DGIdb - HSPB1 Gene Record

HSPB1 3315 Druggable Genome

Alternate Names:

3315
HEAT SHOCK PROTEIN FAMILY B (SMALL) MEMBER 1
HSPB1
CMT2F
HEL-S-102
HMN2B
HS.76067
HSP27
HSP28
Hsp25
SRP27
602195
5246
ENSG00000106211
OTTHUMG00000023228
P04792
HEAT SHOCK PROTEIN 27
BE0003432
T68517

Gene Info:

Target Class	Miscellaneous
Target Subclass	HSP20-like_chaperon
CancerCommons Reported Gene Name	HSP27
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem
Ohno et al., 1997, Solute composition and heat shock proteins in rat renal medulla., Pflugers Arch.
Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem
Kaida et al., 1999, Vasopressin stimulates the induction of heat shock protein 27 and alphaB-crystallin via protein kinase C activation in vascular smooth muscle cells., Exp. Cell Res.
Ebert et al., 2005, Protective role of heat shock protein 27 in gastric mucosal injury., J. Pathol.
Ravindra KC et al., 2015, Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells., Chem Res Toxicol
Mi L et al., 2011, Identification of potential protein targets of isothiocyanates by proteomics., Chem Res Toxicol

APATORSEN HSPB1

Interaction Score: 6.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Trial Name OGX-427

Novel drug target Novel Target

PMIDs:
None found

Sources:
CancerCommons TdgClinicalTrial TTD DrugBank
CYROMAZINE HSPB1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2094499 HSPB1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2332783 HSPB1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DICARBONODITHIOIMIDIC DIAMIDE HSPB1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRASTININE HYDROCHLORIDE HSPB1

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZENETHIOL HSPB1

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BUFOTENINE HSPB1

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL333177 HSPB1

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLOFENIL HSPB1

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROFECOXIB HSPB1

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16041694

Sources:
NCI
CRIDANIMOD HSPB1

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALPHA-TERTHIENYL HSPB1

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RHAMNETIN HSPB1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19296652

Sources:
DTC
HYMECROMONE HSPB1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FEPRAZONE HSPB1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MOMETASONE FUROATE HSPB1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TEROXIRONE HSPB1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
E-GUGGULSTERONE HSPB1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
UREA HSPB1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9094264

Sources:
NCI
ALBENDAZOLE HSPB1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VASOPRESSIN HSPB1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9925748

Sources:
NCI
CHEMBL1935538 HSPB1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22435708

Sources:
DTC
BENZO(K)FLUORANTHENE HSPB1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOXYQUIN HSPB1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOCODAZOLE HSPB1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22435708

Sources:
DTC
ZEARALENONE HSPB1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE HSPB1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENANTHROLINE HSPB1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENETHYLISOTHIOCYANATE HSPB1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21838287

Sources:
DrugBank
OMEPRAZOLE HSPB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ARTENIMOL HSPB1

Interaction Score: 0.04

Interaction Types & Directionality:

ligand

Interaction Info:

PMIDs:
26340163

Sources:
DrugBank
QUERCETIN HSPB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19296652

Sources:
DTC

Ensembl: ENSG00000106211
- Version: 101_38
Alternate Names:

HSPB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P04792
- Version: January-2014
Alternate Names:

HSPB1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass HSP20-like_chaperon

Publications:
CancerCommons: HSPB1
- Version: 25-July-2013
Alternate Names:

3315 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name HSP27

Publications:

DrugBank: BE0003432

Version: 5.1.7

Alternate Names:

HSPB1 DrugBank Gene Name

P04792 UniProt Accession

3315 Entrez Gene Id

Gene Info:

Publications:

Ravindra KC et al., 2015, Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells., Chem Res Toxicol

Mi L et al., 2011, Identification of potential protein targets of isothiocyanates by proteomics., Chem Res Toxicol

NCI: HSPB1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Kaida et al., 1999, Vasopressin stimulates the induction of heat shock protein 27 and alphaB-crystallin via protein kinase C activation in vascular smooth muscle cells., Exp. Cell Res.

Mivechi et al., 1994, Selective expression of heat shock genes during differentiation of human myeloid leukemic cells., Leuk. Res.

García-Bermejo et al., 1995, Modulation of HSP70 and HSP27 gene expression by the differentiation inducer sodium butyrate in U-937 human promonocytic leukemia cells., Leuk. Res.

DTC: HSPB1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem

Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem

HingoraniCasas: ENSG00000106211
- Version: 31-May-2017
Alternate Names:

ENSG00000106211 Gene Symbol

HSPB1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Heat shock protein 27
- Version: 2020.06.01
Alternate Names:

HSP27 TTD Gene Abbreviation

T68517 TTD Target ID

Gene Info:

Publications:

Reported Cancer Type	Prostate
Trial Name	OGX-427
Novel drug target	Novel Target

HSPB1	DrugBank Gene Name
P04792	UniProt Accession
3315	Entrez Gene Id

HSPB1 Gene Record

HSPB1 3315 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Prostate Trial Name OGX-427 Novel drug target Novel Target

PMIDs: None found

Sources: CancerCommons TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16041694

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19296652

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Trial Name OGX-427

Novel drug target Novel Target

PMIDs:
None found

Sources:
CancerCommons TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16041694

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19296652

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9094264

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9925748

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22435708

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22435708

Sources:
DTC

Interaction Types & Directionality:

n/a