3356 |
5-HYDROXYTRYPTAMINE RECEPTOR 2A |
HTR2A |
5-HT2A |
HTR2 |
182135 |
5293 |
ENSG00000102468 |
OTTHUMG00000016881 |
Serotonin receptor 2A |
5-HT-2 |
5-HT-2A |
P28223 |
5HT2A_HUMAN |
BE0000451 |
PA193 |
6 |
5-HT<sub>2A</sub> receptor |
BE0004881 |
5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTOR 2A) (5- HT-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P28223] |
BE0004957 |
5-HT 2A receptor |
T32060 |
NP_000612 |
NM_000621 |
Target Main Class | Receptors |
Target Subclass | Rhodopsin |
Transmembrane Helix Count | 7 |
Target Subclass | GPCR |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Interpro Acc | IPR000276 |
Uniprot Status | Swiss-Prot |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Interpro Type | Family |
Human Readable Name | DRUGGABLE GENOME |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Target Class | Receptors |
Gene Biotype | PROTEIN_CODING |
GuideToPharmacology Gene Category Name | 5-Hydroxytryptamine receptors |
GuideToPharmacology Gene Category ID | 1 |
KINASE |
DRUG RESISTANCE |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
inverse agonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor inverse agonist |
Direct Interaction | yes |
inverse agonist (inhibitory) |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | Pimavanserin |
Details of the Assay for Interaction | Ki determined in membrane radioligand binding assay. |
inverse agonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor inverse agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | iferanserin ointment |
Novel drug target | Established target |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | True |
inverse agonist (inhibitory) |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Trial Name | volinanserin |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
inverse agonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor inverse agonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
n/a |
Trial Name | INN-00835, nemifitide |
Novel drug target | Established target |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | False |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | trazodone extended release, DDS-04A,Oleptro |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | ITI-007, ITI-722 |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Specific Action of the Ligand | Antagonist |
inverse agonist (inhibitory) |
Trial Name | esmirtazapine, ORG-4420 |
Novel drug target | Established target |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Direct Interaction? | True |
Endogenous Drug? | False |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
Trial Name | trelanserin, SL 65.0472 |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
Trial Name | mirtazapine,Remeron, Remeron SolTab, Reflex |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
Trial Name | OPC-34712 |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Trial Name | - |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | lurasidone, SM-13496,Latuda |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
n/a |
Trial Name | Risperdal |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Trial Name | paliperidone ER, paliperidone palmitate |
Novel drug target | Established target |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | Serdolect |
Novel drug target | Established target |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Agonist |
Endogenous Drug? | False |
Direct Interaction? | False |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Trial Name | olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv |
Novel drug target | Established target |
Trial Name | Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac) |
agonist (activating) |
Specific Action of the Ligand | Partial agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Trial Name | Asenapine |
Novel drug target | Established target |
Specific Action of the Ligand | Antagonist |
agonist (activating) |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
inverse agonist (inhibitory) |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | False |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Partial agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Specific Action of the Ligand | Inverse agonist |
antagonist (inhibitory) |
Trial Name | Silenor (SO-101) |
Novel drug target | Established target |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
n/a |
Novel drug target | Established target |
Trial Name | renzapride |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Inverse agonist |
Endogenous Drug? | False |
Direct Interaction? | True |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
agonist (activating) |
antagonist (inhibitory) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
partial agonist (activating) |
agonist (activating) |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Specific Action of the Ligand | Partial agonist |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
n/a |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | True |
n/a |
Trial Name | bifeprunox, DU127090 |
Novel drug target | Established target |
agonist (activating) |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Endogenous Drug? | False |
Specific Action of the Ligand | Full agonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Partial agonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Partial agonist |
Endogenous Drug? | False |
Trial Name | terguride |
antagonist (inhibitory) |
Trial Name | AZ-004 |
Novel drug target | Established target |
Specific Action of the Ligand | Inverse agonist |
binder |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
Specific Action of the Ligand | Inverse agonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
inverse agonist (inhibitory) |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Endogenous Drug? | True |
Specific Action of the Ligand | Full agonist |
agonist (activating) |
antagonist (inhibitory) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
agonist (activating) |
Endogenous Drug? | False |
Specific Action of the Ligand | Partial agonist |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Trial Name | OMS-103HP |
Novel drug target | Established target |
agonist (activating) |
Specific Action of the Ligand | Full agonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | False |
agonist (activating) |
Endogenous Drug? | False |
Specific Action of the Ligand | Full agonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
Specific Action of the Ligand | Antagonist |
other/unknown |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | True |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 2a (5-HT2a) receptor antagonist |
antagonist (inhibitory) |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Trial Name | NPL-2008, Fluoxetine |
Novel drug target | Established target |
HTR2A | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
P28223 | Uniprot Accession |
5HT2A_HUMAN | Uniprot Id |
HTR2A | Gene Symbol |
Target Main Class | Receptors |
Target Subclass | Rhodopsin |
Transmembrane Helix Count | 7 |
HTR2A | Display Id |
5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTOR 2A) (5- HT-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P28223] | Description |
ENSG00000102468 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
3356 | Entrez Gene Id |
5-HYDROXYTRYPTAMINE RECEPTOR 2A | Uniprot Protein Name |
HTR2A | Uniprot Gene Name |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Interpro Acc | IPR000276 |
Uniprot Status | Swiss-Prot |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
HTR2A | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
5293 | HUGO Gene ID |
5293 | HUGO Gene Symbol |
5-hydroxytryptamine receptor 2A | HUGO Gene Name |
GuideToPharmacology Gene Category Name | 5-Hydroxytryptamine receptors |
GuideToPharmacology Gene Category ID | 1 |
G PROTEIN COUPLED RECEPTOR |
PA193 | PharmGKB ID |
HTR2A | DrugBank Gene Name |
P28223 | UniProt Accession |
3356 | Entrez Gene Id |
HTR2A | DrugBank Gene Name |
P28223 | UniProt Accession |
3356 | Entrez Gene Id |
HTR2A | DrugBank Gene Name |
P28223 | UniProt Accession |
3356 | Entrez Gene Id |
HTR2A | TTD Gene Abbreviation |
T32060 | TTD Target ID |
ENSG00000102468 | Gene Symbol |
HTR2A | Ensembl Id |
DRUGGABLE GENOME |
HTR2 | GENE_SYMBOL |
HTR2A | GENE_SYMBOL |
5-hydroxytryptamine receptor 2A | UNIPROT |
5-hydroxytryptamine receptor 2A | Gene Name |
P28223 | UniProt ID |
KINASE |
HTR2 | GO Gene Synonym |
DRUG RESISTANCE, G PROTEIN COUPLED RECEPTOR |
3356 | Gene ID |
5-HT2A | dGene Synonym |
HTR2 | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |