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HSPB2 Gene Record

  • Summary
  • Interactions
  • Claims
  • HSPB2 3316

    Alternate Names:

    3316
    HEAT SHOCK PROTEIN FAMILY B (SMALL) MEMBER 2
    HSPB2
    HSP27
    Hs.78846
    LOH11CR1K
    MKBP
    602179
    5247
    ENSG00000170276
    ENSG00000254445
    OTTHUMG00000166886
    OTTHUMG00000166887
    Heat shock protein beta-2
    Q16082

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    KINASE

    Publications:

    Chauhan et al., 2004, 2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27., Apoptosis
    Yoshida et al., 2004, Methotrexate enhances prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts., Prostaglandins Leukot. Essent. Fatty Acids
    De et al., 2000, Exaggerated human monocyte IL-10 concomitant to minimal TNF-alpha induction by heat-shock protein 27 (Hsp27) suggests Hsp27 is primarily an antiinflammatory stimulus., J. Immunol.
    Beall et al., 1999, Cyclosporine-induced renal artery smooth muscle contraction is associated with increases in the phosphorylation of specific contractile regulatory proteins., Biochim. Biophys. Acta
    Ciocca et al., 1998, Heat shock proteins hsp27 and hsp70: lack of correlation with response to tamoxifen and clinical course of disease in estrogen receptor-positive metastatic breast cancer (a Southwest Oncology Group Study)., Clin. Cancer Res.
    Zhang et al., 2005, Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer., Mol. Cell Proteomics
    Kozawa et al., 2001, Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C., Arch. Biochem. Biophys.
    Bezstarosti et al., Differential proteomic profiling to study the mechanism of cardiac pharmacological preconditioning by resveratrol., J. Cell. Mol. Med.
    Wang et al., 2006, Regulation of proliferation and gene expression in cultured human aortic smooth muscle cells by resveratrol and standardized grape extracts., Biochem. Biophys. Res. Commun.
    Schepers et al., 2005, HSP27 protects AML cells against VP-16-induced apoptosis through modulation of p38 and c-Jun., Exp. Hematol.
  • HERCEPTIN   HSPB2

    Interaction Score: 4.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16048908


    Sources:
    NCI

  • INTERLEUKIN-10   HSPB2

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11034403


    Sources:
    NCI

  • ETOPOSIDE PHOSPHATE   HSPB2

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15911090


    Sources:
    NCI

  • PROPRANOLOL   HSPB2

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11368160


    Sources:
    NCI

  • RESVERATROL   HSPB2

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17125593 16759640


    Sources:
    NCI

  • TAMOXIFEN   HSPB2

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9607585


    Sources:
    NCI

  • CYCLOSPORINE   HSPB2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10076049


    Sources:
    NCI

  • BORTEZOMIB   HSPB2

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15004512


    Sources:
    NCI

  • METHOTREXATE   HSPB2

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15519494


    Sources:
    NCI

  • Ensembl: ENSG00000170276

    • Version: 101_38

    Alternate Names:
    HSPB2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: HSPB2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Kozawa et al., 2001, Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: role of protein kinase C., Arch. Biochem. Biophys.
    Porter et al., 2001, Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists., J. Mol. Endocrinol.
    Horman et al., 1997, Changes in the phosphorylation status of the 27 kDa heat shock protein (HSP27) associated with the modulation of growth and/or differentiation in MCF-7 cells., Cell Prolif.

  • Pharos: HSPB2

    • Version: 01-February-2022

    Alternate Names:
    Heat shock protein beta-2 Gene Name
    Q16082 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21