3350 |
5-HYDROXYTRYPTAMINE RECEPTOR 1A |
HTR1A |
5-HT-1A |
5-HT1A |
5HT1a |
ADRB2RL1 |
ADRBRL1 |
G-21 |
PFMCD |
109760 |
5286 |
ENSG00000178394 |
OTTHUMG00000162279 |
Serotonin receptor 1A |
P08908 |
5HT1A_HUMAN |
PA192 |
5-HYDROXYTRYPTAMINE 1A RECEPTOR (5-HT-1A) (SEROTONIN RECEPTOR 1A) (5- HT1A) (G-21). [SOURCE:UNIPROT/SWISSPROT;ACC:P08908] |
5-HT 1A receptor |
T78709 |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Uniprot Status | Swiss-Prot |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Family |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Interpro Acc | IPR000276 |
Target Main Class | Receptors |
Target Subclass | Rhodopsin |
Target Subclass | GPCR |
Transmembrane Helix Count | 7 |
Target Class | Receptors |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
agonist (activating) |
Trial Name | PRX-00023 |
Novel drug target | Established target |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor agonist |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor agonist |
Direct Interaction | yes |
Trial Name | MN-305 |
n/a |
Trial Name | Gepirone |
Novel drug target | Established target |
n/a |
Novel drug target | Established target |
Trial Name | xaliproden, SR 57746A |
agonist (activating) |
Trial Name | vilazodone hydrochloride, SB 659746A |
Novel drug target | Established target |
agonist (activating) |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
partial agonist (activating) |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor partial agonist |
Direct Interaction | yes |
Trial Name | bifeprunox, DU127090 |
agonist (activating) |
Trial Name | zolmitriptan,Zomig |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | lurasidone, SM-13496,Latuda |
Novel drug target | Established target |
partial agonist (activating) |
agonist (activating) |
Novel drug target | Established target |
Trial Name | OPC-34712 |
Direct Interaction | yes |
agonist (activating) |
Trial Name | naratriptan,Naramig, Amerge |
Novel drug target | Established target |
partial agonist (activating) |
agonist (activating) |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor partial agonist |
Trial Name | Abilify |
agonist (activating) |
Novel drug target | Established target |
Trial Name | Flibanserin |
agonist (activating) |
Trial Name | Lu AA21004 |
Novel drug target | Established target |
partial agonist (activating) |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor partial agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor agonist |
Direct Interaction | yes |
partial agonist (activating) |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor partial agonist |
Direct Interaction | yes |
partial agonist (activating) |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor partial agonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor agonist |
Direct Interaction | yes |
Trial Name | pardoprunox, SLV 308 |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor antagonist |
Direct Interaction | yes |
agonist (activating) |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor agonist |
Direct Interaction | yes |
agonist (activating) |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | Asenapine |
agonist (activating) |
Trial Name | MT 400,Treximet |
Novel drug target | Established target |
Trial Name | NP101,Zelrix |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | iloperidone,Fanapt, Fiapta, Zomaril |
agonist (activating) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 1a (5-HT1a) receptor agonist |
agonist (activating) |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Trial Name | ALKS 3831 |
Trial Name | OREX-003, olanzapine plus zonisamide SR |
Trial Name | Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac) |
HTR1A | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
P08908 | Uniprot Accession |
5-HYDROXYTRYPTAMINE RECEPTOR 1A | Uniprot Protein Name |
3350 | Entrez Gene Id |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Uniprot Status | Swiss-Prot |
Human Readable Name | DRUGGABLE GENOME |
G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME |
ENSG00000178394 | Ensembl Gene Id |
P08908 | Uniprot Accession |
5HT1A_HUMAN | Uniprot Id |
Target Main Class | Receptors |
Target Subclass | Rhodopsin |
Target Subclass | GPCR |
5-HYDROXYTRYPTAMINE 1A RECEPTOR (5-HT-1A) (SEROTONIN RECEPTOR 1A) (5- HT1A) (G-21). [SOURCE:UNIPROT/SWISSPROT;ACC:P08908] | Description |
ENSG00000178394 | Ensembl Gene Id |
HTR1A | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
HTR1A | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
PA192 | PharmGKB ID |
ENSG00000178394 | Gene Symbol |
HTR1A | Ensembl Id |
DRUGGABLE GENOME |
ADRBRL1 | GENE_SYMBOL |
HTR1A | GENE_SYMBOL |
5-hydroxytryptamine receptor 1A | UNIPROT |
ADRB2RL1 | GO Gene Synonym |
ADRBRL1 | GO Gene Synonym |
CELL SURFACE |
3350 | Gene ID |
5-HT-1A | dGene Synonym |
5-HT1A | dGene Synonym |
G PROTEIN COUPLED RECEPTOR |
HTR1A | TTD Gene Abbreviation |
T78709 | TTD Target ID |