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HTR2A Gene Record

  • Summary
  • Interactions
  • Claims
  • HTR2A 3356 Druggable GenomeDrug Resistance

    Alternate Names:

    3356
    5-HYDROXYTRYPTAMINE RECEPTOR 2A
    HTR2A
    5-HT2A
    HTR2
    182135
    5293
    ENSG00000102468
    OTTHUMG00000016881
    Serotonin receptor 2A
    5-HT-2
    5-HT-2A
    P28223
    5HT2A_HUMAN
    BE0000451
    PA193
    6
    5-HT<sub>2A</sub> receptor
    BE0004881
    5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTOR 2A) (5- HT-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P28223]
    BE0004957
    5-HT 2A receptor
    T32060
    NP_000612
    NM_000621

    Gene Info:

    Target Main Class Receptors
    Target Subclass Rhodopsin
    Transmembrane Helix Count 7
    Target Subclass GPCR
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Acc IPR000276
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Interpro Type Family
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Target Class Receptors
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name 5-Hydroxytryptamine receptors
    GuideToPharmacology Gene Category ID 1
    (13 More Sources)

    Gene Categories: Category Details

    KINASE
    DRUG RESISTANCE
    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.
    Yamada et al., 1995, Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice., Biol. Pharm. Bull.
    Kusumi et al., 2000, Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain., J Neural Transm (Vienna)
    Tyson et al., 2004, Are the cognitive effects of atypical antipsychotics influenced by their affinity to 5HT-2A receptors?, Int. J. Neurosci.
    Maeda et al., 2014, Brexpiprazole I: in vitro and in vivo characterization of a novel serotonin-dopamine activity modulator., J. Pharmacol. Exp. Ther.
    Hesselink, 2002, Iloperidone (Novartis)., IDrugs
    Kongsamut et al., 1996, Iloperidone binding to human and rat dopamine and 5-HT receptors., Eur. J. Pharmacol.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Serretti et al., Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders., J Psychiatr Res
    Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
    Sharif et al., 2009, Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes., Exp. Eye Res.
    Sharif, 2010, Serotonin-2 receptor agonists as novel ocular hypotensive agents and their cellular and molecular mechanisms of action., Curr Drug Targets
    Lam, 2000, Clinical pharmacology of dopamine agonists., Pharmacotherapy
    Kumar B et al., 2018, Lumateperone: a new treatment approach for neuropsychiatric disorders., Drugs Today (Barc)
    Wander et al., 1987, Antagonism by neuroleptics of serotonin 5-HT1A and 5-HT2 receptors of normal human brain in vitro., Eur. J. Pharmacol.
    Antkiewicz-Michaluk, The influence of chronic treatment with antidepressant neuroleptics on the central serotonin system., Pol J Pharmacol Pharm
    Khalifa, 2003, Zuclopenthixol facilitates memory retrieval in rats: possible involvement of noradrenergic and serotonergic mechanisms., Pharmacol. Biochem. Behav.
    Gjerden et al., 2009, Association between the use of anticholinergic antiparkinson drugs and safety and receptor drug-binding profiles of antipsychotic agents., Eur. J. Clin. Pharmacol.
    Nyberg et al., 1995, Central D2 receptor occupancy and effects of zuclopenthixol acetate in humans., Int Clin Psychopharmacol
    Lyon et al., 1986, 3,4-Methylenedioxymethamphetamine (MDMA): stereoselective interactions at brain 5-HT1 and 5-HT2 receptors., Psychopharmacology (Berl.)
    Nash et al., 1994, Effect of the R(-) and S(+) isomers of MDA and MDMA on phosphatidyl inositol turnover in cultured cells expressing 5-HT2A or 5-HT2C receptors., Neurosci. Lett.
    Baxter et al., 1994, Further characterization of 5-hydroxytryptamine receptors (putative 5-HT2B) in rat stomach fundus longitudinal muscle., Br. J. Pharmacol.
    Kaumann, 1983, Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors., Naunyn Schmiedebergs Arch. Pharmacol.
    Leysen et al., 1994, Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity., J Clin Psychiatry
    Kroeze et al., 2003, H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs., Neuropsychopharmacology
    Nakamura et al., 2001, Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism., Eur. J. Pharmacol.
    Kobayashi et al., 1996, Cyclobenzaprine, a centrally acting muscle relaxant, acts on descending serotonergic systems., Eur. J. Pharmacol.
    Mestres J et al., 2011, Linking pharmacology to clinical reports: cyclobenzaprine and its possible association with serotonin syndrome., Clin Pharmacol Ther
    Honda et al., 2003, Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors., Eur. J. Pharmacol.
    Grinshpoon et al., 2000, Beneficial effect of the addition of the 5-HT 2A/2C and alpha2 antagonist mianserin to ongoing haloperidol treatment in drug-resistant chronically hospitalized schizophrenic patients., Eur. Psychiatry
    Deeks, 2015, Flibanserin: First Global Approval., Drugs
    Invernizzi et al., 2003, Flibanserin, a potential antidepressant drug, lowers 5-HT and raises dopamine and noradrenaline in the rat prefrontal cortex dialysate: role of 5-HT(1A) receptors., Br. J. Pharmacol.
    Borsini et al., 2002, Pharmacology of flibanserin., CNS Drug Rev
    Peroutka et al., 1981, Two distinct central serotonin receptors with different physiological functions., Science
    Dupont et al., 1996, Epinastine (WAL 801CL) modulates the noncholinergic contraction in guinea-pig airways in vitro by a prejunctional 5-HT1-like receptor., Eur. Respir. J.
    Dupont et al., 1999, Epinastine (WAL 801CL) inhibits the electrical field stimulation-induced cholinergic contraction in guinea pig and human airways in vitro., Eur. Respir. J.
    Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
    Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
    Berger et al., 1996, Trimipramine: a challenge to current concepts on antidepressives., Eur Arch Psychiatry Clin Neurosci
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Richelson et al., 2000, Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds., Life Sci.
    McIntyre et al., 2007, A preclinical and clinical rationale for quetiapine in mood syndromes., Expert Opin Pharmacother
    Goldstein, 1999, Quetiapine fumarate (Seroquel): a new atypical antipsychotic., Drugs Today
    Yatham et al., 2005, Atypical antipsychotics in bipolar depression: potential mechanisms of action., J Clin Psychiatry
    Rauser et al., 2001, Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor., J. Pharmacol. Exp. Ther.
    Choi et al., 2004, Synthesis, receptor binding and functional studies of mesoridazine stereoisomers., Bioorg. Med. Chem. Lett.
    Herrick-Davis et al., 2000, Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors., J. Pharmacol. Exp. Ther.
    Hayslett et al., 2005, Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndrome., Pharmacol. Biochem. Behav.
    Hayslett et al., 2003, Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome., Pharmacol. Biochem. Behav.
    Schreiber et al., 1994, Blockade of the discriminative stimulus effects of DOI by MDL 100,907 and the 'atypical' antipsychotics, clozapine and risperidone., Eur. J. Pharmacol.
    Lindström et al., 2006, Sertindole: efficacy and safety in schizophrenia., Expert Opin Pharmacother
    Hietala et al., 2001, Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment., Psychopharmacology (Berl.)
    Reimold et al., 2007, Occupancy of dopamine D(1), D (2) and serotonin (2A) receptors in schizophrenic patients treated with flupentixol in comparison with risperidone and haloperidol., Psychopharmacology (Berl.)
    Kasho et al., 1998, Serotonin enhances the production of type IV collagen by human mesangial cells., Kidney Int.
    Egan et al., 1998, Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors., Psychopharmacology (Berl.)
