DGIdb - HTR7 Gene Record

HTR7 3363 Druggable Genome

Alternate Names:

3363
5-HYDROXYTRYPTAMINE RECEPTOR 7
HTR7
5-HT7
182137
5302
ENSG00000148680
OTTHUMG00000018732
P34969
5HT7R_HUMAN
BE0000650
5-HT-7
Serotonin receptor 7
5-HT-X
5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (SEROTONIN RECEPTOR 7) (5-HT- X) (5HT7). [SOURCE:UNIPROT/SWISSPROT;ACC:P34969]
5-HT<sub>7</sub> receptor
PA29561
5-HT 7 receptor
T79062
12
NM_000872
NP_000863

Gene Info:

Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Acc	IPR000276
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Family
Uniprot Status	Swiss-Prot
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Name	GPCR, rhodopsin-like, 7TM
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Target Main Class	Receptors
Transmembrane Helix Count	7
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	5-Hydroxytryptamine receptors
GuideToPharmacology Gene Category ID	1

(11 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Lucchelli et al., 2000, The interaction of antidepressant drugs with enteric 5-HT7 receptors., Naunyn Schmiedebergs Arch. Pharmacol.
Liu J et al., 2013, Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline., Eur J Pharmacol
Roth, 1994, Multiple serotonin receptors: clinical and experimental aspects., Ann Clin Psychiatry
Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.
Abbas et al., 2009, Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo., Psychopharmacology (Berl.)
Lacivita E et al., 2012, Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo., J Med Chem
Lovell PJ et al., 2000, A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970)., J Med Chem
Teitler M et al., 2010, Clozapine and other competitive antagonists reactivate risperidone-inactivated h5-HT7 receptors: radioligand binding and functional evidence for GPCR homodimer protomer interactions., Psychopharmacology (Berl)
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
George et al., 2013, Newer antipsychotics and upcoming molecules for schizophrenia., Eur. J. Clin. Pharmacol.
Bobo, 2013, Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults., Expert Rev Clin Pharmacol
Sugimoto et al., 2003, The tricyclic antidepressant clomipramine increases plasma glucose levels of mice., J. Pharmacol. Sci.
Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
Bang-Andersen et al., 2011, Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder., J. Med. Chem.
de Bartolomeis A et al., 2015, Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism., CNS Drugs
Sharif et al., 2009, Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes., Exp. Eye Res.
Fabricant DS et al., 2005, Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa., J Nat Prod
Knight et al., 2009, Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists., Mol. Pharmacol.
Lovenberg et al., 1993, A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms., Neuron
Shen et al., 1993, Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype., J. Biol. Chem.
Corena-McLeod M, 2015, Comparative Pharmacology of Risperidone and Paliperidone., Drugs R D
Kim Y et al., 2014, Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression., Bioorg Med Chem
Stark et al., 2007, Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies., Psychopharmacology (Berl.)
Meltzer, 1995, Role of serotonin in the action of atypical antipsychotic drugs., Clin. Neurosci.
Meltzer, 1999, The role of serotonin in antipsychotic drug action., Neuropsychopharmacology
Ruaño G et al., 2007, Physiogenomic association of statin-related myalgia to serotonin receptors., Muscle Nerve
Shimizu et al., 1997, Down-regulation of 5-hydroxytryptamine7 receptors by dexamethasone in rat frontocortical astrocytes., J. Neurochem.
Dupont et al., 1999, Epinastine (WAL 801CL) inhibits the electrical field stimulation-induced cholinergic contraction in guinea pig and human airways in vitro., Eur. Respir. J.
Kroeze et al., 2003, H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs., Neuropsychopharmacology
Rubio-Beltrán E et al., 2018, Is selective 5-HT<sub>1F</sub> receptor agonism an entity apart from that of the triptans in antimigraine therapy?, Pharmacol Ther
Toohey N et al., 2009, Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other "inactivating antagonists"., Mol Pharmacol
Mestres J et al., 2011, Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome., Clin Pharmacol Ther

CIMIPRONIDINE HTR7

Interaction Score: 1.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16124775

