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HTR1B Gene Record

  • Summary
  • Interactions
  • Claims
  • HTR1B 3351 Druggable Genome

    Alternate Names:

    3351
    5-HYDROXYTRYPTAMINE RECEPTOR 1B
    HTR1B
    5-HT-1B
    5-HT-1D-beta
    5-HT1B
    5-HT1DB
    HTR1D2
    HTR1DB
    S12
    182131
    5287
    ENSG00000135312
    OTTHUMG00000015066
    Serotonin 1D beta receptor
    Serotonin receptor 1B
    5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR 1B) (5- HT1B) (5-HT-1D-BETA) (SEROTONIN 1D BETA RECEPTOR) (S12). [SOURCE:UNIPROT/SWISSPROT;ACC:P28222]
    P28222
    5HT1B_HUMAN
    PA29549
    5-HT 1B receptor
    T07806

    Gene Info:

    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Human Readable Name DRUGGABLE GENOME
    Interpro Type Family
    Interpro Acc IPR000276
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Uniprot Status Swiss-Prot
    Interpro Name GPCR, rhodopsin-like, 7TM
    Uniprot Evidence 1: Evidence at protein level
    Target Main Class Receptors
    Target Subclass Rhodopsin
    Target Subclass GPCR
    Transmembrane Helix Count 7
    Target Class Receptors
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Willems et al., 1999, Pharmacological evidence that alpha1-and alpha2-adrenoceptors mediate vasoconstriction of carotid arteriovenous anastomoses in anaesthetized pigs., Br. J. Pharmacol.
    Villalón et al., 2004, 5-HT1B receptors and alpha 2A/2C-adrenoceptors mediate external carotid vasoconstriction to dihydroergotamine., Eur. J. Pharmacol.
    Buzzi et al., 1991, Evidence for 5-HT1B/1D receptors mediating the antimigraine effect of sumatriptan and dihydroergotamine., Cephalalgia
    Pauwels et al., 1998, Interaction of 5-HT1B/D ligands with recombinant h 5-HT1A receptors: intrinsic activity and modulation by G-protein activation state., Naunyn Schmiedebergs Arch. Pharmacol.
    Yu et al., 1996, 5-Carboxamido-tryptamine, CP-122,288 and dihydroergotamine but not sumatriptan, CP-93,129, and serotonin-5-O-carboxymethyl-glycyl -tyrosinamide block dural plasma protein extravasation in knockout mice that lack 5-hydroxytryptamine1B receptors., Mol. Pharmacol.
    Bang-Andersen et al., 2011, Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder., J. Med. Chem.
    Tfelt-Hansen et al., 2000, Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy., Drugs
    Comer, 2002, Pharmacology of the selective 5-HT(1B/1D) agonist frovatriptan., Headache
    Markus et al., 2007, Frovatriptan review., Expert Opin Pharmacother
    Parsons et al., 1998, Effects of the novel high-affinity 5-HT(1B/1D)-receptor ligand frovatriptan in human isolated basilar and coronary arteries., J. Cardiovasc. Pharmacol.
    Elkind et al., 2004, Pharmacokinetics of frovatriptan in adolescent migraineurs., J Clin Pharmacol
    Buchan et al., 2002, Frovatriptan: a review of drug-drug interactions., Headache
    Dodick et al., 2007, Use of the sustained pain-free plus no adverse events endpoint in clinical trials of triptans in acute migraine., CNS Drugs
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Balbisi, 2006, Frovatriptan: a review of pharmacology, pharmacokinetics and clinical potential in the treatment of menstrual migraine., Ther Clin Risk Manag
    Easthope et al., 2001, Frovatriptan., CNS Drugs
    Deleu et al., 2000, Current and emerging second-generation triptans in acute migraine therapy: a comparative review., J Clin Pharmacol
    Balbisi, 2004, Frovatriptan succinate, a 5-HT1B/1D receptor agonist for migraine., Int. J. Clin. Pract.
    Napier et al., 1999, Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors., Eur. J. Pharmacol.
    van den Broek et al., 2000, Pharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vessels., Eur. J. Pharmacol.
    Lambert et al., 2002, Suppression by eletriptan of the activation of trigeminovascular sensory neurons by glyceryl trinitrate., Brain Res.
    Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.
    Knyihár-Csillik et al., 2000, Effects of eletriptan on the peptidergic innervation of the cerebral dura mater and trigeminal ganglion, and on the expression of c-fos and c-jun in the trigeminal complex of the rat in an experimental migraine model., Eur. J. Neurosci.
    Martin, 1997, Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraine., Cephalalgia
    Pascual, 1998, [Mechanism of action of zolmitriptan]., Neurologia
    Hargreaves et al., 1999, Pathophysiology of migraine--new insights., Can J Neurol Sci
    de Almeida et al., 2001, Zolmitriptan--a 5-HT1B/D agonist, alcohol, and aggression in mice., Psychopharmacology (Berl.)
    Gowin et al., 2010, Zolmitriptan and human aggression: interaction with alcohol., Psychopharmacology (Berl.)
    Whale et al., 1999, Zolmitriptan-induced growth hormone release in humans: mediation by 5-HT1D receptors?, Psychopharmacology (Berl.)