    Murphy GM Jr et al., 2003, Pharmacogenetics of antidepressant medication intolerance., Am J Psychiatry
    Wilkie MJ et al., 2009, Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy., Pharmacogenomics J
    Foster RH et al., 1997, Paroxetine : a review of its pharmacology and therapeutic potential in the management of panic disorder., CNS Drugs
    Meyer et al., 2001, The effect of paroxetine on 5-HT(2A) receptors in depression: an [(18)F]setoperone PET imaging study., Am J Psychiatry
    Bixo et al., 2001, Binding of [3H]paroxetine to serotonin uptake sites and of [3H]lysergic acid diethylamide to 5-HT2A receptors in platelets from women with premenstrual dysphoric disorder during gonadotropin releasing hormone treatment., Psychoneuroendocrinology
    Newcombe F et al., 1969, Alkaloids of the leaves of Voacanga schweinfurthii Stapf., Planta Med
    Tanaka M et al., 2008, Genetic polymorphisms in the 5-hydroxytryptamine type 3B receptor gene and paroxetine-induced nausea., Int J Neuropsychopharmacol
    Kato M et al., 2009, 5-HT2A gene variants influence specific and different aspects of antidepressant response in Japanese and Italian mood disorder patients., Psychiatry Res
    Costall et al., 1995, Behavioural interactions between 5-hydroxytryptophan, neuroleptic agents and 5-HT receptor antagonists in modifying rodent responding to aversive situations., Br. J. Pharmacol.
    Morisset et al., 1999, Atypical neuroleptics enhance histamine turnover in brain via 5-Hydroxytryptamine2A receptor blockade., J. Pharmacol. Exp. Ther.
    Canton et al., 1994, Competitive antagonism of serotonin (5-HT)2C and 5-HT2A receptor-mediated phosphoinositide (PI) turnover by clozapine in the rat: a comparison to other antipsychotics., Neurosci. Lett.
    Andree et al., 1986, Differential effect of subchronic treatment with various neuroleptic agents on serotonin2 receptors in rat cerebral cortex., J. Neurochem.
    Burki, 1986, Binding of psychoactive drugs to rat brain amine receptors, measured ex vivo, and their effects on the metabolism of biogenic amines., Naunyn Schmiedebergs Arch. Pharmacol.
    Broderick et al., 2004, Clozapine and cocaine effects on dopamine and serotonin release in nucleus accumbens during psychostimulant behavior and withdrawal., Prog. Neuropsychopharmacol. Biol. Psychiatry
    McDonald et al., 2003, Enhancement of latent inhibition by two 5-HT2A receptor antagonists only when given at both pre-exposure and conditioning., Psychopharmacology (Berl.)
    Reist et al., 2004, Inter-relationships of intermediate phenotypes for serotonin function, impulsivity, and a 5-HT2A candidate allele: His452Tyr., Mol. Psychiatry
    Arranz et al., 1996, Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine., Neurosci. Lett.
    Salloum NC et al., 2014, Towards the clinical implementation of pharmacogenetics in bipolar disorder., BMC Med
    Heiser et al., 2004, Effects of clozapine and its metabolites on the 5-HT2 receptor system in cortical and hippocampal cells in vitro., Prog. Neuropsychopharmacol. Biol. Psychiatry
    Travis et al., 1998, 5-HT2A receptor blockade in patients with schizophrenia treated with risperidone or clozapine. A SPET study using the novel 5-HT2A ligand 123I-5-I-R-91150., Br J Psychiatry
    Muntasir HA et al., 2006, Inverse agonist activity of sarpogrelate, a selective 5-HT2A-receptor antagonist, at the constitutively active human 5-HT2A receptor., J Pharmacol Sci
    Friedman, 2013, Pimavanserin for the treatment of Parkinson's disease psychosis., Expert Opin Pharmacother
    Bortolozzi et al., 2007, In vivo actions of aripiprazole on serotonergic and dopaminergic systems in rodent brain., Psychopharmacology (Berl.)
    Meltzer et al., 2003, Serotonin receptors: their key role in drugs to treat schizophrenia., Prog. Neuropsychopharmacol. Biol. Psychiatry
    Stark et al., 2007, Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies., Psychopharmacology (Berl.)
    de Bartolomeis A et al., 2015, Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism., CNS Drugs
    Pawlyk AC et al., 2006, Effects of the 5-HT2A antagonist mirtazapine in rat models of thermoregulation., Brain Res
    Celada P et al., 2004, The therapeutic role of 5-HT1A and 5-HT2A receptors in depression., J Psychiatry Neurosci
    Nutt, 1999, Care of depressed patients with anxiety symptoms., J Clin Psychiatry
    Anttila et al., 2001, A review of the pharmacological and clinical profile of mirtazapine., CNS Drug Rev
    Waldinger et al., 2000, Treatment of hot flushes with mirtazapine: four case reports., Maturitas
    Gorman, 1999, Mirtazapine: clinical overview., J Clin Psychiatry
    Westenberg, 1999, Pharmacology of antidepressants: selectivity or multiplicity?, J Clin Psychiatry
    Laakmann et al., 1999, Effects of mirtazapine on growth hormone, prolactin, and cortisol secretion in healthy male subjects., Psychoneuroendocrinology
    Deeks ED et al., 2010, Blonanserin: a review of its use in the management of schizophrenia., CNS Drugs
    Bisson WH et al., 2007, Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs., Proc Natl Acad Sci U S A
    Martin et al., 1982, Ketamine inhibits serotonin uptake in vivo., Neuropharmacology
    Yamada et al., 2002, Prediction and assessment of extrapyramidal side effects induced by risperidone based on dopamine D(2) receptor occupancy., Synapse
    Cohen, Risperidone., Pharmacotherapy
    Megens et al., 1994, Survey on the pharmacodynamics of the new antipsychotic risperidone., Psychopharmacology (Berl.)
    He et al., 1995, A pharmacological, pharmacokinetic and clinical overview of risperidone, a new antipsychotic that blocks serotonin 5-HT2 and dopamine D2 receptors., Int Clin Psychopharmacol
    Taylor et al., 1995, Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug., J Clin Psychiatry
    Horton et al., 1999, Akinetopsia from nefazodone toxicity., Am. J. Ophthalmol.
    Eckler et al., 2003, Nefazodone in the rat: mimicry and antagonism of [-]-DOM-induced stimulus control., Pharmacol. Biochem. Behav.
    Avila et al., 2003, Does nefazodone improve both depression and Parkinson disease? A pilot randomized trial., J Clin Psychopharmacol
    Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
    Meyer et al., 1999, The effects of single dose nefazodone and paroxetine upon 5-HT2A binding potential in humans using [18F]-setoperone PET., Psychopharmacology (Berl.)
    Davis et al., 1997, Nefazodone. A review of its pharmacology and clinical efficacy in the management of major depression., Drugs
    Hidalgo et al., 1999, Nefazodone in post-traumatic stress disorder: results from six open-label trials., Int Clin Psychopharmacol
    Zanoveli et al., 2005, Chronic imipramine treatment sensitizes 5-HT1A and 5-HT 2 A receptors in the dorsal periaqueductal gray matter: evidence from the elevated T-maze test of anxiety., Behav Pharmacol
    Keks et al., 1999, Risperidone (Risperdal): clinical experience with a new antipsychosis drug., Expert Opin Investig Drugs
    López-Rodríguez R et al., 2013, Pharmacodynamic genetic variants related to antipsychotic adverse reactions in healthy volunteers., Pharmacogenomics
    Uchida et al., 2007, Brain neurotransmitter receptor-binding characteristics in rats after oral administration of haloperidol, risperidone and olanzapine., Life Sci.
    Angelucci F et al., 2009, Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study., J Alzheimers Dis
    Correia CT et al., 2010, Pharmacogenetics of risperidone therapy in autism: association analysis of eight candidate genes with drug efficacy and adverse drug reactions., Pharmacogenomics J
    Corena-McLeod M, 2015, Comparative Pharmacology of Risperidone and Paliperidone., Drugs R D
    Fenton et al., 2005, Risperidone: a review of its use in the treatment of bipolar mania., CNS Drugs
    Maffioletti E et al., 2020, Association study between HTR2A rs6313 polymorphism and early response to risperidone and olanzapine in schizophrenia patients., Drug Dev Res
