DGIdb - HTR7 Gene Record

HTR7 3363 Druggable Genome

Alternate Names:

3363
5-HYDROXYTRYPTAMINE RECEPTOR 7
HTR7
5-HT7
182137
5302
ENSG00000148680
OTTHUMG00000018732
P34969
5HT7R_HUMAN
5-HT-7
Serotonin receptor 7
5-HT-X
5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (SEROTONIN RECEPTOR 7) (5-HT- X) (5HT7). [SOURCE:UNIPROT/SWISSPROT;ACC:P34969]
PA29561
5-HT 7 receptor
T79062

Gene Info:

Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Acc	IPR000276
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Family
Uniprot Status	Swiss-Prot
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Interpro Name	GPCR, rhodopsin-like, 7TM
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Target Main Class	Receptors
Transmembrane Helix Count	7
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.
Lacivita E et al., 2012, Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo., J Med Chem
Lovell PJ et al., 2000, A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970)., J Med Chem
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
George et al., 2013, Newer antipsychotics and upcoming molecules for schizophrenia., Eur. J. Clin. Pharmacol.
Bobo, 2013, Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults., Expert Rev Clin Pharmacol
Sugimoto et al., 2003, The tricyclic antidepressant clomipramine increases plasma glucose levels of mice., J. Pharmacol. Sci.
Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
Bang-Andersen et al., 2011, Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder., J. Med. Chem.
Fabricant DS et al., 2005, Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa., J Nat Prod
Kim Y et al., 2014, Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression., Bioorg Med Chem
Stark et al., 2007, Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies., Psychopharmacology (Berl.)
Meltzer, 1995, Role of serotonin in the action of atypical antipsychotic drugs., Clin. Neurosci.
Meltzer, 1999, The role of serotonin in antipsychotic drug action., Neuropsychopharmacology
Ruaño G et al., 2007, Physiogenomic association of statin-related myalgia to serotonin receptors., Muscle Nerve
Shimizu et al., 1997, Down-regulation of 5-hydroxytryptamine7 receptors by dexamethasone in rat frontocortical astrocytes., J. Neurochem.

CIMIPRONIDINE HTR7

Interaction Score: 5.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16124775

Sources:
DTC
FUKINOLIC ACID HTR7

Interaction Score: 5.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16124775

Sources:
DTC
CHEMBL282199 HTR7

Interaction Score: 4.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
22738316 10669560

Sources:
DTC
CHEMBL18840 HTR7

Interaction Score: 2.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25127461

Sources:
DTC
JNJ-18038683 HTR7

Interaction Score: 2.69

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
LY2590443 HTR7

Interaction Score: 1.34

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 7 (5-HT7) receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LURASIDONE HTR7

Interaction Score: 1.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name lurasidone, SM-13496,Latuda

Novel drug target Established target

PMIDs:
23545936

Sources:
TdgClinicalTrial
VORTIOXETINE HTR7

Interaction Score: 0.9

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Lu AA21004

Novel drug target Established target

PMIDs:
21486038

Sources:
TdgClinicalTrial
METHYSERGIDE HTR7

Interaction Score: 0.81

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
14501155

Sources:
TdgClinicalTrial TEND
ZIPRASIDONE HTR7

Interaction Score: 0.75

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17242925 7583621 10432496 17848919

Sources:
TEND
KETANSERIN HTR7

Interaction Score: 0.67

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
22738316

Sources:
DTC
BREXPIPRAZOLE HTR7

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name OPC-34712

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
BIFEPRUNOX HTR7

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name bifeprunox, DU127090

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ASENAPINE HTR7

Interaction Score: 0.45

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial
PARDOPRUNOX HTR7

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pardoprunox, SLV 308

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ILOPERIDONE HTR7

Interaction Score: 0.36

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

PMIDs:
23272794

Sources:
TdgClinicalTrial
CHLORPROMAZINE HTR7

Interaction Score: 0.26

Interaction Types & Directionality:

binder

antagonist (inhibitory)

Interaction Info:

PMIDs:
7908055

Sources:
NCI
CLOZAPINE HTR7

Interaction Score: 0.23

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
7908055 17848919 22738316

Sources:
DTC NCI
PRAVASTATIN HTR7

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17600820

Sources:
PharmGKB
SIMVASTATIN HTR7

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17600820

Sources:
PharmGKB
ATORVASTATIN HTR7

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17600820

Sources:
PharmGKB
OLANZAPINE HTR7

Interaction Score: 0.08

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ALKS 3831

Trial Name OREX-003, olanzapine plus zonisamide SR

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
17848919

Sources:
TdgClinicalTrial
DEXAMETHASONE HTR7

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9166758

Sources:
NCI

Ensembl: ENSG00000148680
- Version: 101_38
Alternate Names:

HTR7 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P34969
- Version: 11-September-2012
Alternate Names:

ENSG00000148680 Ensembl Gene Id

5HT7R_HUMAN Uniprot Id

P34969 Uniprot Accession

Gene Info:

Interpro Short Name 7TM_GPCR_Rhodpsn

Interpro Acc IPR000276

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P34969
- Version: January-2014
Alternate Names:

HTR7 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
TEND: P34969
- Version: 01-August-2011
Alternate Names:

P34969 Uniprot Accession

HTR7 Gene Symbol

3363 Entrez Gene Id

Gene Info:

Target Main Class Receptors

Transmembrane Helix Count 7

Target Subclass Rhodopsin

Publications:
RussLampel: ENSG00000148680
- Version: 26-July-2011
Alternate Names:

5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (SEROTONIN RECEPTOR 7) (5-HT- X) (5HT7). [SOURCE:UNIPROT/SWISSPROT;ACC:P34969] Description

ENSG00000148680 Ensembl Gene Id

HTR7 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: HTR7

Version: 18-August-2020

Alternate Names:

PA29561 PharmGKB ID

Gene Info:

Publications:

Wei YB et al., 2020, A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression., Mol Psychiatry

Ruaño G et al., 2007, Physiogenomic association of statin-related myalgia to serotonin receptors., Muscle Nerve

NCI: HTR7

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.

Shimizu et al., 1997, Down-regulation of 5-hydroxytryptamine7 receptors by dexamethasone in rat frontocortical astrocytes., J. Neurochem.

DTC: HTR7

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Lacivita E et al., 2012, Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo., J Med Chem

Fabricant DS et al., 2005, Cimipronidine, a cyclic guanidine alkaloid from Cimicifuga racemosa., J Nat Prod

Kim Y et al., 2014, Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression., Bioorg Med Chem

HingoraniCasas: ENSG00000148680
- Version: 31-May-2017
Alternate Names:

ENSG00000148680 Gene Symbol

HTR7 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: HTR7
- Version: chembl_23
Alternate Names:

HTR7 GENE_SYMBOL

5-hydroxytryptamine receptor 7 UNIPROT

5-HT-X UNIPROT

Gene Info:

Publications:
dGene: HTR7
- Version: 27-Jun-2013
Alternate Names:

3363 Gene ID

5-HT7 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: 5-HT 7 receptor
- Version: 2020.06.01
Alternate Names:

HTR7 TTD Gene Abbreviation

T79062 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Serotonin 7 (5-HT7) receptor antagonist
Direct Interaction	yes

Trial Name	lurasidone, SM-13496,Latuda
Novel drug target	Established target

Trial Name	bifeprunox, DU127090
Novel drug target	Established target

Trial Name	pardoprunox, SLV 308
Novel drug target	Established target

Trial Name	ALKS 3831
Trial Name	OREX-003, olanzapine plus zonisamide SR
Trial Name	Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

ENSG00000148680	Ensembl Gene Id
5HT7R_HUMAN	Uniprot Id
P34969	Uniprot Accession

5-HYDROXYTRYPTAMINE 7 RECEPTOR (5-HT-7) (SEROTONIN RECEPTOR 7) (5-HT- X) (5HT7). [SOURCE:UNIPROT/SWISSPROT;ACC:P34969]	Description
ENSG00000148680	Ensembl Gene Id
HTR7	Display Id

HTR7	GENE_SYMBOL
5-hydroxytryptamine receptor 7	UNIPROT
5-HT-X	UNIPROT

binder
antagonist (inhibitory)

HTR7 Gene Record

HTR7 3363 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16124775

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16124775

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 22738316 10669560

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25127461

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Serotonin 7 (5-HT7) receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name lurasidone, SM-13496,Latuda Novel drug target Established target

PMIDs: 23545936

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Lu AA21004 Novel drug target Established target

PMIDs: 21486038

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 14501155

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 17242925 7583621 10432496 17848919

Sources: TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 22738316

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name OPC-34712 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name bifeprunox, DU127090 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name Asenapine Novel drug target Established target

PMIDs: 18308814 21655346

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name pardoprunox, SLV 308 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name iloperidone,Fanapt, Fiapta, Zomaril

PMIDs: 23272794

Sources: TdgClinicalTrial

Interaction Types & Directionality: binder antagonist (inhibitory)

Interaction Info:

PMIDs: 7908055

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 7908055 17848919 22738316

Sources: DTC NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
16124775

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16124775

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
22738316 10669560

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25127461

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 7 (5-HT7) receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name lurasidone, SM-13496,Latuda

Novel drug target Established target

PMIDs:
23545936

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Lu AA21004

Novel drug target Established target

PMIDs:
21486038

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
14501155

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
17242925 7583621 10432496 17848919

Sources:
TEND

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
22738316

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name OPC-34712

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name bifeprunox, DU127090

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name pardoprunox, SLV 308

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name iloperidone,Fanapt, Fiapta, Zomaril

PMIDs:
23272794

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

binder

antagonist (inhibitory)

PMIDs:
7908055

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
7908055 17848919 22738316

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
17600820

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17600820

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17600820

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ALKS 3831

Trial Name OREX-003, olanzapine plus zonisamide SR

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
17848919

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
9166758

Sources:
NCI

Alternate Names:

HTR7 Ensembl Gene Name