Sources:
DTC
FUKINOLIC ACID HTR7

Interaction Score: 1.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16124775

Sources:
DTC
JNJ-18038683 HTR7

Interaction Score: 1.75

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TTD GuideToPharmacology
CHEMBL282199 HTR7

Interaction Score: 1.75

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
22738316 10669560

Sources:
DTC DrugBank
CHEMBL18840 HTR7

Interaction Score: 0.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25127461

Sources:
DTC
LURASIDONE HTR7

Interaction Score: 0.58

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
23545936

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology
LY2590443 HTR7

Interaction Score: 0.44

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 7 (5-HT7) receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FLUPERLAPINE HTR7

Interaction Score: 0.44

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Inverse agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
VORTIOXETINE HTR7

Interaction Score: 0.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
21486038

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology
OLEAMIDE HTR7

Interaction Score: 0.29

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Negative

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
METHYSERGIDE HTR7

Interaction Score: 0.26

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Trial Name -

PMIDs:
14501155

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
EPINASTINE HTR7

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10596692

Sources:
DrugBank
CYAMEMAZINE HTR7

Interaction Score: 0.22

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ILOPERIDONE HTR7

Interaction Score: 0.22

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Specific Action of the Ligand Antagonist

PMIDs:
23272794

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology
PIRENPERONE HTR7

Interaction Score: 0.22

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
CYPROHEPTADINE HTR7

Interaction Score: 0.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
20827463

Sources:
DrugBank GuideToPharmacology
ZOLMITRIPTAN HTR7

Interaction Score: 0.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
29352859

Sources:
DrugBank
MESULERGINE HTR7

Interaction Score: 0.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ZIPRASIDONE HTR7

Interaction Score: 0.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
17848919 17242925 7583621 10432496

Sources:
TEND DrugBank GuideToPharmacology
PALIPERIDONE HTR7

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18996971 19509219 20827463

Sources:
DrugBank
ASENAPINE HTR7

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial DrugBank
AMISULPRIDE HTR7

Interaction Score: 0.16

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
19337725

Sources:
DrugBank
LISURIDE HTR7

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18996971 19509219

Sources:
DrugBank
BIFEPRUNOX HTR7

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name bifeprunox, DU127090

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
CYCLOBENZAPRINE HTR7

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
21975349

Sources:
DrugBank
KETANSERIN HTR7

Interaction Score: 0.13

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
22738316

Sources:
DTC GuideToPharmacology
PARDOPRUNOX HTR7

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pardoprunox, SLV 308

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
BREXPIPRAZOLE HTR7

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name OPC-34712

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ZOTEPINE HTR7

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
None found

Sources:
DrugBank GuideToPharmacology
LOFEXIDINE HTR7

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
MIANSERIN HTR7

Interaction Score: 0.1

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
10997731

Sources:
DrugBank GuideToPharmacology
CAPESEROD HTR7

Interaction Score: 0.1

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
None found

Sources:
GuideToPharmacology
CABERGOLINE HTR7

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
18992242

Sources:
DrugBank
DIHYDROERGOTAMINE HTR7

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology
CHLORPROMAZINE HTR7

Interaction Score: 0.09

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
7908055

Sources:
NCI DrugBank GuideToPharmacology
DOPAMINE HTR7

Interaction Score: 0.08

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
8398139 8394362

Sources:
DrugBank
IMIPRAMINE HTR7

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7804391 10997731

Sources:
DrugBank
8-OH-DPAT HTR7

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CLOZAPINE HTR7

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
7908055 22738316 17848919

Sources:
NCI DTC DrugBank GuideToPharmacology
TRYPTAMINE HTR7

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
MAPROTILINE HTR7

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
10997731

Sources:
DrugBank
AMITRIPTYLINE HTR7

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
23142373 10997731

Sources:
DrugBank
AMOXAPINE HTR7

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7908055

Sources:
DrugBank
XANOMELINE HTR7

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ARIPIPRAZOLE HTR7

Interaction Score: 0.06

Interaction Types & Directionality:

partial agonist (activating)

antagonist (inhibitory)

