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HTR1B Gene Record

  • Summary
  • Interactions
  • Claims
  • HTR1B 3351 Druggable Genome

    Alternate Names:

    3351
    5-HYDROXYTRYPTAMINE RECEPTOR 1B
    HTR1B
    5-HT-1B
    5-HT-1D-beta
    5-HT1B
    5-HT1DB
    HTR1D2
    HTR1DB
    S12
    182131
    5287
    ENSG00000135312
    OTTHUMG00000015066
    Serotonin 1D beta receptor
    Serotonin receptor 1B
    5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR 1B) (5- HT1B) (5-HT-1D-BETA) (SEROTONIN 1D BETA RECEPTOR) (S12). [SOURCE:UNIPROT/SWISSPROT;ACC:P28222]
    P28222
    5HT1B_HUMAN
    2
    5-HT<sub>1B</sub> receptor
    BE0000797
    PA29549
    5-HT 1B receptor
    T07806
    NM_000863
    NP_000854

    Gene Info:

    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Status Swiss-Prot
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Evidence 1: Evidence at protein level
    Target Main Class Receptors
    Target Subclass Rhodopsin
    Target Subclass GPCR
    Transmembrane Helix Count 7
    Target Class Receptors
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name 5-Hydroxytryptamine receptors
    GuideToPharmacology Gene Category ID 1
    (9 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Buzzi et al., 1991, Evidence for 5-HT1B/1D receptors mediating the antimigraine effect of sumatriptan and dihydroergotamine., Cephalalgia
    Yu et al., 1996, 5-Carboxamido-tryptamine, CP-122,288 and dihydroergotamine but not sumatriptan, CP-93,129, and serotonin-5-O-carboxymethyl-glycyl -tyrosinamide block dural plasma protein extravasation in knockout mice that lack 5-hydroxytryptamine1B receptors., Mol. Pharmacol.
    Willems et al., 1999, Pharmacological evidence that alpha1-and alpha2-adrenoceptors mediate vasoconstriction of carotid arteriovenous anastomoses in anaesthetized pigs., Br. J. Pharmacol.
    Villalón et al., 2004, 5-HT1B receptors and alpha 2A/2C-adrenoceptors mediate external carotid vasoconstriction to dihydroergotamine., Eur. J. Pharmacol.
    Pauwels et al., 1998, Interaction of 5-HT1B/D ligands with recombinant h 5-HT1A receptors: intrinsic activity and modulation by G-protein activation state., Naunyn Schmiedebergs Arch. Pharmacol.
    Bang-Andersen et al., 2011, Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder., J. Med. Chem.
    Buchan et al., 2002, Frovatriptan: a review of drug-drug interactions., Headache
    Elkind et al., 2004, Pharmacokinetics of frovatriptan in adolescent migraineurs., J Clin Pharmacol
    Deleu et al., 2000, Current and emerging second-generation triptans in acute migraine therapy: a comparative review., J Clin Pharmacol
    Comer, 2002, Pharmacology of the selective 5-HT(1B/1D) agonist frovatriptan., Headache
    Parsons et al., 1998, Effects of the novel high-affinity 5-HT(1B/1D)-receptor ligand frovatriptan in human isolated basilar and coronary arteries., J. Cardiovasc. Pharmacol.
    Balbisi, 2006, Frovatriptan: a review of pharmacology, pharmacokinetics and clinical potential in the treatment of menstrual migraine., Ther Clin Risk Manag
    Markus et al., 2007, Frovatriptan review., Expert Opin Pharmacother
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Easthope et al., 2001, Frovatriptan., CNS Drugs
    Tfelt-Hansen et al., 2000, Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy., Drugs
    Balbisi, 2004, Frovatriptan succinate, a 5-HT1B/1D receptor agonist for migraine., Int. J. Clin. Pract.
    Dodick et al., 2007, Use of the sustained pain-free plus no adverse events endpoint in clinical trials of triptans in acute migraine., CNS Drugs
    Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.
    Lambert et al., 2002, Suppression by eletriptan of the activation of trigeminovascular sensory neurons by glyceryl trinitrate., Brain Res.
    van den Broek et al., 2000, Pharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vessels., Eur. J. Pharmacol.
    Knyihár-Csillik et al., 2000, Effects of eletriptan on the peptidergic innervation of the cerebral dura mater and trigeminal ganglion, and on the expression of c-fos and c-jun in the trigeminal complex of the rat in an experimental migraine model., Eur. J. Neurosci.