    Ujike H et al., 2008, Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study., J Clin Psychiatry
    Sharpley et al., 2005, Olanzapine increases slow wave sleep and sleep continuity in SSRI-resistant depressed patients., J Clin Psychiatry
    Padín et al., 2006, Parallel regulation by olanzapine of the patterns of expression of 5-HT2A and D3 receptors in rat central nervous system and blood cells., Neuropharmacology
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Moresco et al., 2004, Cerebral D2 and 5-HT2 receptor occupancy in Schizophrenic patients treated with olanzapine or clozapine., J. Psychopharmacol. (Oxford)
    Brafford MV et al., 2014, Olanzapine: an antiemetic option for chemotherapy-induced nausea and vomiting., J Adv Pract Oncol
    Thomas P et al., 2008, Correlates of response to Olanzapine in a North Indian Schizophrenia sample., Psychiatry Res
    Laika B et al., 2010, Pharmacogenetics and olanzapine treatment: CYP1A2*1F and serotonergic polymorphisms influence therapeutic outcome., Pharmacogenomics J
    Bymaster et al., 1999, Antagonism by olanzapine of dopamine D1, serotonin2, muscarinic, histamine H1 and alpha 1-adrenergic receptors in vitro., Schizophr. Res.
    Aly SA et al., 2009, Assessment of binding affinity to 5-hydroxytryptamine 2A (5-HT2A) receptor and inverse agonist activity of naftidrofuryl: comparison with those of sarpogrelate., J Pharmacol Sci
    Govitrapong et al., 2002, Platelet serotonin transporter in schizophrenic patients with and without neuroleptic treatment., Neurochem. Int.
    Kim DH et al., 2009, Building a better antipsychotic: receptor targets for the treatment of multiple symptom dimensions of schizophrenia., Neurotherapeutics
    Govitrapong et al., 2000, Platelet 5-HT(2A) receptors in schizophrenic patients with and without neuroleptic treatment., Psychiatry Res
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Nguyen et al., 1989, Down-regulation of tryptamine binding sites following chronic molindone administration. A comparison with responses of dopamine and 5-hydroxytryptamine receptors., Naunyn Schmiedebergs Arch. Pharmacol.
    Prins et al., 2001, Characterization of the receptors involved in the 5-HT-induced excitation of canine antral longitudinal muscle., Br. J. Pharmacol.
    Castilho et al., 1999, Antinociception elicited by aversive stimulation of the inferior colliculus., Pharmacol. Biochem. Behav.
    Connor et al., 2001, Second messengers in platelet aggregation evoked by serotonin and A23187, a calcium ionophore., Life Sci.
    Geerts et al., 1999, Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery., Br. J. Pharmacol.
    Shaw et al., 2000, Role of the 5-HT(2A)receptor and alpha(1)-adrenoceptor in the contractile response of rat pulmonary artery to 5-HT in the presence and absence of nitric oxide., Pulm Pharmacol Ther
    Cussac et al., 2008, Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells., Eur. J. Pharmacol.
    LeWitt PA, 2004, Subcutaneously administered apomorphine: pharmacokinetics and metabolism., Neurology
    Görnemann T et al., 2008, Characterization of the molecular fragment that is responsible for agonism of pergolide at serotonin 5-Hydroxytryptamine2B and 5-Hydroxytryptamine2A receptors., J Pharmacol Exp Ther
    Wander et al., 1986, Antagonism by antidepressants of serotonin S1 and S2 receptors of normal human brain in vitro., Eur. J. Pharmacol.
    Richelson et al., 1984, Antagonism by antidepressants of neurotransmitter receptors of normal human brain in vitro., J. Pharmacol. Exp. Ther.
    Tatsumi et al., 1997, Pharmacological profile of antidepressants and related compounds at human monoamine transporters., Eur. J. Pharmacol.
    Sargent et al., 1998, Clomipramine enhances the cortisol response to 5-HTP: implications for the therapeutic role of 5-HT2 receptors., Psychopharmacology (Berl.)
    Hentall et al., 2000, Correlations between serotonin level and single-cell firing in the rat's nucleus raphe magnus., Neuroscience
    Trifunović et al., 1996, The effects of clomipramine on the excitatory action of ethanol on dopaminergic neurons of the ventral tegmental area in vitro., J. Pharmacol. Exp. Ther.
    Contreras et al., Cortical and septal responses to dorsal raphe nucleus stimulation in the rat: long-term clomipramine actions., Bol Estud Med Biol
    Sugimoto et al., 2003, The tricyclic antidepressant clomipramine increases plasma glucose levels of mice., J. Pharmacol. Sci.
    Bizière et al., 1985, Minaprine, a new drug with antidepressant properties., Drugs Exp Clin Res
    Nabeshima et al., 1989, Effect of minaprine on cycloheximide-induced amnesia in mice., Eur. J. Pharmacol.
    Muramatsu et al., 1988, 5-HT2 antagonists and minaprine block the 5-HT-induced inhibition of dopamine release from rat brain striatal slices., Eur. J. Pharmacol.
    Kodama et al., 1992, Protective effect of minaprine against the abnormal changes of 2-deoxyglucose uptake by rat hippocampal slices induced by hypoxia/hypoglycemia., Jpn. J. Pharmacol.
    Svartengren et al., 1990, Receptor binding properties of amperozide., Pharmacol. Toxicol.
    George et al., 2013, Newer antipsychotics and upcoming molecules for schizophrenia., Eur. J. Clin. Pharmacol.
    Green et al., 2004, Focus on levomepromazine., Curr Med Res Opin
    Kanerva et al., 1999, Brain 5-HT2A receptor occupancy of deramciclane in humans after a single oral administration--a positron emission tomography study., Psychopharmacology (Berl.)
    Uher R et al., 2009, Genetic predictors of response to antidepressants in the GENDEP project., Pharmacogenomics J
    Sanchez C et al., 2014, A comparative review of escitalopram, paroxetine, and sertraline: Are they all alike?, Int Clin Psychopharmacol
    Li et al., 2003, A comparison of the effects of loxapine with ziprasidone and thioridazine on the release of dopamine and acetylcholine in the prefrontal cortex and nucleus accumbens., Psychopharmacology (Berl.)
    Panconesi et al., 1994, Comparison between venoconstrictor effects of sumatriptan and ergotamine in migraine patients., Headache
    Bom et al., 1989, Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5-HT1-like or 5-HT2 receptors., Br. J. Pharmacol.
    Schotte et al., 1996, Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding., Psychopharmacology (Berl.)
    Seeman et al., 1997, Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors., Neuropsychopharmacology
    Sharma A et al., 2003, Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view., Curr Drug Metab
    Adolph O et al., 2012, Promethazine inhibits NMDA-induced currents - new pharmacological aspects of an old drug., Neuropharmacology
    POWE CE et al., 1962, Propiomazine hydrochloride in obstetrical analgesia. A controlled study of 520 patients., JAMA
    Beubler et al., 1990, Stimulatory effects of 5-hydroxytryptamine on fluid secretion and transmural potential difference in rat small intestine are mediated by different receptor subtypes., J. Pharm. Pharmacol.
    Nieto et al., 2000, In vitro effects of 5-hydroxytryptamine and cisapride on the circular smooth muscle of the jejunum of horses., Am. J. Vet. Res.
    Cushing et al., 1993, Serotonin-induced contraction in porcine coronary artery: use of ergolines to support vascular 5-hydroxytryptamine2-receptor heterogeneity., J. Pharmacol. Exp. Ther.
    Tiwari AK et al., 2013, Analysis of 34 candidate genes in bupropion and placebo remission., Int J Neuropsychopharmacol
    Pälvimäki et al., 1996, Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor., Psychopharmacology (Berl.)
    Kast et al., 2007, Treatment schedules for 5-HT2A blocking in progressive multifocal leukoencephalopathy using risperidone or ziprasidone., Bone Marrow Transplant.
    Mamo et al., 2004, A PET study of dopamine D2 and serotonin 5-HT2 receptor occupancy in patients with schizophrenia treated with therapeutic doses of ziprasidone., Am J Psychiatry
