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HTR7 Gene Record

  • Summary
  • Interactions
  • Claims
  • HTR7 3363 Druggable Genome

    Alternate Names:

    3363
    5-HYDROXYTRYPTAMINE RECEPTOR 7
    HTR7
    5-HT7
    182137
    5302
    ENSG00000148680
    OTTHUMG00000018732
    P34969
    5HT7R_HUMAN
    5-HT-7
    Serotonin receptor 7
    5-HT-X
    5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (SEROTONIN RECEPTOR 7) (5-HT- X) (5HT7). [SOURCE:UNIPROT/SWISSPROT;ACC:P34969]
    PA29561
    5-HT 7 receptor
    T79062

    Gene Info:

    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Acc IPR000276
    Uniprot Evidence 1: Evidence at protein level
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Name GPCR, rhodopsin-like, 7TM
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin
    Target Main Class Receptors
    Transmembrane Helix Count 7
    Gene Biotype PROTEIN_CODING
    (8 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.
    Lacivita E et al., 2012, Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo., J Med Chem
    Lovell PJ et al., 2000, A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970)., J Med Chem
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    George et al., 2013, Newer antipsychotics and upcoming molecules for schizophrenia., Eur. J. Clin. Pharmacol.
    Bobo, 2013, Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults., Expert Rev Clin Pharmacol
    Sugimoto et al., 2003, The tricyclic antidepressant clomipramine increases plasma glucose levels of mice., J. Pharmacol. Sci.
    Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
    Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
    Bang-Andersen et al., 2011, Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder., J. Med. Chem.
    Fabricant DS et al., 2005, Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa., J Nat Prod
    Kim Y et al., 2014, Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression., Bioorg Med Chem
    Stark et al., 2007, Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies., Psychopharmacology (Berl.)
    Meltzer, 1995, Role of serotonin in the action of atypical antipsychotic drugs., Clin. Neurosci.
    Meltzer, 1999, The role of serotonin in antipsychotic drug action., Neuropsychopharmacology
    Ruaño G et al., 2007, Physiogenomic association of statin-related myalgia to serotonin receptors., Muscle Nerve
    Shimizu et al., 1997, Down-regulation of 5-hydroxytryptamine7 receptors by dexamethasone in rat frontocortical astrocytes., J. Neurochem.
  • CIMIPRONIDINE   HTR7

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16124775


    Sources:
    DTC

  • FUKINOLIC ACID   HTR7

    Interaction Score: 5.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16124775


    Sources:
    DTC

  • CHEMBL282199   HTR7

    Interaction Score: 4.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    22738316 10669560


    Sources:
    DTC

  • CHEMBL18840   HTR7

    Interaction Score: 2.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25127461


    Sources:
    DTC

  • JNJ-18038683   HTR7

    Interaction Score: 2.69

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LY2590443   HTR7

    Interaction Score: 1.34

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 7 (5-HT7) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LURASIDONE   HTR7

    Interaction Score: 1.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name lurasidone, SM-13496,Latuda
    Novel drug target Established target

    PMIDs:
    23545936


    Sources:
    TdgClinicalTrial

  • VORTIOXETINE   HTR7

    Interaction Score: 0.9

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Lu AA21004
    Novel drug target Established target

    PMIDs:
    21486038


    Sources:
    TdgClinicalTrial

  • METHYSERGIDE   HTR7

    Interaction Score: 0.81

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    14501155


    Sources:
    TdgClinicalTrial TEND

  • ZIPRASIDONE   HTR7

    Interaction Score: 0.75

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17242925 7583621 10432496 17848919


    Sources:
    TEND

  • KETANSERIN   HTR7

    Interaction Score: 0.67

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    22738316


    Sources:
    DTC

  • BREXPIPRAZOLE   HTR7

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name OPC-34712
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • BIFEPRUNOX   HTR7

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name bifeprunox, DU127090
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ASENAPINE   HTR7

    Interaction Score: 0.45

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814 21655346


    Sources:
    TdgClinicalTrial

  • PARDOPRUNOX   HTR7

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name pardoprunox, SLV 308
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ILOPERIDONE   HTR7

    Interaction Score: 0.36

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name iloperidone,Fanapt, Fiapta, Zomaril

    PMIDs:
    23272794


    Sources:
    TdgClinicalTrial

  • CHLORPROMAZINE   HTR7

    Interaction Score: 0.26

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7908055


    Sources:
    NCI

  • CLOZAPINE   HTR7

    Interaction Score: 0.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7908055 17848919 22738316


    Sources:
    DTC NCI

  • PRAVASTATIN   HTR7

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17600820


    Sources:
    PharmGKB

  • SIMVASTATIN   HTR7

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17600820


    Sources:
    PharmGKB

  • ATORVASTATIN   HTR7

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17600820


    Sources:
    PharmGKB

  • OLANZAPINE   HTR7

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name ALKS 3831
    Trial Name OREX-003, olanzapine plus zonisamide SR
    Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

    PMIDs:
    17848919


    Sources:
    TdgClinicalTrial

  • DEXAMETHASONE   HTR7

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9166758


    Sources:
    NCI

  • Ensembl: ENSG00000148680

    • Version: 101_38

    Alternate Names:
    HTR7 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P34969

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000148680 Ensembl Gene Id
    5HT7R_HUMAN Uniprot Id
    P34969 Uniprot Accession

    Gene Info:
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Interpro Acc IPR000276
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P34969

    • Version: January-2014

    Alternate Names:
    HTR7 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • TEND: P34969

    • Version: 01-August-2011

    Alternate Names:
    P34969 Uniprot Accession
    HTR7 Gene Symbol
    3363 Entrez Gene Id

    Gene Info:
    Target Main Class Receptors
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin

    Publications:

  • RussLampel: ENSG00000148680

    • Version: 26-July-2011

    Alternate Names:
    5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (SEROTONIN RECEPTOR 7) (5-HT- X) (5HT7). [SOURCE:UNIPROT/SWISSPROT;ACC:P34969] Description
    ENSG00000148680 Ensembl Gene Id
    HTR7 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: HTR7

    • Version: 18-August-2020

    Alternate Names:
    PA29561 PharmGKB ID

    Gene Info:

    Publications:
    Wei YB et al., 2020, A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression., Mol Psychiatry
    Ruaño G et al., 2007, Physiogenomic association of statin-related myalgia to serotonin receptors., Muscle Nerve

  • NCI: HTR7

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.
    Shimizu et al., 1997, Down-regulation of 5-hydroxytryptamine7 receptors by dexamethasone in rat frontocortical astrocytes., J. Neurochem.

  • DTC: HTR7

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Lacivita E et al., 2012, Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo., J Med Chem
    Fabricant DS et al., 2005, Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa., J Nat Prod
    Kim Y et al., 2014, Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression., Bioorg Med Chem

  • HingoraniCasas: ENSG00000148680

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000148680 Gene Symbol
    HTR7 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: HTR7

    • Version: chembl_23

    Alternate Names:
    HTR7 GENE_SYMBOL
    5-hydroxytryptamine receptor 7 UNIPROT
    5-HT-X UNIPROT

    Gene Info:

    Publications:

  • dGene: HTR7

    • Version: 27-Jun-2013

    Alternate Names:
    3363 Gene ID
    5-HT7 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: 5-HT 7 receptor

    • Version: 2020.06.01

    Alternate Names:
    HTR7 TTD Gene Abbreviation
    T79062 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21