DGIdb - HSPB1 Gene Record

HSPB1 3315 Druggable Genome

Alternate Names:

3315
HEAT SHOCK PROTEIN FAMILY B (SMALL) MEMBER 1
HSPB1
CMT2F
HEL-S-102
HMN2B
HS.76067
HSP27
HSP28
Hsp25
SRP27
602195
5246
ENSG00000106211
OTTHUMG00000023228
P04792
HEAT SHOCK PROTEIN 27
T68517

Gene Info:

Target Class	Miscellaneous
Target Subclass	HSP20-like_chaperon
CancerCommons Reported Gene Name	HSP27
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem
Ohno et al., 1997, Solute composition and heat shock proteins in rat renal medulla., Pflugers Arch.
Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem
Kaida et al., 1999, Vasopressin stimulates the induction of heat shock protein 27 and alphaB-crystallin via protein kinase C activation in vascular smooth muscle cells., Exp. Cell Res.
Ebert et al., 2005, Protective role of heat shock protein 27 in gastric mucosal injury., J. Pathol.

APATORSEN HSPB1

Interaction Score: 6.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Trial Name OGX-427

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial CancerCommons TTD
CYROMAZINE HSPB1

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2094499 HSPB1

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL2332783 HSPB1

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DICARBONODITHIOIMIDIC DIAMIDE HSPB1

Interaction Score: 2.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HYDRASTININE HYDROCHLORIDE HSPB1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BENZENETHIOL HSPB1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BUFOTENINE HSPB1

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL333177 HSPB1

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLOFENIL HSPB1

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROFECOXIB HSPB1

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16041694

Sources:
NCI
CRIDANIMOD HSPB1

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALPHA-TERTHIENYL HSPB1

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
UREA HSPB1

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9094264

Sources:
NCI
RHAMNETIN HSPB1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19296652

Sources:
DTC
HYMECROMONE HSPB1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FEPRAZONE HSPB1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MOMETASONE FUROATE HSPB1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TEROXIRONE HSPB1

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALBENDAZOLE HSPB1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
E-GUGGULSTERONE HSPB1

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VASOPRESSIN HSPB1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9925748

Sources:
NCI
CHEMBL1935538 HSPB1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22435708

Sources:
DTC
BENZO(K)FLUORANTHENE HSPB1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CLOXYQUIN HSPB1

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NOCODAZOLE HSPB1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22435708

Sources:
DTC
ZEARALENONE HSPB1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRIAMTERENE HSPB1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PHENANTHROLINE HSPB1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OMEPRAZOLE HSPB1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUERCETIN HSPB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19296652

Sources:
DTC

Ensembl: ENSG00000106211
- Version: 101_38
Alternate Names:

HSPB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P04792
- Version: January-2014
Alternate Names:

HSPB1 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass HSP20-like_chaperon

Publications:
CancerCommons: HSPB1
- Version: 25-July-2013
Alternate Names:

3315 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name HSP27

Publications:

NCI: HSPB1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Kaida et al., 1999, Vasopressin stimulates the induction of heat shock protein 27 and alphaB-crystallin via protein kinase C activation in vascular smooth muscle cells., Exp. Cell Res.

Mivechi et al., 1994, Selective expression of heat shock genes during differentiation of human myeloid leukemic cells., Leuk. Res.

García-Bermejo et al., 1995, Modulation of HSP70 and HSP27 gene expression by the differentiation inducer sodium butyrate in U-937 human promonocytic leukemia cells., Leuk. Res.

DTC: HSPB1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Wang RE et al., 2009, Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives., J Med Chem

Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem

HingoraniCasas: ENSG00000106211
- Version: 31-May-2017
Alternate Names:

ENSG00000106211 Gene Symbol

HSPB1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Heat shock protein 27
- Version: 2020.06.01
Alternate Names:

HSP27 TTD Gene Abbreviation

T68517 TTD Target ID

Gene Info:

Publications:

Reported Cancer Type	Prostate
Trial Name	OGX-427
Novel drug target	Novel Target

HSPB1 Gene Record

HSPB1 3315 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Reported Cancer Type Prostate Trial Name OGX-427 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial CancerCommons TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16041694

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9094264

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19296652

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Reported Cancer Type Prostate

Trial Name OGX-427

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial CancerCommons TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16041694

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9094264

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
19296652

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9925748

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22435708

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22435708

Sources:
DTC

Interaction Types & Directionality:

n/a