Interaction Info:

PMIDs:
17848919 26346901

Sources:
DrugBank
BROMOCRIPTINE HTR7

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
18996971

Sources:
DrugBank
PRAVASTATIN HTR7

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17600820

Sources:
PharmGKB
FLUPHENAZINE HTR7

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Inverse agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SPIPERONE HTR7

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
SUMATRIPTAN HTR7

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
METERGOLINE HTR7

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
YOHIMBINE HTR7

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
RITANSERIN HTR7

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
METITEPINE HTR7

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
THIORIDAZINE HTR7

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Inverse agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
PERPHENAZINE HTR7

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
None found

Sources:
GuideToPharmacology
RISPERIDONE HTR7

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Inverse agonist

Endogenous Drug? False

PMIDs:
25943458

Sources:
DrugBank GuideToPharmacology
QUETIAPINE HTR7

Interaction Score: 0.04

Interaction Types & Directionality:

ligand

antagonist (inhibitory)

Interaction Info:

PMIDs:
17848919

Sources:
DrugBank
SEROTONIN HTR7

Interaction Score: 0.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology
OLANZAPINE HTR7

Interaction Score: 0.04

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ALKS 3831

Trial Name OREX-003, olanzapine plus zonisamide SR

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
17848919

Sources:
TdgClinicalTrial GuideToPharmacology
HALOPERIDOL HTR7

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
12629531

Sources:
DrugBank GuideToPharmacology
SIMVASTATIN HTR7

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17600820

Sources:
PharmGKB
ATORVASTATIN HTR7

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17600820

Sources:
PharmGKB
LOXAPINE HTR7

Interaction Score: 0.03

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
DEXAMETHASONE HTR7

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9166758

Sources:
NCI

Ensembl: ENSG00000148680
- Version: 101_38
Alternate Names:

HTR7 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P34969
- Version: 11-September-2012
Alternate Names:

ENSG00000148680 Ensembl Gene Id

5HT7R_HUMAN Uniprot Id

P34969 Uniprot Accession

Gene Info:

Interpro Short Name 7TM_GPCR_Rhodpsn

Interpro Acc IPR000276

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P34969
- Version: January-2014
Alternate Names:

HTR7 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
TEND: P34969
- Version: 01-August-2011
Alternate Names:

P34969 Uniprot Accession

HTR7 Gene Symbol

3363 Entrez Gene Id

Gene Info:

Target Main Class Receptors

Transmembrane Helix Count 7

Target Subclass Rhodopsin

Publications:
RussLampel: ENSG00000148680
- Version: 26-July-2011
Alternate Names:

5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (SEROTONIN RECEPTOR 7) (5-HT- X) (5HT7). [SOURCE:UNIPROT/SWISSPROT;ACC:P34969] Description

ENSG00000148680 Ensembl Gene Id

HTR7 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 3363
- Version: 29-September-2020
Alternate Names:

5302 HUGO Gene ID

5302 HUGO Gene Symbol

5-hydroxytryptamine receptor 7 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 5-Hydroxytryptamine receptors

GuideToPharmacology Gene Category ID 1

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

PharmGKB: HTR7

Version: 18-August-2020

Alternate Names:

PA29561 PharmGKB ID

Gene Info:

Publications:

Wei YB et al., 2020, A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression., Mol Psychiatry

Ruaño G et al., 2007, Physiogenomic association of statin-related myalgia to serotonin receptors., Muscle Nerve

DrugBank: BE0000650

Version: 5.1.7

Alternate Names:

HTR7 DrugBank Gene Name

P34969 UniProt Accession

3363 Entrez Gene Id

Gene Info:

Publications:

Sharif et al., 2009, Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes., Exp. Eye Res.

Liu J et al., 2013, Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline., Eur J Pharmacol

Lucchelli et al., 2000, The interaction of antidepressant drugs with enteric 5-HT7 receptors., Naunyn Schmiedebergs Arch. Pharmacol.

