DGIdb - HSPB2 Gene Record

HSPB2 3316

Alternate Names:

3316
HEAT SHOCK PROTEIN FAMILY B (SMALL) MEMBER 2
HSPB2
HSP27
Hs.78846
LOH11CR1K
MKBP
602179
5247
ENSG00000170276
ENSG00000254445
OTTHUMG00000166886
OTTHUMG00000166887
Heat shock protein beta-2
Q16082

Gene Info:

Gene Biotype	PROTEIN_CODING

(0 More Sources)

Gene Categories: Category Details

KINASE

Publications:

Chauhan et al., 2004, 2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27., Apoptosis
Yoshida et al., 2004, Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts., Prostaglandins Leukot. Essent. Fatty Acids
De et al., 2000, Exaggerated human monocyte IL-10 concomitant to minimal TNF-alpha induction by heat-shock protein 27 (Hsp27) suggests Hsp27 is primarily an antiinflammatory stimulus., J. Immunol.
Beall et al., 1999, Cyclosporine-induced renal artery smooth muscle contraction is associated with increases in the phosphorylation of specific contractile regulatory proteins., Biochim. Biophys. Acta
Ciocca et al., 1998, Heat shock proteins hsp27 and hsp70: lack of correlation with response to tamoxifen and clinical course of disease in estrogen receptor-positive metastatic breast cancer (a Southwest Oncology Group Study)., Clin. Cancer Res.
Zhang et al., 2005, Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer., Mol. Cell Proteomics
Kozawa et al., 2001, Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C., Arch. Biochem. Biophys.
Bezstarosti et al., Differential proteomic profiling to study the mechanism of cardiac pharmacological preconditioning by resveratrol., J. Cell. Mol. Med.
Wang et al., 2006, Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts., Biochem. Biophys. Res. Commun.
Schepers et al., 2005, HSP27 protects AML cells against VP-16-induced apoptosis through modulation of p38 and c-Jun., Exp. Hematol.

HERCEPTIN HSPB2

Interaction Score: 4.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16048908

Sources:
NCI
INTERLEUKIN-10 HSPB2

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11034403

Sources:
NCI
ETOPOSIDE PHOSPHATE HSPB2

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15911090

Sources:
NCI
PROPRANOLOL HSPB2

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11368160

Sources:
NCI
RESVERATROL HSPB2

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17125593 16759640

Sources:
NCI
TAMOXIFEN HSPB2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9607585

Sources:
NCI
CYCLOSPORINE HSPB2

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10076049

Sources:
NCI
BORTEZOMIB HSPB2

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15004512

Sources:
NCI
METHOTREXATE HSPB2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15519494

Sources:
NCI

Ensembl: ENSG00000170276
- Version: 101_38
Alternate Names:

HSPB2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

NCI: HSPB2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Kozawa et al., 2001, Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C., Arch. Biochem. Biophys.

Porter et al., 2001, Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists., J. Mol. Endocrinol.

Horman et al., 1997, Changes in the phosphorylation status of the 27 kDa heat shock protein (HSP27) associated with the modulation of growth and/or differentiation in MCF-7 cells., Cell Prolif.

Pharos: HSPB2
- Version: 01-February-2022
Alternate Names:

Heat shock protein beta-2 Gene Name

Q16082 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:

HSPB2 Gene Record

HSPB2 3316

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16048908

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11034403

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15911090

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11368160

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17125593 16759640

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9607585

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10076049

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15004512

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15519494

Sources: NCI

Ensembl: ENSG00000170276

Alternate Names: HSPB2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

NCI: HSPB2

Alternate Names:

Gene Info:

Pharos: HSPB2

Alternate Names: Heat shock protein beta-2 Gene Name Q16082 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
16048908

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11034403

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15911090

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11368160

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17125593 16759640

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9607585

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10076049

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15004512

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15519494

Sources:
NCI

Alternate Names:

HSPB2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

Heat shock protein beta-2 Gene Name

Q16082 UniProt ID

Gene Categories:

KINASE