    Lu et al., 2002, A case of ziprasidone-induced mania and the role of 5-HT2A in mood changes induced by atypical antipsychotics., J Clin Psychiatry
    Mansbach et al., Blockade of drug-induced deficits in prepulse inhibition of acoustic startle by ziprasidone., Pharmacol. Biochem. Behav.
    Ichikawa et al., 2002, Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism., Brain Res.
    Stahl et al., 2003, The psychopharmacology of ziprasidone: receptor-binding properties and real-world psychiatric practice., J Clin Psychiatry
    Rashid et al., 2002, Effects of sarpogrelate, a novel 5-HT2 antagonist, on 5-HT-induced endothelium-dependent relaxations in porcine coronary artery., Jpn. J. Pharmacol.
    Calka et al., Effect of cyproheptadine on serum leptin levels., Adv Ther
    Hoenicke et al., 1992, The discriminative stimulus effects of clozapine in pigeons: involvement of 5-hydroxytryptamine1C and 5-hydroxytryptamine2 receptors., J. Pharmacol. Exp. Ther.
    Callaway et al., 1992, Serotonin 5-HT1-like receptors mediate hyperactivity in rats induced by 3,4-methylenedioxymethamphetamine., Neuropsychopharmacology
    Alarcón de la Lastra et al., 1998, Effects of cinitapride on gastric ulceration and secretion in rats., Inflamm. Res.
    Alarcón-de-la-Lastra Romero et al., 1997, Cinitapride protects against ethanol-induced gastric mucosal injury in rats: role of 5-hydroxytryptamine, prostaglandins and sulfhydryl compounds., Pharmacology
    Ivgy-May et al., 2015, Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial., Sleep Med.
    Bravo L et al., 2019, Monoamines as Drug Targets in Chronic Pain: Focusing on Neuropathic Pain., Front Neurosci
    Sánchez et al., 1999, Comparison of the effects of antidepressants and their metabolites on reuptake of biogenic amines and on receptor binding., Cell. Mol. Neurobiol.
    Sánchez Martín A et al., 2013, Impact of pharmacogenetics on CNS side effects related to efavirenz., Pharmacogenomics
    Beattie et al., 2004, The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo., Br. J. Pharmacol.
    McCormack, 2015, Cariprazine: First Global Approval., Drugs
    Pazzagli et al., 1999, Trazodone increases extracellular serotonin levels in the frontal cortex of rats., Eur. J. Pharmacol.
    Conn et al., 1987, Relative efficacies of piperazines at the phosphoinositide hydrolysis-linked serotonergic (5-HT-2 and 5-HT-1c) receptors., J. Pharmacol. Exp. Ther.
    Luparini et al., 2004, A cortical GABA-5HT interaction in the mechanism of action of the antidepressant trazodone., Prog. Neuropsychopharmacol. Biol. Psychiatry
    Marek et al., 1992, A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action., Psychopharmacology (Berl.)
    Marcoli et al., 2001, Inhibitory presynaptic 5-hydroxytryptamine(2A) receptors regulate evoked glutamate release from rat cerebellar mossy fibers., J. Pharmacol. Exp. Ther.
    Balsara JJ et al., 2005, Effects of the antidepressant trazodone, a 5-HT 2A/2C receptor antagonist, on dopamine-dependent behaviors in rats., Psychopharmacology (Berl)
    Stryjer R et al., 2003, Treatment of neuroleptic-induced akathisia with the 5-HT2A antagonist trazodone., Clin Neuropharmacol
    Cargnin S et al., 2014, Combined effect of common gene variants on response to drug withdrawal therapy in medication overuse headache., Eur J Clin Pharmacol
    Stahl, 2008, Selective histamine H1 antagonism: novel hypnotic and pharmacologic actions challenge classical notions of antihistamines., CNS Spectr
    Maj et al., 1977, Doxepin as a blocker of central serotonin receptors., Pharmakopsychiatr Neuropsychopharmakol
    Lohoff FW et al., 2013, Serotonin receptor 2A (HTR2A) gene polymorphism predicts treatment response to venlafaxine XR in generalized anxiety disorder., Pharmacogenomics J
    Smith RM et al., 2013, Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex., Biol Psychiatry
    Illi A et al., 2009, 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression., Neuroreport
    Demirbugen Oz M et al., 2018, The relationship between the serotonin 2A receptor gene -1438A/G and 102T/C polymorphisms and citalopram/sertraline-induced nausea in major depressed patients., Hum Psychopharmacol
    Paddock S et al., 2007, Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort., Am J Psychiatry
    Pandey DK et al., 2010, A novel 5-HT(2A) receptor antagonist exhibits antidepressant-like effects in a battery of rodent behavioural assays: approaching early-onset antidepressants., Pharmacol Biochem Behav
    Riga MS et al., 2016, The serotonergic hallucinogen 5-methoxy-N,N-dimethyltryptamine disrupts cortical activity in a regionally-selective manner via 5-HT(1A) and 5-HT(2A) receptors., Neuropharmacology
    Kato M et al., 2006, Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients., Neuropsychobiology
    Suzuki Y et al., 2006, Polymorphisms in the 5-hydroxytryptamine 2A receptor and CytochromeP4502D6 genes synergistically predict fluvoxamine-induced side effects in japanese depressed patients., Neuropsychopharmacology
    Fulton A et al., 1982, Assessment of the antidepressant activity of dothiepin and its metabolites by preclinical tests., J Affect Disord
    Abelaira HM et al., 2012, Lamotrigine treatment reverses depressive-like behavior and alters BDNF levels in the brains of maternally deprived adult rats., Pharmacol Biochem Behav
    Ibeas Bih C et al., 2015, Molecular Targets of Cannabidiol in Neurological Disorders., Neurotherapeutics
    Kishi T et al., 2013, Efficacy and tolerability of perospirone in schizophrenia: a systematic review and meta-analysis of randomized controlled trials., CNS Drugs
    Tanaka H et al., 1998, Localization and pharmacological characterization of [3H]perospirone-binding sites in rat brain., Gen Pharmacol
    Belcheva S et al., 1995, Effects on nociception of the Ca2+ and 5-HT antagonist dotarizine and other 5-HT receptor agonists and antagonists., Acta Physiol Pharmacol Bulg
    Farré M et al., 1997, Clinical pharmacokinetics and tolerability of dotarizine in healthy subjects after single and multiple oral administration., Methods Find Exp Clin Pharmacol
    Przegaliński E et al., 1979, The central action of pizotifen., Psychopharmacology (Berl)
    Mylecharane EJ, 1991, 5-HT2 receptor antagonists and migraine therapy., J Neurol
    Fitzgerald et al., 2000, Possible role of valvular serotonin 5-HT(2B) receptors in the cardiopathy associated with fenfluramine., Mol. Pharmacol.
    Rubio-Beltrán E et al., 2018, Is selective 5-HT<sub>1F</sub> receptor agonism an entity apart from that of the triptans in antimigraine therapy?, Pharmacol Ther
    Morales P et al., 2017, An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol., Front Pharmacol
    Jarema M et al., 2011, [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]., Psychiatr Pol
    Acuña-Castillo C et al., 2000, ALEPH-2, a suspected anxiolytic and putative hallucinogenic phenylisopropylamine derivative, is a 5-HT2a and 5-HT2c receptor agonist., Life Sci
    Villalobos CA et al., 2004, 4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes., Br J Pharmacol
    Moya PR et al., 2007, Functional selectivity of hallucinogenic phenethylamine and phenylisopropylamine derivatives at human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors., J Pharmacol Exp Ther
    Fleckenstein et al., 2007, New insights into the mechanism of action of amphetamines., Annu. Rev. Pharmacol. Toxicol.
    Kokoshka et al., 1998, Methamphetamine treatment rapidly inhibits serotonin, but not glutamate, transporters in rat brain., Brain Res.
    Haughey et al., 2000, The effects of methamphetamine on serotonin transporter activity: role of dopamine and hyperthermia., J. Neurochem.
    Su et al., 2009, When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor., Sci Signal
    Pierce et al., 1989, Hallucinogenic drug interactions with neurotransmitter receptor binding sites in human cortex., Psychopharmacology (Berl.)
  • NELOTANSERIN   HTR2A

