3269 |
HISTAMINE RECEPTOR H1 |
HRH1 |
H1-R |
H1R |
HH1R |
hisH1 |
600167 |
5182 |
ENSG00000196639 |
OTTHUMG00000129719 |
P35367 |
HISTAMINE H1 RECEPTOR |
HRH1_HUMAN |
262 |
H<sub>1</sub> receptor |
NM_000861 |
NP_000852 |
HISTAMINE H1 RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P35367] |
BE0000442 |
PA29456 |
T77913 |
Interpro Acc | IPR000276 |
Uniprot Status | Swiss-Prot |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | 7TM_GPCR_Rhodpsn |
Human Readable Name | DRUGGABLE GENOME |
Interpro Name | GPCR, rhodopsin-like, 7TM |
Human Readable Name | G PROTEIN COUPLED RECEPTOR |
Interpro Type | Family |
GuideToPharmacology Gene Category Name | Histamine receptors |
GuideToPharmacology Gene Category ID | 33 |
Transmembrane Helix Count | 7 |
Target Subclass | Rhodopsin |
Target Subclass | GPCR |
Target Main Class | Receptors |
Target Class | Receptors |
Gene Biotype | PROTEIN_CODING |
G PROTEIN COUPLED RECEPTOR |
DRUGGABLE GENOME |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
Mechanism of Interaction | Histamine H1 receptor antagonist |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | True |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | Histamine H1 receptor antagonist |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | fexofenadine + ps/ |
Specific Action of the Ligand | Antagonist |
inhibitor (inhibitory) |
antagonist (inhibitory) |
Trial Name | levocetirizine dihydrochloride,Xusal, Xyzal |
Novel drug target | Established target |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | True |
antagonist (inhibitory) |
Trial Name | Azelastine |
Novel drug target | Established target |
Trial Name | azelastine hydrochloride nasal spray,Astepro |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | Histamine H1 receptor antagonist |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
Specific Action of the Ligand | Antagonist |
n/a |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Histamine H1 receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | ketotifen fumarate,Zaditen, Zaditor |
Novel drug target | Established target |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Trial Name | cetirizine HCl,Zyrtec |
Novel drug target | Established target |
Endogenous Drug? | False |
antagonist (inhibitory) |
Mechanism of Interaction | Histamine H1 receptor antagonist |
Direct Interaction | yes |
n/a |
Trial Name | vapitadine dihydrochloride,Hivenyl |
Novel drug target | Established target |
antagonist (inhibitory) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
Direct Interaction? | True |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Histamine H1 receptor antagonist |
agonist (activating) |
Trial Name | OBE101,Histalean |
Novel drug target | Established target |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
inverse agonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
Details of the Assay for Interaction | Antagonism of 5 nM [<sup>3</sup>H]mepyramine binding in an intact cell assay using U373 MG astrocytoma cells. |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Mechanism of Interaction | Histamine H1 receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Histamine H1 receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Histamine H1 receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Details of the Assay for Interaction | Radioligand displacement membrane binding assay using CHO cells expressing the human H1 receptor and [3H]pyrilamine as tracer. |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
agonist (activating) |
Mechanism of Interaction | Histamine H1 receptor agonist |
Direct Interaction | yes |