DGIdb - HPSE Gene Record

HPSE 10855 Druggable Genome

Alternate Names:

10855
HEPARANASE
HPSE
HPA
HPA1
HPR1
HPSE1
HSE1
604724
5164
ENSG00000173083
OTTHUMG00000130425
HEPARANASE-1
ENDO-GLUCORONIDASE
HEPARANASE 50 KDA SUBUNIT
HEPARANASE 8 KDA SUBUNIT
HEP
Q9Y251
T47623

Gene Info:

Target Class	Enzymes
Target Subclass	EC:3.2.-.-
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Gozalbes R et al., 2013, Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches., Bioorg Med Chem
Benezra et al., 1992, Thrombin enhances degradation of heparan sulfate in the extracellular matrix by tumor cell heparanase., Exp. Cell Res.

AMOPYROQUINE HPSE

Interaction Score: 9.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23415087

Sources:
DTC
AMODIAQUINE HYDROCHLORIDE HPSE

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23415087

Sources:
DTC
NARINGIN HPSE

Interaction Score: 3.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23415087

Sources:
DTC
CHEMBL375673 HPSE

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23415087

Sources:
DTC
HESPERIDIN HPSE

Interaction Score: 1.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23415087

Sources:
DTC
REL-CISAPRIDE HPSE

Interaction Score: 1.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23415087

Sources:
DTC
METERGOLINE HPSE

Interaction Score: 1.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23415087

Sources:
DTC
MUPARFOSTAT HPSE

Interaction Score: 0.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Heparanase inhibitor

Trial Name Muparfostat

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
LABETALOL HPSE

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23415087

Sources:
DTC
ASTEMIZOLE HPSE

Interaction Score: 0.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23415087

Sources:
DTC
THROMBIN HPSE

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1612123

Sources:
NCI
HEPARIN HPSE

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name M118

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SURAMIN HPSE

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000173083
- Version: 101_38
Alternate Names:

HPSE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q9Y251
- Version: January-2014
Alternate Names:

HPSE Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.2.-.-

Publications:

NCI: HPSE

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Elkin et al., 2003, Regulation of heparanase gene expression by estrogen in breast cancer., Cancer Res.

Xu et al., 2007, In vivo and in vitro degradation of heparan sulfate (HS) proteoglycans by HPR1 in pancreatic adenocarcinomas. Loss of cell surface HS suppresses fibroblast growth factor 2-mediated cell signaling and proliferation., J. Biol. Chem.

Wang et al., 1985, Characterization of extracellular matrix-associated glycosaminoglycans produced by untransformed and transformed bovine corneal endothelial cells in culture., Eur. J. Biochem.

DTC: HPSE
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Gozalbes R et al., 2013, Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches., Bioorg Med Chem
HingoraniCasas: ENSG00000173083
- Version: 31-May-2017
Alternate Names:

ENSG00000173083 Gene Symbol

HPSE Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: HEP
- Version: chembl_23
Alternate Names:

HPA GENE_SYMBOL

HPA1 GENE_SYMBOL

HPR1 GENE_SYMBOL

Gene Info:

Publications:
TTD: Heparanase
- Version: 2020.06.01
Alternate Names:

HPSE TTD Gene Abbreviation

T47623 TTD Target ID

Gene Info:

Publications:
Pharos: HPSE
- Version: 01-February-2022
Alternate Names:

Heparanase Gene Name

Q9Y251 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Direct Interaction	yes
Mechanism of Interaction	Heparanase inhibitor
Trial Name	Muparfostat

Trial Name	M118
Novel drug target	Established target

HPSE Gene Record

HPSE 10855 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23415087

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23415087

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23415087

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23415087

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23415087

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23415087

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23415087

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Heparanase inhibitor Trial Name Muparfostat

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23415087

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23415087

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1612123

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Trial Name M118 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Ensembl: ENSG00000173083

Alternate Names: HPSE Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q9Y251

Alternate Names: HPSE Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:3.2.-.-

Publications:

NCI: HPSE

Alternate Names:

Gene Info:

DTC: HPSE

Alternate Names:

Gene Info:

Publications: Gozalbes R et al., 2013, Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches., Bioorg Med Chem

HingoraniCasas: ENSG00000173083

Alternate Names: ENSG00000173083 Gene Symbol HPSE Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: HEP

Alternate Names: HPA GENE_SYMBOL HPA1 GENE_SYMBOL HPR1 GENE_SYMBOL

Interaction Types & Directionality:

n/a

PMIDs:
23415087

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23415087

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23415087

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23415087

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23415087

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23415087

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23415087

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Heparanase inhibitor

Trial Name Muparfostat

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
23415087

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23415087

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
1612123

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name M118

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

HPSE Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

HPSE Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:3.2.-.-

Publications:

Gozalbes R et al., 2013, Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches., Bioorg Med Chem

Alternate Names:

ENSG00000173083 Gene Symbol

HPSE Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

HPA GENE_SYMBOL

HPA1 GENE_SYMBOL

HPR1 GENE_SYMBOL

Alternate Names:

HPSE TTD Gene Abbreviation

T47623 TTD Target ID

Alternate Names:

Heparanase Gene Name

Q9Y251 UniProt ID

Gene Categories:

ENZYME