    Interaction Score: 0.9

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor inverse agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD DrugBank ChemblInteractions

  • PIMAVANSERIN   HTR2A

    Interaction Score: 0.75

    Interaction Types & Directionality:
    inverse agonist (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name Pimavanserin
    Details of the Assay for Interaction Ki determined in membrane radioligand binding assay.

    PMIDs:
    24016069


    Sources:
    TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • TEMANOGREL   HTR2A

    Interaction Score: 0.6

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor inverse agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • PRUVANSERIN   HTR2A

    Interaction Score: 0.6

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • IFERANSERIN   HTR2A

    Interaction Score: 0.6

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name iferanserin ointment
    Novel drug target Established target
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • CHEMBL292821   HTR2A

    Interaction Score: 0.45

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:

    PMIDs:
    15006903 17337633


    Sources:
    DrugBank

  • BUTRIPTYLINE   HTR2A

    Interaction Score: 0.4

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    3816971 6086881 9537821


    Sources:
    DrugBank

  • BLONANSERIN   HTR2A

    Interaction Score: 0.4

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    20030420


    Sources:
    TTD DrugBank GuideToPharmacology

  • SARPOGRELATE   HTR2A

    Interaction Score: 0.37

    Interaction Types & Directionality:
    inverse agonist (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    19672037 17031071


    Sources:
    TTD DrugBank GuideToPharmacology

  • N,N-DIMETHYLTRYPTAMINE   HTR2A

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19278957 2540505


    Sources:
    DrugBank

  • CHEMBL339611   HTR2A

    Interaction Score: 0.3

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    11191631


    Sources:
    DrugBank

  • VOLINANSERIN   HTR2A

    Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Trial Name volinanserin

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial GuideToPharmacology ChemblInteractions

  • EPLIVANSERIN   HTR2A

    Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    DrugBank ChemblInteractions

  • CINITAPRIDE   HTR2A

    Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    9562338 9211565


    Sources:
    DrugBank

  • PIMAVANSERIN TARTRATE   HTR2A

    Interaction Score: 0.3

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor inverse agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMESERGIDE   HTR2A

    Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • SERGOLEXOLE   HTR2A

    Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DERAMCICLANE   HTR2A

    Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    10445375


    Sources:
    DrugBank

  • NEMIFITIDE   HTR2A

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name INN-00835, nemifitide
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • MESORIDAZINE   HTR2A

    Interaction Score: 0.26

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    11561066 15357957 10991983


