DGIdb - HTR1B Gene Record

HTR1B 3351 Druggable Genome

Alternate Names:

3351
5-HYDROXYTRYPTAMINE RECEPTOR 1B
HTR1B
5-HT-1B
5-HT-1D-beta
5-HT1B
5-HT1DB
HTR1D2
HTR1DB
S12
182131
5287
ENSG00000135312
OTTHUMG00000015066
Serotonin 1D beta receptor
Serotonin receptor 1B
5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR 1B) (5- HT1B) (5-HT-1D-BETA) (SEROTONIN 1D BETA RECEPTOR) (S12). [SOURCE:UNIPROT/SWISSPROT;ACC:P28222]
P28222
5HT1B_HUMAN
PA29549
5-HT 1B receptor
T07806

Gene Info:

Human Readable Name	G PROTEIN COUPLED RECEPTOR
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Family
Interpro Acc	IPR000276
Interpro Short Name	7TM_GPCR_Rhodpsn
Uniprot Status	Swiss-Prot
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Evidence	1: Evidence at protein level
Target Main Class	Receptors
Target Subclass	Rhodopsin
Target Subclass	GPCR
Transmembrane Helix Count	7
Target Class	Receptors
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Willems et al., 1999, Pharmacological evidence that alpha1-and alpha2-adrenoceptors mediate vasoconstriction of carotid arteriovenous anastomoses in anaesthetized pigs., Br. J. Pharmacol.
Villalón et al., 2004, 5-HT1B receptors and alpha 2A/2C-adrenoceptors mediate external carotid vasoconstriction to dihydroergotamine., Eur. J. Pharmacol.
Buzzi et al., 1991, Evidence for 5-HT1B/1D receptors mediating the antimigraine effect of sumatriptan and dihydroergotamine., Cephalalgia
Pauwels et al., 1998, Interaction of 5-HT1B/D ligands with recombinant h 5-HT1A receptors: intrinsic activity and modulation by G-protein activation state., Naunyn Schmiedebergs Arch. Pharmacol.
Yu et al., 1996, 5-Carboxamido-tryptamine, CP-122,288 and dihydroergotamine but not sumatriptan, CP-93,129, and serotonin-5-O-carboxymethyl-glycyl -tyrosinamide block dural plasma protein extravasation in knockout mice that lack 5-hydroxytryptamine1B receptors., Mol. Pharmacol.
Bang-Andersen et al., 2011, Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder., J. Med. Chem.
Tfelt-Hansen et al., 2000, Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy., Drugs
Comer, 2002, Pharmacology of the selective 5-HT(1B/1D) agonist frovatriptan., Headache
Markus et al., 2007, Frovatriptan review., Expert Opin Pharmacother
Parsons et al., 1998, Effects of the novel high-affinity 5-HT(1B/1D)-receptor ligand frovatriptan in human isolated basilar and coronary arteries., J. Cardiovasc. Pharmacol.
Elkind et al., 2004, Pharmacokinetics of frovatriptan in adolescent migraineurs., J Clin Pharmacol
Buchan et al., 2002, Frovatriptan: a review of drug-drug interactions., Headache
Dodick et al., 2007, Use of the sustained pain-free plus no adverse events endpoint in clinical trials of triptans in acute migraine., CNS Drugs
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Balbisi, 2006, Frovatriptan: a review of pharmacology, pharmacokinetics and clinical potential in the treatment of menstrual migraine., Ther Clin Risk Manag
Easthope et al., 2001, Frovatriptan., CNS Drugs
Deleu et al., 2000, Current and emerging second-generation triptans in acute migraine therapy: a comparative review., J Clin Pharmacol
Balbisi, 2004, Frovatriptan succinate, a 5-HT1B/1D receptor agonist for migraine., Int. J. Clin. Pract.
Napier et al., 1999, Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors., Eur. J. Pharmacol.
van den Broek et al., 2000, Pharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vessels., Eur. J. Pharmacol.
Lambert et al., 2002, Suppression by eletriptan of the activation of trigeminovascular sensory neurons by glyceryl trinitrate., Brain Res.
Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.
Knyihár-Csillik et al., 2000, Effects of eletriptan on the peptidergic innervation of the cerebral dura mater and trigeminal ganglion, and on the expression of c-fos and c-jun in the trigeminal complex of the rat in an experimental migraine model., Eur. J. Neurosci.
Martin, 1997, Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraine., Cephalalgia
Pascual, 1998, [Mechanism of action of zolmitriptan]., Neurologia
Hargreaves et al., 1999, Pathophysiology of migraine--new insights., Can J Neurol Sci
de Almeida et al., 2001, Zolmitriptan--a 5-HT1B/D agonist, alcohol, and aggression in mice., Psychopharmacology (Berl.)
Gowin et al., 2010, Zolmitriptan and human aggression: interaction with alcohol., Psychopharmacology (Berl.)
Whale et al., 1999, Zolmitriptan-induced growth hormone release in humans: mediation by 5-HT1D receptors?, Psychopharmacology (Berl.)
