DGIdb - IDO1 Gene Record

IDO1 3620 Druggable Genome

Alternate Names:

3620
INDOLEAMINE 2,3-DIOXYGENASE 1
IDO1
IDO
IDO-1
INDO
147435
6059
ENSG00000131203
OTTHUMG00000164057
Indoleamine-pyrrole 2,3-dioxygenase
2829
P14902
PA29869
T89697
NM_002164
NP_002155
BE0000693

Gene Info:

Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	1.13.11.- Dioxygenases
GuideToPharmacology Gene Category ID	899

(7 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Fung SP et al., 2013, Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1)., Bioorg Med Chem
Dolušić E et al., 2011, Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors., Eur J Med Chem
Matsuno K et al., 2010, S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase., Bioorg Med Chem Lett
Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics

EPACADOSTAT IDO1

Interaction Score: 10.65

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TTD GuideToPharmacology ChemblInteractions
CHEMBL1933308 IDO1

Interaction Score: 7.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24262887

Sources:
DTC
CHEMBL1224312 IDO1

Interaction Score: 7.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20688518

Sources:
DTC
CHEMBL1668301 IDO1

Interaction Score: 7.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21419531

Sources:
DTC
CHEMBL14145 IDO1

Interaction Score: 7.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24262887

Sources:
DTC
PF-06840003 IDO1

Interaction Score: 7.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Measuring inhibition of IDO1-induced kynurenine production <i>in vitro</i>.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology
LINRODOSTAT IDO1

Interaction Score: 7.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology
PHENYLHYDRAZINE IDO1

Interaction Score: 3.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24262887

Sources:
DTC
NAVOXIMOD IDO1

Interaction Score: 1.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
NORHARMANE IDO1

Interaction Score: 0.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
2-MERCAPTOBENZOTHIAZOLE IDO1

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24262887

Sources:
DTC
TRYPTANTHRIN IDO1

Interaction Score: 0.71

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
NECROSTATIN IDO1

Interaction Score: 0.71

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Using a purified recombinant human IDO enzyme for <i>in vitro>/i> assays.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
TRYPTOPHAN IDO1

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CANNABIDIOL IDO1

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26264914

Sources:
DrugBank
NABIXIMOLS IDO1

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26264914

Sources:
DrugBank

Ensembl: ENSG00000131203
- Version: 101_38
Alternate Names:

IDO1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacology: 3620
- Version: 29-September-2020
Alternate Names:

6059 HUGO Gene ID

6059 HUGO Gene Symbol

indoleamine 2,3-dioxygenase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 1.13.11.- Dioxygenases

GuideToPharmacology Gene Category ID 899

Gene Categories:

ENZYME

Publications:

DrugBank: BE0000693

Version: 5.1.7

Alternate Names:

IDO1 DrugBank Gene Name

P14902 UniProt Accession

3620 Entrez Gene Id

Gene Info:

Publications:

Samelson-Jones BJ et al., 2006, Interactions between nitric oxide and indoleamine 2,3-dioxygenase., Biochemistry

Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics

DTC: IDO1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Fung SP et al., 2013, Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1)., Bioorg Med Chem

Dolušić E et al., 2011, Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors., Eur J Med Chem

Matsuno K et al., 2010, S-benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000131203
- Version: 31-May-2017
Alternate Names:

ENSG00000131203 Gene Symbol

IDO1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: IDO
- Version: chembl_23
Alternate Names:

INDO GENE_SYMBOL

IDO1 GENE_SYMBOL

Indoleamine 2,3-dioxygenase 1 UNIPROT

Gene Info:

Publications:
PharmGKB: IDO1
- Version: 18-August-2020
Alternate Names:

PA29869 PharmGKB ID

Gene Info:

Publications:
Pharos: IDO1
- Version: 03-September-2020
Alternate Names:

Indoleamine 2,3-dioxygenase 1 Gene Name

P14902 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
Tempus: IDO1
- Version: 11-November-2018
Alternate Names:

IDO1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Indoleamine 2,3-dioxygenase 1
- Version: 2020.06.01
Alternate Names:

IDO1 TTD Gene Abbreviation

T89697 TTD Target ID

Gene Info:

Publications:
ClearityFoundationClinicalTrial: IDO1
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Details of the Assay for Interaction	Measuring inhibition of IDO1-induced kynurenine production <i>in vitro</i>.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

Details of the Assay for Interaction	Using a purified recombinant human IDO enzyme for <i>in vitro>/i> assays.
Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

6059	HUGO Gene ID
6059	HUGO Gene Symbol
indoleamine 2,3-dioxygenase 1	HUGO Gene Name

IDO1	DrugBank Gene Name
P14902	UniProt Accession
3620	Entrez Gene Id

INDO	GENE_SYMBOL
IDO1	GENE_SYMBOL
Indoleamine 2,3-dioxygenase 1	UNIPROT

IDO1 Gene Record

IDO1 3620 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: TTD GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24262887

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20688518

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21419531

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24262887

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Measuring inhibition of IDO1-induced kynurenine production <i>in vitro</i>. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: TTD GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: TTD GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24262887

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24262887

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Details of the Assay for Interaction Using a purified recombinant human IDO enzyme for <i>in vitro>/i> assays. Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 26264914

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 26264914

Sources: DrugBank

Ensembl: ENSG00000131203

Alternate Names: IDO1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacology: 3620

Alternate Names: 6059 HUGO Gene ID 6059 HUGO Gene Symbol indoleamine 2,3-dioxygenase 1 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name 1.13.11.- Dioxygenases GuideToPharmacology Gene Category ID 899

Gene Categories: ENZYME

Publications:

DrugBank: BE0000693

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TTD GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
24262887

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20688518

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21419531

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24262887

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Measuring inhibition of IDO1-induced kynurenine production <i>in vitro</i>.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
24262887

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
24262887

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Details of the Assay for Interaction Using a purified recombinant human IDO enzyme for <i>in vitro>/i> assays.

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26264914

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26264914

Sources:
DrugBank

Alternate Names:

IDO1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

6059 HUGO Gene ID

6059 HUGO Gene Symbol

indoleamine 2,3-dioxygenase 1 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 1.13.11.- Dioxygenases

GuideToPharmacology Gene Category ID 899

Gene Categories:

ENZYME

Alternate Names:

IDO1 DrugBank Gene Name

P14902 UniProt Accession

3620 Entrez Gene Id

Publications:

Samelson-Jones BJ et al., 2006, Interactions between nitric oxide and indoleamine 2,3-dioxygenase., Biochemistry

Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics

Alternate Names:

ENSG00000131203 Gene Symbol

IDO1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

INDO GENE_SYMBOL

IDO1 GENE_SYMBOL

Indoleamine 2,3-dioxygenase 1 UNIPROT

Alternate Names:

PA29869 PharmGKB ID

Alternate Names:

Indoleamine 2,3-dioxygenase 1 Gene Name

P14902 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

IDO1 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

IDO1 TTD Gene Abbreviation

T89697 TTD Target ID