NCI: HTR7

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.

Shimizu et al., 1997, Down-regulation of 5-hydroxytryptamine7 receptors by dexamethasone in rat frontocortical astrocytes., J. Neurochem.

DTC: HTR7

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Lacivita E et al., 2012, Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo., J Med Chem

Fabricant DS et al., 2005, Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa., J Nat Prod

Kim Y et al., 2014, Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression., Bioorg Med Chem

HingoraniCasas: ENSG00000148680
- Version: 31-May-2017
Alternate Names:

ENSG00000148680 Gene Symbol

HTR7 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: HTR7
- Version: chembl_23
Alternate Names:

HTR7 GENE_SYMBOL

5-hydroxytryptamine receptor 7 UNIPROT

5-HT-X UNIPROT

Gene Info:

Publications:
dGene: HTR7
- Version: 27-Jun-2013
Alternate Names:

3363 Gene ID

5-HT7 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: 5-HT 7 receptor
- Version: 2020.06.01
Alternate Names:

HTR7 TTD Gene Abbreviation

T79062 TTD Target ID

Gene Info:

Publications:
GO: HTR7
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False
Direct Interaction?	True

Mechanism of Interaction	Serotonin 7 (5-HT7) receptor antagonist
Direct Interaction	yes

Specific Action of the Ligand	Inverse agonist
Endogenous Drug?	False

Novel drug target	Established target
Trial Name	iloperidone,Fanapt, Fiapta, Zomaril
Specific Action of the Ligand	Antagonist

Trial Name	bifeprunox, DU127090
Novel drug target	Established target

Trial Name	pardoprunox, SLV 308
Novel drug target	Established target

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False

Trial Name	ALKS 3831
Trial Name	OREX-003, olanzapine plus zonisamide SR
Trial Name	Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

ENSG00000148680	Ensembl Gene Id
5HT7R_HUMAN	Uniprot Id
P34969	Uniprot Accession

5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (SEROTONIN RECEPTOR 7) (5-HT- X) (5HT7). [SOURCE:UNIPROT/SWISSPROT;ACC:P34969]	Description
ENSG00000148680	Ensembl Gene Id
HTR7	Display Id

5302	HUGO Gene ID
5302	HUGO Gene Symbol
5-hydroxytryptamine receptor 7	HUGO Gene Name

HTR7	DrugBank Gene Name
P34969	UniProt Accession
3363	Entrez Gene Id

HTR7	GENE_SYMBOL
5-hydroxytryptamine receptor 7	UNIPROT
5-HT-X	UNIPROT

HTR7 Gene Record

HTR7 3363 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16124775

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16124775

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: TTD GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 22738316 10669560

Sources: DTC DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25127461

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Antagonist

PMIDs: 23545936

Sources: TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Serotonin 7 (5-HT7) receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Inverse agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? True

PMIDs: 21486038

Sources: TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: allosteric modulator

Interaction Info: Specific Action of the Ligand Negative Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False Trial Name -

PMIDs: 14501155

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 10596692

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name iloperidone,Fanapt, Fiapta, Zomaril Specific Action of the Ligand Antagonist

PMIDs: 23272794

Sources: TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Antagonist

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Antagonist

PMIDs: 20827463

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 29352859

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Inverse agonist

Interaction Types & Directionality:

n/a

PMIDs:
16124775

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16124775

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TTD GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
22738316 10669560

Sources:
DTC DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
25127461

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
23545936

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 7 (5-HT7) receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Inverse agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
21486038

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

allosteric modulator

Interaction Info:

Specific Action of the Ligand Negative

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

Trial Name -

PMIDs:
14501155

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
10596692

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

Specific Action of the Ligand Antagonist

PMIDs:
23272794

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Antagonist

PMIDs:
20827463

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

PMIDs:
29352859

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inverse agonist

PMIDs:
17848919 17242925 7583621 10432496

Sources:
TEND DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
18996971 19509219 20827463

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
19337725

Sources:
DrugBank