    Reuter et al., 2004, Effects of chronic sumatriptan and zolmitriptan treatment on 5-HT receptor expression and function in rats., Cephalalgia
    Le Grand et al., 2000, Zolmitriptan stimulates a Ca(2+)-dependent K(+) current in C6 glioma cells stably expressing recombinant human 5-HT(1B) receptors., Eur. J. Pharmacol.
    Rubio-Beltrán E et al., 2018, Is selective 5-HT<sub>1F</sub> receptor agonism an entity apart from that of the triptans in antimigraine therapy?, Pharmacol Ther
    Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
    Grånäs et al., 1999, Identification of an amino acid residue important for binding of methiothepin and sumatriptan to the human 5-HT(1B) receptor., Eur. J. Pharmacol.
    Roy et al., 2000, Expression of 5-hydroxytryptamine receptor subtype messenger RNA in interstitial cells from human heart valves., J. Heart Valve Dis.
    Mitsikostas et al., 1999, Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis., Eur. J. Pharmacol.
    Nikai et al., 2008, Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan., Pain
    Razzaque et al., 2002, 5-HT1B-receptors and vascular reactivity in human isolated blood vessels: assessment of the potential craniovascular selectivity of sumatriptan., Br J Clin Pharmacol
    Cohen et al., 1999, Multiple microvascular and astroglial 5-hydroxytryptamine receptor subtypes in human brain: molecular and pharmacologic characterization., J. Cereb. Blood Flow Metab.
    Akin et al., 2002, Involvement of 5-HT1B and 5-HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery., Br. J. Pharmacol.
    Mitsikostas et al., 2002, 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis., Cephalalgia
    Cohen et al., 1999, 5-Hydroxytryptamine(1A) receptor activation enhances norepinephrine release from nerves in the rabbit saphenous vein., J. Pharmacol. Exp. Ther.
    Dupuis et al., 1999, Magnitude of 5-HT1B and 5-HT1A receptor activation in guinea-pig and rat brain: evidence from sumatriptan dimer-mediated [35S]GTPgammaS binding responses., Brain Res. Mol. Brain Res.
    Massiou, 2001, Naratriptan., Curr Med Res Opin
    Hoskin et al., 2004, The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat., Brain Res.
    Lambert, 2005, Preclinical neuropharmacology of naratriptan., CNS Drug Rev
    Dulli, 1999, Naratriptan: an alternative for migraine., Ann Pharmacother
    Akin et al., 2002, Agonist-directed trafficking explaining the difference between response pattern of naratriptan and sumatriptan in rabbit common carotid artery., Br. J. Pharmacol.
    Johnston et al., 2010, Triptans for the management of migraine., Drugs
    Boers et al., 2004, Naratriptan has a selective inhibitory effect on trigeminovascular neurones at central 5-HT1A and 5-HT(1B/1D) receptors in the cat: implications for migraine therapy., Cephalalgia
    Wellington et al., 2002, Rizatriptan: an update of its use in the management of migraine., Drugs
    Wellington et al., 2002, Spotlight on rizatriptan in migraine., CNS Drugs
    Wackenfors et al., 2005, Triptans induce vasoconstriction of human arteries and veins from the thoracic wall., J. Cardiovasc. Pharmacol.
    Williamson et al., 2001, The anti-migraine 5-HT(1B/1D) agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea-pigs., Br. J. Pharmacol.
    Ikemoto et al., 2004, [Rizatriptan (Maxalt), a new entity of triptan for migraine: pharmacology and therapeutic relevance]., Nippon Yakurigaku Zasshi
    Gassó P et al., 2017, Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine., Prog Neuropsychopharmacol Biol Psychiatry
    Shahid et al., 2009, Asenapine: a novel psychopharmacologic agent with a unique human receptor signature., J. Psychopharmacol. (Oxford)
    Citrome, 2011, Role of sublingual asenapine in treatment of schizophrenia., Neuropsychiatr Dis Treat
    Bou et al., 2000, Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine., Eur. J. Pharmacol.
    Fleishaker et al., 2000, Pharmacokinetic interaction between verapamil and almotriptan in healthy volunteers., Clin. Pharmacol. Ther.
    Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
    Villalón et al., 1999, Canine external carotid vasoconstriction to methysergide, ergotamine and dihydroergotamine: role of 5-HT1B/1D receptors and alpha2-adrenoceptors., Br. J. Pharmacol.
    Cohen et al., 2000, Contractile responses to sumatriptan and ergotamine in the rabbit saphenous vein: effect of selective 5-HT(1F) receptor agonists and PGF(2alpha)., Br. J. Pharmacol.
    Valdivia et al., 2004, 5-HT1B receptors, alpha2A/2C- and, to a lesser extent, alpha1-adrenoceptors mediate the external carotid vasoconstriction to ergotamine in vagosympathectomised dogs., Naunyn Schmiedebergs Arch. Pharmacol.
    Amitai M et al., 2016, Pharmacogenetics of citalopram-related side effects in children with depression and/or anxiety disorders., J Neural Transm (Vienna)
  • FROVATRIPTAN   HTR1B