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • TRAZODONE   HTR2A

    Interaction Score: 0.26

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name trazodone extended release, DDS-04A,Oleptro
    Specific Action of the Ligand Antagonist

    PMIDs:
    10594316 3039120 15610924 1365657 7855217 11714900 15614572 12782915


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • LUMATEPERONE   HTR2A

    Interaction Score: 0.26

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name ITI-007, ITI-722
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

    PMIDs:
    30596390


    Sources:
    TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • THIOTHIXENE   HTR2A

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    8593484 10821438


    Sources:
    DrugBank GuideToPharmacology ChemblInteractions

  • NEFAZODONE   HTR2A

    Interaction Score: 0.24

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Antagonist

    PMIDs:
    7649970 10577608 12873632 14520130 7855217 10435395 9098663 10220119


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • MINAPRINE   HTR2A

    Interaction Score: 0.23

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    3836113 2530096 2975224 1361012


    Sources:
    TEND TdgClinicalTrial DrugBank

  • CHEMBL126506   HTR2A

    Interaction Score: 0.22

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    17209801 9666084 17139284 10987842 17016423


    Sources:
    DrugBank

  • DOTARIZINE   HTR2A

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8830881 9379783


    Sources:
    DrugBank

  • ESMIRTAZAPINE   HTR2A

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:
    Trial Name esmirtazapine, ORG-4420
    Novel drug target Established target

    PMIDs:
    26047892


    Sources:
    TdgClinicalTrial DrugBank

  • PIPOTIAZINE   HTR2A

    Interaction Score: 0.22

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8593484 10821438


    Sources:
    DrugBank

  • FLIBANSERIN   HTR2A

    Interaction Score: 0.21

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Direct Interaction? True
    Endogenous Drug? False

    PMIDs:
    26412054 12890707 12177684


    Sources:
    TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • CISAPRIDE   HTR2A

    Interaction Score: 0.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    1969947 11131599 8423526


    Sources:
    DrugBank

  • AMPEROZIDE   HTR2A

    Interaction Score: 0.2

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2154737


    Sources:
    DrugBank

  • TRELANSERIN   HTR2A

    Interaction Score: 0.2

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes
    Trial Name trelanserin, SL 65.0472

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • PROPIOMAZINE   HTR2A

    Interaction Score: 0.19

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12678691 19110200 17139284 17016423 22507664 14488364


    Sources:
    TEND TdgClinicalTrial DrugBank

  • CYPROHEPTADINE   HTR2A

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12498911 12233819 16418149 1403790 1358088


    Sources:
    TEND TdgClinicalTrial DrugBank

  • MIRTAZAPINE   HTR2A

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes
    Trial Name mirtazapine,Remeron, Remeron SolTab, Reflex

    PMIDs:
    17067560 15309042 10446738 11607047 11063897 10446735 10446734 10451911


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • MIDOMAFETAMINE   HTR2A

    Interaction Score: 0.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    2871581 7824160


    Sources:
    TTD DrugBank

  • BREXPIPRAZOLE   HTR2A

    Interaction Score: 0.17

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes
    Trial Name OPC-34712

    PMIDs:
    24947465


    Sources:
    TdgClinicalTrial DrugBank ChemblInteractions

  • CYCLOBENZAPRINE   HTR2A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8884233 21975349 12498911


    Sources:
    TEND TdgClinicalTrial TTD DrugBank

  • METHYSERGIDE   HTR2A

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Trial Name -

    PMIDs:
    11704657 10080233 11720080 10455282 11061982


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • ROLUPERIDONE HYDROCHLORIDE   HTR2A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MOLINDONE HYDROCHLORIDE   HTR2A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ASENAPINE MALEATE   HTR2A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ABAPERIDONE   HTR2A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BL-1020   HTR2A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • LURASIDONE   HTR2A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name lurasidone, SM-13496,Latuda
    Novel drug target Established target

    PMIDs:
    23545936


    Sources:
    TdgClinicalTrial DrugBank

  • MESORIDAZINE BESYLATE   HTR2A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LURASIDONE HYDROCHLORIDE   HTR2A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RISPERDAL   HTR2A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Risperdal
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • THIOPROPERAZINE   HTR2A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8593484 10821438


    Sources:
    DrugBank

  • SB-773812   HTR2A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PALIPERIDONE   HTR2A

    Interaction Score: 0.14

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name paliperidone ER, paliperidone palmitate
    Novel drug target Established target
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

    PMIDs:
    11132243 12211096 7520908 7524043 7531353 7542676


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • THIORIDAZINE   HTR2A

    Interaction Score: 0.14

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    8680734 9918563 7898773 2866233 2423886


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • CHLORPROTHIXENE   HTR2A

    Interaction Score: 0.14

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

    PMIDs:
    2891550 3774629


    Sources:
    TEND TdgClinicalTrial DrugBank ChemblInteractions

  • PROMAZINE   HTR2A

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12106771 19110200 10980325 17139284 17016423


    Sources:
    TEND TdgClinicalTrial DrugBank

  • ZUCLOPENTHIXOL   HTR2A

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    12957216 19644682 8748043


    Sources:
    DrugBank

  • PEROSPIRONE   HTR2A

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inverse agonist (inhibitory)

    Interaction Info:

    PMIDs:
    23812802 9595296


    Sources:
    DrugBank

  • MOLINDONE   HTR2A

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    2586632


    Sources:
    DrugBank GuideToPharmacology

  • EPINASTINE   HTR2A

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8836655 10596692


    Sources:
    DrugBank

  • TEGASEROD   HTR2A

    Interaction Score: 0.12

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15466450


    Sources:
    DrugBank

  • ACEPROMAZINE   HTR2A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8593484 10821438


    Sources:
    DrugBank

  • ILOPERIDONE   HTR2A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Novel drug target Established target

    PMIDs:
    12861482 8997630


    Sources:
    TdgClinicalTrial TTD DrugBank ChemblInteractions

  • SERTINDOLE   HTR2A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Serdolect
    Novel drug target Established target
    Specific Action of the Ligand Antagonist

    PMIDs:
    7530204 16925508 11594443


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • CLOMIPRAMINE   HTR2A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    9862411 10682715 8558452 1296670 14501155


    Sources:
    DrugBank

  • LORPIPRAZOLE   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    22232986


    Sources:
    DrugBank

  • FENFLURAMINE   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10617681


    Sources:
    DrugBank

  • ETOPERIDONE   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7855217


    Sources:
    DrugBank

  • QUETIAPINE FUMARATE   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ZIPRASIDONE HYDROCHLORIDE   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL473186   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • 5-MEO-DMT   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    26477571


    Sources:
    DrugBank

  • ZIPRASIDONE MESYLATE   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BUFOTENINE   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PERGOLIDE   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    18703043 18691132 10641988 18096760


