DGIdb - HTR4 Gene Record

HTR4 3360 Druggable Genome

Alternate Names:

3360
5-HYDROXYTRYPTAMINE RECEPTOR 4
HTR4
5-HT4
5-HT4R
602164
5299
ENSG00000164270
OTTHUMG00000129931
Serotonin receptor 4
5-HT-4
5-HYDROXYTRYPTAMINE 4 RECEPTOR (5-HT-4) (SEROTONIN RECEPTOR 4) (5- HT4). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13639]
5HT4R_HUMAN
Q13639
BE0000084
5-HT<sub>4</sub> receptor
5-HT 4 receptor
T59679
9
NM_000870
NP_000861

Gene Info:

Human Readable Name	G PROTEIN COUPLED RECEPTOR
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Acc	IPR000276
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Name	GPCR, rhodopsin-like, 7TM
Target Subclass	Rhodopsin
Target Main Class	Receptors
Target Subclass	GPCR
Transmembrane Helix Count	7
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	5-Hydroxytryptamine receptors
GuideToPharmacology Gene Category ID	1

(9 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Bharucha et al., 2000, Effects of a serotonin 5-HT(4) receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans., Gut
Meulemans et al., 1992, Is the action of cisapride on the guinea-pig ileum mediated via 5-HT4 receptors?, Eur. J. Pharmacol.
Bach et al., 2001, 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle., Naunyn Schmiedebergs Arch. Pharmacol.
Yuan et al., 1994, Investigation of the role of 5-HT3 and 5-HT4 receptors in ascending and descending reflexes to the circular muscle of guinea-pig small intestine., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Crema et al., 1999, Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo., J. Pharmacol. Exp. Ther.
Cartier et al., 2003, Overexpression of serotonin4 receptors in cisapride-responsive adrenocorticotropin-independent bilateral macronodular adrenal hyperplasia causing Cushing's syndrome., J. Clin. Endocrinol. Metab.
Katayama et al., 1995, [Cisapride, a gastroprokinetic agent, binds to 5-HT4 receptors]., Nippon Yakurigaku Zasshi
Nagakura et al., 1999, Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor., Pharmacol. Res.
Rahme et al., 1999, Electrophysiological and antiarrhythmic effects of the atrial selective 5-HT(4) receptor antagonist RS-100302 in experimental atrial flutter and fibrillation., Circulation
Briejer et al., 1993, Cisapride and a structural analogue, R 76,186, are 5-hydroxytryptamine4 (5-HT4) receptor agonists on the guinea-pig colon ascendens., Naunyn Schmiedebergs Arch. Pharmacol.
Corsetti et al., 2002, Tegaserod: a new 5-HT(4) agonist in the treatment of irritable bowel syndrome., Expert Opin Pharmacother
Beattie et al., 2004, The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo., Br. J. Pharmacol.
Camilleri, 2001, Review article: tegaserod., Aliment. Pharmacol. Ther.
Kamm, 2002, Review article: the complexity of drug development for irritable bowel syndrome., Aliment. Pharmacol. Ther.
Cole et al., 2004, Tegaserod: a serotonin 5-HT4 receptor agonist for treatment of constipation-predominant irritable bowel syndrome., Drugs Today
Arranz et al., 1998, Characterization of the 5-HT4 binding site in human brain., J Neural Transm (Vienna)
Xu R et al., 2010, Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography., J Med Chem
Hedner E et al., 2008, Antifouling activity of a dibrominated cyclopeptide from the marine sponge Geodia barretti., J Nat Prod
Gobbi et al., 1997, Effects of chronic treatment with fluoxetine and citalopram on 5-HT uptake, 5-HT1B autoreceptors, 5-HT3 and 5-HT4 receptors in rats., Naunyn Schmiedebergs Arch. Pharmacol.
Camilleri M et al., 2007, Pharmacodynamic effects of a novel prokinetic 5-HT receptor agonist, ATI-7505, in humans., Neurogastroenterol Motil
Petrascheck M et al., 2007, An antidepressant that extends lifespan in adult Caenorhabditis elegans., Nature
van Wijngaarden et al., 1990, The concept of selectivity in 5-HT receptor research., Eur. J. Pharmacol.
Nakayama et al., 2005, Antiemetic activity of FK1052, a 5-HT3- and 5-HT4-receptor antagonist, in Suncus murinus and ferrets., J. Pharmacol. Sci.
Briejer et al., 2001, The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound., Eur. J. Pharmacol.
Raffa et al., 1996, Lack of binding of acetaminophen to 5-HT receptor or uptake sites (or eleven other binding/uptake assays)., Life Sci.
Craig et al., 1991, Peristalsis evoked by 5-HT and renzapride: evidence for putative 5-HT4 receptor activation., Br. J. Pharmacol.
McCullough et al., 2006, The 5-HT2B antagonist and 5-HT4 agonist activities of tegaserod in the anaesthetized rat., Pharmacol. Res.
Darblade et al., 2005, Piboserod (SB 207266), a selective 5-HT4 receptor antagonist, reduces serotonin potentiation of neurally-mediated contractile responses of human detrusor muscle., World J Urol
Guillemot et al., 2009, Metoclopramide stimulates catecholamine- and granin-derived peptide secretion from pheochromocytoma cells through activation of serotonin type 4 (5-HT4) receptors., Endocr. Relat. Cancer
Bartolini A et al., 2011, Analgesic and antineuropathic drugs acting through central cholinergic mechanisms., Recent Pat CNS Drug Discov
Lee A et al., 2010, Metoclopramide in the treatment of diabetic gastroparesis., Expert Rev Endocrinol Metab
Alarcón de la Lastra et al., 1998, Effects of cinitapride on gastric ulceration and secretion in rats., Inflamm. Res.
Alarcón-de-la-Lastra Romero et al., 1997, Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds., Pharmacology