    Napier et al., 1999, Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors., Eur. J. Pharmacol.
    Martin, 1997, Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraine., Cephalalgia
    Reuter et al., 2004, Effects of chronic sumatriptan and zolmitriptan treatment on 5-HT receptor expression and function in rats., Cephalalgia
    Pascual, 1998, [Mechanism of action of zolmitriptan]., Neurologia
    de Almeida et al., 2001, Zolmitriptan--a 5-HT1B/D agonist, alcohol, and aggression in mice., Psychopharmacology (Berl.)
    Whale et al., 1999, Zolmitriptan-induced growth hormone release in humans: mediation by 5-HT1D receptors?, Psychopharmacology (Berl.)
    Le Grand et al., 2000, Zolmitriptan stimulates a Ca(2+)-dependent K(+) current in C6 glioma cells stably expressing recombinant human 5-HT(1B) receptors., Eur. J. Pharmacol.
    Hargreaves et al., 1999, Pathophysiology of migraine--new insights., Can J Neurol Sci
    Gowin et al., 2010, Zolmitriptan and human aggression: interaction with alcohol., Psychopharmacology (Berl.)
    Rubio-Beltrán E et al., 2018, Is selective 5-HT<sub>1F</sub> receptor agonism an entity apart from that of the triptans in antimigraine therapy?, Pharmacol Ther
    Leonhardt et al., 1989, Detection of a novel serotonin receptor subtype (5-HT1E) in human brain: interaction with a GTP-binding protein., J. Neurochem.
    Ariani et al., 1989, G protein dependent alterations in [125I]iodocyanopindolol and +/- cyanopindolol binding at 5-HT1B binding sites in rat brain membranes., Neurochem. Res.
    Terrón et al., 2-(2-Aminoethyl)-quinoline (D-1997): a novel agonist at 5-hydroxytryptamine1-like receptors in the canine basilar artery., Arch Int Pharmacodyn Ther
    Herrick-Davis et al., 1988, Serotonin 5-HT1D receptors in human prefrontal cortex and caudate: interaction with a GTP binding protein., J. Neurochem.
    Dawson et al., 2000, The role of 5-HT(1A) and 5-HT(1B/1D) receptors on the modulation of acute fluoxetine-induced changes in extracellular 5-HT: the mechanism of action of (+/-)pindolol., Neuropharmacology
    Hjorth et al., 1993, In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol., J. Pharmacol. Exp. Ther.
    Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
    Bailey et al., 1998, Evidence for different 5-HT1B/1D receptors mediating vasoconstriction of equine digital arteries and veins., Eur. J. Pharmacol.
    Choppin et al., 1995, Presence of vasoconstrictor 5HT1-like receptors revealed by precontraction of rabbit isolated mesenteric artery., Br. J. Pharmacol.
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Kvernmo et al., 2008, Receptor-binding and pharmacokinetic properties of dopaminergic agonists., Curr Top Med Chem
    Grånäs et al., 1999, Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor., Eur. J. Pharmacol.
    Akin et al., 2002, Involvement of 5-HT1B and 5-HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery., Br. J. Pharmacol.
    Nikai et al., 2008, Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan., Pain
    Razzaque et al., 2002, 5-HT1B-receptors and vascular reactivity in human isolated blood vessels: assessment of the potential craniovascular selectivity of sumatriptan., Br J Clin Pharmacol
    Mitsikostas et al., 2002, 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis., Cephalalgia
    Dupuis et al., 1999, Magnitude of 5-HT1B and 5-HT1A receptor activation in guinea-pig and rat brain: evidence from sumatriptan dimer-mediated [35S]GTPgammaS binding responses., Brain Res. Mol. Brain Res.
    Roy et al., 2000, Expression of 5-hydroxytryptamine receptor subtype messenger RNA in interstitial cells from human heart valves., J. Heart Valve Dis.
    Cohen et al., 1999, 5-Hydroxytryptamine(1A) receptor activation enhances norepinephrine release from nerves in the rabbit saphenous vein., J. Pharmacol. Exp. Ther.
    Cohen et al., 1999, Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: molecular and pharmacologic characterization., J. Cereb. Blood Flow Metab.
    Mitsikostas et al., 1999, Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis., Eur. J. Pharmacol.
    Lam, 2000, Clinical pharmacology of dopamine agonists., Pharmacotherapy