    Sources:
    DrugBank GuideToPharmacology

  • GLEMANSERIN   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ARIPIPRAZOLE LAUROXIL   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RELENOPRIDE   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • VABICASERIN HYDROCHLORIDE   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RS-102,221   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • THIOTHIXENE HYDROCHLORIDE   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LORCASERIN   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BROLAMFETAMINE   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CARPHENAZINE MALEATE   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ANIRACETAM   HTR2A

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11412837


    Sources:
    TTD DrugBank

  • ZIPRASIDONE   HTR2A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    17450180 15121646 12530423 11509214 17848919 12445705 14728084


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • OLANZAPINE   HTR2A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv
    Novel drug target Established target
    Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

    PMIDs:
    19193342 14530903 17316700 17848919 15816787 19494443 16905159 11752352 15358979 25032030 24885933 19000940 19636338 32462699 10227113 16038601


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • CABERGOLINE   HTR2A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    18691132 18992242 20426763 10641988


    Sources:
    DrugBank GuideToPharmacology

  • ERGOTAMINE   HTR2A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    11752352 8014033 2758221


    Sources:
    DrugBank GuideToPharmacology

  • PAROXETINE   HTR2A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    14514498 18253134 23338224 11136637 11403977 5821956 17697394 19361869


    Sources:
    PharmGKB DrugBank

  • FLUVOXAMINE   HTR2A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16874005 16205777 19361869


    Sources:
    PharmGKB

  • CARIPRAZINE   HTR2A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    26510944


    Sources:
    DrugBank

  • ASENAPINE   HTR2A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target
    Specific Action of the Ligand Antagonist

    PMIDs:
    18308814 21655346 10592235


    Sources:
    TdgClinicalTrial DrugBank GuideToPharmacology

  • PIPAMPERONE   HTR2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    8935801


    Sources:
    DrugBank GuideToPharmacology

  • HALOPERIDOL LACTATE   HTR2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • QUIPAZINE   HTR2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ZICRONAPINE   HTR2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CYAMEMAZINE   HTR2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • KETANSERIN   HTR2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inverse agonist (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    9767524 17031071


    Sources:
    NCI DrugBank GuideToPharmacology

  • HALOPERIDOL DECANOATE   HTR2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LISURIDE   HTR2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    18691132 9600588


    Sources:
    DrugBank GuideToPharmacology

  • DONEPEZIL   HTR2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:

    PMIDs:
    16045972 14643839


    Sources:
    DrugBank

  • RISPERIDONE   HTR2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target
    Specific Action of the Ligand Inverse agonist

    PMIDs:
    15992090 23859574 17316700 11132243 19494443 19997080 25943458 15907153 32462699


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • ZOLMITRIPTAN   HTR2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    29352859


    Sources:
    DrugBank

  • DOXEPIN   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Silenor (SO-101)
    Novel drug target Established target

    PMIDs:
    19179941 309138 7855217


    Sources:
    TdgClinicalTrial DrugBank

  • LYSERGIDE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • OLANZAPINE PAMOATE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LOXAPINE HYDROCHLORIDE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CYCLOBENZAPRINE HYDROCHLORIDE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • REMOXIPRIDE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    9015795


    Sources:
    DrugBank

  • RENZAPRIDE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name renzapride

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • MESULERGINE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CLOZAPINE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inverse agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    14687870 14530903 15037867 8916101 7520908 12973385 24885933 14751426 9926100


    Sources:
    NCI TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • FLUPENTIXOL   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    17111172


    Sources:
    DrugBank

  • TRAZODONE HYDROCHLORIDE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • OCAPERIDONE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    TTD DrugBank

  • QUETIAPINE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    17848919 11132243 17563257 12973385 16038601


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • ARIPIPRAZOLE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Specific Action of the Ligand Partial agonist

    PMIDs:
    17265076 14642974 17242925 26346901


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • PIZOTYLINE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    111296 2045831


    Sources:
    DrugBank

  • ZOTEPINE   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    TTD DrugBank GuideToPharmacology

  • MIANSERIN   HTR2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    11004734


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • THIETHYLPERAZINE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TEND TdgClinicalTrial

  • AMISULPRIDE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15204055


    Sources:
    DrugBank

  • DOTHIEPIN   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    6215444


    Sources:
    DrugBank

  • NEFAZODONE HYDROCHLORIDE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LOXAPINE SUCCINATE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESMIRTAZAPINE MALEATE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRYPTAMINE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology

  • BIFEPRUNOX   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name bifeprunox, DU127090
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • NORTRIPTYLINE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7855217 31942167 10379421


    Sources:
    DrugBank

  • APOMORPHINE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    15037665 18691132


    Sources:
    DrugBank GuideToPharmacology

  • CHEMBL309760   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • FLUPHENAZINE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    17606915


    Sources:
    DrugBank GuideToPharmacology

  • SPIRAMIDE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • AGOMELATINE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • YOHIMBINE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8032658 6136920


    Sources:
    DrugBank

  • BROMOCRIPTINE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    18703043 18691132 10641988


    Sources:
    DrugBank GuideToPharmacology

  • ESCITALOPRAM   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19365399 24424469


    Sources:
    PharmGKB DrugBank

  • TERGURIDE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False
    Trial Name terguride

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial GuideToPharmacology

  • ONDANSETRON   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9767524


    Sources:
    NCI

  • LOXAPINE   HTR2A

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name AZ-004
    Novel drug target Established target
    Specific Action of the Ligand Inverse agonist

    PMIDs:
    12664192


    Sources:
    TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • CHLORPROMAZINE   HTR2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes
    Specific Action of the Ligand Inverse agonist

    PMIDs:
    7908055 8593484 10821438


    Sources:
    DrugBank GuideToPharmacology ChemblInteractions

  • CITALOPRAM   HTR2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23158458 19590397 30221791 17671280


    Sources:
    PharmGKB

  • DROPERIDOL   HTR2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRIMIPRAMINE MALEATE   HTR2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RITANSERIN   HTR2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inverse agonist (inhibitory)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    17031071


    Sources:
    DrugBank GuideToPharmacology

  • MK-212   HTR2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • FLUSPIRILENE   HTR2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    8935801


    Sources:
    DrugBank GuideToPharmacology

  • SEROTONIN   HTR2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? True
    Specific Action of the Ligand Full agonist

    PMIDs:
    7221567


    Sources:
    DrugBank GuideToPharmacology

  • VENLAFAXINE   HTR2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22006095


    Sources:
    PharmGKB

  • PINDOLOL   HTR2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PROMAZINE HYDROCHLORIDE   HTR2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DONITRIPTAN   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • SUMATRIPTAN   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25096645


    Sources:
    PharmGKB

  • BRL-15,572   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CAPESEROD   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Partial agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BUPROPION   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22947179


    Sources:
    PharmGKB

  • KETAMINE   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    6460944


    Sources:
    DrugBank

  • QUINPIROLE   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • AMITRIPTYLINE   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name OMS-103HP
    Novel drug target Established target

    PMIDs:
    19800913 7855217


    Sources:
    TdgClinicalTrial DrugBank

  • EFAVIRENZ   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23859571


    Sources:
    PharmGKB

  • LEVOMEPROMAZINE   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    15701205