CISAPRIDE HTR4

Interaction Score: 4.33

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11034583 1555639 11218067 7952869 11752352 10027842 12519861 7557734 10328995 10556228 8321323

Sources:
NCI TEND TTD DrugBank GuideToPharmacology
PIBOSEROD HTR4

Interaction Score: 4.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
16495076 15902472

Sources:
TTD DrugBank GuideToPharmacology
PF-04995274 HTR4

Interaction Score: 3.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction Measured at the 5-HT<sub>4d</sub> receptor.

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology
REVEXEPRIDE HTR4

Interaction Score: 3.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
PRUCALOPRIDE HTR4

Interaction Score: 3.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist

PMIDs:
11438309

Sources:
DrugBank GuideToPharmacology ChemblInteractions
VELUSETRAG HTR4

Interaction Score: 3.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
None found

Sources:
TTD DrugBank GuideToPharmacology ChemblInteractions
TAK-954 HTR4

Interaction Score: 3.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TTD GuideToPharmacology
CHEMBL401607 HTR4

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18271554

Sources:
DTC
CHEMBL114112 HTR4

Interaction Score: 3.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20812727

Sources:
DTC
TEGASEROD HTR4

Interaction Score: 2.92

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
12150698 15466450 11207504 11752352 11876686 15645012

Sources:
TTD DrugBank GuideToPharmacology
NARONAPRIDE HTR4

Interaction Score: 2.43

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist

Direct Interaction yes

PMIDs:
17187586

Sources:
DrugBank ChemblInteractions
SUVN-D4010 HTR4

Interaction Score: 1.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CINITAPRIDE HTR4

Interaction Score: 1.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
9562338 9211565

Sources:
DrugBank
MOSAPRIDE HTR4

Interaction Score: 1.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology
DA-6886 HTR4

Interaction Score: 1.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ZACOPRIDE HTR4

Interaction Score: 1.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
CISAPRIDE HTR4

Interaction Score: 1.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
RENZAPRIDE HTR4

Interaction Score: 1.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
1364818

Sources:
TTD DrugBank GuideToPharmacology
TICALOPRIDE HTR4

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
LINTOPRIDE HTR4

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
METOCLOPRAMIDE HYDROCHLORIDE HTR4