    Massiou, 2001, Naratriptan., Curr Med Res Opin
    Hoskin et al., 2004, The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat., Brain Res.
    Lambert, 2005, Preclinical neuropharmacology of naratriptan., CNS Drug Rev
    Dulli, 1999, Naratriptan: an alternative for migraine., Ann Pharmacother
    Akin et al., 2002, Agonist-directed trafficking explaining the difference between response pattern of naratriptan and sumatriptan in rabbit common carotid artery., Br. J. Pharmacol.
    Johnston et al., 2010, Triptans for the management of migraine., Drugs
    Boers et al., 2004, Naratriptan has a selective inhibitory effect on trigeminovascular neurones at central 5-HT1A and 5-HT(1B/1D) receptors in the cat: implications for migraine therapy., Cephalalgia
    Wackenfors et al., 2005, Triptans induce vasoconstriction of human arteries and veins from the thoracic wall., J. Cardiovasc. Pharmacol.
    Wellington et al., 2002, Spotlight on rizatriptan in migraine., CNS Drugs
    Wellington et al., 2002, Rizatriptan: an update of its use in the management of migraine., Drugs
    Ikemoto et al., 2004, [Rizatriptan (Maxalt), a new entity of triptan for migraine: pharmacology and therapeutic relevance]., Nippon Yakurigaku Zasshi
    Williamson et al., 2001, The anti-migraine 5-HT(1B/1D) agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea-pigs., Br. J. Pharmacol.
    Gassó P et al., 2017, Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine., Prog Neuropsychopharmacol Biol Psychiatry
    de Bartolomeis A et al., 2015, Update on the Mechanism of Action of Aripiprazole: Translational Insights into Antipsychotic Strategies Beyond Dopamine Receptor Antagonism., CNS Drugs
    Werling et al., 2007, A comparison of the binding profiles of dextromethorphan, memantine, fluoxetine and amitriptyline: treatment of involuntary emotional expression disorder., Exp. Neurol.
    Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
    Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
    Fleishaker et al., 2000, Pharmacokinetic interaction between verapamil and almotriptan in healthy volunteers., Clin. Pharmacol. Ther.
    Bou et al., 2000, Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine., Eur. J. Pharmacol.
    Gozlan et al., 1991, [Preclinical pharmacology of amoxapine and amitriptyline. Implications of serotoninergic and opiodergic systems in their central effect in rats]., Encephale
    Kaumann, 1983, Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors., Naunyn Schmiedebergs Arch. Pharmacol.
    Millan et al., 2000, Agonist and antagonist actions of yohimbine as compared to fluparoxan at alpha(2)-adrenergic receptors (AR)s, serotonin (5-HT)(1A), 5-HT(1B), 5-HT(1D) and dopamine D(2) and D(3) receptors. Significance for the modulation of frontocortical monoaminergic transmission and depressive states., Synapse
    Villalón et al., 1999, Canine external carotid vasoconstriction to methysergide, ergotamine and dihydroergotamine: role of 5-HT1B/1D receptors and alpha2-adrenoceptors., Br. J. Pharmacol.
    Valdivia et al., 2004, 5-HT1B receptors, alpha2A/2C- and, to a lesser extent, alpha1-adrenoceptors mediate the external carotid vasoconstriction to ergotamine in vagosympathectomised dogs., Naunyn Schmiedebergs Arch. Pharmacol.
    Cohen et al., 2000, Contractile responses to sumatriptan and ergotamine in the rabbit saphenous vein: effect of selective 5-HT(1F) receptor agonists and PGF(2alpha)., Br. J. Pharmacol.
    van Wijngaarden et al., 1990, The concept of selectivity in 5-HT receptor research., Eur. J. Pharmacol.
    Schmidt et al., 2001, Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile., Eur. J. Pharmacol.
    Matsumoto et al., 1992, Characterization of 5-hydroxytryptamine1B receptors in rat spinal cord via [125I]iodocyanopindolol binding and inhibition of [3H]-5-hydroxytryptamine release., J. Pharmacol. Exp. Ther.
    Amitai M et al., 2016, Pharmacogenetics of citalopram-related side effects in children with depression and/or anxiety disorders., J Neural Transm (Vienna)
    Mylecharane EJ, 1991, 5-HT2 receptor antagonists and migraine therapy., J Neurol
  • FROVATRIPTAN   HTR1B