Reuter et al., 2004, Effects of chronic sumatriptan and zolmitriptan treatment on 5-HT receptor expression and function in rats., Cephalalgia
Le Grand et al., 2000, Zolmitriptan stimulates a Ca(2+)-dependent K(+) current in C6 glioma cells stably expressing recombinant human 5-HT(1B) receptors., Eur. J. Pharmacol.
Rubio-Beltrán E et al., 2018, Is selective 5-HT<sub>1F</sub> receptor agonism an entity apart from that of the triptans in antimigraine therapy?, Pharmacol Ther
Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
Grånäs et al., 1999, Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor., Eur. J. Pharmacol.
Roy et al., 2000, Expression of 5-hydroxytryptamine receptor subtype messenger RNA in interstitial cells from human heart valves., J. Heart Valve Dis.
Mitsikostas et al., 1999, Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis., Eur. J. Pharmacol.
Nikai et al., 2008, Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan., Pain
Razzaque et al., 2002, 5-HT1B-receptors and vascular reactivity in human isolated blood vessels: assessment of the potential craniovascular selectivity of sumatriptan., Br J Clin Pharmacol
Cohen et al., 1999, Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: molecular and pharmacologic characterization., J. Cereb. Blood Flow Metab.
Akin et al., 2002, Involvement of 5-HT1B and 5-HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery., Br. J. Pharmacol.
Mitsikostas et al., 2002, 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis., Cephalalgia
Cohen et al., 1999, 5-Hydroxytryptamine(1A) receptor activation enhances norepinephrine release from nerves in the rabbit saphenous vein., J. Pharmacol. Exp. Ther.
Dupuis et al., 1999, Magnitude of 5-HT1B and 5-HT1A receptor activation in guinea-pig and rat brain: evidence from sumatriptan dimer-mediated [35S]GTPgammaS binding responses., Brain Res. Mol. Brain Res.
Massiou, 2001, Naratriptan., Curr Med Res Opin
Hoskin et al., 2004, The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat., Brain Res.
Lambert, 2005, Preclinical neuropharmacology of naratriptan., CNS Drug Rev
Dulli, 1999, Naratriptan: an alternative for migraine., Ann Pharmacother
Akin et al., 2002, Agonist-directed trafficking explaining the difference between response pattern of naratriptan and sumatriptan in rabbit common carotid artery., Br. J. Pharmacol.
Johnston et al., 2010, Triptans for the management of migraine., Drugs
Boers et al., 2004, Naratriptan has a selective inhibitory effect on trigeminovascular neurones at central 5-HT1A and 5-HT(1B/1D) receptors in the cat: implications for migraine therapy., Cephalalgia
Wellington et al., 2002, Rizatriptan: an update of its use in the management of migraine., Drugs
Wellington et al., 2002, Spotlight on rizatriptan in migraine., CNS Drugs
Wackenfors et al., 2005, Triptans induce vasoconstriction of human arteries and veins from the thoracic wall., J. Cardiovasc. Pharmacol.
Williamson et al., 2001, The anti-migraine 5-HT(1B/1D) agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea-pigs., Br. J. Pharmacol.
Ikemoto et al., 2004, [Rizatriptan (Maxalt), a new entity of triptan for migraine: pharmacology and therapeutic relevance]., Nippon Yakurigaku Zasshi
Gassó P et al., 2017, Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine., Prog Neuropsychopharmacol Biol Psychiatry
Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
Bou et al., 2000, Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine., Eur. J. Pharmacol.
Fleishaker et al., 2000, Pharmacokinetic interaction between verapamil and almotriptan in healthy volunteers., Clin. Pharmacol. Ther.
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Villalón et al., 1999, Canine external carotid vasoconstriction to methysergide, ergotamine and dihydroergotamine: role of 5-HT1B/1D receptors and alpha2-adrenoceptors., Br. J. Pharmacol.
Cohen et al., 2000, Contractile responses to sumatriptan and ergotamine in the rabbit saphenous vein: effect of selective 5-HT(1F) receptor agonists and PGF(2alpha)., Br. J. Pharmacol.
Valdivia et al., 2004, 5-HT1B receptors, alpha2A/2C- and, to a lesser extent, alpha1-adrenoceptors mediate the external carotid vasoconstriction to ergotamine in vagosympathectomised dogs., Naunyn Schmiedebergs Arch. Pharmacol.
Amitai M et al., 2016, Pharmacogenetics of citalopram-related side effects in children with depression and/or anxiety disorders., J Neural Transm (Vienna)

