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HTR1F Gene Record

  • Summary
  • Interactions
  • Claims
  • HTR1F 3355 Druggable Genome

    Alternate Names:

    3355
    5-HYDROXYTRYPTAMINE RECEPTOR 1F
    HTR1F
    5-HT-1F
    5-HT1F
    5HT6
    HTR1EL
    MR77
    182134
    5292
    ENSG00000179097
    OTTHUMG00000159008
    P30939
    5HT1F_HUMAN
    Serotonin receptor 1F
    BE0000460
    5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTOR 1F). [SOURCE:UNIPROT/SWISSPROT;ACC:P30939]
    5
    5-HT<sub>1F</sub> receptor
    5-HT 1F receptor
    T78656
    NM_000866
    NP_000857

    Gene Info:

    Transmembrane Helix Count 7
    Target Subclass GPCR
    Target Main Class Receptors
    Target Subclass Rhodopsin
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Uniprot Evidence 2: Evidence at transcript level
    Interpro Acc IPR000276
    Interpro Name GPCR, rhodopsin-like, 7TM
    Target Class Receptors
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name 5-Hydroxytryptamine receptors
    GuideToPharmacology Gene Category ID 1
    (8 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Massiou, 2001, Naratriptan., Curr Med Res Opin
    Hoskin et al., 2004, The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat., Brain Res.
    Villalón et al., 2002, An introduction to migraine: from ancient treatment to functional pharmacology and antimigraine therapy., Proc. West. Pharmacol. Soc.
    Villalón et al., 2003, Migraine: pathophysiology, pharmacology, treatment and future trends., Curr Vasc Pharmacol
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Goadsby et al., 2003, Evidence for serotonin (5-HT)1B, 5-HT1D and 5-HT1F receptor inhibitory effects on trigeminal neurons with craniovascular input., Neuroscience
    Tfelt-Hansen et al., 2000, Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy., Drugs
    Wainscott et al., 1998, Human 5-HT1F receptor-stimulated [35S]GTPgammaS binding: correlation with inhibition of guinea pig dural plasma protein extravasation., Eur. J. Pharmacol.
    Pauwels et al., Present and future of 5-HT receptor agonists as antimigraine drugs., Clin Neuropharmacol
    Nikai et al., 2008, Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan., Pain
    Mitsikostas et al., 2002, 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis., Cephalalgia
    Cohen et al., 2000, Contractile responses to sumatriptan and ergotamine in the rabbit saphenous vein: effect of selective 5-HT(1F) receptor agonists and PGF(2alpha)., Br. J. Pharmacol.
    Janssen et al., 2004, Influence of 5-HT1 receptor agonists on feline stomach relaxation., Eur. J. Pharmacol.
    Razzaque et al., 1999, Vasoconstriction in human isolated middle meningeal arteries: determining the contribution of 5-HT1B- and 5-HT1F-receptor activation., Br J Clin Pharmacol
    Mitsikostas et al., 1999, Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis., Eur. J. Pharmacol.
    Bigal et al., 2003, Ergotamine and dihydroergotamine: a review., Curr Pain Headache Rep
    Reuter U et al., 2015, The pharmacological profile and clinical prospects of the oral 5-HT1F receptor agonist lasmiditan in the acute treatment of migraine., Ther Adv Neurol Disord
    Martin, 1997, Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraine., Cephalalgia
    Bhalla et al., 2002, Molecular cloning and expression of the porcine trigeminal ganglion cDNA encoding a 5-ht(1F) receptor., Eur. J. Pharmacol.
    Reuter et al., 2004, Effects of chronic sumatriptan and zolmitriptan treatment on 5-HT receptor expression and function in rats., Cephalalgia
    Rubio-Beltrán E et al., 2018, Is selective 5-HT<sub>1F</sub> receptor agonism an entity apart from that of the triptans in antimigraine therapy?, Pharmacol Ther
    Adham et al., 1993, Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase., Proc. Natl. Acad. Sci. U.S.A.
    Jähnichen et al., 2004, Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery., Naunyn Schmiedebergs Arch. Pharmacol.
    Napier et al., 1999, Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors., Eur. J. Pharmacol.
  • LASMIDITAN   HTR1F

    Interaction Score: 11.36

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name lasmiditan, COL-144, LY-573144
    Novel drug target Established target
    Mechanism of Interaction Serotonin 1f (5-HT1f) receptor agonist

    PMIDs:
    25584073


    Sources:
    TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • NARATRIPTAN   HTR1F

    Interaction Score: 4.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Novel drug target Established target

    PMIDs:
    12463278 14725972 12434581 15320857 11752352 14614913 11152011


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • RIZATRIPTAN   HTR1F

    Interaction Score: 2.65

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    9718276 12434581 15320857 11752352 14614913