    Interaction Score: 4.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name frovatriptan,Frovelan, Frova
    Novel drug target Established target
    Specific Action of the Ligand Agonist

    PMIDs:
    12028322 15342617 10883409 12028320 9700983 18360605 18001261 11752352 11735616 11152011 15311727 17190530


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • ALMOTRIPTAN   HTR1B

    Interaction Score: 3.69

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Agonist

    PMIDs:
    11050304 11069595 11752352 10824628 11134654 10193663


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • NARATRIPTAN   HTR1B

    Interaction Score: 2.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    12463278 14725972 16389295 10410185 12010764 11752352 20687618 14728705 11152011 9650800


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • RIZATRIPTAN   HTR1B

    Interaction Score: 1.62

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    15821444 12269863 12093318 11752352 15056946 9650800 11487512


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology

  • ZOLMITRIPTAN   HTR1B

    Interaction Score: 1.39

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist
    Direct Interaction yes
    Trial Name zolmitriptan,Zomig

    PMIDs:
    11513839 9399012 15096229 9859690 11594437 10463324 10844127 10563228 11752352 20407761 29352859


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • ELETRIPTAN   HTR1B

    Interaction Score: 1.23

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    11513839 12384251 11050304 11069595 11752352 10193663


    Sources:
    TEND TTD DrugBank GuideToPharmacology

  • BOPINDOLOL   HTR1B

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2664084 2512511 7944828 3141589 10727715


    Sources:
    DrugBank

  • SUMATRIPTAN   HTR1B

    Interaction Score: 0.66

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name MT 400,Treximet
    Novel drug target Established target
    Trial Name NP101,Zelrix

    PMIDs:
    10513577 12010765 18723285 11874390 12110114 10101238 11752352 10772044 10454495 10458598 10225363


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • DIHYDROERGOTAMINE   HTR1B

    Interaction Score: 0.59

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name MT 300
    Novel drug target Established target
    Trial Name MAP-0004, TEMPO Migraine,Levadex

    PMIDs:
    1660351 8622623 10455274 14744615 9650800


    Sources:
    TdgClinicalTrial DrugBank GuideToPharmacology

  • PINDOLOL   HTR1B

    Interaction Score: 0.55

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    2664084 2512511 7944828 3141589 10727715


    Sources:
    DrugBank

  • TRELANSERIN   HTR1B

    Interaction Score: 0.49

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name trelanserin, SL 65.0472
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor antagonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ALNIDITAN   HTR1B

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • NARATRIPTAN HYDROCHLORIDE   HTR1B

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RIZATRIPTAN BENZOATE   HTR1B

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SUMATRIPTAN SUCCINATE   HTR1B

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL159332   HTR1B

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • AVITRIPTAN   HTR1B

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • FROVATRIPTAN SUCCINATE   HTR1B

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PENBUTOLOL   HTR1B

    Interaction Score: 0.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8098761


    Sources:
    DrugBank

  • ERGOTAMINE   HTR1B

    Interaction Score: 0.3

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10188968 15224175 10455274 11015308


