• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

HNMT Gene Record

  • Summary
  • Interactions
  • Claims
  • HNMT 3176 Druggable Genome

    Alternate Names:

    3176
    HISTAMINE N-METHYLTRANSFERASE
    HNMT
    HMT
    HNMT-S1
    HNMT-S2
    MRT51
    605238
    5028
    ENSG00000150540
    OTTHUMG00000131751
    P50135
    PA190
    T17448

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Michaelis S et al., 2012, Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2)., J Med Chem
    Yokoyama et al., 2007, Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice., Eur. J. Pharmacol.
    Barth et al., 1975, Effect of amodiaquine on gastric histamine methyltransferase and on histamine-stimulated gastric secretion., Br. J. Pharmacol.
    Nowak et al., 1980, Effect of amodiaquine on histamine level and histamine-methyltransferase activity in the rat brain., Arch. Immunol. Ther. Exp. (Warsz.)
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Kim SH et al., 2009, Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria., Allergy
  • AMODIAQUINE   HNMT

    Interaction Score: 12.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17222819 1203620 6789797 11752352


    Sources:
    TTD

  • METOPRINE   HNMT

    Interaction Score: 8.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    TTD

  • DABIGATRAN   HNMT

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22494098


    Sources:
    DTC

  • DIPHENHYDRAMINE   HNMT

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ASPIRIN   HNMT

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19178400


    Sources:
    PharmGKB

  • Ensembl: ENSG00000150540

    • Version: 101_38

    Alternate Names:
    HNMT Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: HNMT

    • Version: 18-August-2020

    Alternate Names:
    PA190 PharmGKB ID

    Gene Info:

    Publications:
    Kim SH et al., 2009, Histamine N-methyltransferase 939A>G polymorphism affects mRNA stability in patients with acetylsalicylic acid-intolerant chronic urticaria., Allergy
    Visscher H et al., 2013, Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children., Pediatr Blood Cancer
    Visscher H et al., 2012, Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children., J Clin Oncol

  • DTC: HNMT

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Michaelis S et al., 2012, Dabigatran and dabigatran ethyl ester: potent inhibitors of ribosyldihydronicotinamide dehydrogenase (NQO2)., J Med Chem

  • HingoraniCasas: ENSG00000150540

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000150540 Gene Symbol
    HNMT Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: HNMT

    • Version: 19.3

    Alternate Names:
    ENSG00000150540 Ensembl Gene ID
    Histamine N-methyltransferase Human Protein Atlas Gene Description
    P50135 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • TTD: Histamine N-methyltransferase

    • Version: 2020.06.01

    Alternate Names:
    HNMT TTD Gene Abbreviation
    T17448 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: HNMT

    • Version: 01-February-2022

    Alternate Names:
    Histamine N-methyltransferase Gene Name
    P50135 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21