Interaction Score: 0.54

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RELENOPRIDE HTR4

Interaction Score: 0.54

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
TROPISETRON HTR4

Interaction Score: 0.49

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
9826103

Sources:
NCI GuideToPharmacology
METOCLOPRAMIDE HTR4

Interaction Score: 0.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
18948374 21585331 21278804

Sources:
DrugBank
CAPESEROD HTR4

Interaction Score: 0.36

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 4 (5-HT4) receptor partial agonist

Specific Action of the Ligand Partial agonist

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
TEGASEROD MALEATE HTR4

Interaction Score: 0.27

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 4 (5-HT4) receptor partial agonist

PMIDs:
None found

Sources:
ChemblInteractions
ONDANSETRON HTR4

Interaction Score: 0.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
2164935

Sources:
DrugBank
VILAZODONE HTR4

Interaction Score: 0.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
ZOLMITRIPTAN HTR4

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TEND
METITEPINE HTR4

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18033297

Sources:
DTC
MIANSERIN HTR4

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18033297

Sources:
DTC
FLUOXETINE HTR4

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9228186

Sources:
NCI
ACETAMINOPHEN HTR4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8699917

Sources:
NCI
SEROTONIN HTR4

Interaction Score: 0.07

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? True

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology
CISPLATIN HTR4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16079468

Sources:
NCI

Ensembl: ENSG00000164270
- Version: 101_38
Alternate Names:

HTR4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000164270
- Version: 26-July-2011
Alternate Names:

ENSG00000164270 Ensembl Gene Id

5-HYDROXYTRYPTAMINE 4 RECEPTOR (5-HT-4) (SEROTONIN RECEPTOR 4) (5- HT4). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13639] Description

HTR4 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: Q13639
- Version: 01-August-2011
Alternate Names:

Q13639 Uniprot Accession

3360 Entrez Gene Id

HTR4 Gene Symbol

Gene Info:

Target Main Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HopkinsGroom: Q13639
- Version: 11-September-2012
Alternate Names:

5-HYDROXYTRYPTAMINE RECEPTOR 4 Uniprot Protein Name

5HT4R_HUMAN Uniprot Id

Q13639 Uniprot Accession

Gene Info:

Interpro Short Name 7TM_GPCR_Rhodpsn

Interpro Acc IPR000276

Human Readable Name DRUGGABLE GENOME

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 3360
- Version: 29-September-2020
Alternate Names:

5299 HUGO Gene ID

5299 HUGO Gene Symbol

5-hydroxytryptamine receptor 4 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name 5-Hydroxytryptamine receptors

GuideToPharmacology Gene Category ID 1

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

DrugBank: BE0000084

Version: 5.1.7

Alternate Names:

HTR4 DrugBank Gene Name

Q13639 UniProt Accession

3360 Entrez Gene Id

Gene Info:

Publications:

Bharucha et al., 2000, Effects of a serotonin 5-HT(4) receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans., Gut

Bach et al., 2001, 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle., Naunyn Schmiedebergs Arch. Pharmacol.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

NCI: HTR4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Gobbi et al., 1997, Effects of chronic treatment with fluoxetine and citalopram on 5-HT uptake, 5-HT1B autoreceptors, 5-HT3 and 5-HT4 receptors in rats., Naunyn Schmiedebergs Arch. Pharmacol.

Nakayama et al., 2005, Antiemetic activity of FK1052, a 5-HT3- and 5-HT4-receptor antagonist, in Suncus murinus and ferrets., J. Pharmacol. Sci.

