3357 |
5-HYDROXYTRYPTAMINE RECEPTOR 2B |
HTR2B |
5-HT(2B) |
5-HT-2B |
5-HT2B |
601122 |
5294 |
ENSG00000135914 |
OTTHUMG00000133222 |
BE0000393 |
P41595 |
5HT2B_HUMAN |
Serotonin receptor 2B |
5-HYDROXYTRYPTAMINE 2B RECEPTOR (5-HT-2B) (SEROTONIN RECEPTOR 2B). [SOURCE:UNIPROT/SWISSPROT;ACC:P41595] |
7 |
5-HT<sub>2B</sub> receptor |
5-HT 2B receptor |
T31204 |
NM_000867 |
NP_000858 |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Status | Swiss-Prot |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Acc | IPR000276 |
Interpro Type | Family |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Transmembrane Helix Count | 7 |
Target Main Class | Receptors |
Gene Biotype | PROTEIN_CODING |
GuideToPharmacology Gene Category Name | 5-Hydroxytryptamine receptors |
GuideToPharmacology Gene Category ID | 1 |
KINASE |
DRUG RESISTANCE |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
antagonist (inhibitory) |
Trial Name | PRX-08066 |
Novel drug target | Established target |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Biased agonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Trial Name | agomelatine, AGO178C, S-20098,Valdoxan, Thymanax |
Novel drug target | Established target |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
Specific Action of the Ligand | Agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
partial agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2b (5-HT2b) receptor partial agonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2b (5-HT2b) receptor antagonist |
antagonist (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
agonist (activating) |
Specific Action of the Ligand | Partial agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Endogenous Drug? | False |
Direct Interaction? | False |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
Details of the Assay for Interaction | Biased for β-arrestin signalling. |
Specific Action of the Ligand | Biased agonist |
Endogenous Drug? | False |
agonist (activating) |
Endogenous Drug? | False |
Specific Action of the Ligand | Full agonist |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
n/a |
Trial Name | renzapride |
Novel drug target | Established target |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | Asenapine |
agonist (activating) |
antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Partial agonist |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
Specific Action of the Ligand | Partial agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Trial Name | Silenor (SO-101) |
Novel drug target | Established target |
agonist (activating) |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Trial Name | terguride |
Novel drug target | Established target |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
antagonist (inhibitory) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
Specific Action of the Ligand | Partial agonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Partial agonist |
Endogenous Drug? | False |
agonist (activating) |
Endogenous Drug? | False |
Specific Action of the Ligand | Full agonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
n/a |
Trial Name | - |
Novel drug target | Established target |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
binder |
antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
n/a |
Novel drug target | Established target |
Trial Name | Seroquel |
agonist (activating) |
Endogenous Drug? | True |
Specific Action of the Ligand | Full agonist |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
HTR2B | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
P41595 | Uniprot Accession |
HTR2B | Gene Symbol |
3357 | Entrez Gene Id |
Target Subclass | Rhodopsin |
Transmembrane Helix Count | 7 |
Target Subclass | GPCR |
5-HYDROXYTRYPTAMINE RECEPTOR 2B | Uniprot Protein Name |
P41595 | Uniprot Accession |
5HT2B_HUMAN | Uniprot Id |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Status | Swiss-Prot |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
ENSG00000135914 | Ensembl Gene Id |
HTR2B | Display Id |
5-HYDROXYTRYPTAMINE 2B RECEPTOR (5-HT-2B) (SEROTONIN RECEPTOR 2B). [SOURCE:UNIPROT/SWISSPROT;ACC:P41595] | Description |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
HTR2B | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
5294 | HUGO Gene ID |
5294 | HUGO Gene Symbol |
5-hydroxytryptamine receptor 2B | HUGO Gene Name |
GuideToPharmacology Gene Category Name | 5-Hydroxytryptamine receptors |
GuideToPharmacology Gene Category ID | 1 |
G PROTEIN COUPLED RECEPTOR |
HTR2B | DrugBank Gene Name |
P41595 | UniProt Accession |
3357 | Entrez Gene Id |
HTR2B | GENE_SYMBOL |
5-hydroxytryptamine receptor 2B | UNIPROT |
Serotonin receptor 2B | UNIPROT |
ENSG00000135914 | Gene Symbol |
HTR2B | Ensembl Id |
DRUGGABLE GENOME |
P41595 | UniProt ID |
5-hydroxytryptamine receptor 2B | Gene Name |
KINASE |
3357 | Gene ID |
5-HT(2B) | dGene Synonym |
5-HT2B | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |
HTR2B | TTD Gene Abbreviation |
T31204 | TTD Target ID |
DRUG RESISTANCE, G PROTEIN COUPLED RECEPTOR |