    Interaction Score: 14.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name frovatriptan,Frovelan, Frova
    Novel drug target Established target

    PMIDs:
    11152011 12028320 18001261 9700983 15342617 12028322 17190530 11752352 18360605 11735616 10883409 15311727


    Sources:
    TdgClinicalTrial TEND TTD

  • RIZATRIPTAN   HTR1B

    Interaction Score: 8.43

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    12093318 12269863 15821444 11487512 9650800 11752352 15056946


    Sources:
    TdgClinicalTrial TEND

  • ALMOTRIPTAN   HTR1B

    Interaction Score: 7.49

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name almotriptan,Axert, Almogran, Amignul
    Novel drug target Established target

    PMIDs:
    10193663 11050304 11134654 11752352 10824628 11069595


    Sources:
    TdgClinicalTrial TEND

  • NARATRIPTAN   HTR1B

    Interaction Score: 6.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name naratriptan,Naramig, Amerge
    Novel drug target Established target

    PMIDs:
    12463278 14725972 16389295 10410185 12010764 11752352 20687618 14728705 11152011 9650800


    Sources:
    TdgClinicalTrial TEND TTD

  • ERGOTAMINE   HTR1B

    Interaction Score: 5.62

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10455274 10188968 11015308 15224175


    Sources:
    TdgClinicalTrial TEND

  • ZOLMITRIPTAN   HTR1B

    Interaction Score: 5.62

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist
    Direct Interaction yes
    Trial Name zolmitriptan,Zomig

    PMIDs:
    9399012 9859690 10563228 11513839 11594437 20407761 10463324 11752352 15096229 10844127 29352859


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • ELETRIPTAN   HTR1B

    Interaction Score: 5.0

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    10193663 11050304 12384251 11513839 11752352 11069595


    Sources:
    TEND TTD

  • DIHYDROERGOTAMINE   HTR1B

    Interaction Score: 2.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name MT 300
    Novel drug target Established target
    Trial Name MAP-0004, TEMPO Migraine,Levadex

    PMIDs:
    10455274 14744615 1660351 9650800 8622623


    Sources:
    TdgClinicalTrial

  • SUMATRIPTAN   HTR1B

    Interaction Score: 1.87

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name MT 400,Treximet
    Novel drug target Established target
    Trial Name NP101,Zelrix

    PMIDs:
    10513577 10772044 10225363 18723285 11874390 10458598 12010765 12110114 11752352 10454495 10101238


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • TRELANSERIN   HTR1B

    Interaction Score: 1.25

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name trelanserin, SL 65.0472
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor antagonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • DONITRIPTAN   HTR1B

    Interaction Score: 1.25

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • NARATRIPTAN HYDROCHLORIDE   HTR1B

    Interaction Score: 0.94

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RIZATRIPTAN BENZOATE   HTR1B

    Interaction Score: 0.94

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SUMATRIPTAN SUCCINATE   HTR1B