FROVATRIPTAN HTR1B

Interaction Score: 14.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name frovatriptan,Frovelan, Frova

Novel drug target Established target

PMIDs:
11152011 12028320 18001261 9700983 15342617 12028322 17190530 11752352 18360605 11735616 10883409 15311727

Sources:
TdgClinicalTrial TEND TTD
RIZATRIPTAN HTR1B

Interaction Score: 8.43

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12093318 12269863 15821444 11487512 9650800 11752352 15056946

Sources:
TdgClinicalTrial TEND
ALMOTRIPTAN HTR1B

Interaction Score: 7.49

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name almotriptan,Axert, Almogran, Amignul

Novel drug target Established target

PMIDs:
10193663 11050304 11134654 11752352 10824628 11069595

Sources:
TdgClinicalTrial TEND
NARATRIPTAN HTR1B

Interaction Score: 6.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name naratriptan,Naramig, Amerge

Novel drug target Established target

PMIDs:
12463278 14725972 16389295 10410185 12010764 11752352 20687618 14728705 11152011 9650800

Sources:
TdgClinicalTrial TEND TTD
ERGOTAMINE HTR1B

Interaction Score: 5.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10455274 10188968 11015308 15224175

Sources:
TdgClinicalTrial TEND
ZOLMITRIPTAN HTR1B

Interaction Score: 5.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

Direct Interaction yes

Trial Name zolmitriptan,Zomig

PMIDs:
9399012 9859690 10563228 11513839 11594437 20407761 10463324 11752352 15096229 10844127 29352859

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ELETRIPTAN HTR1B

Interaction Score: 5.0

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
10193663 11050304 12384251 11513839 11752352 11069595

Sources:
TEND TTD
DIHYDROERGOTAMINE HTR1B

Interaction Score: 2.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MT 300

Novel drug target Established target

Trial Name MAP-0004, TEMPO Migraine,Levadex

PMIDs:
10455274 14744615 1660351 9650800 8622623

Sources:
TdgClinicalTrial
SUMATRIPTAN HTR1B

Interaction Score: 1.87

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MT 400,Treximet

Novel drug target Established target

Trial Name NP101,Zelrix

PMIDs:
10513577 10772044 10225363 18723285 11874390 10458598 12010765 12110114 11752352 10454495 10101238

Sources:
TdgClinicalTrial ChemblInteractions TEND
TRELANSERIN HTR1B

Interaction Score: 1.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name trelanserin, SL 65.0472

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
DONITRIPTAN HTR1B

Interaction Score: 1.25

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
NARATRIPTAN HYDROCHLORIDE HTR1B

Interaction Score: 0.94

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RIZATRIPTAN BENZOATE HTR1B

Interaction Score: 0.94

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SUMATRIPTAN SUCCINATE HTR1B

Interaction Score: 0.94

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
FROVATRIPTAN SUCCINATE HTR1B

Interaction Score: 0.94

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
ALMOTRIPTAN MALATE HTR1B

Interaction Score: 0.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ELETRIPTAN HYDROBROMIDE HTR1B

