIN   IFNG

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1899122


    Sources:
    NCI

  • PREDNISONE   IFNG

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10784002


    Sources:
    NCI

  • IBUPROFEN   IFNG

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8931897


    Sources:
    NCI

  • CYCLOPHOSPHAMIDE   IFNG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10823419


    Sources:
    NCI

  • CISPLATIN   IFNG

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8044830


    Sources:
    NCI

  • Ensembl: ENSG00000111537

    • Version: 101_38

    Alternate Names:
    IFNG Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P01579

    • Version: January-2014

    Alternate Names:
    IFNG Gene Symbol

    Gene Info:
    Target Class Ligand
    Target Subclass Ligand
    Target Subclass interferon

    Publications:

  • PharmGKB: IFNG

    • Version: 18-August-2020

    Alternate Names:
    PA29674 PharmGKB ID

    Gene Info:

    Publications:
    Bank S et al., 2014, Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease., Pharmacogenomics J

  • NCI: IFNG

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Sakurai et al., 2000, Effects of macrophage-colony-stimulating factor on cyclophosphamide-injected mouse NK1.1+ cell activity., Cancer Immunol. Immunother.
    Yagi et al., 1997, [Cytokine-secreting cells in relapsing multiple sclerosis patients treated with high-dose intravenous methylprednisolone]., Rinsho Shinkeigaku
    Manusama et al., Toxicity and antitumor activity of interferon gamma alone and in combinations with TNFalpha and melphalan in isolated limb perfusion in the BN175 sarcoma tumor model in rats., Oncol. Rep.

  • ChemblInteractions: IFNG

    • Version: chembl_23

    Alternate Names:
    IFNG GENE_SYMBOL
    Interferon gamma UNIPROT
    Immune interferon UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000111537

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000111537 Gene Symbol
    IFNG Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Interferon-gamma

    • Version: 2020.06.01

    Alternate Names:
    IFNG TTD Gene Abbreviation
    T77664 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21