    Sources:
    DrugBank GuideToPharmacology

  • ZOLMITRIPTAN   HTR1F

    Interaction Score: 2.52

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name zolmitriptan,Zomig
    Novel drug target Established target
    Specific Action of the Ligand Full agonist

    PMIDs:
    9399012 9718276 11834243 15096229 12434581 15320857 11752352 29352859


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • CHEMBL101690   HTR1F

    Interaction Score: 1.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ELETRIPTAN   HTR1F

    Interaction Score: 1.58

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    11834243 15185063 10193663


    Sources:
    DrugBank GuideToPharmacology

  • SUMATRIPTAN   HTR1F

    Interaction Score: 1.26

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    10367177 18723285 12110114 11015308 15178373 10073743 11752352 10225363


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • ELETRIPTAN HYDROBROMIDE   HTR1F

    Interaction Score: 0.63

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Serotonin 1f (5-HT1f) receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ALMOTRIPTAN MALATE   HTR1F

    Interaction Score: 0.63

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 1f (5-HT1f) receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL1256797   HTR1F

    Interaction Score: 0.47

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • METHYSERGIDE   HTR1F

    Interaction Score: 0.33

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    8380639


    Sources:
    DrugBank GuideToPharmacology

  • ERGOTAMINE   HTR1F

    Interaction Score: 0.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    12525272


    Sources:
    DrugBank GuideToPharmacology

  • 5-MEO-DMT   HTR1F

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DONITRIPTAN   HTR1F

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BRL-15,572   HTR1F

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Partial agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DIHYDROERGOTAMINE   HTR1F

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • METHYLERGONOVINE   HTR1F

    Interaction Score: 0.17

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • 8-OH-DPAT   HTR1F

    Interaction Score: 0.17

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • TRYPTAMINE   HTR1F

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • XANOMELINE   HTR1F

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • YOHIMBINE   HTR1F

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • SERTINDOLE   HTR1F

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • METERGOLINE   HTR1F

    Interaction Score: 0.1

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • METITEPINE   HTR1F

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • SEROTONIN   HTR1F

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • MIANSERIN   HTR1F

    Interaction Score: 0.07

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • QUETIAPINE   HTR1F

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • RISPERIDONE   HTR1F

    Interaction Score: 0.03

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • OLANZAPINE   HTR1F

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • CLOZAPINE   HTR1F

    Interaction Score: 0.02

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • Ensembl: ENSG00000179097

    • Version: 101_38

    Alternate Names:
    HTR1F Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P30939

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000179097 Ensembl Gene Id
    P30939 Uniprot Accession
    HTR1F Gene Symbol

    Gene Info:
    Transmembrane Helix Count 7
    Target Subclass GPCR
    Target Main Class Receptors

    Publications:

  • RussLampel: ENSG00000179097

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000179097 Ensembl Gene Id
    5-HYDROXYTRYPTAMINE 1F RECEPTOR (5-HT-1F) (SEROTONIN RECEPTOR 1F). [SOURCE:UNIPROT/SWISSPROT;ACC:P30939] Description
    HTR1F Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P30939

    • Version: January-2014

    Alternate Names:
    HTR1F Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • HopkinsGroom: P30939

    • Version: 11-September-2012

    Alternate Names:
    HTR1F Uniprot Gene Name
    3355 Entrez Gene Id
    P30939 Uniprot Accession

    Gene Info:
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name 7TM_GPCR_Rhodpsn

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 3355

    • Version: 29-September-2020

    Alternate Names:
    5292 HUGO Gene ID
    5292 HUGO Gene Symbol
    5-hydroxytryptamine receptor 1F HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name 5-Hydroxytryptamine receptors
    GuideToPharmacology Gene Category ID 1

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • DrugBank: BE0000460

    • Version: 5.1.7

    Alternate Names:
    HTR1F DrugBank Gene Name
    P30939 UniProt Accession
    3355 Entrez Gene Id

    Gene Info:

    Publications:
    Adham et al., 1993, Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase., Proc. Natl. Acad. Sci. U.S.A.
    Pauwels et al., Present and future of 5-HT receptor agonists as antimigraine drugs., Clin Neuropharmacol
    Nikai et al., 2008, Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan., Pain

  • HingoraniCasas: ENSG00000179097

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000179097 Gene Symbol
    HTR1F Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: HTR1EL

    • Version: chembl_23

    Alternate Names:
    HTR1EL GENE_SYMBOL
    HTR1F GENE_SYMBOL
    5-hydroxytryptamine receptor 1F UNIPROT

    Gene Info:

    Publications:

  • GO: HTR1F

    • Version: 05-September-2020

    Alternate Names:
    HTR1EL GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: HTR1F

    • Version: 27-Jun-2013

    Alternate Names:
    3355 Gene ID
    5-HT-1F dGene Synonym
    5-HT1F dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: 5-HT 1F receptor

    • Version: 2020.06.01

    Alternate Names:
    HTR1F TTD Gene Abbreviation
    T78656 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21