Interaction Score: 0.62

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions
ELTOPRAZINE HTR1B

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
VORTIOXETINE HTR1B

Interaction Score: 0.62

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Trial Name Lu AA21004

Novel drug target Established target

PMIDs:
21486038

Sources:
TdgClinicalTrial
LIOTHYRONINE HTR1B

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
GSK163090 HTR1B

Interaction Score: 0.47

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
NEFAZODONE HTR1B

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
CLOMIPRAMINE HTR1B

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
ASENAPINE HTR1B

Interaction Score: 0.31

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name Asenapine

Novel drug target Established target

PMIDs:
18308814 21655346

Sources:
TdgClinicalTrial
VENLAFAXINE HTR1B

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
FLUPHENAZINE HTR1B

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ERGOLOID MESYLATES HTR1B

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PAROXETINE HTR1B

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
FLUOXETINE HTR1B

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28025020

Sources:
PharmGKB
CITALOPRAM HTR1B

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27324805

Sources:
PharmGKB
ESCITALOPRAM HTR1B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LITHIUM HTR1B

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21449676

Sources:
PharmGKB
OLANZAPINE HTR1B

Interaction Score: 0.06

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv

Novel drug target Established target

Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

PMIDs:
17848919

Sources:
TdgClinicalTrial

Ensembl: ENSG00000135312
- Version: 101_38
Alternate Names:

HTR1B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000135312

Version: 26-July-2011

Alternate Names:

5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR 1B) (5- HT1B) (5-HT-1D-BETA) (SEROTONIN 1D BETA RECEPTOR) (S12). [SOURCE:UNIPROT/SWISSPROT;ACC:P28222] Description

ENSG00000135312 Ensembl Gene Id

HTR1B Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P28222
- Version: January-2014
Alternate Names:

HTR1B Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
TEND: P28222
- Version: 01-August-2011
Alternate Names:

P28222 Uniprot Accession

HTR1B Gene Symbol

ENSG00000135312 Ensembl Gene Id

Gene Info:

Target Main Class Receptors

Target Subclass Rhodopsin

Target Subclass GPCR

Publications:
HopkinsGroom: P28222
- Version: 11-September-2012
Alternate Names:

ENSG00000135312 Ensembl Gene Id

5-HYDROXYTRYPTAMINE RECEPTOR 1B Uniprot Protein Name

HTR1B Uniprot Gene Name

Gene Info:

Interpro Type Family

Interpro Acc IPR000276

Human Readable Name G PROTEIN COUPLED RECEPTOR

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

PharmGKB: HTR1B

Version: 18-August-2020

Alternate Names:

PA29549 PharmGKB ID

Gene Info:

Publications:

Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics

Gassó P et al., 2017, Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine., Prog Neuropsychopharmacol Biol Psychiatry

Amitai M et al., 2016, Pharmacogenetics of citalopram-related side effects in children with depression and/or anxiety disorders., J Neural Transm (Vienna)

ChemblInteractions: HTR1DB
- Version: chembl_23
Alternate Names:

HTR1DB GENE_SYMBOL

HTR1B GENE_SYMBOL

5-hydroxytryptamine receptor 1B UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000135312
- Version: 31-May-2017
Alternate Names:

ENSG00000135312 Gene Symbol

HTR1B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: HTR1B
- Version: 27-Jun-2013
Alternate Names:

3351 Gene ID

5-HT1B dGene Synonym

5-HT1DB dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: 5-HT 1B receptor
- Version: 2020.06.01
Alternate Names:

HTR1B TTD Gene Abbreviation

T07806 TTD Target ID

Gene Info:

Publications:

Trial Name	frovatriptan,Frovelan, Frova
Novel drug target	Established target

Trial Name	almotriptan,Axert, Almogran, Amignul
Novel drug target	Established target

Trial Name	naratriptan,Naramig, Amerge
Novel drug target	Established target

Mechanism of Interaction	Serotonin 1b (5-HT1b) receptor agonist
Direct Interaction	yes
Trial Name	zolmitriptan,Zomig

Trial Name	MT 300
Novel drug target	Established target
Trial Name	MAP-0004, TEMPO Migraine,Levadex