    Interaction Score: 0.94

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FROVATRIPTAN SUCCINATE   HTR1B

    Interaction Score: 0.94

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ALMOTRIPTAN MALATE   HTR1B

    Interaction Score: 0.62

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ELETRIPTAN HYDROBROMIDE   HTR1B

    Interaction Score: 0.62

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ELTOPRAZINE   HTR1B

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • VORTIOXETINE   HTR1B

    Interaction Score: 0.62

    Interaction Types & Directionality:
    partial agonist (activating)
    agonist (activating)

    Interaction Info:
    Trial Name Lu AA21004
    Novel drug target Established target

    PMIDs:
    21486038


    Sources:
    TdgClinicalTrial

  • LIOTHYRONINE   HTR1B

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • GSK163090   HTR1B

    Interaction Score: 0.47

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NEFAZODONE   HTR1B

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • CLOMIPRAMINE   HTR1B

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • ASENAPINE   HTR1B

    Interaction Score: 0.31

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name Asenapine
    Novel drug target Established target

    PMIDs:
    18308814 21655346


    Sources:
    TdgClinicalTrial

  • VENLAFAXINE   HTR1B

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • FLUPHENAZINE   HTR1B

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ERGOLOID MESYLATES   HTR1B

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Serotonin 1b (5-HT1b) receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PAROXETINE   HTR1B

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • FLUOXETINE   HTR1B

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28025020


    Sources:
    PharmGKB

  • CITALOPRAM   HTR1B

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27324805


    Sources:
    PharmGKB

  • ESCITALOPRAM   HTR1B

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LITHIUM   HTR1B

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21449676


    Sources:
    PharmGKB

  • OLANZAPINE   HTR1B

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Trial Name olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv
    Novel drug target Established target
    Trial Name Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac)

    PMIDs:
    17848919


    Sources:
    TdgClinicalTrial

  • Ensembl: ENSG00000135312

    • Version: 101_38

    Alternate Names:
    HTR1B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000135312

    • Version: 26-July-2011

    Alternate Names:
    5-HYDROXYTRYPTAMINE 1B RECEPTOR (5-HT-1B) (SEROTONIN RECEPTOR 1B) (5- HT1B) (5-HT-1D-BETA) (SEROTONIN 1D BETA RECEPTOR) (S12). [SOURCE:UNIPROT/SWISSPROT;ACC:P28222] Description
    ENSG00000135312 Ensembl Gene Id
    HTR1B Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P28222

    • Version: January-2014

    Alternate Names:
    HTR1B Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • TEND: P28222

    • Version: 01-August-2011

    Alternate Names:
    P28222 Uniprot Accession
    HTR1B Gene Symbol
    ENSG00000135312 Ensembl Gene Id

    Gene Info:
    Target Main Class Receptors
    Target Subclass Rhodopsin
    Target Subclass GPCR

    Publications:

  • HopkinsGroom: P28222

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000135312 Ensembl Gene Id
    5-HYDROXYTRYPTAMINE RECEPTOR 1B Uniprot Protein Name
    HTR1B Uniprot Gene Name

    Gene Info:
    Interpro Type Family
    Interpro Acc IPR000276
    Human Readable Name G PROTEIN COUPLED RECEPTOR

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • PharmGKB: HTR1B

    • Version: 18-August-2020

    Alternate Names:
    PA29549 PharmGKB ID

    Gene Info:

    Publications:
    Perroud N et al., 2011, Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample., Pharmacogenomics
    Gassó P et al., 2017, Epigenetic and genetic variants in the HTR1B gene and clinical improvement in children and adolescents treated with fluoxetine., Prog Neuropsychopharmacol Biol Psychiatry
    Amitai M et al., 2016, Pharmacogenetics of citalopram-related side effects in children with depression and/or anxiety disorders., J Neural Transm (Vienna)

  • ChemblInteractions: HTR1DB

    • Version: chembl_23

    Alternate Names:
    HTR1DB GENE_SYMBOL
    HTR1B GENE_SYMBOL
    5-hydroxytryptamine receptor 1B UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000135312

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000135312 Gene Symbol
    HTR1B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • dGene: HTR1B

    • Version: 27-Jun-2013

    Alternate Names:
    3351 Gene ID
    5-HT1B dGene Synonym
    5-HT1DB dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: 5-HT 1B receptor

    • Version: 2020.06.01

    Alternate Names:
    HTR1B TTD Gene Abbreviation
    T07806 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21