    Sources:
    TEND TdgClinicalTrial DrugBank

  • VORTIOXETINE   HTR1B

    Interaction Score: 0.27

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Partial agonist

    PMIDs:
    21486038


    Sources:
    TdgClinicalTrial DrugBank GuideToPharmacology

  • GR-55562   HTR1B

    Interaction Score: 0.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • DONITRIPTAN   HTR1B

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology ChemblInteractions

  • ALMOTRIPTAN MALATE   HTR1B

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ELETRIPTAN HYDROBROMIDE   HTR1B

    Interaction Score: 0.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ELTOPRAZINE   HTR1B

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • GSK163090   HTR1B

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ASENAPINE   HTR1B

    Interaction Score: 0.17

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist
    Trial Name Asenapine

    PMIDs:
    18308814 21655346


    Sources:
    TdgClinicalTrial DrugBank GuideToPharmacology

  • LIOTHYRONINE   HTR1B

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • PERGOLIDE   HTR1B

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    18691132 10641988


    Sources:
    DrugBank GuideToPharmacology

  • YOHIMBINE   HTR1B

    Interaction Score: 0.16

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    6136920 10611634


    Sources:
    DrugBank GuideToPharmacology

  • CABERGOLINE   HTR1B

    Interaction Score: 0.15

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    18691132 10641988


    Sources:
    DrugBank GuideToPharmacology

  • DAPOXETINE   HTR1B

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • METHYSERGIDE   HTR1B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    binder
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    1738111


    Sources:
    DrugBank GuideToPharmacology

  • LISURIDE   HTR1B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    18691132


    Sources:
    DrugBank GuideToPharmacology

  • PROPRANOLOL   HTR1B

    Interaction Score: 0.12

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    9760032 7881730


    Sources:
    DrugBank

  • ONDANSETRON   HTR1B

    Interaction Score: 0.11

    Interaction Types & Directionality:
    other/unknown

    Interaction Info:

    PMIDs:
    2164935


    Sources:
    DrugBank

  • RAUWOLSCINE   HTR1B

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • NEFAZODONE   HTR1B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • PIZOTYLINE   HTR1B

    Interaction Score: 0.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    2045831


    Sources:
    DrugBank

  • VENLAFAXINE   HTR1B

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • BROMOCRIPTINE   HTR1B

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    18691132 10641988


    Sources:
    DrugBank GuideToPharmacology

  • CLOMIPRAMINE   HTR1B

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • ZIPRASIDONE   HTR1B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    17848919 11513838


    Sources:
    DrugBank GuideToPharmacology

  • CAPESEROD   HTR1B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • BRL-15,572   HTR1B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Partial agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • 8-OH-DPAT   HTR1B

    Interaction Score: 0.07

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ARIPIPRAZOLE   HTR1B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    ligand
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    17848919 26346901


    Sources:
    DrugBank GuideToPharmacology

  • OXYMETAZOLINE   HTR1B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ERGOLOID MESYLATES   HTR1B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PIPAMPERONE   HTR1B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • TRYPTAMINE   HTR1B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? True
    Specific Action of the Ligand Full agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • APOMORPHINE   HTR1B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    18691132


    Sources:
    DrugBank

  • TERGURIDE   HTR1B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Partial agonist

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ROXINDOLE   HTR1B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • AMOXAPINE   HTR1B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    1666997


    Sources:
    DrugBank

  • XANOMELINE   HTR1B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • OCAPERIDONE   HTR1B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ZOTEPINE   HTR1B

    Interaction Score: 0.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • PAROXETINE   HTR1B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • CITALOPRAM   HTR1B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27324805


    Sources:
    PharmGKB

  • FLUOXETINE   HTR1B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28025020


    Sources:
    PharmGKB

  • FLUPHENAZINE   HTR1B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SERTINDOLE   HTR1B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • METERGOLINE   HTR1B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • KETANSERIN   HTR1B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • AMITRIPTYLINE   HTR1B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    17689532