Trial Name	MT 400,Treximet
Novel drug target	Established target
Trial Name	NP101,Zelrix

Direct Interaction	yes
Mechanism of Interaction	Serotonin 1b (5-HT1b) receptor antagonist

Trial Name	olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv
Novel drug target	Established target
Trial Name	Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR 1B) (5- HT1B) (5-HT-1D-BETA) (SEROTONIN 1D BETA RECEPTOR) (S12). [SOURCE:UNIPROT/SWISSPROT;ACC:P28222]	Description
ENSG00000135312	Ensembl Gene Id
HTR1B	Display Id

P28222	Uniprot Accession
HTR1B	Gene Symbol
ENSG00000135312	Ensembl Gene Id

HTR1DB	GENE_SYMBOL
HTR1B	GENE_SYMBOL
5-hydroxytryptamine receptor 1B	UNIPROT

HTR1B Gene Record

HTR1B 3351 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name frovatriptan,Frovelan, Frova Novel drug target Established target

PMIDs: 11152011 12028320 18001261 9700983 15342617 12028322 17190530 11752352 18360605 11735616 10883409 15311727

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12093318 12269863 15821444 11487512 9650800 11752352 15056946

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name almotriptan,Axert, Almogran, Amignul Novel drug target Established target

PMIDs: 10193663 11050304 11134654 11752352 10824628 11069595

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name naratriptan,Naramig, Amerge Novel drug target Established target

PMIDs: 12463278 14725972 16389295 10410185 12010764 11752352 20687618 14728705 11152011 9650800

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10455274 10188968 11015308 15224175

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist Direct Interaction yes Trial Name zolmitriptan,Zomig

PMIDs: 9399012 9859690 10563228 11513839 11594437 20407761 10463324 11752352 15096229 10844127 29352859

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 10193663 11050304 12384251 11513839 11752352 11069595

Sources: TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name MT 300 Novel drug target Established target Trial Name MAP-0004, TEMPO Migraine,Levadex

PMIDs: 10455274 14744615 1660351 9650800 8622623

Sources: TdgClinicalTrial

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name MT 400,Treximet Novel drug target Established target Trial Name NP101,Zelrix

PMIDs: 10513577 10772044 10225363 18723285 11874390 10458598 12010765 12110114 11752352 10454495 10101238

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name trelanserin, SL 65.0472 Mechanism of Interaction Serotonin 1b (5-HT1b) receptor antagonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: partial agonist (activating) agonist (activating)

Interaction Info: Trial Name Lu AA21004 Novel drug target Established target

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name frovatriptan,Frovelan, Frova

Novel drug target Established target

PMIDs:
11152011 12028320 18001261 9700983 15342617 12028322 17190530 11752352 18360605 11735616 10883409 15311727

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12093318 12269863 15821444 11487512 9650800 11752352 15056946

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name almotriptan,Axert, Almogran, Amignul

Novel drug target Established target

PMIDs:
10193663 11050304 11134654 11752352 10824628 11069595

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name naratriptan,Naramig, Amerge

Novel drug target Established target

PMIDs:
12463278 14725972 16389295 10410185 12010764 11752352 20687618 14728705 11152011 9650800

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10455274 10188968 11015308 15224175

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

Direct Interaction yes

Trial Name zolmitriptan,Zomig

PMIDs:
9399012 9859690 10563228 11513839 11594437 20407761 10463324 11752352 15096229 10844127 29352859

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

PMIDs:
10193663 11050304 12384251 11513839 11752352 11069595

Sources:
TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MT 300

Novel drug target Established target

Trial Name MAP-0004, TEMPO Migraine,Levadex

PMIDs:
10455274 14744615 1660351 9650800 8622623

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MT 400,Treximet

Novel drug target Established target

Trial Name NP101,Zelrix

PMIDs:
10513577 10772044 10225363 18723285 11874390 10458598 12010765 12110114 11752352 10454495 10101238

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name trelanserin, SL 65.0472

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

partial agonist (activating)

agonist (activating)

Interaction Info:

Trial Name Lu AA21004

Novel drug target Established target

PMIDs:
21486038

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
21449676

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 1b (5-HT1b) receptor antagonist

PMIDs:
None found