Arranz et al., 1998, Characterization of the 5-HT4 binding site in human brain., J Neural Transm (Vienna)

DTC: HTR4

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Petrascheck M et al., 2007, An antidepressant that extends lifespan in adult Caenorhabditis elegans., Nature

Hedner E et al., 2008, Antifouling activity of a dibrominated cyclopeptide from the marine sponge Geodia barretti., J Nat Prod

Xu R et al., 2010, Synthesis, structure-affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission tomography., J Med Chem

ChemblInteractions: HTR4
- Version: chembl_23
Alternate Names:

HTR4 GENE_SYMBOL

5-hydroxytryptamine receptor 4 UNIPROT

Serotonin receptor 4 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000164270
- Version: 31-May-2017
Alternate Names:

ENSG00000164270 Gene Symbol

HTR4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: HTR4
- Version: 27-Jun-2013
Alternate Names:

3360 Gene ID

5-HT4 dGene Synonym

5-HT4R dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: 5-HT 4 receptor
- Version: 2020.06.01
Alternate Names:

HTR4 TTD Gene Abbreviation

T59679 TTD Target ID

Gene Info:

Publications:
GO: HTR4
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Specific Action of the Ligand	Partial agonist
Endogenous Drug?	False
Direct Interaction?	True

Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

Details of the Assay for Interaction	Measured at the 5-HT<sub>4d</sub> receptor.
Specific Action of the Ligand	Partial agonist
Endogenous Drug?	False

Mechanism of Interaction	Serotonin 4 (5-HT4) receptor agonist
Direct Interaction	yes

Specific Action of the Ligand	Agonist
Endogenous Drug?	False
Direct Interaction?	True

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False

Direct Interaction	yes
Mechanism of Interaction	Serotonin 4 (5-HT4) receptor partial agonist
Specific Action of the Ligand	Partial agonist

ENSG00000164270	Ensembl Gene Id
5-HYDROXYTRYPTAMINE 4 RECEPTOR (5-HT-4) (SEROTONIN RECEPTOR 4) (5- HT4). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13639]	Description
HTR4	Display Id

5-HYDROXYTRYPTAMINE RECEPTOR 4	Uniprot Protein Name
5HT4R_HUMAN	Uniprot Id
Q13639	Uniprot Accession

5299	HUGO Gene ID
5299	HUGO Gene Symbol
5-hydroxytryptamine receptor 4	HUGO Gene Name

HTR4	DrugBank Gene Name
Q13639	UniProt Accession
3360	Entrez Gene Id

HTR4	GENE_SYMBOL
5-hydroxytryptamine receptor 4	UNIPROT
Serotonin receptor 4	UNIPROT

HTR4 Gene Record

HTR4 3360 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False Direct Interaction? True

PMIDs: 11034583 1555639 11218067 7952869 11752352 10027842 12519861 7557734 10328995 10556228 8321323

Sources: NCI TEND TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 16495076 15902472

Sources: TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Details of the Assay for Interaction Measured at the 5-HT<sub>4d</sub> receptor. Specific Action of the Ligand Partial agonist Endogenous Drug? False

PMIDs: None found

Sources: TTD GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist Direct Interaction yes

PMIDs: None found

Sources: TTD ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist

PMIDs: 11438309

Sources: DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Agonist

PMIDs: None found

Sources: TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: TTD GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18271554

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20812727

Sources: DTC

Interaction Types & Directionality: partial agonist (activating) agonist (activating) antagonist (inhibitory)

Interaction Info: Specific Action of the Ligand Partial agonist Endogenous Drug? False

PMIDs: 12150698 15466450 11207504 11752352 11876686 15645012

Sources: TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist Direct Interaction yes

PMIDs: 17187586

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 9562338 9211565

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: None found

Sources: TTD GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: 1364818

Sources: TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11034583 1555639 11218067 7952869 11752352 10027842 12519861 7557734 10328995 10556228 8321323

Sources:
NCI TEND TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
16495076 15902472

Sources:
TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of the Assay for Interaction Measured at the 5-HT<sub>4d</sub> receptor.

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist

PMIDs:
11438309

Sources:
DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Agonist

PMIDs:
None found

Sources:
TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TTD GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
18271554

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
20812727

Sources:
DTC

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

PMIDs:
12150698 15466450 11207504 11752352 11876686 15645012

Sources:
TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist

Direct Interaction yes

PMIDs:
17187586

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

PMIDs:
9562338 9211565

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
1364818

Sources:
TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 4 (5-HT4) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Partial agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found