    Sources:
    DrugBank

  • TRIMIPRAMINE   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    8863001


    Sources:
    DrugBank

  • IMIPRAMINE   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7855217 16170231


    Sources:
    DrugBank

  • 8-OH-DPAT   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • TRIFLUOPERAZINE HYDROCHLORIDE   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VORTIOXETINE   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • METHYLERGONOVINE   HTR2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CHEMBL609728   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • MAPROTILINE   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    7221567


    Sources:
    DrugBank

  • DESIPRAMINE   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    7855217


    Sources:
    DrugBank

  • TEDATIOXETINE   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ROXINDOLE   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CANNABIDIOL   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    28701957 26264914


    Sources:
    DrugBank

  • AMOXAPINE   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8876023


    Sources:
    DrugBank

  • XANOMELINE   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • THIORIDAZINE HYDROCHLORIDE   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PIMOZIDE   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology ChemblInteractions

  • HALOPERIDOL   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    other/unknown
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    7520908 12629531


    Sources:
    DrugBank GuideToPharmacology ChemblInteractions

  • CHLORPROMAZINE HYDROCHLORIDE   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SPIPERONE   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • METERGOLINE   HTR2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • LAMOTRIGINE   HTR2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    22306746


    Sources:
    DrugBank

  • DULOXETINE   HTR2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • METITEPINE   HTR2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PERPHENAZINE   HTR2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • NABIXIMOLS   HTR2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26264914


    Sources:
    DrugBank

  • LITHIUM   HTR2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10758249


    Sources:
    NCI

  • PROCHLORPERAZINE   HTR2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • TRIFLUOPERAZINE   HTR2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • FLUOXETINE   HTR2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name NPL-2008, Fluoxetine
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Ensembl: ENSG00000102468

    • Version: 101_38

    Alternate Names:
    HTR2A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P28223

    • Version: 01-August-2011

    Alternate Names:
    P28223 Uniprot Accession
    5HT2A_HUMAN Uniprot Id
    HTR2A Gene Symbol

    Gene Info:
    Target Main Class Receptors
    Target Subclass Rhodopsin
    Transmembrane Helix Count 7

    Publications:

  • RussLampel: ENSG00000102468

    • Version: 26-July-2011

    Alternate Names:
    HTR2A Display Id
    5-HYDROXYTRYPTAMINE 2A RECEPTOR (5-HT-2A) (SEROTONIN RECEPTOR 2A) (5- HT-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P28223] Description
    ENSG00000102468 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P28223

    • Version: 11-September-2012

    Alternate Names:
    3356 Entrez Gene Id
    5-HYDROXYTRYPTAMINE RECEPTOR 2A Uniprot Protein Name
    HTR2A Uniprot Gene Name

    Gene Info:
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Acc IPR000276
    Uniprot Status Swiss-Prot

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P28223

    • Version: January-2014

    Alternate Names:
    HTR2A Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • GuideToPharmacology: 3356

    • Version: 29-September-2020

    Alternate Names:
    5293 HUGO Gene ID
    5293 HUGO Gene Symbol
    5-hydroxytryptamine receptor 2A HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name 5-Hydroxytryptamine receptors
    GuideToPharmacology Gene Category ID 1

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • PharmGKB: HTR2A

    • Version: 18-August-2020

    Alternate Names:
    PA193 PharmGKB ID

    Gene Info:

    Publications:
    Tiwari AK et al., 2013, Analysis of 34 candidate genes in bupropion and placebo remission., Int J Neuropsychopharmacol
    Ujike H et al., 2008, Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study., J Clin Psychiatry
    Angelucci F et al., 2009, Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study., J Alzheimers Dis

  • DrugBank: BE0004881

    • Version: 5.1.7

    Alternate Names:
    HTR2A DrugBank Gene Name
    P28223 UniProt Accession
    3356 Entrez Gene Id

    Gene Info:

    Publications:
    Roth et al., 1994, Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors., J. Pharmacol. Exp. Ther.

  • DrugBank: BE0004957

    • Version: 5.1.7

    Alternate Names:
    HTR2A DrugBank Gene Name
    P28223 UniProt Accession
    3356 Entrez Gene Id

    Gene Info:

    Publications:
    Martin et al., 1982, Ketamine inhibits serotonin uptake in vivo., Neuropharmacology
    Ivgy-May et al., 2015, Esmirtazapine in non-elderly adult patients with primary insomnia: efficacy and safety from a randomized, 6-week sleep laboratory trial., Sleep Med.

  • DrugBank: BE0000451

    • Version: 5.1.7

    Alternate Names:
    HTR2A DrugBank Gene Name
    P28223 UniProt Accession
    3356 Entrez Gene Id

    Gene Info:

    Publications:
    Prins et al., 2001, Characterization of the receptors involved in the 5-HT-induced excitation of canine antral longitudinal muscle., Br. J. Pharmacol.
    Castilho et al., 1999, Antinociception elicited by aversive stimulation of the inferior colliculus., Pharmacol. Biochem. Behav.
    Connor et al., 2001, Second messengers in platelet aggregation evoked by serotonin and A23187, a calcium ionophore., Life Sci.

  • TTD: 5-HT 2A receptor

    • Version: 2020.06.01

    Alternate Names:
    HTR2A TTD Gene Abbreviation
    T32060 TTD Target ID

    Gene Info:

    Publications:
    Guo JD et al., 2009, Bi-directional modulation of bed nucleus of stria terminalis neurons by 5-HT: molecular expression and functional properties of excitatory 5-HT receptor subtypes., Neuroscience
    Chen J et al., 2011, Novel ocular antihypertensive compounds in clinical trials., Clin Ophthalmol

  • NCI: HTR2A

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Serretti et al., Serotonin receptor 2A, 2C, 1A genes and response to lithium prophylaxis in mood disorders., J Psychiatr Res
    Kasho et al., 1998, Serotonin enhances the production of type IV collagen by human mesangial cells., Kidney Int.
    Arranz et al., 1996, Analysis of a structural polymorphism in the 5-HT2A receptor and clinical response to clozapine., Neurosci. Lett.

  • HingoraniCasas: ENSG00000102468

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000102468 Gene Symbol
    HTR2A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: HTR2

    • Version: chembl_23

    Alternate Names:
    HTR2 GENE_SYMBOL
    HTR2A GENE_SYMBOL
    5-hydroxytryptamine receptor 2A UNIPROT

    Gene Info:

    Publications:

  • Pharos: HTR2A

    • Version: 03-September-2020

    Alternate Names:
    5-hydroxytryptamine receptor 2A Gene Name
    P28223 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • GO: HTR2A

    • Version: 05-September-2020

    Alternate Names:
    HTR2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE, G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: HTR2A

    • Version: 27-Jun-2013

    Alternate Names:
    3356 Gene ID
    5-HT2A dGene Synonym
    HTR2 dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21