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HSPB1 Gene Record

  • Summary
  • Interactions
  • Claims
  • HSPB1 3315 Druggable Genome

    Alternate Names:

    3315
    HEAT SHOCK PROTEIN FAMILY B (SMALL) MEMBER 1
    HSPB1
    CMT2F
    HEL-S-102
    HMN2B
    HS.76067
    HSP27
    HSP28
    Hsp25
    SRP27
    602195
    5246
    ENSG00000106211
    OTTHUMG00000023228
    P04792
    HEAT SHOCK PROTEIN 27
    BE0003432
    T68517

    Gene Info:

    Target Class Miscellaneous
    Target Subclass HSP20-like_chaperon
    CancerCommons Reported Gene Name HSP27
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem
    Ohno et al., 1997, Solute composition and heat shock proteins in rat renal medulla., Pflugers Arch.
    Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem
    Kaida et al., 1999, Vasopressin stimulates the induction of heat shock protein 27 and alphaB-crystallin via protein kinase C activation in vascular smooth muscle cells., Exp. Cell Res.
    Ebert et al., 2005, Protective role of heat shock protein 27 in gastric mucosal injury., J. Pathol.
    Ravindra KC et al., 2015, Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells., Chem Res Toxicol
    Mi L et al., 2011, Identification of potential protein targets of isothiocyanates by proteomics., Chem Res Toxicol
  • APATORSEN   HSPB1

    Interaction Score: 6.89

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Reported Cancer Type Prostate
    Trial Name OGX-427
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    CancerCommons TdgClinicalTrial TTD DrugBank

  • CYROMAZINE   HSPB1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL2094499   HSPB1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL2332783   HSPB1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DICARBONODITHIOIMIDIC DIAMIDE   HSPB1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDRASTININE HYDROCHLORIDE   HSPB1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BENZENETHIOL   HSPB1

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • BUFOTENINE   HSPB1

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL333177   HSPB1

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYCLOFENIL   HSPB1

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ROFECOXIB   HSPB1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16041694


    Sources:
    NCI

  • CRIDANIMOD   HSPB1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ALPHA-TERTHIENYL   HSPB1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • RHAMNETIN   HSPB1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19296652


    Sources:
    DTC

  • HYMECROMONE   HSPB1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FEPRAZONE   HSPB1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • MOMETASONE FUROATE   HSPB1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEROXIRONE   HSPB1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • E-GUGGULSTERONE   HSPB1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • UREA   HSPB1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9094264


    Sources:
    NCI

  • ALBENDAZOLE   HSPB1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • VASOPRESSIN   HSPB1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9925748


    Sources:
    NCI

  • CHEMBL1935538   HSPB1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22435708


    Sources:
    DTC

  • BENZO(K)FLUORANTHENE   HSPB1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CLOXYQUIN   HSPB1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NOCODAZOLE   HSPB1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22435708


    Sources:
    DTC

  • ZEARALENONE   HSPB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TRIAMTERENE   HSPB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENANTHROLINE   HSPB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PHENETHYLISOTHIOCYANATE   HSPB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21838287


    Sources:
    DrugBank

  • OMEPRAZOLE   HSPB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ARTENIMOL   HSPB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    26340163


    Sources:
    DrugBank

  • QUERCETIN   HSPB1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19296652


    Sources:
    DTC

  • Ensembl: ENSG00000106211

    • Version: 101_38

    Alternate Names:
    HSPB1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P04792

    • Version: January-2014

    Alternate Names:
    HSPB1 Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass HSP20-like_chaperon

    Publications:

  • CancerCommons: HSPB1

    • Version: 25-July-2013

    Alternate Names:
    3315 Entrez Gene ID

    Gene Info:
    CancerCommons Reported Gene Name HSP27

    Publications:

  • DrugBank: BE0003432

    • Version: 5.1.7

    Alternate Names:
    HSPB1 DrugBank Gene Name
    P04792 UniProt Accession
    3315 Entrez Gene Id

    Gene Info:

    Publications:
    Ravindra KC et al., 2015, Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells., Chem Res Toxicol
    Mi L et al., 2011, Identification of potential protein targets of isothiocyanates by proteomics., Chem Res Toxicol

  • NCI: HSPB1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Kaida et al., 1999, Vasopressin stimulates the induction of heat shock protein 27 and alphaB-crystallin via protein kinase C activation in vascular smooth muscle cells., Exp. Cell Res.
    Mivechi et al., 1994, Selective expression of heat shock genes during differentiation of human myeloid leukemic cells., Leuk. Res.
    García-Bermejo et al., 1995, Modulation of HSP70 and HSP27 gene expression by the differentiation inducer sodium butyrate in U-937 human promonocytic leukemia cells., Leuk. Res.

  • DTC: HSPB1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem
    Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem

  • HingoraniCasas: ENSG00000106211

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000106211 Gene Symbol
    HSPB1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Heat shock protein 27

    • Version: 2020.06.01

    Alternate Names:
    HSP27 TTD Gene Abbreviation
    T68517 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21