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HSD11B1 Gene Record

  • Summary
  • Interactions
  • Claims
  • HSD11B1 3290 Druggable Genome

    Alternate Names:

    3290
    HYDROXYSTEROID 11-BETA DEHYDROGENASE 1
    HSD11B1
    11-DH
    11-beta-HSD1
    CORTRD2
    HDL
    HSD11
    HSD11B
    HSD11L
    SDR26C1
    600713
    5208
    ENSG00000117594
    OTTHUMG00000036481
    P28845
    DHI1_HUMAN
    CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1
    CORTICOSTEROID 11-BETA-DEHYDROGENASE, ISOZYME 1 (EC 1.1.1.146) (11-DH) (11-BETA-HYDROXYSTEROID DEHYDROGENASE 1) (11-BETA-HSD1). [SOURCE:UNIPROT/SWISSPROT;ACC:P28845]
    PA29476
    Corticosteroid 11-beta-dehydrogenase 1
    T65200

    Gene Info:

    Interpro Name Short-chain dehydrogenase/reductase SDR
    Interpro Short Name DH_sc/Rdtase_SDR
    Interpro Type Family
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR002198
    Human Readable Name DRUGGABLE GENOME
    Human Readable Name SHORT CHAIN DEHYDROGENASE REDUCTASE
    Target Class Enzymes
    Target Subclass EC:1.1.1.146
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    SHORT CHAIN DEHYDROGENASE REDUCTASE
    ENZYME

    Publications:

    Rollinger JM et al., 2010, 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches., Bioorg Med Chem
    Liu X et al., 2015, Associations of HSD11B1 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients with prednisone combined therapy., Drug Metab Dispos
  • CHEMBL604538   HSD11B1

    Interaction Score: 17.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20100662


    Sources:
    DTC

  • TORMENTIC ACID METHYL ESTER   HSD11B1

    Interaction Score: 17.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20100662


    Sources:
    DTC

  • GLYCYRRHIZIN   HSD11B1

    Interaction Score: 4.42

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • AZD-4017   HSD11B1

    Interaction Score: 2.94

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • URSOLIC ACID   HSD11B1

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20100662


    Sources:
    DTC

  • FLAVANONE   HSD11B1

    Interaction Score: 1.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TACROLIMUS   HSD11B1

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25587129


    Sources:
    PharmGKB

  • Ensembl: ENSG00000117594

    • Version: 101_38

    Alternate Names:
    HSD11B1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P28845

    • Version: January-2014

    Alternate Names:
    HSD11B1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.1.1.146

    Publications:

  • HopkinsGroom: P28845

    • Version: 11-September-2012

    Alternate Names:
    3290 Entrez Gene Id
    DHI1_HUMAN Uniprot Id
    ENSG00000117594 Ensembl Gene Id

    Gene Info:
    Interpro Name Short-chain dehydrogenase/reductase SDR
    Interpro Short Name DH_sc/Rdtase_SDR
    Interpro Type Family

    Gene Categories:
    DRUGGABLE GENOME, SHORT CHAIN DEHYDROGENASE REDUCTASE

    Publications:

  • RussLampel: ENSG00000117594

    • Version: 26-July-2011

    Alternate Names:
    CORTICOSTEROID 11-BETA-DEHYDROGENASE, ISOZYME 1 (EC 1.1.1.146) (11-DH) (11-BETA-HYDROXYSTEROID DEHYDROGENASE 1) (11-BETA-HSD1). [SOURCE:UNIPROT/SWISSPROT;ACC:P28845] Description
    HSD11B1 Display Id
    ENSG00000117594 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: HSD11B1

    • Version: 18-August-2020

    Alternate Names:
    PA29476 PharmGKB ID

    Gene Info:

    Publications:
    Liu X et al., 2015, Associations of HSD11B1 polymorphisms with tacrolimus concentrations in Chinese renal transplant recipients with prednisone combined therapy., Drug Metab Dispos

  • DTC: HSD11B1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Rollinger JM et al., 2010, 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches., Bioorg Med Chem

  • HingoraniCasas: ENSG00000117594

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000117594 Gene Symbol
    HSD11B1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: HSD11B1

    • Version: 19.3

    Alternate Names:
    ENSG00000117594 Ensembl Gene ID
    HSD11 Human Protein Atlas Gene Synonym
    HSD11B Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • TTD: Corticosteroid 11-beta-dehydrogenase 1

    • Version: 2020.06.01

    Alternate Names:
    HSD11B1 TTD Gene Abbreviation
    T65200 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: HSD11B1

    • Version: 01-February-2022

    Alternate Names:
    Corticosteroid 11-beta-dehydrogenase isozyme 1 Gene Name
    P28845 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21