    Sources:
    DrugBank

  • METITEPINE   HTR1B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inverse agonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • RITANSERIN   HTR1B

    Interaction Score: 0.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • SEROTONIN   HTR1B

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • QUETIAPINE   HTR1B

    Interaction Score: 0.03

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    17848919


    Sources:
    DrugBank

  • OLANZAPINE   HTR1B

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv
    Novel drug target Established target
    Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

    PMIDs:
    17848919


    Sources:
    TdgClinicalTrial GuideToPharmacology

  • LITHIUM   HTR1B

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • ESCITALOPRAM   HTR1B

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CLOZAPINE   HTR1B

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False

    PMIDs:
    17848919


    Sources:
    DrugBank GuideToPharmacology

  • LOXAPINE   HTR1B

    Interaction Score: 0.02

    Interaction Types & Directionality:
    binder

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • RISPERIDONE   HTR1B

    Interaction Score: 0.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • Ensembl: ENSG00000135312

    • Version: 101_38

    Alternate Names:
    HTR1B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000135312

    • Version: 26-July-2011

    Alternate Names:
    5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR 1B) (5- HT1B) (5-HT-1D-BETA) (SEROTONIN 1D BETA RECEPTOR) (S12). [SOURCE:UNIPROT/SWISSPROT;ACC:P28222] Description
    ENSG00000135312 Ensembl Gene Id
    HTR1B Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P28222

    • Version: January-2014

    Alternate Names:
    HTR1B Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • TEND: P28222

    • Version: 01-August-2011

    Alternate Names:
    P28222 Uniprot Accession
    HTR1B Gene Symbol
    ENSG00000135312 Ensembl Gene Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass Rhodopsin
    Target Subclass GPCR

    Publications:

  • HopkinsGroom: P28222

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000135312 Ensembl Gene Id
    5-HYDROXYTRYPTAMINE RECEPTOR 1B Uniprot Protein Name
    HTR1B Uniprot Gene Name

    Gene Info:
    Interpro Type Family
    Interpro Acc IPR000276
    Human Readable Name G PROTEIN COUPLED RECEPTOR

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 3351

    • Version: 29-September-2020

    Alternate Names:
    5287 HUGO Gene ID
    5287 HUGO Gene Symbol
    5-hydroxytryptamine receptor 1B HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name 5-Hydroxytryptamine receptors
    GuideToPharmacology Gene Category ID 1

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • PharmGKB: HTR1B

    • Version: 18-August-2020

    Alternate Names:
    PA29549 PharmGKB ID

    Gene Info:

    Publications:
    Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
    Gassó P et al., 2017, Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine., Prog Neuropsychopharmacol Biol Psychiatry
    Amitai M et al., 2016, Pharmacogenetics of citalopram-related side effects in children with depression and/or anxiety disorders., J Neural Transm (Vienna)

  • DrugBank: BE0000797

    • Version: 5.1.7

    Alternate Names:
    HTR1B DrugBank Gene Name
    P28222 UniProt Accession
    3351 Entrez Gene Id

    Gene Info:

    Publications:
    Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.
    Lambert et al., 2002, Suppression by eletriptan of the activation of trigeminovascular sensory neurons by glyceryl trinitrate., Brain Res.
    van den Broek et al., 2000, Pharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vessels., Eur. J. Pharmacol.

  • ChemblInteractions: HTR1DB

    • Version: chembl_23

    Alternate Names:
    HTR1DB GENE_SYMBOL
    HTR1B GENE_SYMBOL
    5-hydroxytryptamine receptor 1B UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000135312

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000135312 Gene Symbol
    HTR1B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: HTR1B

    • Version: 05-September-2020

    Alternate Names:
    HTR1DB GO Gene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • dGene: HTR1B

    • Version: 27-Jun-2013

    Alternate Names:
    3351 Gene ID
    5-HT1B dGene Synonym
    5-HT1DB dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: 5-HT 1B receptor

    • Version: 2020.06.01

    Alternate Names:
    HTR1B TTD Gene Abbreviation
    T07806 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21